P31152
SS
Gene name |
MAPK4 (ERK4, PRKM4) |
Protein name |
Mitogen-activated protein kinase 4 |
Names |
MAP kinase 4 , MAPK 4 , EC 2.7.11.24 , Extracellular signal-regulated kinase 4 , ERK-4 , MAP kinase isoform p63 , p63-MAPK |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5596 |
EC number |
2.7.11.-: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
MAPK1 encodes Mitogen-activated protein kinase 1, and is involved in diverse cellular responses by phosphorylating cytoplasmic and nuclear proteins. Unlike other MAP kinases, MAPK1 activates via dual phosphorylation of Thr-186 and Tyr-193 within the activation lip, and mutations at Q105 alone were sufficient for autoactivation. Additionally, in the inactive form, L76, Q10 and I87 form a structural unit that restrains intramolecular autophosphorylation by preventing interactions between activation lip residues and the catalytic base (D149) needed for phosphoryl transfer. Mutations at L76, I87 and additionally S153 increased basal specific activity via autophosphorylation of Thr-186 and Tyr-193.
Autoinhibitory domains (AIDs)
Target domain |
20-312 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
167-193 (Activation loop from InterPro)
Target domain |
20-312 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
167-193 (Activation loop from InterPro)
Target domain |
20-312 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Emrick MA et al. (2006) "The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity", Proceedings of the National Academy of Sciences of the United States of America, 103, 18101-6
- Emrick MA et al. (2001) "Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations", The Journal of biological chemistry, 276, 46469-79
Autoinhibited structure
Activated structure
1 structures for P31152
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P31152-F1 | Predicted | AlphaFoldDB |
506 variants for P31152
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
COSM473900 CA402510890 rs1309062743 |
2 | A>T | kidney Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA8964217 rs749775353 |
3 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs572593041 CA8964219 |
5 | G>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8964220 rs748473611 |
6 | D>A | No |
ClinGen ExAC gnomAD |
|
|
CA402510933 rs1406034662 |
8 | I>T | No |
ClinGen TOPMed |
|
|
CA8964221 rs772545058 |
8 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs541638701 CA8964223 |
10 | S>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1042753382 CA300449525 |
10 | S>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1042753382 CA300449524 |
10 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
CA402510943 rs541638701 |
10 | S>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1402455259 CA402510965 |
13 | G>E | No |
ClinGen gnomAD |
|
|
rs1265554205 CA402510963 |
13 | G>R | No |
ClinGen Ensembl |
|
|
CA402510967 rs1402455259 |
13 | G>V | No |
ClinGen gnomAD |
|
|
rs765272318 CA8964227 |
15 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759503690 CA8964226 |
15 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs34207571 CA8964230 |
17 | G>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs374524649 CA8964229 |
17 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA402510992 rs1237683118 |
18 | G>R | No |
ClinGen gnomAD |
|
|
rs750579920 CA8964231 |
19 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA8964232 rs536389282 |
19 | R>H | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 22 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs959869255 CA300449526 |
27 | G>D | No |
ClinGen TOPMed |
|
|
rs755417970 CA8964235 |
29 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs1158452814 CA402511072 |
30 | V>A | No |
ClinGen gnomAD |
|
|
CA8964236 rs779378577 |
30 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA402511078 rs1289362577 |
31 | N>S | No |
ClinGen TOPMed |
|
|
CA402511091 rs1422015306 |
33 | L>S | No |
ClinGen gnomAD |
|
|
rs748756367 CA8964237 |
34 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs772293615 CA8964239 |
36 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1598884005 CA402511118 |
38 | V>G | No |
ClinGen Ensembl |
|
|
CA402511116 rs3752087 |
38 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA8964242 rs3752087 VAR_042254 |
38 | V>M | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA8964243 rs770735277 |
39 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs199879399 CA8964245 |
41 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA8964244 rs776211637 |
41 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402511142 rs1224428573 |
42 | A>V | No |
ClinGen gnomAD |
|
|
rs775288765 CA8964247 |
43 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA8964248 rs762992386 |
44 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA300449528 rs920644770 |
44 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA402511168 rs1598884079 |
46 | V>G | No |
ClinGen Ensembl |
|
|
CA8964250 rs367684848 |
47 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1191684708 CA402511172 |
47 | A>V | No |
ClinGen TOPMed |
|
|
CA8964251 rs760849669 |
48 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs760849669 CA402511174 |
48 | V>M | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 49 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8964252 rs532114080 |
50 | K>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs140972647 CA8964253 |
52 | A>D | No |
ClinGen ExAC gnomAD |
|
|
rs140972647 CA300449529 |
52 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA8964256 rs61747609 |
55 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8964258 rs565759866 |
56 | A>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA402511225 rs1378385642 |
56 | A>S | No |
ClinGen gnomAD |
|
|
rs369990219 CA8964259 |
57 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs373566179 CA8964260 |
57 | R>H | Variant assessed as Somatic; 0.0001864 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1229998825 CA402511235 |
58 | S>G | No |
ClinGen gnomAD |
|
|
CA300449531 rs559455057 |
58 | S>I | No |
ClinGen Ensembl |
|
|
rs1370440592 CA402511262 |
61 | H>R | No |
ClinGen TOPMed |
|
|
rs1204026862 CA402511268 |
62 | A>T | No |
ClinGen gnomAD |
|
|
rs745586840 CA8964262 |
