AiPD: Autoinhibited Protein Database

P29992

Gene name	GNA11 (GA11)
Protein name	Guanine nucleotide-binding protein subunit alpha-11
Names	G alpha-11 , G-protein subunit alpha-11 , Guanine nucleotide-binding protein G, y subunit alpha
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2767
EC number
Protein Class

Descriptions

Gαi1 is a G-protein alpha subunit that plays a crucial role in signal transduction pathway initiated by G-protein-coupled receptor (GPCR) activation. G proteins function as transducers downstream of GPCRs in numerous signaling cascades. The alpha subunit contains the guanine nucleotide binding site and alternates between an active (GTP-bound state) and an inactive (GDP-bound state). Activated GPCR induces conformational change in Gαi1, which allows for GDP-to-GTP exchange by binding to the GPCR-binding site within a Ras-like domain, leading to dissociation of the Gαi1 subunit and initiation of downstream signaling.

Autoinhibitory domains (AIDs)

68-182 (α-H domain) SS

Target domain	189-353 (Ras-like domain)
Relief mechanism	Ligand binding, Partner binding
Assay

AID

68-182 (α-H domain)

Target domain

189-353 (Ras-like domain)

Relief mechanism

Ligand binding (GTP binding), Partner binding(Binding of activated GPCR)

Assay

Accessory elements

No accessory elements

References

Goricanec D et al. (2016) "Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding", Proceedings of the National Academy of Sciences of the United States of America, 113, E3629-38

Coleman DE et al. (1999) "Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex", The Journal of biological chemistry, 274, 16669-72

Lutz S et al. (2007) "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs", Science (New York, N.Y.), 318, 1923-7

Autoinhibited structure

Activated structure

4 structures for P29992

Entry ID	Method	Resolution	Chain	Position	Source
6OIJ	EM	330 A	A	36-359	PDB
7RKF	EM	400 A	A	25-359	PDB
7TRY	EM	370 A	A	25-359	PDB
AF-P29992-F1	Predicted				AlphaFoldDB

