AiPD: Autoinhibited Protein Database

P30291

Gene name	WEE1
Protein name	Wee1-like protein kinase
Names	WEE1hu, Wee1A kinase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7465
EC number	2.7.10.2: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-319 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

7-319 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

462-481 (Activation loop from InterPro)

Target domain	299-569 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

23 structures for P30291

Entry ID	Method	Resolution	Chain	Position	Source
1X8B	X-ray	181 A	A	291-575	PDB
2IN6	X-ray	190 A	A	291-575	PDB
2IO6	X-ray	220 A	A	291-575	PDB
2Z2W	X-ray	222 A	A	291-575	PDB
3BI6	X-ray	220 A	A	291-575	PDB
3BIZ	X-ray	220 A	A	291-575	PDB
3CQE	X-ray	250 A	A	291-575	PDB
3CR0	X-ray	230 A	A	291-575	PDB
5V5Y	X-ray	190 A	A	291-575	PDB
5VC3	X-ray	197 A	A	291-575	PDB
5VC4	X-ray	210 A	A	291-575	PDB
5VC5	X-ray	193 A	A	291-575	PDB
5VC6	X-ray	200 A	A	291-575	PDB
5VD2	X-ray	205 A	A	291-575	PDB
5VD4	X-ray	202 A	A	291-575	PDB
5VD5	X-ray	205 A	A	291-575	PDB
5VD7	X-ray	208 A	A	291-575	PDB
5VD8	X-ray	185 A	A	291-575	PDB
5VD9	X-ray	187 A	A	291-575	PDB
5VDA	X-ray	210 A	A	291-575	PDB
7N3U	X-ray	265 A	A	291-575	PDB
8BJU	X-ray	153 A	A	291-575	PDB
AF-P30291-F1	Predicted				AlphaFoldDB