62 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA8964264 COSM4153985 rs372835108 |
64 | R>* | kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs762751290 CA8964265 |
64 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1445721545 CA402511299 |
67 | K>R | No |
ClinGen gnomAD |
|
|
rs1176611427 CA402511314 |
69 | I>S | No |
ClinGen TOPMed |
|
|
CA8964266 rs768671292 |
69 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs761581511 CA402511318 |
70 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761581511 CA8964268 |
70 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA8964267 rs200603915 |
70 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA8964269 rs767365680 |
71 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs754028426 CA8964270 |
71 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs754028426 CA402511321 |
71 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402511349 rs1360934897 |
75 | D>E | No |
ClinGen gnomAD |
|
|
CA8964273 rs752849769 |
75 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs758762362 CA402511357 |
76 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1259782608 CA402511355 COSM709396 |
76 | N>S | lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA8964276 rs764672737 |
78 | V>I | Variant assessed as Somatic; 4.662e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA8964277 rs752066432 |
79 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs1040441186 CA300449536 |
80 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs757694990 CA8964278 |
81 | Y>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402511384 rs1262531603 |
81 | Y>H | No |
ClinGen gnomAD |
|
|
rs755853041 CA8964281 |
82 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA402511390 COSM1719459 rs745497107 |
82 | E>K | NS [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA8964280 rs745497107 |
82 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA300449537 rs905689204 |
83 | V>L | No |
ClinGen TOPMed |
|
|
rs779393411 CA8964282 |
84 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA402511408 rs1474431030 |
85 | G>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1479229970 CA402511409 |
85 | G>D | No |
ClinGen gnomAD |
|
|
rs1474431030 CA402511406 |
85 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1352655359 CA402511434 |
89 | T>A | No |
ClinGen TOPMed |
|
|
rs774339790 CA8964285 |
90 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402511452 rs1315697641 |
92 | Q>* | No |
ClinGen gnomAD |
|
|
rs1027949763 CA300449538 |
93 | G>S | No |
ClinGen TOPMed |
|
|
rs1294730849 CA402511473 |
95 | L>Q | No |
ClinGen gnomAD |
|
|
CA300449540 rs950749935 |
96 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA402511490 rs1299763767 |
97 | K>N | No |
ClinGen gnomAD |
|
|
rs886982579 CA300449541 |
99 | S>C | No |
ClinGen gnomAD |
|
|
rs886982579 CA402511500 |
99 | S>G | No |
ClinGen gnomAD |
|
|
COSM438188 rs199714690 CA8964288 |
100 | V>M | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs556250636 CA8964289 |
101 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1598884577 CA402511524 |
103 | I>L | No |
ClinGen Ensembl |
|
|
COSM563769 CA8964292 rs763078166 |
104 | V>I | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1484460760 CA402511540 |
105 | Q>R | No |
ClinGen TOPMed |
|
|
CA402511548 rs1265734803 |
106 | E>G | No |
ClinGen gnomAD |
|
|
rs1205047488 CA402511564 |
108 | M>T | No |
ClinGen TOPMed |
|
|
rs757891465 CA8964295 |
109 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1243889116 CA402511585 |
111 | D>G | No |
ClinGen TOPMed |
|
|
CA8964297 rs200812352 |
111 | D>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA8964298 rs755657525 |
112 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA8964299 rs186595195 |
114 | R>C | Variant assessed as Somatic; 4.723e-05 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs541494122 CA8964300 |
114 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs541494122 CA402511602 |
114 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 116 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA300449544 rs906983934 |
119 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
CA8964303 rs376833028 |
120 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1350074631 CA402511662 |
124 | E>G | No |
ClinGen gnomAD |
|
|
rs777398945 CA8964306 |
127 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402511705 rs1268558083 |
130 | M>I | No |
ClinGen gnomAD |
|
|
rs775778917 CA8964308 |
130 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs990376602 CA300449545 |
132 | Q>K | No |
ClinGen Ensembl |
|
|
rs1452931608 CA402511728 |
134 | L>I | No |
ClinGen gnomAD |
|
|
rs375617264 CA8964310 |
135 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8964312 rs762370225 |
136 | G>R | No |
ClinGen ExAC |
|
|
CA300449546 rs895465186 |
138 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1419067905 CA402511767 |
140 | I>N | No |
ClinGen gnomAD |
|
|
rs761093842 CA8964315 |
140 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA8964316 rs766691554 |
142 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA402511785 COSM1725117 rs754605852 |
143 | A>S | liver [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA8964318 rs754605852 |
143 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs752206576 CA8964321 |
145 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1166485386 CA402511843 |
152 | P>T | No |
ClinGen gnomAD |
|
|
rs201642307 CA8964322 |
153 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs371208782 CA300449549 |
155 | I>M | No |
ClinGen ESP gnomAD |
|
|
rs777672526 CA8964323 |
155 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1271844815 CA402511902 |
160 | E>G | No |
ClinGen gnomAD |
|
|
CA402511909 rs770730467 |
161 | D>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8964325 rs770730467 |
161 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402511919 rs376363938 |
163 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8964327 rs376363938 |
163 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1188194409 CA402511924 |
164 | L>I | No |
ClinGen gnomAD |
|
|
rs375005333 CA8964329 |
167 | G>E | No |
ClinGen ESP ExAC |
|
|
CA8964331 rs772337922 |
170 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA300449550 rs909222744 |
