P31007

EV
Gene name
dlg1
Protein name
Disks large 1 tumor suppressor protein
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG1725
EC number
Protein Class
DISCS LARGE (PTHR23119)

Descriptions

Dlg1 is a member of the membrane-associated guanylate kinase (MAGUK) family of PDZ domain-containing proteins and regulates surface expression of NMDA receptors. PDZ domain adjacent to SH3 and SH3 domain interacts with GK domain for autoinhibition.

Autoinhibitory domains (AIDs)

481-571 (PDZ 3 domain) EV

Target domain

760-948 (GK domain)

Relief mechanism

Ligand binding

Assay

Split protein assay, Mutagenesis experiment

581-681 (SH3 domain) EV

Target domain

760-948 (GK domain)

Relief mechanism

Partner binding, Others

Assay

Deletion assay, Mutagenesis experiment

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P31007

Entry ID Method Resolution Chain Position Source
3TVT X-ray 160 A A 618-970 PDB
4RP3 X-ray 136 A A/B 1-97 PDB
4RP4 X-ray 142 A A/B 1-97 PDB
4RP5 X-ray 165 A A/B 1-97 PDB
AF-P31007-F1 Predicted AlphaFoldDB

No variants for P31007

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P31007

No associated diseases with P31007

8 regional properties for P31007

Type Name Position InterPro Accession
domain SH3 domain 620 - 690 IPR001452
domain PDZ domain 216 - 303 IPR001478-1
domain PDZ domain 330 - 421 IPR001478-2
domain PDZ domain 506 - 587 IPR001478-3
domain L27 domain 4 - 67 IPR004172
domain Guanylate kinase/L-type calcium channel beta subunit 779 - 958 IPR008145
domain L27-1 6 - 63 IPR015143
conserved_site Guanylate kinase, conserved site 812 - 829 IPR020590

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Basolateral cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm, cytoskeleton
  • Cell junction, septate junction
  • Cytoskeleton- and membrane-associated
  • Located at the cytoplasmic face of the membrane in the cellular blastoderm and becomes associated with septate junctions which begin to form between epithelial cells at the time of dorsal closure
  • In adult flies, located at the apical-lateral membrane boundary of epithelial cells
PANTHER Family PTHR23119 DISCS LARGE
PANTHER Subfamily PTHR23119:SF51 DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN
PANTHER Protein Class scaffold/adaptor protein
PANTHER Pathway Category No pathway information available

22 GO annotations of cellular component

Name Definition
apical cortex The region that lies just beneath the plasma membrane on the apical edge of a cell.
apicolateral plasma membrane The apical end of the lateral plasma membrane of epithelial cells.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
lateral plasma membrane The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
leading edge membrane The portion of the plasma membrane surrounding the leading edge of a motile cell.
neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density membrane The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
septate junction A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods.
smooth septate junction A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions.
subsynaptic reticulum An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
terminal bouton Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
tricellular tight junction An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet.
type I terminal bouton Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
type Ib terminal bouton Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons.

1 GO annotations of molecular function

Name Definition
guanylate kinase activity Catalysis of the reaction: ATP + GMP = ADP + GDP.