345 variants for P30291

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA379640713 rs1490413296	5	S>G		No	ClinGen gnomAD
CA379640719 rs1235774372	6	R>G		No	ClinGen gnomAD
CA379640723 rs1456968233	6	R>L		No	ClinGen TOPMed gnomAD
rs1456968233 CA379640721	6	R>Q		No	ClinGen TOPMed gnomAD
rs1201221715 CA379640724	7	Q>K		No	ClinGen TOPMed gnomAD
rs1487399032 CA379640743	9	P>L		No	ClinGen TOPMed
CA379640754 rs1240021878	11	P>S		No	ClinGen gnomAD
CA5879780 rs758698298	14	R>S		No	ClinGen ExAC gnomAD
CA379640777 rs1331216603	15	A>P		No	ClinGen TOPMed
rs1331216603 CA379640776	15	A>S		No	ClinGen TOPMed
rs1589975648 CA379640785	16	G>A		No	ClinGen Ensembl
rs1323782444 CA379640793	18	A>T		No	ClinGen TOPMed
CA379640812 rs1302989028	20	T>I		No	ClinGen TOPMed
rs1217796362 CA379640820	22	R>G		No	ClinGen TOPMed
rs1456140670 CA379640826	23	Q>E		No	ClinGen TOPMed gnomAD
rs1456140670 CA379640825	23	Q>K		No	ClinGen TOPMed gnomAD
rs1470356965 CA379640866	28	S>L		No	ClinGen TOPMed
rs1319947021 CA379640862	28	S>P		No	ClinGen TOPMed
rs1446190064 CA379640891	32	D>Y		No	ClinGen TOPMed gnomAD
rs1305232726 CA379640919	35	E>D		No	ClinGen gnomAD
CA379640925 rs1036824733	36	E>G		No	ClinGen TOPMed
rs1036824733 CA217605843	36	E>V		No	ClinGen TOPMed
rs1232552511 CA379640959	40	E>D		No	ClinGen Ensembl
rs1308287570 CA379640956	40	E>G		No	ClinGen gnomAD
rs1319255800 CA379640990	43	E>G		No	ClinGen gnomAD
TCGA novel	44	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs995396311 CA217605858	44	G>S		No	ClinGen TOPMed gnomAD
rs747081323 CA5879784	46	G>S		No	ClinGen ExAC gnomAD
rs1482412007 CA379641058	48	S>N		No	ClinGen gnomAD
rs1231132809 CA379641081	50	G>W		No	ClinGen TOPMed
rs12805035 CA217605860	54	A>V		No	ClinGen Ensembl
CA379641229 rs1453380033	58	P>L		No	ClinGen TOPMed
rs1165655100 CA379641369	65	A>T		No	ClinGen gnomAD
CA379641380 rs1451128435	65	A>V		No	ClinGen TOPMed
CA379641446 rs1198788004	69	T>P		No	ClinGen gnomAD
CA217605866 rs1023266012	70	E>Q		No	ClinGen TOPMed
CA379641519 rs1274512411	72	G>R		No	ClinGen TOPMed gnomAD
CA379641559 rs1274937429	73	P>L		No	ClinGen TOPMed
CA379641546 rs1482709095	73	P>S		No	ClinGen TOPMed
rs970339281 CA217605869	75	R>C		No	ClinGen TOPMed
CA379641668 rs1461487296	77	R>H		No	ClinGen TOPMed gnomAD
rs1461487296 CA379641676	77	R>P		No	ClinGen TOPMed gnomAD
rs1298831486 CA379641695	78	S>*		No	ClinGen TOPMed gnomAD
rs1298831486 CA379641697	78	S>L		No	ClinGen TOPMed gnomAD
CA217605872 rs1031152118	80	G>R		No	ClinGen TOPMed
CA217605874 rs370387004	81	P>L		No	ClinGen 1000Genomes ExAC TOPMed
rs370387004 CA5879789	81	P>Q		No	ClinGen 1000Genomes ExAC TOPMed
CA5879788 rs770269668	81	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1310125504 CA379641773	82	A>T		No	ClinGen TOPMed
CA379641802 rs1431336503	82	A>V		No	ClinGen TOPMed
rs749583455 CA5879791	83	P>T		No	ClinGen ExAC
rs956596936 CA379641843	84	G>D		No	ClinGen TOPMed gnomAD
rs956596936 CA217605881	84	G>V		No	ClinGen TOPMed gnomAD
CA379641873 rs1248649604	85	S>R		No	ClinGen gnomAD
CA217605888 rs915199641	87	G>R		No	ClinGen TOPMed
rs915199641 CA379641894	87	G>S		No	ClinGen TOPMed
rs558374573 CA5879793	88	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA379641978 rs1481901514	89	L>P		No	ClinGen TOPMed
CA379642018 rs1421847458	90	E>D		No	ClinGen TOPMed gnomAD
rs578111142 CA5879794	90	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA379642070 rs1465160716	91	E>D		No	ClinGen gnomAD
