AiPD: Autoinhibited Protein Database

P30679

Gene name	GNA15 (GNA16)
Protein name	Guanine nucleotide-binding protein subunit alpha-15
Names	G alpha-15 , G-protein subunit alpha-15 , Epididymis tissue protein Li 17E , Guanine nucleotide-binding protein subunit alpha-16 , G alpha-16 , G-protein subunit alpha-16
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2769
EC number
Protein Class

Descriptions

Gαi1 is a G-protein alpha subunit that plays a crucial role in signal transduction pathway initiated by G-protein-coupled receptor (GPCR) activation. G proteins function as transducers downstream of GPCRs in numerous signaling cascades. The alpha subunit contains the guanine nucleotide binding site and alternates between an active (GTP-bound state) and an inactive (GDP-bound state). Activated GPCR induces conformational change in Gαi1, which allows for GDP-to-GTP exchange by binding to the GPCR-binding site within a Ras-like domain, leading to dissociation of the Gαi1 subunit and initiation of downstream signaling.

Autoinhibitory domains (AIDs)

71-185 (α-H domain) SS

Target domain	192-368 (Ras-like domain)
Relief mechanism	Ligand binding, Partner binding
Assay

AID

71-185 (α-H domain)

Target domain

192-368 (Ras-like domain)

Relief mechanism

Ligand binding (GTP binding), Partner binding(Binding of activated GPCR)

Assay

Accessory elements

No accessory elements

References

Goricanec D et al. (2016) "Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding", Proceedings of the National Academy of Sciences of the United States of America, 113, E3629-38

Coleman DE et al. (1999) "Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex", The Journal of biological chemistry, 274, 16669-72

Lutz S et al. (2007) "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs", Science (New York, N.Y.), 318, 1923-7

Autoinhibited structure

Activated structure

1 structures for P30679

Entry ID	Method	Resolution	Chain	Position	Source
AF-P30679-F1	Predicted				AlphaFoldDB