978 variants for P29992

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV000857316 rs200234790	32	D>G	Familial hypocalciuric hypercalcemia 2 [ClinVar]	Yes	ClinVar Ensembl dbSNP
rs1335558363 RCV001706737	54	T>M	Familial hypocalciuric hypercalcemia 2 [ClinVar]	Yes	ClinVar dbSNP gnomAD
VAR_070165 CA144607 RCV002504951 rs587777021 RCV000054478 RCV001853077	60	R>C	Autosomal dominant hypocalcemia 2 Familial hypocalciuric hypercalcemia 2 HYPOC2 [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
CA170731 RCV000144048 rs587777707	60	R>L	Autosomal dominant hypocalcemia 2 [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
rs756991534 RCV002480772 RCV001236129	96	T>M	Variant assessed as Somatic; MODERATE impact. Familial hypocalciuric hypercalcemia 2 [NCI-TCGA, ClinVar]	Yes	ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
CA144604 rs587777019 VAR_070166 RCV000054475	135	L>Q	Familial hypocalciuric hypercalcemia 2 HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
rs587777020 CA144605 RCV002514274 VAR_070167 RCV000054476	181	R>Q	Autosomal dominant hypocalcemia 2 HYPOC2; induces an increase in sensitivity to changes in extracellular calcium concentrations [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
RCV002254302 RCV000662311 RCV001526637 RCV001526569 RCV001706699 rs1555702147 COSM21651	183	R>C	eye Lobular capillary hemangiomas Capillary malformation CLOVES syndrome Variant assessed as Somatic; MODERATE impact. skin [Cosmic, ClinVar, NCI-TCGA]	Yes	NCI-TCGA Cosmic cosmic curated ClinVar Ensembl NCI-TCGA dbSNP
RCV002486585 rs768371546 RCV001989592	198	N>H	Familial hypocalciuric hypercalcemia 2 [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
VAR_070168 CA144602 rs672601249 RCV000054474	200	I>missing	Familial hypocalciuric hypercalcemia 2 HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt dbSNP
VAR_070168 rs672601249	200	I>del	HHC2; induces a decrease in sensitivity to changes in extracellular calcium concentrations [UniProt]	Yes	UniProt dbSNP
RCV000444127 RCV002254297 CA16602475 RCV000425425 RCV000437415 COSM52969 rs1057519742 RCV003128401	209	Q>L	eye Variant assessed as Somatic; MODERATE impact. Melanoma skin Uveal melanoma meninges Malignant melanoma of skin [Cosmic, NCI-TCGA, ClinVar]	Yes	ClinGen NCI-TCGA Cosmic cosmic curated ClinVar Ensembl NCI-TCGA dbSNP
RCV000432719 RCV000425941 COSM52970 rs1057519742 CA16602474	209	Q>P	eye Melanoma Uveal melanoma meninges [Cosmic, ClinVar]	Yes	ClinGen cosmic curated ClinVar Ensembl dbSNP
RCV000054479 VAR_070169 CA144608 rs587777022	211	S>W	Autosomal dominant hypocalcemia 2 HYPOC2 [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt ExAC dbSNP gnomAD
rs144829732 RCV001320866 RCV002493677 COSM4076641	269	V>I	Variant assessed as Somatic; MODERATE impact. Familial hypocalciuric hypercalcemia 2 [NCI-TCGA, ClinVar]	Yes	NCI-TCGA Cosmic ClinVar 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs140749796 VAR_070170 RCV000054477 CA144606	341	F>L	Autosomal dominant hypocalcemia 2 HYPOC2; induces an increase in sensitivity to changes in extracellular calcium concentrations [ClinVar, UniProt]	Yes	ESP ExAC TOPMed gnomAD ClinGen ClinVar UniProt dbSNP
rs2145300227	2	T>A		No	Ensembl
rs1417344175	2	T>I		No	gnomAD
rs1913317207	3	L>P		No	Ensembl
rs2145300247	4	E>G		No	Ensembl
rs2145300242	4	E>Q		No	Ensembl
rs2145300247	4	E>V		No	Ensembl
rs2145300250	5	S>A		No	Ensembl
rs1913317498	6	M>I		No	Ensembl
rs1387105467	6	M>L		No	TOPMed gnomAD
rs1599293107	6	M>T		No	Ensembl
rs1387105467	6	M>V		No	TOPMed gnomAD
rs1401199158	7	M>R		No	gnomAD
rs1401199158	7	M>T		No	gnomAD
rs1913317570	7	M>V		No	Ensembl
rs1913317685	8	A>P		No	TOPMed
RCV001934609 rs141078172	8	A>V		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs2145300277	9	C>G		No	Ensembl
rs2145300285	9	C>W		No	Ensembl
rs2145300284	9	C>Y		No	Ensembl
rs2145300289	10	C>*		No	Ensembl
rs2145300289	10	C>W		No	Ensembl
rs1913317841	11	L>V		No	TOPMed
rs2145300305	12	S>G		No	Ensembl
rs1913317982	13	D>G		No	TOPMed gnomAD
rs1338184866	14	E>G		No	gnomAD
rs1913318065	14	E>Q		No	TOPMed
rs2145300320	15	V>E		No	Ensembl
rs2145300320	15	V>G		No	Ensembl
rs1913318349	18	S>C		No	Ensembl
rs1242029660	20	R>W		No	gnomAD
rs2145300340	21	I>S		No	Ensembl
rs2145300347	23	A>T		No	Ensembl
rs1913318572	24	E>V		No	TOPMed
rs1479867877	28	Q>*		No	TOPMed
rs1479867877	28	Q>K		No	TOPMed
rs1913318778	30	R>L		No	TOPMed
COSM3932990 rs2145300360	30	R>W	urinary_tract [Cosmic]	No	cosmic curated Ensembl
rs1599293133	31	R>W		No	TOPMed
rs1913318982	32	D>Y		No	TOPMed gnomAD
rs1913319191	34	R>C		No	Ensembl
rs1913319191	34	R>G		No	Ensembl
rs2145300391	35	D>G		No	Ensembl
rs2145300387	35	D>N		No	Ensembl
rs773203722	36	A>S		No	ExAC gnomAD
rs773203722	36	A>T		No	ExAC gnomAD
rs2145300399	36	A>V		No	Ensembl
rs1486864119	37	R>L		No	TOPMed gnomAD
rs1486864119	37	R>Q		No	TOPMed gnomAD
rs2145300421	39	E>Q		No	Ensembl
rs1342252945	42	L>V		No	TOPMed
rs1007210976	45	L>I		No	Ensembl
TCGA novel	45	L>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2145315422	46	G>D		No	Ensembl
rs762714189	47	T>M		No	ExAC gnomAD
rs1913735988	49	E>K		No	TOPMed
rs1913736061 RCV001206089	50	S>N		No	ClinVar Ensembl dbSNP
rs377224539 RCV001212608	51	G>R		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs2145315453	53	S>N		No	Ensembl
rs2145315466	55	F>I		No	Ensembl
COSM4827188	56	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs755993488	56	I>T		No	ExAC gnomAD
rs2145315478	58	Q>*		No	Ensembl
rs1913736679	59	M>T		No	Ensembl
rs1913736617	59	M>V		No	TOPMed
rs587777707	60	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs2145315498	61	I>N		No	Ensembl
rs2145315515	64	G>D		No	Ensembl
rs1477351940	64	G>R		No	TOPMed gnomAD
rs1477351940	64	G>S		No	TOPMed gnomAD
rs2145315515	64	G>V		No	Ensembl
rs147528229	65	A>S		No	1000Genomes ESP ExAC TOPMed gnomAD
RCV000889157 rs147528229 CA159920 RCV000121154	65	A>T		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs868681560	66	G>D		No	Ensembl
COSM178570 rs1163458352	66	G>S	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs1913737726	68	S>L		No	gnomAD
rs916041207	70	E>*		No	TOPMed
rs140301317 RCV001893620	73	R>C		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs140301317	73	R>G		No	ESP ExAC TOPMed gnomAD
rs769019097	73	R>H		No	ExAC gnomAD
rs769019097	73	R>L		No	ExAC gnomAD
rs769019097	73	R>P		No	ExAC gnomAD
rs2145315565	74	G>D		No	Ensembl
rs777092144	74	G>S		No	ExAC TOPMed gnomAD
rs1391411006	76	T>I		No	Ensembl
rs1671522857 RCV001201717	77	K>R		No	ClinVar Ensembl dbSNP
rs1232791367	78	L>I		No	gnomAD
rs2145315595	79	V>D		No	Ensembl