rs1359053286 CA379642044	91	E>K		No	ClinGen TOPMed
rs1482013415 CA379642105	92	D>E		No	ClinGen gnomAD
rs1171403021 CA379642078	92	D>N		No	ClinGen gnomAD
rs1446188482 CA379642160	96	P>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA379642206 rs1388489704	97	G>V		No	ClinGen gnomAD
rs201792218 CA5879797	98	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1171472258 CA379642263	100	P>L		No	ClinGen TOPMed gnomAD
rs1336587847 CA379642310	102	A>V		No	ClinGen gnomAD
rs1454866793 CA379642321	103	D>G		No	ClinGen gnomAD
CA379642315 rs1407506822	103	D>Y		No	ClinGen gnomAD
CA379642332 rs1295845820	104	E>*		No	ClinGen gnomAD
rs1361783443 CA379642350	105	A>G		No	ClinGen gnomAD
rs1361783443 CA379642351	105	A>V		No	ClinGen gnomAD
rs1309885288 CA379642370	107	G>D		No	ClinGen gnomAD
CA217605914 rs919320477	107	G>S		No	ClinGen TOPMed gnomAD
rs1392741567 CA379642418	110	E>D		No	ClinGen TOPMed
CA379642446 rs1589975809	112	D>E		No	ClinGen Ensembl
rs930860061 CA217605923	117	E>D		No	ClinGen TOPMed
CA5879802 rs766538588	124	P>L		No	ClinGen ExAC gnomAD
CA379642650 rs1412044624	128	P>L		No	ClinGen TOPMed
CA217605934 rs894614859	129	A>T		No	ClinGen TOPMed gnomAD
rs1045938382 CA217605937	133	F>Y		No	ClinGen TOPMed
TCGA novel	136	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866472787 CA217605939	139	S>*		No	ClinGen Ensembl
CA5879807 rs756613979	140	P>R		No	ClinGen ExAC gnomAD
CA379642727 rs1290558582	141	V>L		No	ClinGen gnomAD
rs1490779324 CA379642734	142	R>C		No	ClinGen gnomAD
rs749689471 CA5879809	145	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1344953879 CA379642760	146	P>Q		No	ClinGen gnomAD
rs779127514 CA5879811	148	D>N		No	ClinGen ExAC TOPMed gnomAD
CA379642781 rs1226701639	149	A>V		No	ClinGen TOPMed
CA5879814 rs776285384	151	P>L		No	ClinGen ExAC gnomAD
CA379642797 rs1233615959	152	R>L		No	ClinGen TOPMed
CA379642807 rs1332622305	154	C>Y		No	ClinGen TOPMed
CA217605964 rs1030785325	155	G>A		No	ClinGen TOPMed
rs1386136110 CA379642817	156	A>T		No	ClinGen TOPMed
CA379642827 rs1589975849	157	R>P		No	ClinGen Ensembl
rs892209142 CA217605969	158	R>Q		No	ClinGen TOPMed gnomAD
CA379642833 rs1321948457	159	A>T		No	ClinGen TOPMed
CA5879815 rs562855683	159	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA379642838 rs1589975851 COSM35760	160	G>S	central_nervous_system [Cosmic]	No	ClinGen cosmic curated Ensembl
CA379642874 rs1410718910	163	R>C		No	ClinGen TOPMed
rs1565086640 CA379642880	163	R>L		No	ClinGen Ensembl
CA379642887 rs1479179298	164	R>H		No	ClinGen TOPMed
CA217605978 rs1022143825	164	R>S		No	ClinGen TOPMed gnomAD
CA217605979 rs953161766	165	S>W		No	ClinGen TOPMed gnomAD
CA379642948 rs1450610689	168	P>S		No	ClinGen TOPMed
CA379642972 rs1283532535	170	H>P		No	ClinGen gnomAD
CA379642986 rs1206853790	171	P>L		No	ClinGen TOPMed
CA379642993 rs1464503540	172	G>A		No	ClinGen TOPMed
rs773244106 CA217605986	173	T>P		No	ClinGen ExAC TOPMed gnomAD
rs773244106 CA5879817	173	T>S		No	ClinGen ExAC TOPMed gnomAD
CA379643074 rs972466534	180	R>H		No	ClinGen TOPMed gnomAD
rs972466534 CA217605998	180	R>L		No	ClinGen TOPMed gnomAD
rs1344109411 CA379643104	183	R>P		No	ClinGen TOPMed
rs985733771 CA217703777	199	R>G		No	ClinGen TOPMed
rs779402741 CA5879828	199	R>Q		No	ClinGen ExAC gnomAD
TCGA novel	203	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA217703781 rs756507839	203	S>T		No	ClinGen Ensembl
CA379843728 rs1565087187	207	K>R		No	ClinGen Ensembl