452 variants for P30679

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1360472964	3	R>C		No	TOPMed gnomAD
rs75723333	3	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs75723333	3	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1359117471	4	S>L		No	gnomAD
rs1914460664	7	W>R		No	Ensembl
rs1914460721	7	W>S		No	TOPMed
rs376509314	8	R>C		No	ESP ExAC TOPMed gnomAD
rs368219827	8	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs376509314	8	R>S		No	ESP ExAC TOPMed gnomAD
rs1240374665	9	C>*		No	gnomAD
rs1192549861	9	C>R		No	gnomAD
rs909320865	11	P>L		No	TOPMed
rs1474389894	12	W>C		No	gnomAD
rs1472159971	12	W>R		No	gnomAD
rs1159293046	12	W>S		No	TOPMed gnomAD
rs758392333	15	T>M		No	ExAC TOPMed gnomAD
rs751274515	16	E>D		No	ExAC TOPMed gnomAD
rs979316332	17	D>E		No	Ensembl
rs755254026	17	D>V		No	ExAC gnomAD
rs1914461534	18	E>A		No	TOPMed gnomAD
rs1362058901	19	K>M		No	gnomAD
rs1400840530	20	A>V		No	gnomAD
rs1324102337	21	A>D		No	gnomAD
rs1914461790	21	A>T		No	Ensembl
rs374928184	22	A>S		No	ESP ExAC TOPMed gnomAD
rs374928184	22	A>T		No	ESP ExAC TOPMed gnomAD
rs771387678	23	R>L		No	ExAC TOPMed gnomAD
rs771387678	23	R>Q		No	ExAC TOPMed gnomAD
rs749833575	23	R>W		No	ExAC TOPMed gnomAD
rs1599316388	24	V>G		No	Ensembl
rs1351694404	24	V>L		No	TOPMed gnomAD
rs1351694404	24	V>M		No	TOPMed gnomAD
rs866327080	26	Q>H		No	TOPMed
rs1204709662	26	Q>R		No	gnomAD
rs200281819	27	E>D		No	1000Genomes ExAC TOPMed gnomAD
rs1444156721	28	I>T		No	TOPMed gnomAD
rs1205539525	29	N>K		No	TOPMed gnomAD
rs1914462784	30	R>K		No	Ensembl
rs1243645856	31	I>T		No	gnomAD
rs1914462950	33	L>S		No	Ensembl
rs746158062	34	E>*		No	ExAC TOPMed gnomAD
rs746158062	34	E>K		No	ExAC TOPMed gnomAD
rs768354703	34	E>V		No	ExAC TOPMed gnomAD
rs1157589821	35	Q>H		No	gnomAD
rs1382167803	37	K>Q		No	TOPMed gnomAD
rs369043343	38	Q>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs761540533	40	R>C		No	ExAC TOPMed gnomAD
rs761540533	40	R>G		No	ExAC TOPMed gnomAD
rs764892056	40	R>H		No	ExAC TOPMed gnomAD
rs764892056	40	R>L		No	ExAC TOPMed gnomAD
rs764892056	40	R>P		No	ExAC TOPMed gnomAD
rs1336689193	41	G>E		No	gnomAD
rs766182128	41	G>R		No	ExAC TOPMed gnomAD
rs766182128	41	G>W		No	ExAC TOPMed gnomAD
TCGA novel	42	E>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1382366407	44	K>E		No	Ensembl
rs751384202	46	L>P		No	ExAC gnomAD
rs1224199384 COSM1711603	48	L>F	skin [Cosmic]	No	cosmic curated gnomAD
TCGA novel rs1347269720	48	L>W	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
TCGA novel	50	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2144850916	51	G>D		No	Ensembl
rs772875677	52	E>A		No	ExAC TOPMed
rs953694957	52	E>K		No	gnomAD
rs1226527441	53	S>C		No	gnomAD
rs912651393	53	S>R		No	gnomAD
rs1462808020 COSM1392338	54	G>R	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1361276117	54	G>V		No	gnomAD
rs1222837047	56	S>G		No	gnomAD
rs1290547277	56	S>I		No	TOPMed gnomAD
rs1290547277	56	S>N		No	TOPMed gnomAD
rs1218721506	57	T>A		No	TOPMed gnomAD
rs1489677427	59	I>V		No	gnomAD
rs1914791565	60	K>R		No	gnomAD
rs866353382	61	Q>K		No	Ensembl
rs762498774	61	Q>R		No	ExAC TOPMed gnomAD
rs1428444766	62	M>I		No	TOPMed gnomAD
rs1914792097	65	I>V		No	Ensembl
rs774223240	67	G>R		No	ExAC TOPMed gnomAD
rs774223240	67	G>S		No	ExAC TOPMed gnomAD