rs777099166 RCV001996464	79	V>I		No	ClinVar ExAC dbSNP gnomAD
rs2145315597 RCV002050632	80	Y>*		No	ClinVar Ensembl dbSNP
rs1402723163	81	Q>R		No	TOPMed
rs2145315609	82	N>K		No	Ensembl
rs1487847863	83	I>V		No	gnomAD
rs74913870	84	F>S		No	Ensembl
rs1599302109	85	T>P		No	Ensembl
rs374089777	86	A>P		No	ESP TOPMed gnomAD
rs374089777	86	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP NCI-TCGA TOPMed gnomAD
rs2145315643	87	M>I		No	Ensembl
rs1475313918	87	M>V		No	TOPMed gnomAD
rs1913739644	88	Q>*		No	gnomAD
rs1913739644	88	Q>E		No	gnomAD
rs2145315653	89	A>D		No	Ensembl
rs760710011	89	A>T		No	ExAC gnomAD
rs941191833	92	R>L		No	TOPMed gnomAD
rs941191833	92	R>Q		No	TOPMed gnomAD
RCV001890163 rs753693838	92	R>W		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs2145315677	93	A>P		No	Ensembl
rs2145315685	93	A>V		No	Ensembl
rs975342398	94	M>V		No	TOPMed
rs1456020858	95	E>D		No	TOPMed gnomAD
rs1297795462	95	E>G		No	Ensembl
rs1380208656	96	T>A		No	gnomAD
rs1380208656	96	T>S		No	gnomAD
rs2145315708	97	L>H		No	Ensembl
rs2145315708	97	L>P		No	Ensembl
rs1913740506	98	K>Q		No	TOPMed
rs1376341794	98	K>R		No	TOPMed gnomAD
rs758603549	103	Y>*		No	ExAC TOPMed gnomAD
rs2145315725	103	Y>D		No	Ensembl
rs1913740780	104	E>K		No	TOPMed
rs1913740843	105	Q>H		No	TOPMed gnomAD
rs1306652036	106	N>S		No	gnomAD
rs1051216341	107	K>M		No	Ensembl
COSM994453	108	A>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2145318412	108	A>D		No	Ensembl
rs2145318412	108	A>G		No	Ensembl
rs2145318411	108	A>P		No	Ensembl
rs2145318411	108	A>T		No	Ensembl
rs2145318412	108	A>V		No	Ensembl
rs751665166	109	N>I		No	ExAC TOPMed gnomAD
rs751665166	109	N>S		No	ExAC TOPMed gnomAD
rs759791665	110	A>E		No	ExAC gnomAD
rs759791665	110	A>V		No	ExAC gnomAD
rs2145318433	111	L>I		No	Ensembl
rs2145318442	112	L>P		No	Ensembl
rs2145318442	112	L>Q		No	Ensembl
rs752795403	112	L>V		No	ExAC TOPMed gnomAD
rs2145318451	113	I>F		No	Ensembl
rs2145318459	113	I>M		No	Ensembl
rs2145318454	113	I>S		No	Ensembl
rs2145318451	113	I>V		No	Ensembl
rs1215008332	114	R>G		No	TOPMed gnomAD
rs541350337	114	R>L		No	ExAC TOPMed gnomAD
rs541350337	114	R>P		No	ExAC TOPMed gnomAD
rs541350337	114	R>Q		No	ExAC TOPMed gnomAD
COSM3822624 rs1215008332	114	R>W	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1197262629	115	E>D		No	TOPMed gnomAD
rs2145318481	115	E>G		No	Ensembl
rs1451507571	115	E>K		No	gnomAD
rs1451507571	115	E>Q		No	gnomAD
rs2145318481	115	E>V		No	Ensembl
rs1913825787	116	V>L		No	Ensembl
rs1913825787	116	V>M		No	Ensembl
rs778378225	117	D>E		No	ExAC TOPMed gnomAD
rs2145318497	117	D>G		No	Ensembl
rs1368778199	117	D>H		No	TOPMed gnomAD
rs1368778199	117	D>N		No	TOPMed gnomAD
rs2145318497	117	D>V		No	Ensembl
rs1368778199	117	D>Y		No	TOPMed gnomAD
rs754271296	118	V>L		No	ExAC TOPMed gnomAD
rs754271296	118	V>M		No	ExAC TOPMed gnomAD
rs2145318530	119	E>G		No	Ensembl
rs2145318525	119	E>K		No	Ensembl
rs2145318530	119	E>V		No	Ensembl
rs2145318536	120	K>E		No	Ensembl
rs2145318537	120	K>M		No	Ensembl
rs1913826360	120	K>N		No	Ensembl
rs2145318537	120	K>R		No	Ensembl
rs2145318550	121	V>A		No	Ensembl
rs2145318550	121	V>E		No	Ensembl
rs2145318550	121	V>G		No	Ensembl
rs2145318547	121	V>L		No	Ensembl
rs2145318561	122	T>A		No	Ensembl
rs1308091091	122	T>I		No	Ensembl
rs1308091091	122	T>S		No	Ensembl
rs2145318569	123	T>A		No	Ensembl
rs879188402	123	T>I		No	TOPMed
rs879188402	123	T>S		No	TOPMed
rs2145318569	123	T>S		No	Ensembl
rs559730941	124	F>L		No	1000Genomes ExAC TOPMed gnomAD
rs1170008066	125	E>*		No	TOPMed gnomAD
rs1165709212	125	E>D		No	gnomAD
rs2145318587	125	E>G		No	Ensembl
rs1170008066	125	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1170008066	125	E>Q		No	TOPMed gnomAD
rs2145318587	125	E>V		No	Ensembl
rs746693359	126	H>L		No	ExAC gnomAD
rs2145318599	126	H>N		No	Ensembl
rs1913827194	126	H>Q		No	TOPMed
rs746693359	126	H>R		No	ExAC gnomAD
rs2145318599	126	H>Y		No	Ensembl
rs2145318610	127	Q>*		No	Ensembl
rs2145318621	127	Q>H		No	Ensembl
rs2145318614	127	Q>L		No	Ensembl
rs2145318614	127	Q>R		No	Ensembl
rs531521209	128	Y>*		No	ExAC TOPMed gnomAD
rs2145318631	128	Y>C		No	Ensembl
rs2145318624	128	Y>D		No	Ensembl
rs2145318631	128	Y>F		No	Ensembl
rs2145318624	128	Y>N		No	Ensembl
rs2145318647	129	V>A		No	Ensembl
rs2145318647	129	V>D		No	Ensembl
rs2145318647	129	V>G		No	Ensembl
rs780718032	129	V>I		No	ExAC TOPMed gnomAD
rs780718032	129	V>L		No	ExAC TOPMed gnomAD
rs2145318655	130	S>C		No	Ensembl
rs2145318655	130	S>G		No	Ensembl
rs2145318662	130	S>N		No	Ensembl
rs2145318668	130	S>R		No	Ensembl
rs2145318662	130	S>T		No	Ensembl
rs2145318672	131	A>G		No	Ensembl
rs2145318669	131	A>P		No	Ensembl
rs2145318669	131	A>T		No	Ensembl
rs2145318672	131	A>V		No	Ensembl
rs2145318679	132	I>F		No	Ensembl
rs2145318686 COSM1524860	132	I>M	lung [Cosmic]	No	cosmic curated Ensembl
rs2145318683	132	I>N		No	Ensembl
rs2145318683	132	I>S		No	Ensembl
COSM710493 rs2145318679	132	I>V	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs1568282988	133	K>*		No	Ensembl
rs1568282988	133	K>E		No	Ensembl
rs2145318695	133	K>M		No	Ensembl
rs2145318699	133	K>N		No	Ensembl
rs371712160	134	T>I		No	ESP gnomAD
rs371712160	134	T>N		No	ESP gnomAD
rs2145318702	134	T>S		No	Ensembl
rs371712160	134	T>S		No	ESP gnomAD
rs2145318713	135	L>M		No	Ensembl
rs587777019	135	L>P		No	Ensembl
rs2145318713	135	L>V		No	Ensembl
rs2145318722	136	W>*		No	Ensembl
rs2145318722	136	W>C		No	Ensembl
rs2145318732	137	E>G		No	Ensembl
rs773074121	137	E>K		No	ExAC gnomAD
rs773074121	137	E>Q		No	ExAC gnomAD
rs2145318732	137	E>V		No	Ensembl
rs2145318748	138	D>A		No	Ensembl
rs762810586	138	D>E		No	ExAC gnomAD
rs2145318748	138	D>G		No	Ensembl
rs2145318744	138	D>H		No	Ensembl
rs2145318744	138	D>N		No	Ensembl
rs2145318748	138	D>V		No	Ensembl
rs2145318744	138	D>Y		No	Ensembl
rs2145318759	139	P>A		No	Ensembl
rs1173495934	139	P>L		No	TOPMed
rs1173495934	139	P>Q		No	TOPMed
rs1173495934	139	P>R		No	TOPMed
rs2145318759	139	P>S		No	Ensembl
rs2145318759	139	P>T		No	Ensembl
rs2145318772	140	G>A		No	Ensembl
rs2145318772	140	G>D		No	Ensembl
rs1913828034	140	G>R		No	TOPMed
rs1913828034	140	G>S		No	TOPMed
rs2145318784	141	I>F		No	Ensembl
rs2145318791	141	I>M		No	Ensembl
rs1913828183	141	I>T		No	Ensembl
rs2145318784	141	I>V		No	Ensembl
rs2145318796	142	Q>*		No	Ensembl
rs2145318796	142	Q>E		No	Ensembl
rs2145318801	142	Q>H		No	Ensembl
rs2145318796	142	Q>K		No	Ensembl
rs2145318800	142	Q>L		No	Ensembl
rs2145318805	143	E>*		No	Ensembl
rs2145318805	143	E>Q		No	Ensembl
rs2145318821	144	C>F		No	Ensembl
rs2145318812	144	C>G		No	Ensembl
rs2145318821	144	C>S		No	Ensembl
rs2145318812	144	C>S		No	Ensembl
rs2145318824	144	C>W		No	Ensembl