rs34412975 CA5879829 RCV000972075 VAR_041302	210	G>C		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5879830 rs34412975	210	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA379843777 rs1237876107	211	S>N		No	ClinGen TOPMed gnomAD
rs1232752009 CA379843805	215	M>T		No	ClinGen gnomAD
CA5879832 rs747692475	215	M>V		No	ClinGen ExAC TOPMed gnomAD
CA5879833 rs769467349	217	T>A		No	ClinGen ExAC gnomAD
rs772824743 CA5879834	219	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA379843854 rs1383738142	222	K>R		No	ClinGen gnomAD
CA5879835 rs749503240	224	E>Q		No	ClinGen ExAC gnomAD
CA5879836 rs570132856	225	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA379843882 rs1427186270	226	D>G		No	ClinGen gnomAD
rs774197082 CA379843880	226	D>H		No	ClinGen ExAC gnomAD
CA5879837 rs774197082	226	D>Y		No	ClinGen ExAC gnomAD
CA5879838 rs759191432	227	V>E		No	ClinGen ExAC gnomAD
CA5879839 rs768899313	228	R>Q		No	ClinGen ExAC gnomAD
rs1565087230 CA379843901	229	Q>H		No	ClinGen Ensembl
rs1444262566 CA379843896	229	Q>K		No	ClinGen gnomAD
rs752960652 CA5879840	229	Q>P		No	ClinGen ExAC gnomAD
CA5879841 rs370082104	232	Q>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	237	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5879843 rs753859170	241	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	242	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1194353544 CA379843991	243	L>V		No	ClinGen gnomAD
CA379844000 rs1272371469	244	L>W		No	ClinGen gnomAD
rs547746842 CA5879845	245	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1207216979 CA379844011	246	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs750823367 CA5879846	252	R>H		No	ClinGen ExAC gnomAD
CA379844073 rs1444348899	253	R>C		No	ClinGen TOPMed gnomAD
CA379844076 rs1475320501	253	R>H		No	ClinGen TOPMed
rs1444348899 CA379844069	253	R>S		No	ClinGen TOPMed gnomAD
TCGA novel	254	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA217704725 rs1049015057 COSM1358024	255	K>R	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
rs150127351 CA5879847	258	Y>C		No	ClinGen ESP ExAC gnomAD
CA5879848 rs780534747	260	N>K		No	ClinGen ExAC gnomAD
CA379844231 rs1338665259	262	S>T		No	ClinGen gnomAD
rs1007055999 CA217705094	263	C>W		No	ClinGen TOPMed
rs1192064095 CA379844250	263	C>Y		No	ClinGen Ensembl
rs1381459292 CA379844313	268	E>K		No	ClinGen TOPMed gnomAD
rs1589976678 CA379844342	269	A>V		No	ClinGen Ensembl
COSM1232716 rs1327251858 CA379844407	271	D>G	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA217705100 rs553599700	272	Y>F		No	ClinGen 1000Genomes
rs1290265960 CA379844431	272	Y>H		No	ClinGen gnomAD
CA379844475 rs1432901315	273	E>D		No	ClinGen gnomAD
rs1281436464 CA379844498	275	E>K		No	ClinGen gnomAD
CA379844535 rs1322974894	276	D>G		No	ClinGen gnomAD
TCGA novel	279	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379844625 rs758950288	280	P>H		No	ClinGen ExAC TOPMed gnomAD
rs758950288 CA5879866	280	P>L		No	ClinGen ExAC TOPMed gnomAD
CA217705108 rs965622635	281	A>P		No	ClinGen TOPMed
CA379844662 rs1348937577	282	K>R		No	ClinGen gnomAD
TCGA novel	286	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1490358619 CA379844828	287	T>I		No	ClinGen gnomAD
CA217705206 rs1040392017	288	E>A		No	ClinGen gnomAD
rs776677778 CA5879881	288	E>K		No	ClinGen ExAC gnomAD