171 | L>S | No |
ClinGen Ensembl |
|
|
CA8964334 rs766712842 |
175 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA8964333 rs761132815 |
175 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA402512026 rs1197869642 |
179 | Y>H | No |
ClinGen TOPMed |
|
|
CA402512033 rs1268146326 |
180 | S>T | No |
ClinGen TOPMed |
|
|
rs942036831 CA300449551 |
181 | H>L | No |
ClinGen Ensembl |
|
|
rs1230173093 CA402512039 |
181 | H>N | No |
ClinGen gnomAD |
|
|
rs759161909 CA8964336 |
182 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1484980462 CA402512049 |
182 | K>R | No |
ClinGen TOPMed |
|
|
rs762644192 CA8964359 |
184 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA402443258 rs763546618 |
188 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA8964361 rs763546618 |
188 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA8964360 rs763546618 |
188 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA402443265 rs1379475152 |
189 | L>F | No |
ClinGen gnomAD |
|
|
CA402443259 rs1176842081 |
189 | L>M | No |
ClinGen gnomAD |
|
|
rs1192529503 CA402443275 |
191 | T>K | No |
ClinGen gnomAD |
|
|
rs1300064098 CA402443279 |
192 | K>E | No |
ClinGen TOPMed |
|
|
CA402443282 rs1395594119 |
192 | K>R | No |
ClinGen gnomAD |
|
|
rs757155966 CA8964362 |
194 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
rs532503517 CA8964363 |
195 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750434954 CA8964364 |
195 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8964368 rs758722448 |
198 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA300035691 rs758722448 |
198 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777838970 CA8964369 |
198 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs747073199 CA8964370 |
202 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747073199 CA8964371 |
202 | S>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8964372 rs776998927 |
203 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs374923849 CA8964373 |
204 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8964374 rs374923849 |
204 | N>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA402443411 rs1355834781 |
207 | T>S | No |
ClinGen gnomAD |
|
|
rs775856107 CA8964375 |
209 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs926401405 CA300035730 |
211 | D>N | No |
ClinGen gnomAD |
|
| TCGA novel | 211 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs368403152 CA8964378 |
212 | M>I | No |
ClinGen ESP ExAC gnomAD |
|
|
rs773858770 CA8964380 |
215 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA8964382 rs767125390 |
216 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA402443525 rs1342845897 |
217 | C>R | No |
ClinGen TOPMed |
|
| TCGA novel | 220 | A>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs201585776 CA8964384 COSM215742 |
224 | T>M | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
| TCGA novel | 227 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 229 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1598947380 CA402443672 |
229 | F>S | No |
ClinGen Ensembl |
|
|
CA300041154 rs865958659 |
231 | G>E | No |
ClinGen Ensembl |
|
|
rs927271474 CA300041178 |
232 | A>S | No |
ClinGen TOPMed |
|
|
rs1598956986 CA402445254 |
232 | A>V | No |
ClinGen Ensembl |
|
|
CA300041182 rs751114736 |
233 | H>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA402445272 rs1229809789 |
234 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA402445295 rs1194333980 |
236 | E>K | No |
ClinGen TOPMed |
|
|
rs1316264789 CA402445344 CA402445340 |
238 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
CA402445391 rs1258743379 |
242 | L>P | No |
ClinGen gnomAD |
|
|
rs1459157933 CA402445409 |
243 | E>D | No |
ClinGen gnomAD |
|
|
CA8964402 rs554696722 |
247 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA402445476 rs1183929480 |
248 | I>S | No |
ClinGen TOPMed gnomAD |
|
|
CA402445474 rs1183929480 |
248 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA8964404 rs369281315 |
249 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs375703786 CA8964403 |
249 | R>W | No |
ClinGen ESP ExAC gnomAD |
|
|
CA8964405 rs753884087 |
250 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA8964406 rs759399423 |
251 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs751707902 CA8964409 |
254 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765118542 CA8964407 |
254 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs267605202 CA300041263 |
255 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA8964410 rs781093343 |
257 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402445596 rs781093343 |
257 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750506974 CA8964411 |
258 | R>K | No |
ClinGen ExAC gnomAD |
|
|
rs1005469240 CA300041274 |
260 | M>T | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 262 | S>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8964413 rs780530095 |
263 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs1040505157 CA300041293 |
264 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
CA300041299 rs561889001 |
266 | S>C | No |
ClinGen 1000Genomes |
|
|
CA402445714 rs1278052081 |
267 | T>A | No |
ClinGen gnomAD |
|
|
CA402445721 rs1473394621 |
267 | T>I | No |
ClinGen TOPMed |
|
|
CA402445724 rs1370302548 |
268 | W>R | No |
ClinGen TOPMed |
|
|
CA402445756 rs1598957311 |
270 | V>G | No |
ClinGen Ensembl |
|
|
CA300041301 rs144944694 |
271 | K>R | No |
ClinGen Ensembl |
|
|
CA8964414 rs749864708 |
272 | R>K | No |
ClinGen ExAC gnomAD |
|
|
CA8964415 rs768874032 |
275 | R>C | Variant assessed as Somatic; 0.0001398 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA8964416 rs779386468 |
275 | R>H | Variant assessed as Somatic; 4.659e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA8964417 rs747712489 |
276 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA402445842 rs1568098065 |
279 | P>L | No |
ClinGen Ensembl |
|
|
CA8964419 rs200724420 |
283 | S>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA402446113 rs1350754149 |
286 | I>V | No |
ClinGen gnomAD |
|
|
CA402446120 rs1289895947 |
287 | D>N | No |
ClinGen gnomAD |
|
|
rs777563467 CA8964436 |
287 | D>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1376773153 CA402446142 |