rs1402393684	67	G>V		No	TOPMed
rs148867971	68	A>T		No	ESP ExAC TOPMed gnomAD
rs1304482491	69	G>D		No	gnomAD
rs752447530	69	G>S		No	ExAC TOPMed gnomAD
rs1914792990	70	Y>*		No	TOPMed
rs1293328313	70	Y>H		No	gnomAD
COSM1392339 rs1914793059	71	S>L	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed
TCGA novel	71	S>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs779034100	72	E>G		No	ExAC TOPMed gnomAD
rs1246435230	72	E>K		No	TOPMed gnomAD
rs1246435230	72	E>Q		No	TOPMed gnomAD
rs779034100	72	E>V		No	ExAC TOPMed gnomAD
rs573354292	74	E>K		No	1000Genomes ExAC gnomAD
rs573354292	74	E>Q		No	1000Genomes ExAC gnomAD
rs758911514	75	R>C		No	ExAC TOPMed gnomAD
rs1260835156 COSM4687377	75	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs747333396	76	K>Q		No	ExAC gnomAD
rs1914793833	76	K>R		No	TOPMed
rs1914793905	77	G>D		No	TOPMed gnomAD
rs867328918	78	F>L		No	Ensembl
rs1914794130	78	F>S		No	Ensembl
rs1245473019	79	R>G		No	TOPMed gnomAD
rs377345709	79	R>Q		No	ESP ExAC TOPMed gnomAD
rs1245473019	79	R>W		No	TOPMed gnomAD
rs541029560	80	P>S		No	1000Genomes ExAC gnomAD
rs759422477	82	V>F		No	ExAC TOPMed gnomAD
rs759422477	82	V>I		No	ExAC TOPMed gnomAD
rs759422477	82	V>L		No	ExAC TOPMed gnomAD
rs760394355	83	Y>H		No	ExAC TOPMed gnomAD
rs1318539355	85	N>K		No	TOPMed gnomAD
rs1309913328	86	I>S		No	TOPMed
rs1408195475	86	I>V		No	TOPMed gnomAD
rs140597256	88	V>L		No	ESP TOPMed gnomAD
rs140597256	88	V>M		No	ESP TOPMed gnomAD
rs1376644489	90	M>I		No	gnomAD
rs1914795414	90	M>T		No	Ensembl
rs757375947	91	R>P		No	TOPMed
rs757375947	91	R>Q		No	TOPMed
rs1307234170	92	A>P		No	TOPMed gnomAD
rs1265601037	93	M>I		No	gnomAD
rs373914616	93	M>T		No	ESP ExAC TOPMed gnomAD
rs1315852699	93	M>V		No	gnomAD
rs1914796053	94	I>L		No	TOPMed
rs1203510941	95	E>G		No	gnomAD
rs1462163503	95	E>K		No	gnomAD
rs1178039894	97	M>I		No	gnomAD
rs564736265	97	M>R		No	1000Genomes ExAC gnomAD
rs564736265	97	M>T		No	1000Genomes ExAC gnomAD
rs925980060	97	M>V		No	TOPMed gnomAD
rs1417467645	99	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs765270851	99	R>W		No	ExAC gnomAD
rs1470280131	102	I>F		No	gnomAD
rs1914796966	102	I>M		No	TOPMed
rs758854339	102	I>S		No	ExAC TOPMed gnomAD
rs1470280131	102	I>V		No	gnomAD
rs145733927	103	P>A		No	ESP ExAC TOPMed gnomAD
rs1444066811	104	F>S		No	TOPMed gnomAD
rs377517036	105	S>I		No	ESP ExAC TOPMed gnomAD
rs377517036	105	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs755461939	105	S>R		No	ExAC TOPMed gnomAD
rs1187519069	106	R>W		No	TOPMed
rs748943590	108	E>K		No	ExAC gnomAD
rs1261785199	109	S>N		No	gnomAD
rs1253541109	110	K>N		No	TOPMed
rs2144851270	110	K>T		No	Ensembl
rs200110632	111	H>L		No	1000Genomes ExAC TOPMed gnomAD
rs200110632	111	H>R		No	1000Genomes ExAC TOPMed gnomAD
rs141840304	111	H>Y		No	ESP ExAC TOPMed gnomAD
rs1415802898	112	H>Q		No	TOPMed gnomAD
rs771240163	113	A>P		No	ExAC gnomAD
rs375635151	113	A>V		No	ESP TOPMed
RCV000969111 rs139115108	114	S>N		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs772040139	114	S>R		No	ExAC gnomAD
rs774583770	114	S>R		No	ExAC gnomAD
rs149877401	117	M>I		No	1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel rs1914842437	117	M>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
TCGA novel	119	Q>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1914842765	121	P>R		No	TOPMed