TCGA novel	290	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs537127750 CA5879883	296	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5879887 rs751983981	309	E>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	318	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1379512468 CA379845359	323	C>F		No	ClinGen gnomAD
CA5879891 rs202076024	329	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA379845614 rs1589976851	339	D>G		No	ClinGen Ensembl
rs1000062488 CA217705220	339	D>N		No	ClinGen gnomAD
rs771172428 CA5879922	354	G>R		No	ClinGen ExAC gnomAD
rs1186713184 CA379845849	356	H>Y		No	ClinGen TOPMed
TCGA novel	358	H>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1034994378 CA217705408	358	H>Q		No	ClinGen gnomAD
rs1213387294 CA379846454	373	L>V		No	ClinGen gnomAD
rs1216361016 CA379846539 COSM1730971	378	Y>C	liver [Cosmic]	No	ClinGen cosmic curated TOPMed
rs17854721 CA217705431	379	C>R		No	ClinGen Ensembl
CA5879951 rs373820687	385	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA217705960 rs373820687	385	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA379847194 rs1448985005	386	D>N		No	ClinGen gnomAD
rs138462032 CA5879953	387	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA379847210 rs1381826397	387	A>T		No	ClinGen gnomAD
rs767383358 CA379847225	388	I>L		No	ClinGen ExAC TOPMed gnomAD
CA5879956 rs752718693	388	I>T		No	ClinGen ExAC gnomAD
rs767383358 CA5879955	388	I>V		No	ClinGen ExAC TOPMed gnomAD
rs923885305 CA217705961	391	N>K		No	ClinGen Ensembl
rs755980888 CA5879957	392	Y>C		No	ClinGen ExAC gnomAD
CA5879958 rs764051622	393	R>G		No	ClinGen ExAC gnomAD
rs901828711 CA217705962	395	M>V		No	ClinGen TOPMed
CA5879959 rs753622971	397	Y>N		No	ClinGen ExAC gnomAD
rs1187748568 CA379847422	401	A>G		No	ClinGen gnomAD
CA379847496 rs1458610766	412	R>*		No	ClinGen TOPMed
CA5879962 COSM242252 rs144031261	412	R>Q	prostate [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
TCGA novel	414	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758546650 CA5879963	416	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs760102237 CA217705963	420	M>V		No	ClinGen Ensembl
rs779977294 CA5879964	421	S>F		No	ClinGen ExAC gnomAD
TCGA novel	422	L>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	426	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379847599 rs1174249833	427	I>V		No	ClinGen gnomAD
CA379847615 rs1470261507	429	P>S		No	ClinGen TOPMed
rs147537355 CA5879978	434	I>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5879977 rs147537355	434	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA379847980 rs368181613	436	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5879979 rs368181613	436	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1341153639 CA379847982	437	T>A		No	ClinGen gnomAD
CA379847986 rs1282895147	437	T>N		No	ClinGen TOPMed
CA217706392 rs549439989	438	S>P		No	ClinGen Ensembl
rs1401953665 CA379847993	439	I>V		No	ClinGen TOPMed gnomAD
rs1340925534 CA379848004	440	P>L		No	ClinGen TOPMed
rs758537908 CA5879980	443	A>T		No	ClinGen ExAC gnomAD
CA5879981 rs780245459	443	A>V		No	ClinGen ExAC gnomAD
rs751525556 CA5879983	447	G>A		No	ClinGen ExAC gnomAD
rs751525556 CA5879984	447	G>V		No	ClinGen ExAC gnomAD
rs554525969 CA5879985	448	D>G		No	ClinGen 1000Genomes ExAC gnomAD
rs200402463 CA217706395	450	D>Y		No	ClinGen 1000Genomes
CA5879986 rs748540296	451	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA217706397 rs372628405	453	A>T		No	ClinGen ESP TOPMed gnomAD
