P29974
PR
Gene name |
Cnga1 (Cncg, Cncg1) |
Protein name |
cGMP-gated cation channel alpha-1 |
Names |
Cyclic nucleotide-gated cation channel 1, Cyclic nucleotide-gated channel alpha-1, CNG channel alpha-1, CNG-1, CNG1, Cyclic nucleotide-gated channel, photoreceptor, Rod photoreceptor cGMP-gated channel subunit alpha |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12788 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P29974
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P29974-F1 | Predicted | AlphaFoldDB |
40 variants for P29974
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs31533909 | 40 | D>E | No | EVA | |
| rs3388771396 | 51 | E>V | No | EVA | |
| rs3388754555 | 52 | N>G* | No | EVA | |
| rs3388771324 | 56 | F>I | No | EVA | |
| rs3388769043 | 70 | R>K | No | EVA | |
| rs3388766656 | 77 | T>N | No | EVA | |
| rs3388750537 | 101 | K>N | No | EVA | |
| rs52256971 | 138 | E>D | No | EVA | |
| rs3395702801 | 161 | L>P | No | EVA | |
| rs3388737698 | 162 | F>V | No | EVA | |
| rs3388757441 | 165 | T>S | No | EVA | |
| rs3388764611 | 167 | P>L | No | EVA | |
| rs3388747007 | 185 | Q>H | No | EVA | |
| rs3388765499 | 189 | L>P | No | EVA | |
| rs239276078 | 233 | K>R | No | EVA | |
| rs3395731677 | 243 | L>Q | No | EVA | |
| rs3395659876 | 247 | P>L | No | EVA | |
| rs3388764603 | 266 | R>P | No | EVA | |
| rs3388765493 | 313 | I>N | No | EVA | |
| rs3388771352 | 341 | Y>H | No | EVA | |
| rs3388764642 | 387 | N>K | No | EVA | |
| rs3388762435 | 389 | G>R | No | EVA | |
| rs3388754549 | 399 | R>P | No | EVA | |
| rs3388766470 | 429 | W>* | No | EVA | |
| rs3388750526 | 437 | K>E | No | EVA | |
| rs3388769082 | 460 | N>S | No | EVA | |
| rs3388760040 | 461 | V>I | No | EVA | |
| rs3388757736 | 473 | A>V | No | EVA | |
| rs3388765052 | 477 | A>D | No | EVA | |
| rs3388769015 | 482 | E>D | No | EVA | |
| rs3388762004 | 503 | D>E | No | EVA | |
| rs3388754556 | 503 | D>E | No | EVA | |
| rs3388760009 | 512 | K>N | No | EVA | |
| rs3388746644 | 518 | V>M | No | EVA | |
| rs3388762008 | 546 | G>D | No | EVA | |
| rs3388766458 | 560 | I>F | No | EVA | |
| rs3388754599 | 561 | G>S | No | EVA | |
| rs3388746620 | 564 | D>Y | No | EVA | |
| rs3388750542 | 584 | K>I | No | EVA | |
| rs3388762009 | 590 | K>* | No | EVA |
No associated diseases with P29974
5 regional properties for P29974
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 471 - 595 | IPR000595 |
| domain | Ion transport domain | 159 - 398 | IPR005821 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 498 - 514 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 536 - 559 | IPR018488-2 |
| domain | Cyclic nucleotide-gated channel, C-terminal leucine zipper domain | 587 - 656 | IPR032406 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| intracellular cyclic nucleotide activated cation channel complex | A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| photoreceptor outer segment | The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. |
| photoreceptor outer segment membrane | The membrane surrounding the outer segment of a vertebrate photoreceptor. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| terminal bouton | Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| cGMP binding | Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| intracellular cAMP-activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. |
| intracellular cGMP-activated cation channel activity | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. |
| protein-containing complex binding | Binding to a macromolecular complex. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cation transmembrane transport | The process in which a cation is transported across a membrane. |
| membrane depolarization | The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. |
| regulation of cytosolic calcium ion concentration | Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. |
| response to stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. |
| visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q03041 | CNGA2 | Cyclic nucleotide-gated olfactory channel | Bos taurus (Bovine) | PR |
| Q29441 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Bos taurus (Bovine) | PR |
| Q00194 | CNGA1 | cGMP-gated cation channel alpha-1 | Bos taurus (Bovine) | PR |
| Q90805 | Cyclic nucleotide-gated channel cone photoreceptor subunit alpha | Gallus gallus (Chicken) | PR | |
| Q90980 | Cyclic nucleotide-gated channel rod photoreceptor subunit alpha | Gallus gallus (Chicken) | PR | |
| Q28279 | CNGA1 | cGMP-gated cation channel alpha-1 | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q16280 | CNGA2 | Cyclic nucleotide-gated olfactory channel | Homo sapiens (Human) | PR |
| Q16281 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Homo sapiens (Human) | PR |
| P29973 | CNGA1 | cGMP-gated cation channel alpha-1 | Homo sapiens (Human) | PR |
| Q62398 | Cnga2 | Cyclic nucleotide-gated olfactory channel | Mus musculus (Mouse) | PR |
| Q9JJZ8 | Cnga3 | Cyclic nucleotide-gated cation channel alpha-3 | Mus musculus (Mouse) | PR |
| Q00195 | Cnga2 | Cyclic nucleotide-gated olfactory channel | Rattus norvegicus (Rat) | PR |
| Q62927 | Cnga1 | cGMP-gated cation channel alpha-1 | Rattus norvegicus (Rat) | PR |
| Q9SKD7 | CNGC3 | Probable cyclic nucleotide-gated ion channel 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SU64 | CNGC16 | Probable cyclic nucleotide-gated ion channel 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDR2 | CNGC19 | Putative cyclic nucleotide-gated ion channel 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKTNIINTWH | SFVNIPNVIV | PAIEKEIRRM | ENGACSSFSD | DDNGSLSEES | ENEDSFFRSN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SYKRRGPSQR | EQHLPGTMAL | FNVNNSSNKD | QEPKEKKKKK | KEKKSKADDK | NENKKDPEKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KKKEKEKEKK | KKEEKTKEKK | EEEKKEVVVI | DPSGNTYYNW | LFCITLPVMY | NWTMIIARAC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FDELQSDYLE | YWLIFDYVSD | VVYLADMFVR | TRTGYLEQGL | LVKDRMKLIE | KYKANLQFKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DVLSVIPTDL | LYIKFGWNYP | EIRLNRLLRI | SRMFEFFQRT | ETRTNYPNIF | RISNLVMYIV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IIIHWNACVY | YSISKAIGFG | NDTWVYPDVN | DPEFGRLARK | YVYSLYWSTL | TLTTIGETPP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PVLDSEYIFV | VVDFLIGVLI | FATIVGNIGS | MISNMNAARA | EFQSRVDAIK | QYMNFRNVSK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DMEKRVIKWF | DYLWTNKKTV | DEREVLRYLP | DKLRAEIAIN | VHLDTLKKVR | IFADCEAGLL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VELVLKLQPQ | VYSPGDYICK | KGDIGREMYI | IKEGKLAVVA | DDGITQFVVL | SDGSYFGEIS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ILNIKGSKAG | NRRTANIKSI | GYSDLFCLSK | DDLMEALTEY | PDAKTMLEEK | GRQILMKDGL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LDINIANMGS | DPKDLEEKVT | RMEGSVDLLQ | TRFARILAEY | ESMQQKLKQR | LTKVEKFLKP |
| 670 | 680 | ||||
| LIETEFSALE | EPGGESELTE | SLQD |