290 | E>G | No |
ClinGen TOPMed gnomAD |
|
|
CA402446150 rs371938450 |
291 | K>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs371938450 CA8964438 |
291 | K>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs374522930 CA8964439 |
293 | L>M | No |
ClinGen ESP ExAC gnomAD |
|
|
rs762228429 CA300044287 |
297 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
rs762228429 CA402446188 |
297 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs762228429 CA402446187 |
297 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
CA300044295 rs267605203 |
300 | R>C | Variant assessed as Somatic; 0.0002319 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1196170573 CA402446213 |
300 | R>H | No |
ClinGen gnomAD |
|
|
rs769776274 CA8964441 |
305 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs745753582 CA8964440 |
305 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402446276 rs1180443921 |
310 | P>H | No |
ClinGen gnomAD |
|
|
rs1180443921 CA402446278 |
310 | P>L | No |
ClinGen gnomAD |
|
|
rs775090015 CA8964442 |
312 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402446288 rs1333933438 |
312 | M>V | No |
ClinGen TOPMed |
|
|
rs183692158 CA8964445 |
317 | C>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs753916970 CA8964448 |
321 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755379765 CA8964449 |
326 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402446430 rs1407432002 |
327 | P>L | No |
ClinGen TOPMed |
|
|
rs1357972254 CA402446438 |
328 | F>S | No |
ClinGen gnomAD |
|
|
rs753210882 CA8964451 |
329 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA402446444 rs753210882 |
329 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs758758015 CA8964452 |
329 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs1158475696 CA402446515 |
335 | D>A | No |
ClinGen TOPMed |
|
|
CA402446517 rs371446025 |
335 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201688372 CA8964453 |
335 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs757002674 CA8964455 |
336 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA8964456 rs780784133 |
338 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs1023559689 CA402446543 |
338 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
CA300044449 COSM1734644 rs1023559689 |
338 | V>M | Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA8964457 rs199859025 |
340 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8964459 rs775496825 |
342 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA8964460 rs749227781 COSM1523762 |
345 | S>R | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA402446637 rs768420694 CA8964461 |
346 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 349 | N>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs368928539 CA300044490 |
349 | N>T | No |
ClinGen ESP TOPMed |
|
|
rs1277174119 CA402446680 |
350 | W>C | No |
ClinGen gnomAD |
|
|
rs1240720505 CA402446691 |
351 | D>E | No |
ClinGen TOPMed |
|
|
rs776771680 CA8964465 |
352 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs186466272 CA8964466 |
352 | T>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs186466272 CA300044513 |
352 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs758995326 CA8964469 |
353 | C>R | No |
ClinGen ExAC gnomAD |
|
|
rs376409655 CA300044556 |
354 | S>C | No |
ClinGen TOPMed |
|
|
CA402446729 rs1343755237 |
355 | S>Y | No |
ClinGen TOPMed |
|
|
rs963266480 CA300047310 |
358 | P>A | No |
ClinGen gnomAD |
|
|
rs963266480 CA402446943 |
358 | P>T | No |
ClinGen gnomAD |
|
|
CA300047311 rs751428718 |
359 | V>L | No |
ClinGen gnomAD |
|
|
rs750072736 CA8964492 |
360 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA402446963 rs1386835561 |
360 | S>R | No |
ClinGen gnomAD |
|
|
rs755747467 CA8964493 |
361 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1426858848 COSM1480365 CA402446980 |
363 | S>L | Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA402446993 rs1309636778 |
365 | L>R | No |
ClinGen gnomAD |
|
|
rs1263887552 CA402447013 |
368 | R>Q | No |
ClinGen gnomAD |
|
|
COSM988880 CA402447012 rs774005634 |
368 | R>W | Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs753357393 CA8964495 |
370 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8964497 rs3752089 VAR_042255 |
371 | R>P | No |
ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
CA8964498 rs3752089 |
371 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8964496 rs754538065 |
371 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA8964500 rs777450496 |
372 | C>W | No |
ClinGen ExAC gnomAD |
|
|
CA8964499 rs771831359 |
372 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1381237624 CA402447039 |
373 | Q>* | No |
ClinGen gnomAD |
|
|
CA300047361 rs554214382 |
375 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA402447070 rs1223603219 |
377 | E>G | No |
ClinGen TOPMed |
|
| TCGA novel | 377 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs769911478 CA8964502 |
378 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA402447083 rs775584394 |
379 | Q>L | No |
ClinGen ExAC gnomAD |
|
|
CA8964503 rs775584394 |
379 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs532854587 CA8964504 |
380 | R>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs768923919 CA8964505 |
380 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA402447103 rs1331946854 |
382 | P>L | No |
ClinGen gnomAD |
|
|
CA402447102 rs1331946854 |
382 | P>R | No |
ClinGen gnomAD |
|
|
rs1226375797 CA402447110 |
384 | A>T | No |
ClinGen gnomAD |
|
|
CA402447118 rs1321306497 |
385 | G>C | No |
ClinGen gnomAD |
|
| TCGA novel | 388 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs760312632 CA402447170 |
393 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760312632 CA8964511 |
393 | V>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750789115 CA8964510 |
393 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402447196 rs753551722 |
397 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs753551722 CA8964513 |
397 | P>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs764772500 COSM189595 CA8964515 |
398 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA8964516 rs752580397 |
398 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA402447201 rs752580397 |