rs2145318821	144	C>Y		No	Ensembl
rs759718861	145	Y>*		No	ExAC TOPMed gnomAD
rs2145318829	145	Y>C		No	Ensembl
rs2145318829	145	Y>F		No	Ensembl
rs2145318826	145	Y>H		No	Ensembl
rs2145318826	145	Y>N		No	Ensembl
rs2145318829	145	Y>S		No	Ensembl
rs2145318839	146	D>E		No	Ensembl
rs778757346	146	D>H		No	TOPMed gnomAD
rs778757346	146	D>N		No	TOPMed gnomAD
COSM2750391 rs767809613	147	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs767809613	147	R>G		No	ExAC gnomAD
rs1035292287 COSM474501	147	R>H	kidney [Cosmic]	No	cosmic curated gnomAD
rs1035292287	147	R>L		No	gnomAD
rs1035292287	147	R>P		No	gnomAD
rs767809613	147	R>S		No	ExAC gnomAD
rs1261353288	148	R>G		No	gnomAD
rs2145318861 TCGA novel	148	R>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2145318863	148	R>S		No	Ensembl
rs2145318861	148	R>T		No	Ensembl
rs1261353288	148	R>W		No	gnomAD
rs1913828735	149	R>C		No	TOPMed
rs1913828735	149	R>G		No	TOPMed
TCGA novel rs1913828804	149	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1913828804	149	R>P		No	gnomAD
rs1181395352	150	E>D		No	TOPMed gnomAD
rs752848608	150	E>K		No	ExAC gnomAD
rs752848608	150	E>Q		No	ExAC gnomAD
rs2145318881	150	E>V		No	Ensembl
rs2145318891	151	Y>*		No	Ensembl
rs2145318886	151	Y>D		No	Ensembl
rs2145318886	151	Y>H		No	Ensembl
rs2145318886	151	Y>N		No	Ensembl
rs2145318893	152	Q>*		No	Ensembl
rs760781651	152	Q>H		No	ExAC gnomAD
rs2145318893	152	Q>K		No	Ensembl
rs2145318895	152	Q>L		No	Ensembl
rs2145318895	152	Q>R		No	Ensembl
rs2145318910	153	L>H		No	Ensembl
rs2145318910	153	L>P		No	Ensembl
rs2145318906	153	L>V		No	Ensembl
rs2145318925 TCGA novel	154	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2145318925	154	S>F		No	Ensembl
rs2145318917	154	S>P		No	Ensembl
rs2145318917	154	S>T		No	Ensembl
rs779191241	155	D>N		No	ExAC TOPMed gnomAD
rs2145318934	156	S>F		No	Ensembl
rs2145318943	157	A>D		No	Ensembl
rs2145318943	157	A>G		No	Ensembl
rs2145318940	157	A>P		No	Ensembl
rs2145318940	157	A>T		No	Ensembl
rs2145318943	157	A>V		No	Ensembl
rs750766195	158	K>*		No	ExAC gnomAD
rs750766195	158	K>E		No	ExAC gnomAD
rs754616176	158	K>N		No	ExAC gnomAD
rs1469665156	159	Y>*		No	gnomAD
rs2145318957	159	Y>D		No	Ensembl
rs2145318957	159	Y>H		No	Ensembl
rs2145318957	159	Y>N		No	Ensembl
rs2145320665	160	Y>*		No	Ensembl
rs2145320660	160	Y>C		No	Ensembl
rs2145320660	160	Y>F		No	Ensembl
rs2145320651	160	Y>H		No	Ensembl
rs2145320651	160	Y>N		No	Ensembl
rs2145320660	160	Y>S		No	Ensembl
rs2145320674	162	T>A		No	Ensembl
rs1913871468	162	T>I		No	TOPMed
rs2145320674	162	T>P		No	Ensembl
rs2145320674	162	T>S		No	Ensembl
rs1913871468	162	T>S		No	TOPMed
rs2145320692	163	D>A		No	Ensembl
rs141926949	163	D>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2145320692	163	D>G		No	Ensembl
rs2145320689	163	D>H		No	Ensembl
rs2145320689	163	D>N		No	Ensembl
rs2145320692	163	D>V		No	Ensembl
rs2145320703	164	V>A		No	Ensembl
rs2145320703	164	V>D		No	Ensembl
COSM1208385 rs2145320703	164	V>G	large_intestine [Cosmic]	No	cosmic curated Ensembl
rs775624350 COSM1392332	164	V>I	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs775624350	164	V>L		No	1000Genomes ExAC TOPMed gnomAD
rs2145320713	165	D>A		No	Ensembl
rs2145320721	165	D>E		No	Ensembl
rs2145320713	165	D>G		No	Ensembl
rs2145320708	165	D>H		No	Ensembl
rs2145320708	165	D>N		No	Ensembl
rs2145320713	165	D>V		No	Ensembl
rs2145320708	165	D>Y		No	Ensembl
rs2145320726	166	R>C		No	Ensembl
rs2145320726	166	R>G		No	Ensembl
rs2145320729	166	R>H		No	Ensembl
rs2145320729	166	R>L		No	Ensembl
rs2145320729	166	R>P		No	Ensembl
rs2145320726	166	R>S		No	Ensembl
rs2145320739	167	I>F		No	Ensembl
rs2145320739	167	I>L		No	Ensembl
rs756722832	167	I>M		No	ExAC TOPMed gnomAD
rs2145320747	168	A>G		No	Ensembl
rs1913871940	168	A>S		No	TOPMed
RCV001954868 rs1913871940	168	A>T		No	ClinVar TOPMed dbSNP
rs2145320747	168	A>V		No	Ensembl
rs2145320757	169	T>I		No	Ensembl
rs2145320754	169	T>P		No	Ensembl
rs2145320754	169	T>S		No	Ensembl
rs2145320757	169	T>S		No	Ensembl
rs2145320766	170	L>F		No	Ensembl
RCV001431863 rs191421665	170	L>M		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs2145320779	171	G>A		No	Ensembl
rs2145320776	171	G>C		No	Ensembl
rs2145320779	171	G>D		No	Ensembl
rs2145320776	171	G>R		No	Ensembl
TCGA novel rs2145320776	171	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2145320779	171	G>V		No	Ensembl
RCV001876746 rs1568283562	172	Y>*		No	Ensembl ClinVar dbSNP
rs2145320795	173	L>M		No	Ensembl
rs2145320802	173	L>P		No	Ensembl
rs2145320802	173	L>Q		No	Ensembl
rs2145320795	173	L>V		No	Ensembl
rs2145320807	174	P>A		No	Ensembl
rs2145320809	174	P>H		No	Ensembl
rs2145320809	174	P>L		No	Ensembl
rs2145320809	174	P>R		No	Ensembl
rs2145320807	174	P>S		No	Ensembl
rs2145320807	174	P>T		No	Ensembl
rs2145320826	175	T>I		No	Ensembl
rs2145320826	175	T>N		No	Ensembl
rs2145320817	175	T>S		No	Ensembl
rs2145320826	175	T>S		No	Ensembl
rs2145320834	176	Q>*		No	Ensembl
rs2145320834	176	Q>E		No	Ensembl
rs2145320843	176	Q>H		No	Ensembl
rs2145320834	176	Q>K		No	Ensembl
rs2145320839	176	Q>L		No	Ensembl
rs2145320847	177	Q>*		No	Ensembl
rs2145320847	177	Q>E		No	Ensembl
rs2145320853	177	Q>H		No	Ensembl
rs2145320847	177	Q>K		No	Ensembl
rs2145320849	177	Q>L		No	Ensembl
rs2145320849	177	Q>R		No	Ensembl
rs2145320860	178	D>A		No	Ensembl
rs146295413	178	D>E		No	ESP ExAC TOPMed gnomAD
rs2145320860	178	D>G		No	Ensembl
rs2145320855	178	D>H		No	Ensembl
rs2145320855	178	D>N		No	Ensembl
rs2145320860	178	D>V		No	Ensembl
rs2145320874	179	V>A		No	Ensembl
rs2145320874	179	V>E		No	Ensembl
rs2145320874	179	V>G		No	Ensembl
rs2145320870	179	V>L		No	Ensembl
rs2145320870	179	V>M		No	Ensembl
rs2145320884	180	L>M		No	Ensembl
rs2145320889	180	L>P		No	Ensembl
rs2145320889	180	L>Q		No	Ensembl
rs2145320884	180	L>V		No	Ensembl
rs1391552100	181	R>G		No	TOPMed gnomAD
rs587777020	181	R>L		No	Ensembl
rs1391552100	181	R>W		No	TOPMed gnomAD
rs2145320919	182	V>A		No	Ensembl
rs2145320919	182	V>D		No	Ensembl
rs2145320909	182	V>F		No	Ensembl
rs2145320919	182	V>G		No	Ensembl
rs2145320909	182	V>I		No	Ensembl
rs2145320909	182	V>L		No	Ensembl
rs2145320931	183	R>C		No	Ensembl
rs1555702147	183	R>G		No	Ensembl
rs1913872981 COSM52973	183	R>H	skin [Cosmic]	No	cosmic curated Ensembl
COSM1392333 rs1913872981	183	R>L	large_intestine [Cosmic]	No	cosmic curated Ensembl
rs1913872981	183	R>P		No	Ensembl
rs1555702147	183	R>S		No	Ensembl
rs2145320960	184	V>A		No	Ensembl
rs2145320960	184	V>E		No	Ensembl
rs2145320960	184	V>G		No	Ensembl
rs2145320950	184	V>L		No	Ensembl
COSM6038089 rs2145320950	184	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2145320965	185	P>A		No	Ensembl