rs199808779 CA5879987	454	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA5879988 rs140162029	455	N>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA217706398 rs908881551	455	N>S		No	ClinGen TOPMed gnomAD
rs369028164 CA5879989	457	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs34883479 CA5879990	458	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA379848119 rs1158229033	458	M>T		No	ClinGen gnomAD
CA379848135 rs1191563773	460	K>T		No	ClinGen TOPMed
TCGA novel	464	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749561677 CA5880008	468	T>I		No	ClinGen ExAC gnomAD
CA5880009 rs771783134	469	R>G		No	ClinGen ExAC gnomAD
rs139320767 CA217706402	471	S>P		No	ClinGen ESP gnomAD
rs139320767 CA379848218	471	S>T		No	ClinGen ESP gnomAD
CA5880011 VAR_041303 rs56411856	472	S>I		No	ClinGen UniProt ExAC dbSNP gnomAD
CA217706403 rs866677842	473	P>S		No	ClinGen Ensembl
CA5880012 rs532283069	475	V>G		No	ClinGen 1000Genomes ExAC gnomAD
rs1446773814 CA379848243	475	V>I		No	ClinGen gnomAD
CA5880014 rs761910453	481	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5880015 rs769549337	483	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs769549337 CA379848300	483	L>V		No	ClinGen ExAC TOPMed gnomAD
rs773071613 CA5880016	485	N>S		No	ClinGen ExAC gnomAD
CA217706405 rs943452383	487	V>I		No	ClinGen Ensembl
CA5880035 rs769792166	491	N>Y		No	ClinGen ExAC gnomAD
CA5880037 rs749218829	496	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1183855666 CA379848411	497	K>N		No	ClinGen gnomAD
rs1259714543 CA379848430	500	I>T		No	ClinGen gnomAD
CA217706535 rs889431573	501	F>L		No	ClinGen TOPMed gnomAD
CA5880040 rs759817943	509	C>R		No	ClinGen ExAC TOPMed gnomAD
rs767672052 CA5880041	509	C>Y		No	ClinGen ExAC gnomAD
rs760634830 CA5880043	510	A>T		No	ClinGen ExAC gnomAD
CA5880044 rs764207549	513	A>T		No	ClinGen ExAC gnomAD
rs757769724 CA5880046	515	P>T		No	ClinGen ExAC TOPMed gnomAD
CA379848530 rs1326890678	517	P>A		No	ClinGen TOPMed
COSM1232715 rs1380981911 CA379848534	517	P>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA217706544 rs943817876	518	R>I		No	ClinGen TOPMed
CA379848553 rs1387234986	520	G>A		No	ClinGen TOPMed
CA5880051 rs747723878	524	H>R		No	ClinGen ExAC gnomAD
rs755618904 CA5880052	528	Q>H		No	ClinGen ExAC gnomAD
rs1479739864 CA379848622	530	R>G		No	ClinGen gnomAD
rs777310825 CA5880053	532	P>S		No	ClinGen ExAC gnomAD
CA379848642 rs1589981514	533	R>Q		No	ClinGen Ensembl
CA5880054 rs749237978 COSM1232717	533	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs770894091 CA5880055	534	I>M		No	ClinGen ExAC TOPMed gnomAD
rs774134779 CA5880056	537	V>A		No	ClinGen ExAC gnomAD
rs764158086 CA217706562	538	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA379848682 rs1419998009	540	Q>E		No	ClinGen gnomAD
CA379848690 rs1299496701	541	E>K		No	ClinGen TOPMed gnomAD
CA379848710 rs1363216392	543	T>I		No	ClinGen gnomAD
rs774381175 CA5880059	544	E>G		No	ClinGen ExAC gnomAD
rs1294063903 CA379848724	545	L>F		No	ClinGen gnomAD
rs768676134 CA5880061	547	K>N		No	ClinGen ExAC gnomAD
CA5880060 rs760933338	547	K>T		No	ClinGen ExAC gnomAD
CA5880074 rs185380974	548	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1311780625 CA379848772	550	I>S		No	ClinGen gnomAD
CA379848766 rs1447765031	550	I>V		No	ClinGen gnomAD
CA217706589 rs970706601	552	P>A		No	ClinGen TOPMed
CA379848797 rs1364443579	552	P>R		No	ClinGen TOPMed