rs761059634	124	V>A		No	ExAC TOPMed gnomAD
rs1400750567	126	T>K		No	TOPMed gnomAD
TCGA novel	126	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs764555365	128	E>A		No	ExAC gnomAD
rs1159274987	129	K>Q		No	TOPMed
rs371651845	130	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs371651845	130	R>G		No	ESP ExAC TOPMed gnomAD
rs765960537	130	R>H		No	ExAC gnomAD
rs765960537	130	R>L		No	ExAC gnomAD
rs751076987	131	Y>*		No	ExAC gnomAD
rs902119948	131	Y>C		No	TOPMed gnomAD
rs902119948	131	Y>S		No	TOPMed gnomAD
rs1242908457	132	A>S		No	gnomAD
rs1351583596	133	A>V		No	gnomAD
rs752729213	134	A>S		No	ExAC TOPMed gnomAD
rs752729213	134	A>T		No	ExAC TOPMed gnomAD
rs1914844186	135	M>I		No	Ensembl
rs1260773989	135	M>L		No	TOPMed
rs62127298	136	Q>K		No	Ensembl
rs1205441758	136	Q>R		No	gnomAD
rs1243554188	137	W>*		No	gnomAD
rs1914844555	138	L>R		No	Ensembl
COSM1564525	139	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs777656970	139	W>G		No	ExAC TOPMed gnomAD
rs749044353	140	R>G		No	ExAC gnomAD
rs771281132	140	R>T		No	ExAC TOPMed gnomAD
rs1599325501	141	D>G		No	Ensembl
rs779344852	141	D>N		No	ExAC gnomAD
rs779344852	141	D>Y		No	ExAC gnomAD
rs772239006	142	A>G		No	ExAC TOPMed gnomAD
rs772239006	142	A>V		No	ExAC TOPMed gnomAD
rs1914845429	143	G>S		No	TOPMed
rs369811746	145	R>G		No	ESP ExAC TOPMed gnomAD
COSM3787631 rs1914845604	145	R>Q	pancreas [Cosmic]	No	cosmic curated TOPMed
rs369811746	145	R>W		No	ESP ExAC TOPMed gnomAD
rs1006352290	146	A>D		No	TOPMed
rs766783580	146	A>T		No	Ensembl
rs310680	147	C>F		No	1000Genomes ESP ExAC gnomAD
TCGA novel	147	C>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
VAR_028000 rs310680	147	C>Y		No	UniProt 1000Genomes ESP ExAC dbSNP gnomAD
rs765585779	148	Y>C		No	ExAC TOPMed gnomAD
rs1326276918	149	E>D		No	Ensembl
rs1245753040	149	E>V		No	TOPMed
rs774052972 COSM1208390	150	R>C	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs774052972	150	R>G		No	ExAC TOPMed gnomAD
rs759088980	150	R>H		No	ExAC TOPMed gnomAD
rs752109453	151	R>W		No	ExAC TOPMed gnomAD
rs1345791697	152	R>L		No	gnomAD
rs1263645841	152	R>W		No	TOPMed gnomAD
rs867791191 COSM3532103	153	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs764054033	155	H>N		No	ExAC TOPMed gnomAD
rs764054033	155	H>Y		No	ExAC TOPMed gnomAD
rs980800256	157	L>P		No	TOPMed gnomAD
rs1914847547 COSM1208391	158	D>N	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed
rs778829713	158	D>V		No	ExAC gnomAD
rs746129065	159	S>*		No	ExAC gnomAD
rs747001611	161	V>L		No	ExAC TOPMed gnomAD
rs747001611	161	V>M		No	ExAC TOPMed gnomAD
rs1372088870	162	Y>H		No	TOPMed gnomAD
rs868282050	163	Y>C		No	Ensembl
rs865832368	163	Y>H		No	Ensembl
rs1914885378	166	H>N		No	TOPMed
COSM994463	167	L>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs201656938	168	E>D		No	1000Genomes ExAC TOPMed gnomAD
rs756566543	168	E>G		No	Ensembl
rs76346810	168	E>K		No	Ensembl
rs199847220	169	R>C		No	ESP ExAC TOPMed gnomAD
rs751779470	169	R>H		No	ExAC TOPMed gnomAD
rs199847220	169	R>S		No	ESP ExAC TOPMed gnomAD
rs1187081050	170	I>L		No	TOPMed gnomAD
rs755162317	171	T>A		No	ExAC gnomAD
rs1445502765	171	T>I		No	gnomAD
rs755162317	171	T>P		No	ExAC gnomAD
rs749787028	172	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2144855125	173	E>G		No	Ensembl