rs2145320983	186	T>N		No	Ensembl
rs2145320979	186	T>S		No	Ensembl
rs2145320983	186	T>S		No	Ensembl
rs2145321000	187	T>A		No	Ensembl
rs1867306467	187	T>I		No	TOPMed
rs1867306467	187	T>N		No	TOPMed
rs2145321000	187	T>P		No	Ensembl
rs1867306467	187	T>S		No	TOPMed
rs2145321000	187	T>S		No	Ensembl
rs2145321022	188	G>A		No	Ensembl
rs2145321018	188	G>C		No	Ensembl
rs2145321022	188	G>D		No	Ensembl
rs2145321018	188	G>R		No	Ensembl
rs2145321018	188	G>S		No	Ensembl
rs2145321022	188	G>V		No	Ensembl
rs2145321032	189	I>F		No	Ensembl
rs2145321032	189	I>L		No	Ensembl
rs1913873393	189	I>M		No	TOPMed
rs2145321040	189	I>N		No	Ensembl
rs2145321040	189	I>S		No	Ensembl
rs2145321040	189	I>T		No	Ensembl
rs2145321032	189	I>V		No	Ensembl
rs1913873486	190	I>F		No	TOPMed
rs1913873486	190	I>L		No	TOPMed
rs2145321061	190	I>N		No	Ensembl
rs2145321061	190	I>S		No	Ensembl
rs2145321061	190	I>T		No	Ensembl
rs1913873486	190	I>V		No	TOPMed
rs748179180	191	E>D		No	ExAC gnomAD
rs2145321073	191	E>G		No	Ensembl
CA403308094 RCV000518852 rs1317391449	191	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ClinVar NCI-TCGA dbSNP gnomAD
rs2145321073	191	E>V		No	Ensembl
rs2145321091	192	Y>*		No	Ensembl
rs2145321080	192	Y>D		No	Ensembl
rs2145321088	192	Y>F		No	Ensembl
rs2145321080	192	Y>H		No	Ensembl
rs2145321080	192	Y>N		No	Ensembl
rs1913873977	193	P>A		No	TOPMed gnomAD
rs2145321104	193	P>L		No	Ensembl
rs2145321104	193	P>R		No	Ensembl
rs1913873977	193	P>S		No	TOPMed gnomAD
rs1913873977	193	P>T		No	TOPMed gnomAD
rs1913874066	194	F>I		No	Ensembl
rs902387291	194	F>L		No	TOPMed gnomAD
rs1913874066	194	F>L		No	Ensembl
rs2145321114	194	F>Y		No	Ensembl
rs1913874281	195	D>A		No	Ensembl
rs2145321133	195	D>E		No	Ensembl
rs1913874281	195	D>G		No	Ensembl
rs769982397	195	D>H		No	ExAC TOPMed gnomAD
rs769982397	195	D>N		No	ExAC TOPMed gnomAD
rs1913874281	195	D>V		No	Ensembl
rs769982397	195	D>Y		No	ExAC TOPMed gnomAD
rs1210308648	196	L>M		No	gnomAD
rs1210308648	196	L>V		No	gnomAD
rs2145321155	197	E>D		No	Ensembl
rs1913874470	197	E>G		No	TOPMed
rs1913874470	197	E>V		No	TOPMed
rs1431166394	198	N>I		No	gnomAD
rs2145321165	198	N>K		No	Ensembl
rs1431166394	198	N>S		No	gnomAD
rs1431166394	198	N>T		No	gnomAD
rs768371546	198	N>Y		No	ExAC TOPMed gnomAD
rs2145321172	199	I>F		No	Ensembl
rs2145321172	199	I>L		No	Ensembl
rs2145321181	199	I>M		No	Ensembl
rs2145321176	199	I>N		No	Ensembl
rs2145321176	199	I>S		No	Ensembl
rs2145321176	199	I>T		No	Ensembl
rs2145321190	200	I>F		No	Ensembl
rs2145321190	200	I>L		No	Ensembl
rs527451247	200	I>M		No	1000Genomes ExAC TOPMed gnomAD
rs2145321199	200	I>N		No	Ensembl
rs2145321199	200	I>T		No	Ensembl
rs2145321212	201	F>I		No	Ensembl
rs1913875017	201	F>L		No	TOPMed
rs2145321215	201	F>Y		No	Ensembl
rs2145321228	202	R>G		No	Ensembl
rs2145321233	202	R>L		No	Ensembl
rs2145321233	202	R>P		No	Ensembl
rs2145321233	202	R>Q		No	Ensembl
rs2145321228	202	R>W		No	Ensembl
COSM3532097 rs766426049	203	M>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs2145325885	204	V>G		No	Ensembl
rs2145325878	204	V>L		No	Ensembl
rs2145325878	204	V>M		No	Ensembl
rs2145325910	205	D>E		No	Ensembl
rs2145325904	205	D>G		No	Ensembl
rs2145325897	205	D>H		No	Ensembl
rs2145325897	205	D>N		No	Ensembl
rs2145325904	205	D>V		No	Ensembl
rs2145325897	205	D>Y		No	Ensembl
rs1913993801	206	V>L		No	Ensembl
rs1913993801	206	V>M		No	Ensembl
rs2145325931	207	G>A		No	Ensembl
rs2145325927	207	G>R		No	Ensembl
rs2145325931	207	G>V		No	Ensembl
rs2145325927	207	G>W		No	Ensembl
rs2145325949	208	G>A		No	Ensembl
COSM1392334	208	G>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2145325949	208	G>D		No	Ensembl
rs2145325942	208	G>R		No	Ensembl
rs2145325942	208	G>S		No	Ensembl
rs2145325949	208	G>V		No	Ensembl
COSM1392335 rs2145325959	209	Q>*	large_intestine [Cosmic]	No	cosmic curated Ensembl
rs2145325959	209	Q>E		No	Ensembl
COSM1717778 rs2145325982	209	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA Cosmic
COSM238583 rs2145325959	209	Q>K	prostate [Cosmic]	No	cosmic curated Ensembl
RCV002254467 rs1057519742 COSM1666996	209	Q>R	eye Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ClinVar Ensembl dbSNP
rs767395295	210	R>G		No	ExAC TOPMed gnomAD
rs2145325989	210	R>P		No	Ensembl
rs2145325989	210	R>Q		No	Ensembl
rs767395295	210	R>W		No	ExAC TOPMed gnomAD
rs587777022	211	S>*		No	ExAC gnomAD
rs587777022	211	S>L		No	ExAC gnomAD
rs2145326000	211	S>P		No	Ensembl
rs2145326000	211	S>T		No	Ensembl
rs2145326016	212	E>*		No	Ensembl
rs2145326021	212	E>G		No	Ensembl
rs2145326016	212	E>K		No	Ensembl
rs2145326016	212	E>Q		No	Ensembl
rs2145326021	212	E>V		No	Ensembl
rs2145326034	213	R>P		No	Ensembl
rs2145326034	213	R>Q		No	Ensembl
rs777912441	213	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2145326046	214	R>G		No	Ensembl
rs2145326050	214	R>K		No	Ensembl
rs2145326050	214	R>M		No	Ensembl
rs749372899	214	R>S		No	ExAC gnomAD
rs2145326046	214	R>W		No	Ensembl
rs2145326057	215	K>E		No	Ensembl
rs2145326065	215	K>M		No	Ensembl
RCV001948613 rs1913995254	215	K>N		No	ClinVar Ensembl dbSNP
rs2145326057	215	K>Q		No	Ensembl
rs2145326065	215	K>R		No	Ensembl
rs2145326079	216	W>*		No	Ensembl
rs2145326076	216	W>*		No	Ensembl
rs2145326079	216	W>C		No	Ensembl
rs1913995370	216	W>G		No	Ensembl
RCV001754726 rs1913995370	216	W>R		No	ClinVar Ensembl dbSNP
rs2145326082	217	I>F		No	Ensembl
rs2145326082	217	I>L		No	Ensembl
rs2145326087	217	I>M		No	Ensembl
rs2145326082	217	I>V		No	Ensembl
rs2145326097	218	H>D		No	Ensembl
rs2145326102	218	H>L		No	Ensembl
rs2145326097	218	H>N		No	Ensembl
rs2145326105	218	H>Q		No	Ensembl
rs2145326119	219	C>F		No	Ensembl
rs2145326111	219	C>S		No	Ensembl
rs2145326119	219	C>S		No	Ensembl
rs2145326119	219	C>Y		No	Ensembl
rs2145326123	220	F>I		No	Ensembl
rs2145326128 RCV001917878	220	F>S		No	ClinVar Ensembl dbSNP
rs2145326128	220	F>Y		No	Ensembl
rs2145326135	221	E>*		No	Ensembl
rs757393272	221	E>D		No	ExAC TOPMed gnomAD
rs2145326142	221	E>G		No	Ensembl
rs2145326135	221	E>K		No	Ensembl
rs2145326135 COSM3822626	221	E>Q	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs2145326142	221	E>V		No	Ensembl
rs2145326154	222	N>D		No	Ensembl
rs2145326159	222	N>I		No	Ensembl
rs754620313	222	N>K		No	TOPMed gnomAD
rs2145326159	222	N>S		No	Ensembl
rs2145326159	222	N>T		No	Ensembl
rs2145326154	222	N>Y		No	Ensembl
rs2145326170	223	V>E		No	Ensembl
rs2145326170	223	V>G		No	Ensembl
rs778948783	223	V>L		No	ExAC TOPMed gnomAD
COSM51687 rs778948783	223	V>M	skin [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs2145326180	224	T>I		No	Ensembl
rs2145326180	224	T>K		No	Ensembl
rs2145326180	224	T>R		No	Ensembl
rs2145326186	225	S>C		No	Ensembl