rs771907098 CA5880075	554	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs867986077 CA217706590	555	E>K		No	ClinGen Ensembl
rs867986077 CA217706591	555	E>Q		No	ClinGen Ensembl
rs1315056937 CA379848888	559	S>L		No	ClinGen TOPMed
CA217706592 rs978181152	561	M>V		No	ClinGen TOPMed gnomAD
rs779886469 CA5880076	562	A>V		No	ClinGen ExAC gnomAD
rs747261635 CA5880077	563	L>V		No	ClinGen ExAC gnomAD
rs776589600 CA5880079	565	K>Q		No	ClinGen ExAC gnomAD
rs200001674 CA5880082 CA5880081	568	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs148751172 CA5880086	572	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1442884083 CA379849072	574	R>I		No	ClinGen TOPMed
rs763743496 CA5880087	575	K>R		No	ClinGen ExAC gnomAD
CA379849144 rs756801426	579	Q>E		No	ClinGen ExAC gnomAD
CA5880089 rs756801426	579	Q>K		No	ClinGen ExAC gnomAD
rs369658374 CA379849179	581	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
COSM933651 CA5880090 rs369658374	581	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA379849189 rs1447666670	582	I>T		No	ClinGen gnomAD
rs750419276 CA5880091	582	I>V		No	ClinGen ExAC gnomAD
TCGA novel	583	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	585	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761717168 CA5880093	589	F>L		No	ClinGen ExAC TOPMed gnomAD
rs746763681 CA5880094	592	S>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	597	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776395108 CA5880105	601	A>E		No	ClinGen ExAC gnomAD
rs1273411856 CA379849449	601	A>T		No	ClinGen gnomAD
CA5880106 rs761442214	602	Q>H		No	ClinGen ExAC gnomAD
CA379849465 rs1565091641	603	M>T		No	ClinGen Ensembl
CA5880107 rs764799333	614	F>S		No	ClinGen ExAC gnomAD
CA379849547 rs1215242751	615	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs991795889 CA217707032	615	T>S		No	ClinGen Ensembl
CA379849558 rs1263358618	616	D>E		No	ClinGen gnomAD
CA5880108 rs201194150	617	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs979306559 CA379849560	617	R>W		No	ClinGen TOPMed gnomAD
CA5880109 rs758348531	618	M>V		No	ClinGen ExAC TOPMed gnomAD
CA379849575 rs1478253696	619	A>G		No	ClinGen TOPMed gnomAD
rs1478253696 CA379849576	619	A>V		No	ClinGen TOPMed gnomAD
CA5880110 rs766293614	621	R>G		No	ClinGen ExAC gnomAD
rs751339750 CA5880111	622	S>F		No	ClinGen ExAC gnomAD
rs1418159470 CA379849596	623	T>P		No	ClinGen gnomAD
CA5880112 rs754839923	624	T>N		No	ClinGen ExAC gnomAD
rs1301122679 CA379849626	627	N>S		No	ClinGen gnomAD
rs918130908 CA217707046	628	R>K		No	ClinGen TOPMed gnomAD
CA379849632 rs918130908	628	R>T		No	ClinGen TOPMed gnomAD
TCGA novel	629	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379849641 rs1330843873	629	T>I		No	ClinGen TOPMed gnomAD
rs1387770972 CA379849646	630	S>C		No	ClinGen TOPMed
rs756401440 CA5880115	631	R>*		No	ClinGen ExAC TOPMed gnomAD
CA379849651 rs1239031645	631	R>L		No	ClinGen TOPMed gnomAD
CA379849649 rs1239031645	631	R>Q		No	ClinGen TOPMed gnomAD
CA379849653 rs1286088425	632	L>F		No	ClinGen gnomAD
rs199938345 CA5880116	633	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA217707055 rs943372651	635	K>R		No	ClinGen TOPMed gnomAD
CA379849700 rs1451905047	638	N>K		No	ClinGen gnomAD
CA379849705 rs1200711521	639	R>H		No	ClinGen gnomAD
rs771361900 CA5880118	640	S>F		No	ClinGen ExAC
rs774964765 CA5880119	642	S>N		No	ClinGen ExAC gnomAD
CA379849742 rs1382153901	645	I>T		No	ClinGen gnomAD
rs1158323030 CA379849739	645	I>V		No	ClinGen gnomAD