COSM108657 rs139079286	173	E>K	skin [Cosmic]	No	cosmic curated Ensembl
rs1914886660	174	G>D		No	Ensembl
rs1478806817	174	G>S		No	TOPMed gnomAD
rs1914886729 COSM3959885	175	Y>C	lung [Cosmic]	No	cosmic curated TOPMed
rs201355990 COSM4076646	176	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1389308286	177	P>L		No	TOPMed gnomAD
rs1389308286	177	P>R		No	TOPMed gnomAD
rs746672546	178	T>I		No	ExAC TOPMed gnomAD
rs1318333423	179	A>G		No	TOPMed gnomAD
rs1318333423	179	A>V		No	TOPMed gnomAD
rs1205782310	180	Q>P		No	TOPMed gnomAD
rs1205782310	180	Q>R		No	TOPMed gnomAD
rs143953630	182	V>M		No	ESP ExAC TOPMed gnomAD
rs761338145	184	R>C		No	ExAC TOPMed gnomAD
rs200432733	184	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs200432733	184	R>L		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	185	S>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs773083225	186	R>C		No	ExAC gnomAD
rs867130891 COSM710491	186	R>H	lung endometrium central_nervous_system [Cosmic]	No	cosmic curated Ensembl
rs2230330 RCV000973222	187	M>I		No	1000Genomes ESP ExAC TOPMed gnomAD ClinVar dbSNP
rs1599326429	187	M>T		No	gnomAD
rs751333139	191	G>D		No	ExAC TOPMed gnomAD
rs1914888165	191	G>S		No	gnomAD
rs1914888310	192	I>V		No	Ensembl
rs115644662	193	N>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1914888459	193	N>S		No	Ensembl
rs775021862 COSM178593	194	E>K	large_intestine [Cosmic]	No	cosmic curated gnomAD
rs1914888964	195	Y>H		No	TOPMed
rs756241789	196	C>R		No	ExAC gnomAD
rs1914889207	197	F>S		No	Ensembl
rs1156831129	198	S>P		No	TOPMed gnomAD
rs151214875 COSM1208393	199	V>M	oesophagus large_intestine [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs1914889588	200	Q>E		No	gnomAD
rs369602953	201	K>N		No	ESP ExAC TOPMed gnomAD
rs754338447	201	K>Q		No	ExAC gnomAD
rs968239084	201	K>R		No	TOPMed
rs1253691718	204	L>V		No	TOPMed
rs1288462652	205	R>Q		No	gnomAD
rs746938649	205	R>W		No	ExAC TOPMed gnomAD
rs1914999642	207	V>G		No	TOPMed
rs755751411	207	V>M		No	ExAC gnomAD
rs367834807	208	D>G		No	ESP ExAC TOPMed gnomAD
TCGA novel	209	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs748777205	209	V>I		No	ExAC gnomAD
rs770781206	210	G>R		No	ExAC TOPMed gnomAD
rs774341405	211	G>D		No	ExAC TOPMed gnomAD
rs774341405	211	G>V		No	ExAC TOPMed gnomAD
rs1377254685	213	K>Q		No	gnomAD
rs771890721	216	R>C		No	ExAC TOPMed gnomAD
rs775221783	216	R>H		No	ExAC gnomAD
rs1349909924	217	K>*		No	gnomAD
TCGA novel	217	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM3532107	219	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs796975912	219	W>C		No	TOPMed
rs1436462432	219	W>G		No	gnomAD
rs1436462432	219	W>R		No	gnomAD
COSM4076647	220	I>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1915001464	221	H>N		No	gnomAD
rs1296430786	222	C>R		No	TOPMed gnomAD
rs1915001855	224	E>D		No	Ensembl
rs1915002017	226	V>E		No	Ensembl
rs1915002193	227	I>N		No	Ensembl
rs1365825471	230	I>T		No	TOPMed gnomAD
rs764319987	230	I>V		No	ExAC TOPMed gnomAD
rs2144859641	231	Y>C		No	Ensembl
rs1295511630	232	L>P		No	TOPMed gnomAD
rs1295511630	232	L>R		No	TOPMed gnomAD
rs762017781	236	S>G		No	ExAC gnomAD
rs1915003388	236	S>N		No	Ensembl
rs146483408	238	Y>*		No	ESP ExAC TOPMed gnomAD