rs2145326186	225	S>F		No	Ensembl
rs2145326186	225	S>Y		No	Ensembl
rs2145326191	226	I>F		No	Ensembl
rs2145326191	226	I>L		No	Ensembl
rs371149978	226	I>M		No	ESP ExAC TOPMed gnomAD
rs2145326197	226	I>N		No	Ensembl
rs2145326197	226	I>S		No	Ensembl
rs2145326197	226	I>T		No	Ensembl
rs2145326213	227	M>K		No	Ensembl
rs2145326210	227	M>L		No	Ensembl
rs2145326213	227	M>T		No	Ensembl
rs2145326220	228	F>I		No	Ensembl
rs2145326220	228	F>L		No	Ensembl
rs2145326227	228	F>L		No	Ensembl
rs2145326225	228	F>S		No	Ensembl
rs2145326225	228	F>Y		No	Ensembl
rs2145326232	229	L>F		No	Ensembl
rs2145326236	229	L>H		No	Ensembl
rs2145326232	229	L>I		No	Ensembl
TCGA novel rs2145326232	229	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs2145326249	230	V>A		No	Ensembl
rs2145326249	230	V>D		No	Ensembl
rs2145326249	230	V>G		No	Ensembl
rs1309810840	230	V>I		No	TOPMed gnomAD
rs1309810840	230	V>L		No	TOPMed gnomAD
rs769503200	231	A>P		No	ExAC gnomAD
rs769503200	231	A>S		No	ExAC gnomAD
COSM5513428 rs769503200	231	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs2145326267	232	L>F		No	Ensembl
rs2145326270	232	L>H		No	Ensembl
rs2145326267	232	L>I		No	Ensembl
rs2145326270	232	L>P		No	Ensembl
rs2145326267	232	L>V		No	Ensembl
rs2145326281	233	S>G		No	Ensembl
rs2145326286	233	S>I		No	Ensembl
rs2145326286	233	S>N		No	Ensembl
rs1220448139	233	S>R		No	TOPMed
rs2145326286	233	S>T		No	Ensembl
rs2145326296	234	E>*		No	Ensembl
rs2096726116	234	E>D		No	Ensembl
rs2145326296	234	E>K		No	Ensembl
rs2145326296	234	E>Q		No	Ensembl
rs2145326300	234	E>V		No	Ensembl
COSM117887 rs138168314	235	Y>*	ovary [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs2145326314	235	Y>C		No	Ensembl
rs2145326314	235	Y>F		No	Ensembl
rs2145326308	235	Y>N		No	Ensembl
rs2145326314	235	Y>S		No	Ensembl
rs1913997186	236	D>E		No	Ensembl
rs1568284925	236	D>G		No	Ensembl
rs2145326325	236	D>H		No	Ensembl
rs2145326325	236	D>N		No	Ensembl
rs1568284925	236	D>V		No	Ensembl
rs2145326325	236	D>Y		No	Ensembl
rs1913997296	237	Q>*		No	gnomAD
rs1913997296	237	Q>E		No	gnomAD
rs2145326347	237	Q>H		No	Ensembl
rs1913997296	237	Q>K		No	gnomAD
rs2145326344	237	Q>L		No	Ensembl
rs2145326357	238	V>D		No	Ensembl
rs2145326352	238	V>I		No	Ensembl
rs2145326352	238	V>L		No	Ensembl
rs2145326363	239	L>M		No	Ensembl
rs2145326363	239	L>V		No	Ensembl
rs1291813342	240	V>A		No	TOPMed
rs766046727	240	V>L		No	ExAC gnomAD
rs766046727	240	V>M		No	ExAC gnomAD
rs2145326380	241	E>*		No	Ensembl
rs2145326391	241	E>D		No	Ensembl
rs2145326386	241	E>G		No	Ensembl
rs2145326380	241	E>K		No	Ensembl
rs2145326380	241	E>Q		No	Ensembl
rs2145326386	241	E>V		No	Ensembl
rs1007967128	242	S>A		No	TOPMed gnomAD
rs773976709	242	S>L		No	ExAC gnomAD
rs1007967128	242	S>P		No	TOPMed gnomAD
rs1007967128	242	S>T		No	TOPMed gnomAD
rs773976709	242	S>W		No	ExAC gnomAD
rs2145326422	243	D>E		No	Ensembl
rs767308128	243	D>G		No	ExAC gnomAD
rs1295243293	243	D>H		No	TOPMed gnomAD
rs1295243293	243	D>N		No	TOPMed gnomAD
rs1295243293	243	D>Y		No	TOPMed gnomAD
rs2145326428	244	N>I		No	Ensembl
rs752549242	244	N>K		No	ExAC gnomAD
rs2145326428	244	N>S		No	Ensembl
rs2145326428	244	N>T		No	Ensembl
rs2145326425	244	N>Y		No	Ensembl
rs1913998229	245	E>*		No	Ensembl
rs1913998329	245	E>D		No	Ensembl
rs2145326437	245	E>G		No	Ensembl
rs1913998229 COSM4856803	245	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs1913998229	245	E>Q		No	Ensembl
rs2145326437	245	E>V		No	Ensembl
rs1568285021	246	N>D		No	Ensembl
rs1914003795	246	N>K		No	Ensembl
rs1914003734	246	N>S		No	TOPMed
rs1208115313	247	R>Q		No	TOPMed
rs778362669	247	R>W		No	ExAC gnomAD
TCGA novel	250	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs745528917 TCGA novel	250	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA
rs2145326878	253	A>D		No	Ensembl
TCGA novel	253	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2145326878	253	A>V		No	Ensembl
TCGA novel	256	R>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs529942770 RCV001351660	256	R>P		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs529942770	256	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs775040372 COSM13668	256	R>W	skin [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs1297128070	259	I>T		No	gnomAD
rs761542744	260	T>A		No	ExAC gnomAD
rs1449570989	261	Y>C		No	TOPMed gnomAD
rs765454337	263	W>C		No	ExAC gnomAD
rs1914005297	265	Q>R		No	gnomAD
rs1914005484	266	N>K		No	gnomAD
rs1599307687	266	N>T		No	Ensembl
rs2145326944	267	S>F		No	Ensembl
COSM4076640	268	S>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4902024	268	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs144829732	269	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1471377402	270	I>V		No	gnomAD
rs1914005944	271	L>P		No	Ensembl
rs2145326975	273	L>H		No	Ensembl
rs2145326980 RCV001986651	274	N>S		No	ClinVar Ensembl dbSNP
rs2145326983	275	K>N		No	Ensembl
rs2145326992	277	D>E		No	Ensembl
rs2145326995	279	L>M		No	Ensembl
rs1161111839	280	E>D		No	TOPMed
rs1409264282	280	E>K		No	Ensembl
rs1444263678	281	D>A		No	gnomAD
rs2145327008	281	D>E		No	Ensembl
rs2145327016	283	I>V		No	Ensembl
rs1238030187	285	Y>H		No	gnomAD
COSM1582395 rs1914006634	286	S>L	stomach [Cosmic]	No	cosmic curated TOPMed
rs2145327043	287	H>L		No	Ensembl
rs2145327053	289	V>M		No	Ensembl
TCGA novel rs2145327059	290	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs756612392	292	F>L		No	ExAC gnomAD
COSM1325348	292	F>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1420026055	292	F>Y		No	gnomAD
rs1914007224 COSM3892222	293	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
TCGA novel	294	E>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs745554999	294	E>K		No	ExAC
rs745554999	294	E>Q		No	ExAC
rs147368872	295	F>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1208131352	296	D>N		No	TOPMed
rs1914057553	297	G>A		No	Ensembl
rs2145327096	297	G>S		No	Ensembl
rs1259650887	298	P>L		No	TOPMed gnomAD
rs1439859917	299	Q>P		No	gnomAD
rs919502623	300	R>Q		No	TOPMed gnomAD
rs1461947710	300	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs2145328797	301	D>G		No	Ensembl
rs139538868	302	A>T		No	ESP ExAC TOPMed gnomAD
rs1914058249 RCV002019769	303	Q>E		No	ClinVar TOPMed dbSNP
rs1914058249	303	Q>K		No	TOPMed
rs762218250	304	A>E		No	ExAC TOPMed gnomAD
rs2145328805	304	A>T		No	Ensembl
rs762218250	304	A>V		No	ExAC TOPMed gnomAD
rs2145328824	305	A>E		No	Ensembl
rs2145328824	305	A>G		No	Ensembl
rs2145328819	305	A>T		No	Ensembl
rs2145328824	305	A>V		No	Ensembl
rs1914058676 COSM1524859 COSM6150641	306	R>L	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic TOPMed
rs1914058676	306	R>Q		No	TOPMed