398 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA8964518 rs777557048 |
400 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA402447214 rs1343672832 |
400 | D>V | No |
ClinGen TOPMed |
|
|
rs755536587 CA8964522 |
402 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
CA300047505 rs199532611 |
403 | S>C | No |
ClinGen Ensembl |
|
|
rs780137571 CA8964523 |
404 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8964524 rs546684210 |
405 | S>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA8964525 rs546684210 |
405 | S>P | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA8964527 rs559848519 |
406 | E>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA402447248 rs774597846 |
406 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA8964526 rs774597846 |
406 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA8964528 rs772465108 |
407 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs935581904 CA300047619 |
407 | R>L | No |
ClinGen Ensembl |
|
|
CA402447277 rs1208651431 |
410 | E>D | No |
ClinGen gnomAD |
|
|
CA402447271 rs1408840127 |
410 | E>K | No |
ClinGen gnomAD |
|
|
CA402447285 rs1480106782 |
411 | Q>H | No |
ClinGen TOPMed |
|
|
CA8964529 rs773824081 |
412 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402447291 rs773824081 |
412 | S>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8964531 rs766804571 |
413 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402447300 rs1241191743 |
414 | S>P | No |
ClinGen TOPMed |
|
|
rs1477320598 CA402447305 |
415 | S>T | No |
ClinGen gnomAD |
|
|
CA402447321 rs1270486766 |
416 | M>I | No |
ClinGen TOPMed |
|
|
rs528858237 CA402447315 |
416 | M>L | No |
ClinGen 1000Genomes gnomAD |
|
|
CA8964533 rs759208387 |
416 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs528858237 CA300047636 |
416 | M>V | No |
ClinGen 1000Genomes gnomAD |
|
|
CA8964534 rs764684614 |
418 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1359730408 CA402447344 |
418 | R>H | No |
ClinGen gnomAD |
|
|
rs758297008 CA8964536 |
419 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA402447350 rs1296157254 |
419 | A>T | No |
ClinGen gnomAD |
|
|
rs1399649402 CA402447361 |
420 | F>V | No |
ClinGen gnomAD |
|
|
rs763925644 CA8964537 |
423 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1217606297 CA402447412 |
424 | Y>C | No |
ClinGen gnomAD |
|
|
rs751581034 CA8964538 |
424 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA8964540 rs781183183 |
425 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1284356652 CA402447430 |
426 | R>C | No |
ClinGen gnomAD |
|
| TCGA novel | 426 | R>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 427 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 427 | S>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs755284302 CA8964542 |
429 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA402447491 rs1190195622 |
431 | K>R | No |
ClinGen gnomAD |
|
|
CA300047694 rs867298401 |
434 | S>L | No |
ClinGen TOPMed gnomAD |
|
|
rs747597763 CA8964547 |
436 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201371342 CA402447578 CA8964548 |
439 | D>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs777010622 CA300047720 |
440 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA402447587 rs1347244750 |
440 | K>R | No |
ClinGen gnomAD |
|
|
CA402447627 rs1406765113 |
444 | R>H | No |
ClinGen TOPMed |
|
|
rs764881429 CA8964551 |
445 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs867334063 CA300047726 |
445 | D>N | No |
ClinGen Ensembl |
|
|
CA8964552 rs202060655 |
446 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1285906945 CA402447658 |
447 | K>R | No |
ClinGen gnomAD |
|
|
CA8964553 rs371041289 |
448 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA300047770 rs371041289 |
448 | P>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA402447672 rs371041289 |
448 | P>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8964554 rs763702680 |
449 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA300047771 rs1045622449 |
449 | H>Y | No |
ClinGen TOPMed |
|
|
CA300047791 rs867616899 CA300047782 |
450 | H>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA402447689 rs1469729608 |
450 | H>Y | No |
ClinGen gnomAD |
|
| TCGA novel | 451 | Y>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1461115239 CA402447706 |
451 | Y>C | No |
ClinGen TOPMed |
|
|
CA300047818 rs751431559 |
452 | S>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751431559 CA8964555 |
452 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402447717 rs751431559 |
452 | S>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8964557 rs767382743 |
455 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402447791 CA402447789 rs1403838720 |
459 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
rs887662159 CA300047827 |
459 | D>H | No |
ClinGen TOPMed |
|
|
CA300047834 rs867304442 |
463 | W>* | No |
ClinGen Ensembl |
|
|
CA402447848 rs1313128780 |
465 | Q>* | No |
ClinGen TOPMed |
|
|
rs1451691594 CA402447858 |
465 | Q>H | No |
ClinGen TOPMed |
|
|
CA402447854 rs1286170217 |
465 | Q>R | No |
ClinGen Ensembl |
|
|
rs1443679870 CA402447868 COSM4131008 |
466 | A>E | thyroid [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs1395319571 CA402447862 |
466 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1443679870 CA402447871 |
466 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs779269473 CA402447902 |
469 | A>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779269473 CA8964560 |
469 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA8964561 rs752999098 |
470 | P>H | No |
ClinGen ExAC gnomAD |
|
|
CA402447909 rs752999098 |
470 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA300047880 rs1006217417 |
470 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA8964562 rs566180692 |
471 | P>H | No |
ClinGen ExAC gnomAD |
|
|
rs1273189801 CA402447915 |
471 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA8964563 rs777927956 |
472 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1438377046 CA402447930 |
473 | A>S | No |
ClinGen gnomAD |
|
|
CA8964564 rs747432926 |
473 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA300047957 rs539499065 |
475 | G>E | No |
ClinGen 1000Genomes |
|
|
rs1347123605 CA402447966 |
477 | A>P | No |
ClinGen gnomAD |
|
|
rs1463072484 CA402447985 |