35 GO annotations of biological process

Name Definition
anterior/posterior axis specification, follicular epithelium Polarization of the follicle cells of an insect ovary along the anterior/posterior axis.
asymmetric protein localization involved in cell fate determination Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.
basal protein localization Any process in which a protein is transported to, or maintained in, basal regions of the cell.
behavioral response to ethanol Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
cell fate commitment involved in pattern specification The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type.
cell fate specification The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
cell-cell adhesion The attachment of one cell to another cell via adhesion molecules.
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
dorsal closure The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
establishment of mitotic spindle orientation A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
establishment of spindle orientation Any process that set the alignment of spindle relative to other cellular structures.
establishment or maintenance of epithelial cell apical/basal polarity Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
establishment or maintenance of polarity of follicular epithelium Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet.
establishment or maintenance of polarity of larval imaginal disc epithelium Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium.
gravitaxis The directed movement of a motile cell or organism in response to gravity.
locomotor rhythm The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
male courtship behavior The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster.
mating behavior The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.
morphogenesis of a polarized epithelium The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.
morphogenesis of follicular epithelium The process in which the anatomical structures of a follicular epithelium are generated and organized.
morphogenesis of larval imaginal disc epithelium The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized.
negative regulation of imaginal disc growth Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth.
negative regulation of peptidoglycan recognition protein signaling pathway Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
ovarian follicle cell development The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
pole plasm protein localization Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.
positive phototaxis The directed movement of a cell or organism towards a source of light.
positive regulation of synaptic assembly at neuromuscular junction Any process that activates or increases the frequency, rate or extent of synaptic assembly at neuromuscular junction.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
receptor clustering The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
receptor localization to synapse Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
regulation of epidermal growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
septate junction assembly The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
synaptic assembly at neuromuscular junction The assembly of a synapse at a neuromuscular junction.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12959 DLG1 Disks large homolog 1 Homo sapiens (Human) SS
P78352 DLG4 Disks large homolog 4 Homo sapiens (Human) SS
Q92796 DLG3 Disks large homolog 3 Homo sapiens (Human) SS
Q15700 DLG2 Disks large homolog 2 Homo sapiens (Human) SS
Q91XM9 Dlg2 Disks large homolog 2 Mus musculus (Mouse) SS
P70175 Dlg3 Disks large homolog 3 Mus musculus (Mouse) SS
Q62108 Dlg4 Disks large homolog 4 Mus musculus (Mouse) SS
Q811D0 Dlg1 Disks large homolog 1 Mus musculus (Mouse) SS
Q63622 Dlg2 Disks large homolog 2 Rattus norvegicus (Rat) EV
P31016 Dlg4 Disks large homolog 4 Rattus norvegicus (Rat) SS
Q62696 Dlg1 Disks large homolog 1 Rattus norvegicus (Rat) SS
Q62936 Dlg3 Disks large homolog 3 Rattus norvegicus (Rat) SS
G5ECY0 dlg-1 Disks large homolog 1 Caenorhabditis elegans SS
Q28C55 dlg1 Disks large homolog 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q5PYH7 dlg2 Disks large homolog 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5PYH5 dlg1l Discs large homolog 1-like protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q6R005 dlg4 Disks large homolog 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MPVKKQEAHR ALELLEDYHA RLSEPQDRAL RIAIERVIRI FKSRLFQALL DIQEFYELTL
70 80 90 100 110 120
LDDSKSIQQK TAETLQIATK WEKDGQAVKI ADFIKSSNLN RNCAYEFNND ASSNQTNQSA
130 140 150 160 170 180
LNQNPIANNV SAQAQAEALS RTFKSELEEI LNQRMRIESD TENAKEPTVE QQQKQQQAQQ
190 200 210 220 230 240
RSSRSPQQQN PQQQQGSKSR SGSQTVNGDD SWLYEDIQLE RGNSGLGFSI AGGTDNPHIG
250 260 270 280 290 300
TDTSIYITKL ISGGAAAADG RLSINDIIVS VNDVSVVDVP HASAVDALKK AGNVVKLHVK
310 320 330 340 350 360
RKRGTATTPA AGSAAGDARD SAASGPKVIE IDLVKGGKGL GFSIAGGIGN QHIPGDNGIY
370 380 390 400 410 420
VTKLMDGGAA QVDGRLSIGD KLIAVRTNGS EKNLENVTHE LAVATLKSIT DKVTLIIGKT
430 440 450 460 470 480
QHLTTSASGG GGGGLSSGQQ LSQSQSQLAT SQSQSQVHQQ QHATPMVNSQ STEPGSRYAS
490 500 510 520 530 540
TNVLAAVPPG TPRAVSTEDI TREPRTITIQ KGPQGLGFNI VGGEDGQGIY VSFILAGGPA
550 560 570 580 590 600
DLGSELKRGD QLLSVNNVNL THATHEEAAQ ALKTSGGVVT LLAQYRPEEY NRFEARIQEL
610 620 630 640 650 660
KQQAALGAGG SGTLLRTTQK RSLYVRALFD YDPNRDDGLP SRGLPFKHGD ILHVTNASDD
670 680 690 700 710 720
EWWQARRVLG DNEDEQIGIV PSKRRWERKM RARDRSVKFQ GHAAANNNLD KQSTLDRKKK
730 740 750 760 770 780
NFTFSRKFPF MKSRDEKNED GSDQEPFMLC YTQDDANAEG ASEENVLSYE AVQRLSINYT
790 800 810 820 830 840
RPVIILGPLK DRINDDLISE YPDKFGSCVP HTTRPKREYE VDGRDYHFVS SREQMERDIQ
850 860 870 880 890 900
NHLFIEAGQY NDNLYGTSVA SVREVAEKGK HCILDVSGNA IKRLQVAQLY PVAVFIKPKS
910 920 930 940 950 960
VDSVMEMNRR MTEEQAKKTY ERAIKMEQEF GEYFTGVVQG DTIEEIYSKV KSMIWSQSGP
TIWVPSKESL