rs1317335037	306	R>W		No	TOPMed gnomAD
rs2145328837	307	E>*		No	Ensembl
rs928378285	307	E>G		No	TOPMed
rs2145328844	308	F>L		No	Ensembl
rs2145328841	308	F>L		No	Ensembl
rs2145328841	308	F>V		No	Ensembl
rs759218880	309	I>F		No	ExAC gnomAD
rs2145328855	309	I>N		No	Ensembl
rs759218880	309	I>V		No	ExAC gnomAD
rs767110044	310	L>P		No	ExAC gnomAD
rs1914058930	311	K>E		No	TOPMed
rs2145328879	311	K>M		No	Ensembl
rs1914059041	312	M>I		No	gnomAD
rs1489377886	312	M>T		No	gnomAD
rs752162469	313	F>L		No	ExAC TOPMed gnomAD
rs772471502	314	V>L		No	TOPMed gnomAD
rs772471502	314	V>M		No	TOPMed gnomAD
rs2145328898	315	D>A		No	Ensembl
rs2145328902	315	D>E		No	Ensembl
rs2145328898	315	D>G		No	Ensembl
rs386352309 CA232204 RCV000122497	315	D>N		No	ClinGen ClinVar Ensembl dbSNP
rs2145328898	315	D>V		No	Ensembl
rs1914059378	316	L>M		No	Ensembl
rs2145328906	316	L>P		No	Ensembl
rs2145328909	317	N>D		No	Ensembl
rs2145328911	317	N>I		No	Ensembl
rs2145328916	317	N>K		No	Ensembl
rs2145328911	317	N>T		No	Ensembl
rs2145328921	318	P>H		No	Ensembl
rs2145328921	318	P>L		No	Ensembl
rs2145328935	319	D>A		No	Ensembl
rs1363672004	319	D>E		No	TOPMed
rs2145328935	319	D>G		No	Ensembl
rs777133920	319	D>H		No	ExAC TOPMed gnomAD
rs777133920	319	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2145328935	319	D>V		No	Ensembl
rs753862594	320	S>I		No	ExAC gnomAD
rs753862594	320	S>N		No	ExAC gnomAD
rs150929326	320	S>R		No	1000Genomes ExAC TOPMed gnomAD
rs753862594	320	S>T		No	ExAC gnomAD
rs2145328959	321	D>A		No	Ensembl
rs1914059892	321	D>E		No	gnomAD
rs1427351200	321	D>H		No	gnomAD
rs1427351200 RCV001368173	321	D>N		No	ClinVar dbSNP gnomAD
rs2145328959	321	D>V		No	Ensembl
rs2145328965	322	K>E		No	Ensembl
rs2145328972	322	K>M		No	Ensembl
rs1416858721	322	K>N		No	TOPMed
rs2145328982	323	I>L		No	Ensembl
rs2145328985	323	I>T		No	Ensembl
rs201368515	324	I>F		No	1000Genomes ExAC gnomAD
rs201368515	324	I>L		No	1000Genomes ExAC gnomAD
rs2145328997	324	I>T		No	Ensembl
rs201368515	324	I>V		No	1000Genomes ExAC gnomAD
rs2145329006	325	Y>F		No	Ensembl
rs2145329002	325	Y>N		No	Ensembl
rs2145329006	325	Y>S		No	Ensembl
rs1364056722 RCV001908903	326	S>A		No	ClinVar dbSNP gnomAD
rs2145329022	326	S>L		No	Ensembl
rs1364056722	326	S>P		No	gnomAD
rs2145329036	327	H>L		No	Ensembl
rs2145329031	327	H>N		No	Ensembl
rs2145329036	327	H>P		No	Ensembl
COSM3532100	327	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2145329031	327	H>Y		No	Ensembl
rs2145329051	328	F>I		No	Ensembl
rs747189004	328	F>L		No	ExAC gnomAD
rs2145329058	328	F>S		No	Ensembl
rs1298964952	329	T>M		No	TOPMed gnomAD
rs2145329066	329	T>P		No	Ensembl
rs1298964952	329	T>R		No	TOPMed gnomAD
rs2145329066	329	T>S		No	Ensembl
rs2145329098	330	C>*		No	Ensembl
rs2145329086	330	C>R		No	Ensembl
rs2145329094	330	C>S		No	Ensembl
rs2145329086	330	C>S		No	Ensembl
rs2145329098	330	C>W		No	Ensembl
rs2145329113	331	A>D		No	Ensembl
rs2145329106	331	A>P		No	Ensembl
rs2145329106	331	A>T		No	Ensembl
rs2145329113	331	A>V		No	Ensembl
rs1201897778	332	T>I		No	TOPMed
rs1201897778	332	T>N		No	TOPMed
rs1201897778	332	T>S		No	TOPMed
rs1323407613	333	D>G		No	gnomAD
rs776555145	333	D>H		No	1000Genomes ExAC gnomAD
COSM994456 rs776555145	333	D>N	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs1323407613	333	D>V		No	gnomAD
rs776555145	333	D>Y		No	1000Genomes ExAC gnomAD
rs2145329153	334	T>A		No	Ensembl
rs2145329159	334	T>M		No	Ensembl
rs2145329159	334	T>R		No	Ensembl
rs2145329168	335	E>*		No	Ensembl
rs1290800871	335	E>D		No	gnomAD
rs2145329172	335	E>G		No	Ensembl
rs2145329168	335	E>K		No	Ensembl
rs2145329168	335	E>Q		No	Ensembl
rs2145329172	335	E>V		No	Ensembl
rs928679789	336	N>K		No	TOPMed gnomAD
rs770247248	336	N>S		No	ExAC gnomAD
rs770247248	336	N>T		No	ExAC gnomAD
rs2145329184	336	N>Y		No	Ensembl
rs2145329190	337	I>F		No	Ensembl
rs1356009409	337	I>M		No	TOPMed gnomAD
rs2145329193	337	I>N		No	Ensembl
rs2145329193	337	I>S		No	Ensembl
rs2145329193	337	I>T		No	Ensembl
rs773591539	338	R>C		No	ExAC gnomAD
rs2145329202	338	R>H		No	Ensembl
rs2145329202	338	R>L		No	Ensembl
rs2145329202	338	R>P		No	Ensembl
rs2145329222	339	F>C		No	Ensembl
rs2145329215	339	F>I		No	Ensembl
rs763245208	339	F>L		No	ExAC gnomAD
rs2145329215	339	F>L		No	Ensembl
rs2145329234	340	V>E		No	Ensembl
rs2145329234	340	V>G		No	Ensembl
rs2145329230	340	V>L		No	Ensembl
rs2145329230 RCV002018914	340	V>M		No	ClinVar Ensembl dbSNP
rs2145329244	341	F>I		No	Ensembl
rs2145329244	341	F>V		No	Ensembl
rs2145329256 COSM4431940	342	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs2145329259	342	A>V		No	Ensembl
rs1424927429	343	A>D		No	gnomAD
rs1424927429	343	A>G		No	gnomAD
rs752451221	343	A>T		No	ExAC gnomAD
rs1424927429	343	A>V		No	gnomAD
rs2145329292	344	V>A		No	Ensembl
rs2145329292	344	V>E		No	Ensembl
rs2145329292	344	V>G		No	Ensembl
rs1383785285	344	V>L		No	gnomAD
rs1383785285 COSM994458	344	V>M	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs763698658	345	K>N		No	ExAC TOPMed
rs2145329298	345	K>R		No	Ensembl
rs2145329308	346	D>A		No	Ensembl
rs2145329314	346	D>E		No	Ensembl
rs2145329308	346	D>G		No	Ensembl
rs2145329304	346	D>H		No	Ensembl
rs2145329304	346	D>N		No	Ensembl
rs2145329308	346	D>V		No	Ensembl
RCV002269119 rs2145329319	347	T>A		No	ClinVar Ensembl dbSNP
rs2145329322	347	T>I		No	Ensembl
rs2145329322	347	T>S		No	Ensembl
rs1914062147	348	I>M		No	TOPMed
rs2145329327	348	I>N		No	Ensembl
rs2145329333	349	L>P		No	Ensembl
rs2145329333	349	L>Q		No	Ensembl
rs2145329341	350	Q>*		No	Ensembl
rs2145329347	350	Q>L		No	Ensembl
rs2145329351	351	L>H		No	Ensembl
rs2145329351	351	L>P		No	Ensembl
rs753245806	351	L>V		No	ExAC TOPMed gnomAD
rs2145329362	352	N>K		No	Ensembl
rs376124717	352	N>S		No	ESP ExAC TOPMed gnomAD
rs376124717	352	N>T		No	ESP ExAC TOPMed gnomAD
rs2145329363	353	L>H		No	Ensembl
rs543962567	354	K>E		No	TOPMed gnomAD
rs2145329372	354	K>N		No	Ensembl
rs543962567	354	K>Q		No	TOPMed gnomAD
rs2145329375	355	E>*		No	Ensembl
rs1158680732	355	E>D		No	TOPMed gnomAD
rs2145329375	355	E>K		No	Ensembl
rs2145329375	355	E>Q		No	Ensembl
rs2145329398	356	Y>*		No	Ensembl
rs1914062614	356	Y>C		No	Ensembl
rs2145329387	356	Y>D		No	Ensembl
rs2145329387	356	Y>H		No	Ensembl
rs2145329387	356	Y>N		No	Ensembl
rs1914062614	356	Y>S		No	Ensembl
rs1914062675	357	N>K		No	Ensembl
rs2145329403	357	N>S		No	Ensembl
rs2145329403	357	N>T		No	Ensembl
rs2145329412	358	L>P		No	Ensembl
rs2145329412	358	L>Q		No	Ensembl
rs2145329422	359	V>D		No	Ensembl
rs2145329417	359	V>F		No	Ensembl
rs2145329417	359	V>L		No	Ensembl
rs2145329436	360	V>C		No	Ensembl
rs2145329429	360	V>R		No	Ensembl
rs2145329436	360	V>W		No	Ensembl