478 | D>A | No |
ClinGen TOPMed gnomAD |
|
|
CA402447983 rs1418921128 |
478 | D>N | No |
ClinGen gnomAD |
|
|
CA402448000 rs1030394148 |
479 | T>K | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 479 | T>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1030394148 CA300047985 |
479 | T>R | No |
ClinGen TOPMed gnomAD |
|
|
CA402448019 rs1383783696 |
481 | A>G | No |
ClinGen TOPMed |
|
|
CA402448027 rs1392499285 |
482 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1331242961 CA402448037 |
483 | E>K | No |
ClinGen gnomAD |
|
| TCGA novel | 485 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs746218319 CA8964567 |
485 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746218319 CA402448059 |
485 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA300048025 rs867565788 |
487 | A>D | No |
ClinGen Ensembl |
|
|
rs775093065 CA8964569 |
489 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1568102986 CA402448120 |
490 | F>L | No |
ClinGen Ensembl |
|
|
rs1216233572 CA402448160 |
493 | I>T | No |
ClinGen gnomAD |
|
|
CA402448166 rs1256899214 |
494 | A>T | No |
ClinGen gnomAD |
|
|
rs1339951700 CA402448173 |
494 | A>V | No |
ClinGen gnomAD |
|
|
CA402448224 rs1276173026 |
499 | S>G | No |
ClinGen gnomAD |
|
|
rs866384416 CA300048036 |
502 | G>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1273519953 CA402448274 |
503 | G>A | No |
ClinGen Ensembl |
|
|
rs1394810630 CA402448289 |
505 | E>Q | No |
ClinGen gnomAD |
|
|
rs1258451369 CA402448303 |
506 | H>D | No |
ClinGen TOPMed gnomAD |
|
|
rs866724311 CA300048043 |
506 | H>Q | No |
ClinGen TOPMed |
|
|
CA402448304 rs1258451369 |
506 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs1191534606 CA402448328 |
507 | A>V | No |
ClinGen gnomAD |
|
|
rs1372606225 CA402448335 |
508 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1372606225 CA402448337 |
508 | S>T | No |
ClinGen TOPMed gnomAD |
|
|
rs989851014 CA300048046 |
509 | P>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA402448344 rs1462882733 |
509 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA402448361 rs1316044113 |
510 | P>L | No |
ClinGen TOPMed |
|
| TCGA novel | 510 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs762718061 CA8964570 |
511 | A>T | No |
ClinGen ExAC TOPMed |
|
|
rs1313926250 CA402448370 |
511 | A>V | No |
ClinGen gnomAD |
|
|
rs1377257004 CA402448374 |
512 | D>N | No |
ClinGen gnomAD |
|
|
rs1397786363 CA402448384 |
513 | D>N | No |
ClinGen gnomAD |
|
|
CA8964572 rs573296530 |
515 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1370111019 CA402448428 |
517 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA8964573 rs761591123 |
517 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402448427 rs1370111019 |
517 | R>S | No |
ClinGen TOPMed gnomAD |
|
|
CA402448459 rs1344271289 |
520 | A>P | No |
ClinGen gnomAD |
|
|
CA8964575 rs750446711 |
521 | S>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8964576 rs555824518 |
521 | S>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs555824518 CA402448472 |
521 | S>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8964577 rs766321769 |
522 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA300048089 rs766321769 |
522 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402448475 rs766321769 |
522 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402448496 rs1429181689 |
523 | P>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1429181689 CA402448500 |
523 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1261055141 CA402448483 |
523 | P>S | No |
ClinGen gnomAD |
|
|
rs758675898 CA300048096 |
524 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| rs1282228187 | 524 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs758675898 CA8964579 |
524 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402448507 rs1454241979 |
524 | G>V | No |
ClinGen gnomAD |
|
|
CA402448511 rs1223625736 |
525 | R>C | No |
ClinGen TOPMed |
|
|
CA402448510 rs1223625736 |
525 | R>G | No |
ClinGen TOPMed |
|
|
CA402448512 rs796234051 |
525 | R>H | No |
ClinGen gnomAD |
|
|
rs796234051 CA300048103 |
525 | R>L | No |
ClinGen gnomAD |
|
|
CA402448519 rs1417419801 |
526 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA402448518 rs1417419801 |
526 | P>R | No |
ClinGen gnomAD |
|
|
CA402448520 rs1385306374 |
527 | A>T | No |
ClinGen gnomAD |
|
|
rs751670980 CA8964582 |
527 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8964583 rs757385194 |
528 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402448531 rs757385194 |
528 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 530 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1305269217 CA402448558 |
531 | G>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1305269217 CA402448554 |
531 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs746414624 CA8964585 |
534 | S>N | No |
ClinGen ExAC |
|
|
rs889167744 CA300048141 |
535 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
CA402448598 rs1459139621 |
535 | P>T | No |
ClinGen TOPMed |
|
|
rs1265400798 COSM1214514 CA402448627 |
538 | D>N | large_intestine [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs1194819991 CA402448649 |
540 | D>H | No |
ClinGen gnomAD |
|
|
rs1438220005 CA402448659 |
541 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
CA402448658 rs1438220005 |
541 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
CA8964588 rs748855629 |
543 | I>L | No |
ClinGen ExAC gnomAD |
|
|
rs745838538 CA300048174 |
543 | I>S | No |
ClinGen Ensembl |
|
|
rs768362441 CA8964589 |
544 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs1428180163 CA402448697 |
545 | R>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA402448705 rs1291247724 |
546 | A>T | No |
ClinGen gnomAD |
|
|
CA402448711 rs1400535293 |
546 | A>V | No |
ClinGen gnomAD |
|
|
rs761397895 CA8964591 |
548 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs1441472742 CA402448729 |
548 | K>N | No |
ClinGen gnomAD |
|
|
rs368327562 CA8964592 |
549 | L>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA402448742 rs1374656534 |
550 | C>R | No |
ClinGen gnomAD |
|
|
rs773258325 CA8964593 |
552 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs1241461518 CA402448797 |
554 | E>D | No |
ClinGen gnomAD |
|
|
COSM1214515 rs766233770 CA8964595 |