TCGA novel	239	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM5389308	239	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs375791169	241	C>Y		No	ESP TOPMed gnomAD
rs1220789775	242	L>P		No	gnomAD
rs1374119223	242	L>V		No	TOPMed gnomAD
TCGA novel	243	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1029823852	244	E>*		No	TOPMed gnomAD
TCGA novel	244	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1915003870	244	E>G		No	Ensembl
rs1029823852	244	E>K		No	TOPMed gnomAD
rs1029823852	244	E>Q		No	TOPMed gnomAD
rs1443850109	246	N>H		No	TOPMed gnomAD
rs1915004065	246	N>S		No	gnomAD
rs1011689952	247	Q>R		No	TOPMed gnomAD
TCGA novel	248	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM3718248 rs200649442	250	R>C	liver [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs773385959	250	R>H		No	ExAC TOPMed gnomAD
rs145665648	251	M>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1252636922	251	M>R		No	TOPMed gnomAD
rs145665648	251	M>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1351158900	252	K>Q		No	gnomAD
COSM4154156 rs199709383	254	S>R	kidney [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs760016259	256	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	258	F>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1395054270	259	G>V		No	TOPMed gnomAD
rs1656782963	260	T>S		No	TOPMed
TCGA novel	261	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1915062291	262	L>Q		No	TOPMed
TCGA novel	263	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM4831239	263	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1441521059	263	E>K		No	gnomAD
rs767761894	265	P>T		No	ExAC gnomAD
rs1915062623	266	W>S		No	TOPMed
rs753564320	268	K>R		No	ExAC TOPMed gnomAD
rs756817009	269	S>N		No	ExAC gnomAD
COSM418342	270	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1304349285	271	S>F		No	TOPMed gnomAD
rs1481671679	272	V>I		No	gnomAD
rs1173531250	273	I>V		No	gnomAD
COSM4404302 rs1915063259	274	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs749873249	274	L>R		No	ExAC gnomAD
rs1474419176	278	K>N		No	gnomAD
rs1915063693	279	T>S		No	Ensembl
rs1156779924	280	D>N		No	TOPMed gnomAD
rs746905865	282	L>P		No	ExAC gnomAD
rs143247880	283	E>G		No	ESP ExAC TOPMed gnomAD
rs1915064470	284	E>*		No	Ensembl
rs1915064622	286	I>V		No	TOPMed gnomAD
rs1275247896	287	P>L		No	TOPMed gnomAD
rs868247802 COSM3532108	287	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
rs1198409269	288	T>A		No	gnomAD
rs773440731	288	T>I		No	ExAC TOPMed gnomAD
TCGA novel	288	T>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1483130427	289	S>F		No	TOPMed gnomAD
rs1483130427	289	S>Y		No	TOPMed gnomAD
rs1266791223	290	H>Q		No	TOPMed gnomAD
rs1203827962	292	A>S		No	gnomAD
rs1203827962	292	A>T		No	gnomAD
rs1248897452	293	T>A		No	gnomAD
rs1200174902	294	Y>C		No	gnomAD
rs763062805	295	F>I		No	ExAC gnomAD
rs1330649492	296	P>L		No	TOPMed gnomAD
rs759941706	299	Q>*		No	ExAC gnomAD
rs1915066345	299	Q>R		No	TOPMed
rs1555707385	300	G>R		No	gnomAD
rs1555707385	300	G>S		No	gnomAD
rs1446504412	300	G>V		No	gnomAD
rs1272031360	301	P>L		No	TOPMed gnomAD
COSM142295	301	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1357304874	302	K>E		No	TOPMed gnomAD
rs774252847	302	K>N		No	ExAC gnomAD
rs1915169237	302	K>R		No	TOPMed
rs1915169386	304	D>Y		No	Ensembl