No associated diseases with P29992

3 regional properties for P29992

Type	Name	Position	InterPro Accession
domain	Muniscin, C-terminal	539 - 804	IPR018808
domain	Mu homology domain	537 - 805	IPR028565
domain	SGIP1, mu-homology domain	539 - 805	IPR037984

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Lipid-anchor Cytoplasm	In testicular cells, expressed exclusively in the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
heterotrimeric G-protein complex	Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
photoreceptor outer segment	The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

7 GO annotations of molecular function

Name	Definition
enzyme regulator activity	Binds to and modulates the activity of an enzyme.
G protein activity	A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
G protein-coupled receptor binding	Binding to a G protein-coupled receptor.
G-protein beta/gamma-subunit complex binding	Binding to a complex of G-protein beta/gamma subunits.
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction
metal ion binding	Binding to a metal ion.

19 GO annotations of biological process

Name	Definition
action potential	A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).
cellular response to pH	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
cranial skeletal system development	The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.
developmental pigmentation	The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
endothelin receptor signaling pathway	A G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
entrainment of circadian clock	The synchronization of a circadian rhythm to environmental time cues such as light.
G protein-coupled acetylcholine receptor signaling pathway	A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription.
heart development	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
ion channel modulating, G protein-coupled receptor signaling pathway	The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of an ion channel.
ligand-gated ion channel signaling pathway	The series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription.
phospholipase C-activating dopamine receptor signaling pathway	A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
phototransduction, visible light	The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
positive regulation of insulin secretion	Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
regulation of blood pressure	Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
regulation of melanocyte differentiation	Any process that modulates the frequency, rate or extent of melanocyte differentiation.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
skeletal system development	The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

29 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P38408	GNA14	Guanine nucleotide-binding protein subunit alpha-14	Bos taurus (Bovine)	PR
P23625	Galphaq	G protein alpha q subunit	Drosophila melanogaster (Fruit fly)	PR
O95837	GNA14	Guanine nucleotide-binding protein subunit alpha-14	Homo sapiens (Human)	SS
P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	Homo sapiens (Human)	SS
P50148	GNAQ	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P11488	GNAT1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P19087	GNAT2	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P08754	GNAI3	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
A8MTJ3	GNAT3	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P19086	GNAZ	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	Homo sapiens (Human)	SS
Q03113	GNA12	Guanine nucleotide-binding protein subunit alpha-12	Homo sapiens (Human)	SS
P38405	GNAL	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P04899	GNAI2	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P63096	GNAI1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	EV
P09471	GNAO1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P21279	Gnaq	Guanine nucleotide-binding protein G(q) subunit alpha	Mus musculus (Mouse)	PR
P30678	Gna15	Guanine nucleotide-binding protein subunit alpha-15	Mus musculus (Mouse)	PR
Q2PKF4	GNAQ	Guanine nucleotide-binding protein G(q) subunit alpha	Sus scrofa (Pig)	PR
P93564	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Solanum tuberosum (Potato)	SS
O88302	Gna15	Guanine nucleotide-binding protein subunit alpha-15	Rattus norvegicus (Rat)	SS
P82471	Gnaq	Guanine nucleotide-binding protein G	Rattus norvegicus (Rat)	SS
Q9JID2	Gna11	Guanine nucleotide-binding protein subunit alpha-11	Rattus norvegicus (Rat)	SS
Q0DJ33	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Oryza sativa subsp. japonica (Rice)	SS
P49084	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Glycine max (Soybean) (Glycine hispida)	SS
P93163	GPA2	Guanine nucleotide-binding protein alpha-2 subunit	Glycine max (Soybean) (Glycine hispida)	SS
O80462	XLG1	Extra-large guanine nucleotide-binding protein 1	Arabidopsis thaliana (Mouse-ear cress)	PR
P18064	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Arabidopsis thaliana (Mouse-ear cress)	SS
P26981	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	SS

10	20	30	40	50	60
MTLESMMACC	LSDEVKESKR	INAEIEKQLR	RDKRDARREL	KLLLLGTGES	GKSTFIKQMR
70	80	90	100	110	120
IIHGAGYSEE	DKRGFTKLVY	QNIFTAMQAM	IRAMETLKIL	YKYEQNKANA	LLIREVDVEK
130	140	150	160	170	180
VTTFEHQYVS	AIKTLWEDPG	IQECYDRRRE	YQLSDSAKYY	LTDVDRIATL	GYLPTQQDVL
190	200	210	220	230	240
RVRVPTTGII	EYPFDLENII	FRMVDVGGQR	SERRKWIHCF	ENVTSIMFLV	ALSEYDQVLV
250	260	270	280	290	300
ESDNENRMEE	SKALFRTIIT	YPWFQNSSVI	LFLNKKDLLE	DKILYSHLVD	YFPEFDGPQR
310	320	330	340	350
DAQAAREFIL	KMFVDLNPDS	DKIIYSHFTC	ATDTENIRFV	FAAVKDTILQ	LNLKEYNLV