554 | E>K | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA402448788 rs766233770 |
554 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA402448806 rs958306924 |
555 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
CA300048210 rs958306924 |
555 | D>V | No |
ClinGen TOPMed gnomAD |
|
|
CA300048215 rs575979411 |
556 | L>V | No |
ClinGen 1000Genomes TOPMed |
|
| TCGA novel | 557 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1255410504 CA402448838 |
558 | D>G | No |
ClinGen gnomAD |
|
|
rs1456861829 CA402448865 |
560 | K>T | No |
ClinGen gnomAD |
|
|
CA402448885 rs1176934968 |
562 | G>D | No |
ClinGen gnomAD |
|
|
rs1437770365 CA402448883 |
562 | G>R | No |
ClinGen TOPMed |
|
|
rs757297774 CA8964600 |
563 | D>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA300048237 rs757297774 |
563 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
COSM988881 CA8964601 rs767633456 |
567 | A>V | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA402448956 rs1389410185 |
569 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA402448970 rs1166513447 |
570 | P>S | No |
ClinGen gnomAD |
|
|
CA402448966 rs1166513447 |
570 | P>T | No |
ClinGen gnomAD |
|
|
CA402448995 rs780218522 |
573 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749679166 CA8964605 |
573 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8964604 rs780218522 |
573 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8964606 rs755359327 |
574 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs1242360778 CA402448998 |
574 | G>R | No |
ClinGen TOPMed |
|
|
CA8964607 rs778627157 |
575 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs747847970 CA8964608 |
575 | D>V | No |
ClinGen ExAC gnomAD |
|
|
rs1444105911 CA402449009 |
576 | L>I | No |
ClinGen TOPMed |
|
|
CA8964610 rs202116209 |
577 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA300048312 rs202116209 |
577 | V>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1194759675 CA402449035 |
580 | E>K | No |
ClinGen TOPMed |
|
|
CA402449046 rs1275151343 |
581 | A>V | No |
ClinGen gnomAD |
|
|
rs1306226522 CA402449065 |
584 | K>R | No |
ClinGen gnomAD |
|
|
CA300048325 rs7506742 |
585 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1276345326 CA402449082 |
586 | R>S | No |
ClinGen TOPMed |
|
|
CA402449091 rs1243385988 |
587 | W>C | No |
ClinGen TOPMed |
|
|
rs1204444978 CA402449084 |
587 | W>R | No |
ClinGen gnomAD |
|
| rs746873598 | 588 | W>= | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
No associated diseases with P31152
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.- | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase activity | Catalysis of the reaction |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
92 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P16892 | FUS3 | Mitogen-activated protein kinase FUS3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| P14681 | KSS1 | Mitogen-activated protein kinase KSS1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| A5PKJ4 | MAPK7 | Mitogen-activated protein kinase 7 | Bos taurus (Bovine) | SS |
| Q3T0N5 | MAPK13 | Mitogen-activated protein kinase 13 | Bos taurus (Bovine) | SS |
| P46196 | MAPK1 | Mitogen-activated protein kinase 1 | Bos taurus (Bovine) | SS |
| Q5F3W3 | MAPK6 | Mitogen-activated protein kinase 6 | Gallus gallus (Chicken) | SS |
| Q95NE7 | MAPK14 | Mitogen-activated protein kinase 14 | Pan troglodytes (Chimpanzee) | SS |
| Q9N272 | MAPK13 | Mitogen-activated protein kinase 13 | Pan troglodytes (Chimpanzee) | SS |
| Q9W354 | Erk7 | Extracellular signal-regulated kinase 7 | Drosophila melanogaster (Fruit fly) | SS |
| O61443 | p38b | Mitogen-activated protein kinase p38b | Drosophila melanogaster (Fruit fly) | SS |
| O62618 | p38a | Mitogen-activated protein kinase p38a | Drosophila melanogaster (Fruit fly) | SS |
| P83100 | p38c | Putative mitogen-activated protein kinase 14C | Drosophila melanogaster (Fruit fly) | SS |
| P40417 | rl | Mitogen-activated protein kinase ERK-A | Drosophila melanogaster (Fruit fly) | SS |
| Q16659 | MAPK6 | Mitogen-activated protein kinase 6 | Homo sapiens (Human) | SS |
| P20794 | MAK | Serine/threonine-protein kinase MAK | Homo sapiens (Human) | PR |
| Q9UQ07 | MOK | MAPK/MAK/MRK overlapping kinase | Homo sapiens (Human) | PR |
| Q8TD08 | MAPK15 | Mitogen-activated protein kinase 15 | Homo sapiens (Human) | SS |
| P45984 | MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens (Human) | SS |
| P45983 | MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens (Human) | EV |
| P53779 | MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens (Human) | EV |
| Q9UBE8 | NLK | Serine/threonine-protein kinase NLK | Homo sapiens (Human) | SS |
| P27361 | MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens (Human) | SS |
| P28482 | MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens (Human) | EV |
| Q13164 | MAPK7 | Mitogen-activated protein kinase 7 | Homo sapiens (Human) | SS |
| P53778 | MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens (Human) | SS |
| O15264 | MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens (Human) | SS |
| Q15759 | MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens (Human) | SS |
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens (Human) | SS |
| Q9Z1B7 | Mapk13 | Mitogen-activated protein kinase 13 | Mus musculus (Mouse) | SS |
| P47811 | Mapk14 | Mitogen-activated protein kinase 14 | Mus musculus (Mouse) | SS |
| Q63844 | Mapk3 | Mitogen-activated protein kinase 3 | Mus musculus (Mouse) | SS |
| P63085 | Mapk1 | Mitogen-activated protein kinase 1 | Mus musculus (Mouse) | SS |
| Q9WVS8 | Mapk7 | Mitogen-activated protein kinase 7 | Mus musculus (Mouse) | SS |
| Q9WUI1 | Mapk11 | Mitogen-activated protein kinase 11 | Mus musculus (Mouse) | SS |
| O08911 | Mapk12 | Mitogen-activated protein kinase 12 | Mus musculus (Mouse) | SS |
| Q80Y86 | Mapk15 | Mitogen-activated protein kinase 15 | Mus musculus (Mouse) | SS |
| Q61532 | Mapk6 | Mitogen-activated protein kinase 6 | Mus musculus (Mouse) | SS |
| Q6P5G0 | Mapk4 | Mitogen-activated protein kinase 4 | Mus musculus (Mouse) | SS |
| P70618 | Mapk14 | Mitogen-activated protein kinase 14 | Rattus norvegicus (Rat) | SS |
| Q9WTY9 | Mapk13 | Mitogen-activated protein kinase 13 | Rattus norvegicus (Rat) | SS |