rs1017132181	308	A>T		No	Ensembl
COSM4849707	309	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs746406189	309	K>Q		No	ExAC gnomAD
rs772397465	309	K>R		No	ExAC gnomAD
rs1568300677	310	R>K		No	Ensembl
rs963088906	311	F>L		No	Ensembl
rs2144866821	312	I>T		No	Ensembl
rs1324531419	313	L>P		No	TOPMed gnomAD
rs775924021	313	L>V		No	ExAC TOPMed gnomAD
rs761093347	314	D>V		No	ExAC gnomAD
rs1354906492	315	M>K		No	TOPMed gnomAD
rs1915170059	315	M>L		No	TOPMed gnomAD
rs201928137	317	T>M		No	ExAC TOPMed gnomAD
rs1393781581	317	T>S		No	TOPMed
rs1599332869	320	Y>H		No	Ensembl
rs955365992	321	T>I		No	TOPMed gnomAD
rs955365992	321	T>N		No	TOPMed gnomAD
rs762561049	321	T>P		No	ExAC TOPMed gnomAD
TCGA novel rs372928786	322	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD NCI-TCGA
rs1915171324	323	C>Y		No	TOPMed gnomAD
rs754957377	324	V>G		No	ExAC TOPMed gnomAD
rs767291635	325	D>G		No	ExAC TOPMed gnomAD
rs752679814	326	G>C		No	ExAC TOPMed gnomAD
rs1389192934	326	G>D		No	gnomAD
rs752679814	326	G>R		No	ExAC TOPMed gnomAD
rs752679814	326	G>S		No	ExAC TOPMed gnomAD
rs777690665	327	P>S		No	ExAC TOPMed gnomAD
rs757502333	328	E>D		No	ExAC TOPMed gnomAD
rs1396214838 COSM123390	328	E>K	upper_aerodigestive_tract Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs745864047	332	K>E		No	ExAC TOPMed gnomAD
rs772184102	332	K>R		No	ExAC gnomAD
rs747491972	334	A>P		No	ExAC TOPMed gnomAD
rs747491972	334	A>S		No	ExAC TOPMed gnomAD
rs747491972	334	A>T		No	ExAC TOPMed gnomAD
rs1483718966	334	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1465632602	335	R>*		No	Ensembl
rs1915172756	335	R>L		No	Ensembl
rs867088858	338	R>C		No	TOPMed gnomAD
rs1184334208	338	R>H		No	gnomAD
rs867088858	338	R>S		No	TOPMed gnomAD
rs1028072297	339	L>F		No	TOPMed
rs1599332950	340	F>S		No	Ensembl
rs1337172056	342	H>R		No	TOPMed gnomAD
rs765889898	342	H>Y		No	ExAC gnomAD
rs1360637442	343	Y>C		No	TOPMed gnomAD
rs2144866959	344	T>I		No	Ensembl
rs1271750566	344	T>S		No	TOPMed gnomAD
rs544907753	346	A>T		No	1000Genomes ExAC gnomAD
rs752734019	349	T>A		No	ExAC gnomAD
rs764576537	350	Q>H		No	ExAC TOPMed gnomAD
rs764000592	353	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs764000592	353	R>G		No	ExAC TOPMed gnomAD
COSM3692602	353	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs764000592	353	R>S		No	ExAC TOPMed gnomAD
rs2144866997	356	F>L		No	Ensembl
rs1915174393	356	F>V		No	gnomAD
rs867394387	357	K>N		No	Ensembl
rs1232858885	357	K>R		No	TOPMed gnomAD
rs757501367	359	V>L		No	ExAC TOPMed gnomAD
rs2144867011	360	R>Q		No	Ensembl
rs1205964029	360	R>W		No	TOPMed gnomAD
rs1816137028	362	S>L		No	TOPMed
rs1482702897	363	V>L		No	TOPMed gnomAD
rs1482702897	363	V>M		No	TOPMed gnomAD
rs779067884	364	L>F		No	ExAC gnomAD
rs779067884	364	L>V		No	ExAC gnomAD
rs1433555721	365	A>S		No	TOPMed gnomAD
rs1433555721	365	A>T		No	TOPMed gnomAD
COSM107599 rs144051973	366	R>C	skin [Cosmic]	No	cosmic curated TOPMed gnomAD
rs144051973	366	R>S		No	TOPMed gnomAD
rs758456407	369	D>E		No	ExAC TOPMed gnomAD
TCGA novel	369	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1394097918	371	I>V		No	TOPMed
rs780149273	372	N>H		No	ExAC gnomAD
rs575093003	372	N>I		No	1000Genomes ExAC TOPMed gnomAD
rs575093003	372	N>S		No	1000Genomes ExAC TOPMed gnomAD
rs1440710887	373	L>V		No	gnomAD