No associated diseases with P30291

3 regional properties for P30291

Type	Name	Position	InterPro Accession
conserved_site	14-3-3 protein, conserved site	45 - 55	IPR023409-1
conserved_site	14-3-3 protein, conserved site	217 - 236	IPR023409-2
domain	14-3-3 domain	7 - 248	IPR023410

Functions

		Description
EC Number	2.7.10.2	Protein-tyrosine kinases
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding	Binding to a magnesium (Mg) ion.
non-membrane spanning protein tyrosine kinase activity	Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

6 GO annotations of biological process

Name	Definition
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
establishment of cell polarity	The specification and formation of anisotropic intracellular organization or cell growth patterns.
G2/M transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
microtubule cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
negative regulation of G1/S transition of mitotic cell cycle	Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
neuron projection morphogenesis	The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9P2K8	EIF2AK4	eIF-2-alpha kinase GCN2	Homo sapiens (Human)	EV
Q99640	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (Human)	PR
P19525	EIF2AK2	Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (Human)	PR
Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	Homo sapiens (Human)	PR
P47810	Wee1	Wee1-like protein kinase	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSFLSRQQPP	PPRRAGAACT	LRQKLIFSPC	SDCEEEEEEE	EEEGSGHSTG	EDSAFQEPDS
70	80	90	100	110	120
PLPPARSPTE	PGPERRRSPG	PAPGSPGELE	EDLLLPGACP	GADEAGGGAE	GDSWEEEGFG
130	140	150	160	170	180
SSSPVKSPAA	PYFLGSSFSP	VRCGGPGDAS	PRGCGARRAG	EGRRSPRPDH	PGTPPHKTFR
190	200	210	220	230	240
KLRLFDTPHT	PKSLLSKARG	IDSSSVKLRG	SSLFMDTEKS	GKREFDVRQT	PQVNINPFTP
250	260	270	280	290	300
DSLLLHSSGQ	CRRRKRTYWN	DSCGEDMEAS	DYELEDETRP	AKRITITESN	MKSRYTTEFH
310	320	330	340	350	360
ELEKIGSGEF	GSVFKCVKRL	DGCIYAIKRS	KKPLAGSVDE	QNALREVYAH	AVLGQHSHVV
370	380	390	400	410	420
RYFSAWAEDD	HMLIQNEYCN	GGSLADAISE	NYRIMSYFKE	AELKDLLLQV	GRGLRYIHSM
430	440	450	460	470	480
SLVHMDIKPS	NIFISRTSIP	NAASEEGDED	DWASNKVMFK	IGDLGHVTRI	SSPQVEEGDS
490	500	510	520	530	540
RFLANEVLQE	NYTHLPKADI	FALALTVVCA	AGAEPLPRNG	DQWHEIRQGR	LPRIPQVLSQ
550	560	570	580	590	600
EFTELLKVMI	HPDPERRPSA	MALVKHSVLL	SASRKSAEQL	RIELNAEKFK	NSLLQKELKK
610	620	630	640
AQMAKAAAEE	RALFTDRMAT	RSTTQSNRTS	RLIGKKMNRS	VSLTIY