P29620

PR
Gene name
CDKD-1 (R2)
Protein name
Cyclin-dependent kinase D-1
Names
CDKD1, CDC2+/CDC28-related protein kinase R2, CDK-activating kinase R2, CAK-R2
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4338689
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

294-424 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

158-181 (Activation loop from InterPro)

Target domain

19-299 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P29620

Entry ID Method Resolution Chain Position Source
AF-P29620-F1 Predicted AlphaFoldDB

No variants for P29620

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P29620

No associated diseases with P29620

3 regional properties for P29620

Type Name Position InterPro Accession
domain Protein kinase domain 19 - 299 IPR000719
active_site Serine/threonine-protein kinase, active site 137 - 149 IPR008271
binding_site Protein kinase, ATP binding site 25 - 49 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription factor TFIIK complex A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

4 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein phosphorylation The process of introducing a phosphate group on to a protein.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IZL9 CDK20 Cyclin-dependent kinase 20 Homo sapiens (Human) PR
Q9JHU3 Cdk20 Cyclin-dependent kinase 20 Mus musculus (Mouse) PR
Q4KM34 Cdk20 Cyclin-dependent kinase 20 Rattus norvegicus (Rat) PR
Q5Z754 CDKF-1 Cyclin-dependent kinase F-1 Oryza sativa subsp japonica (Rice) PR
Q9C9U2 CDKD-1 Cyclin-dependent kinase D-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMT0 CDKD-3 Cyclin-dependent kinase D-3 Arabidopsis thaliana (Mouse-ear cress) PR
A8WIP6 cdk20 Cyclin-dependent kinase 20 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MASGDGGDDA GVKRVADRYL KREVLGEGTY GVVFKAVDTK TGNTVAIKKI RLGKYKEGVN
70 80 90 100 110 120
FTALREIKLL KELKDSNIIE LIDAFPYKGN LHLVFEFMET DLEAVIRDRN IVLSPADTKS
130 140 150 160 170 180
YIQMMLKGLA FCHKKWVLHR DMKPNNLLIG ADGQLKLADF GLARIFGSPE RNFTHQVFAR
190 200 210 220 230 240
WYRAPELLFG TKQYGSAVDI WAAGCIFAEL LLRRPFLQGS SDIDQLGKIF AAFGTPKSSQ
250 260 270 280 290 300
WPDMVYLPDY VEYQFVSAPP LRSLFPMASD DALDLLSRMF TYDPKARITA QQALEHRYFL
310 320 330 340 350 360
SVPAPTKPSQ LPRPPPKGDS GNNKIPDLNL QDGPVVLSPP RKLRRVTAHE GMEVHMHRAD
370 380 390 400 410 420
RTEEHPSGAR HMDDMSSQSS RIPMSVDVGA IFGTRPAPRP TLNSADKSRL KRKLDMDPEF
GYTE