No associated diseases with P30679

No regional properties for P30679

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P30679

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
heterotrimeric G-protein complex	Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

5 GO annotations of molecular function

Name	Definition
G protein-coupled receptor binding	Binding to a G protein-coupled receptor.
G-protein beta/gamma-subunit complex binding	Binding to a complex of G-protein beta/gamma subunits.
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction
metal ion binding	Binding to a metal ion.

6 GO annotations of biological process

Name	Definition
action potential	A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.
activation of phospholipase C activity	The initiation of the activity of the inactive enzyme phospolipase C as the result of The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand.
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).
calcium-mediated signaling	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
phospholipase C-activating dopamine receptor signaling pathway	A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

29 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P38408	GNA14	Guanine nucleotide-binding protein subunit alpha-14	Bos taurus (Bovine)	PR
P23625	Galphaq	G protein alpha q subunit	Drosophila melanogaster (Fruit fly)	PR
O95837	GNA14	Guanine nucleotide-binding protein subunit alpha-14	Homo sapiens (Human)	SS
P29992	GNA11	Guanine nucleotide-binding protein subunit alpha-11	Homo sapiens (Human)	SS
P50148	GNAQ	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P11488	GNAT1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P19087	GNAT2	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P08754	GNAI3	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
A8MTJ3	GNAT3	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P19086	GNAZ	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	Homo sapiens (Human)	SS
Q03113	GNA12	Guanine nucleotide-binding protein subunit alpha-12	Homo sapiens (Human)	SS
P38405	GNAL	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P04899	GNAI2	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P63096	GNAI1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	EV
P09471	GNAO1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P21279	Gnaq	Guanine nucleotide-binding protein G(q) subunit alpha	Mus musculus (Mouse)	PR
P30678	Gna15	Guanine nucleotide-binding protein subunit alpha-15	Mus musculus (Mouse)	PR
Q2PKF4	GNAQ	Guanine nucleotide-binding protein G(q) subunit alpha	Sus scrofa (Pig)	PR
P93564	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Solanum tuberosum (Potato)	SS
Q9JID2	Gna11	Guanine nucleotide-binding protein subunit alpha-11	Rattus norvegicus (Rat)	SS
P82471	Gnaq	Guanine nucleotide-binding protein G	Rattus norvegicus (Rat)	SS
O88302	Gna15	Guanine nucleotide-binding protein subunit alpha-15	Rattus norvegicus (Rat)	SS
Q0DJ33	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Oryza sativa subsp. japonica (Rice)	SS
P49084	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Glycine max (Soybean) (Glycine hispida)	SS
P93163	GPA2	Guanine nucleotide-binding protein alpha-2 subunit	Glycine max (Soybean) (Glycine hispida)	SS
O80462	XLG1	Extra-large guanine nucleotide-binding protein 1	Arabidopsis thaliana (Mouse-ear cress)	PR
P18064	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Arabidopsis thaliana (Mouse-ear cress)	SS
P26981	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	SS

10	20	30	40	50	60
MARSLTWRCC	PWCLTEDEKA	AARVDQEINR	ILLEQKKQDR	GELKLLLLGP	GESGKSTFIK
70	80	90	100	110	120
QMRIIHGAGY	SEEERKGFRP	LVYQNIFVSM	RAMIEAMERL	QIPFSRPESK	HHASLVMSQD
130	140	150	160	170	180
PYKVTTFEKR	YAAAMQWLWR	DAGIRACYER	RREFHLLDSA	VYYLSHLERI	TEEGYVPTAQ
190	200	210	220	230	240
DVLRSRMPTT	GINEYCFSVQ	KTNLRIVDVG	GQKSERKKWI	HCFENVIALI	YLASLSEYDQ
250	260	270	280	290	300
CLEENNQENR	MKESLALFGT	ILELPWFKST	SVILFLNKTD	ILEEKIPTSH	LATYFPSFQG
310	320	330	340	350	360
PKQDAEAAKR	FILDMYTRMY	TGCVDGPEGS	KKGARSRRLF	SHYTCATDTQ	NIRKVFKDVR
370
DSVLARYLDE	INLL