| P63086 | Mapk1 | Mitogen-activated protein kinase 1 | Rattus norvegicus (Rat) | SS |
| Q9Z2A6 | Mapk15 | Mitogen-activated protein kinase 15 | Rattus norvegicus (Rat) | SS |
| P21708 | Mapk3 | Mitogen-activated protein kinase 3 | Rattus norvegicus (Rat) | SS |
| Q63538 | Mapk12 | Mitogen-activated protein kinase 12 | Rattus norvegicus (Rat) | SS |
| P0C865 | Mapk7 | Mitogen-activated protein kinase 7 | Rattus norvegicus (Rat) | SS |
| P27704 | Mapk6 | Mitogen-activated protein kinase 6 | Rattus norvegicus (Rat) | SS |
| Q63454 | Mapk4 | Mitogen-activated protein kinase 4 | Rattus norvegicus (Rat) | SS |
| Q5ZCI1 | MPK10 | Mitogen-activated protein kinase 10 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5VP69 | MPK16 | Mitogen-activated protein kinase 16 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5SN53 | MPK8 | Mitogen-activated protein kinase 8 | Oryza sativa subsp. japonica (Rice) | SS |
| Q0E459 | MPK13 | Mitogen-activated protein kinase 13 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6Z437 | MPK3 | Mitogen-activated protein kinase 3 | Oryza sativa subsp. japonica (Rice) | SS |
| Q75KK8 | MPK14 | Mitogen-activated protein kinase 14 | Oryza sativa subsp. japonica (Rice) | SS |
| Q67C40 | MPK7 | Mitogen-activated protein kinase 7 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6L5F7 | MPK17 | Mitogen-activated protein kinase 17 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5VN19 | MPK11 | Mitogen-activated protein kinase 11 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5Z859 | MPK4 | Mitogen-activated protein kinase 4 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5Z9J0 | MPK12 | Mitogen-activated protein kinase 12 | Oryza sativa subsp. japonica (Rice) | SS |
| Q53N72 | MPK15 | Mitogen-activated protein kinase 15 | Oryza sativa subsp. japonica (Rice) | SS |
| Q336X9 | MPK6 | Mitogen-activated protein kinase 6 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5J4W4 | MPK2 | Mitogen-activated protein kinase 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q84UI5 | MPK1 | Mitogen-activated protein kinase 1 | Oryza sativa subsp. japonica (Rice) | SS |
| Q10N20 | MPK5 | Mitogen-activated protein kinase 5 | Oryza sativa subsp. japonica (Rice) | SS |
| Q17446 | pmk-1 | Mitogen-activated protein kinase pmk-1 | Caenorhabditis elegans | SS |
| Q11179 | mapk-15 | Mitogen-activated protein kinase 15 | Caenorhabditis elegans | SS |
| Q8MXI4 | pmk-2 | Mitogen-activated protein kinase pmk-2 | Caenorhabditis elegans | SS |
| O44514 | pmk-3 | Mitogen-activated protein kinase pmk-3 | Caenorhabditis elegans | PR |
| G5EBT1 | sma-5 | Mitogen-activated protein kinase sma-5 | Caenorhabditis elegans | SS |
| P39745 | mpk-1 | Mitogen-activated protein kinase mpk-1 | Caenorhabditis elegans | SS |
| Q39021 | MPK1 | Mitogen-activated protein kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LM33 | MPK8 | Mitogen-activated protein kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C5C0 | MPK18 | Mitogen-activated protein kinase 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39022 | MPK2 | Mitogen-activated protein kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C9U4 | MPK15 | Mitogen-activated protein kinase 15 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84M93 | MPK17 | Mitogen-activated protein kinase 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39027 | MPK7 | Mitogen-activated protein kinase 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SJG9 | MPK20 | Mitogen-activated protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LUC3 | MPK19 | Mitogen-activated protein kinase 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LV37 | MPK9 | Mitogen-activated protein kinase 9 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23236 | MPK14 | Mitogen-activated protein kinase 14 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8W4J2 | MPK16 | Mitogen-activated protein kinase 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39023 | MPK3 | Mitogen-activated protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39024 | MPK4 | Mitogen-activated protein kinase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39025 | MPK5 | Mitogen-activated protein kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39026 | MPK6 | Mitogen-activated protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M1Z5 | MPK10 | Mitogen-activated protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GYQ5 | MPK12 | Mitogen-activated protein kinase 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LMM5 | MPK11 | Mitogen-activated protein kinase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LQQ9 | MPK13 | Mitogen-activated protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O42376 | mapk12 | Mitogen-activated protein kinase 12 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DGE1 | mapk14b | Mitogen-activated protein kinase 14B | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DGE2 | mapk14a | Mitogen-activated protein kinase 14A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEKGDCIAS | VYGYDLGGRF | VDFQPLGFGV | NGLVLSAVDS | RACRKVAVKK | IALSDARSMK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HALREIKIIR | RLDHDNIVKV | YEVLGPKGTD | LQGELFKFSV | AYIVQEYMET | DLARLLEQGT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LAEEHAKLFM | YQLLRGLKYI | HSANVLHRDL | KPANIFISTE | DLVLKIGDFG | LARIVDQHYS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HKGYLSEGLV | TKWYRSPRLL | LSPNNYTKAI | DMWAAGCILA | EMLTGRMLFA | GAHELEQMQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ILETIPVIRE | EDKDELLRVM | PSFVSSTWEV | KRPLRKLLPE | VNSEAIDFLE | KILTFNPMDR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LTAEMGLQHP | YMSPYSCPED | EPTSQHPFRI | EDEIDDIVLM | AANQSQLSNW | DTCSSRYPVS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSSDLEWRPD | RCQDASEVQR | DPRAGSAPLA | EDVQVDPRKD | SHSSSERFLE | QSHSSMERAF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EADYGRSCDY | KVGSPSYLDK | LLWRDNKPHH | YSEPKLILDL | SHWKQAAGAP | PTATGLADTG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AREDEPASLF | LEIAQWVKST | QGGPEHASPP | ADDPERRLSA | SPPGRPAPVD | GGASPQFDLD |
| 550 | 560 | 570 | 580 | ||
| VFISRALKLC | TKPEDLPDNK | LGDLNGACIP | EHPGDLVQTE | AFSKERW |