AiPD: Autoinhibited Protein Database

P29590

Gene name	PML (MYL, PP8675, RNF71, TRIM19)
Protein name	Protein PML
Names	E3 SUMO-protein ligase PML, Promyelocytic leukemia protein, RING finger protein 71, RING-type E3 SUMO transferase PML, Tripartite motif-containing protein 19, TRIM19
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5371
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-74 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

20 structures for P29590

Entry ID	Method	Resolution	Chain	Position	Source
1BOR	NMR	-	A	49-104	PDB
2MVW	NMR	-	A/B	120-168	PDB
2MWX	NMR	-	A	49-104	PDB
4WJN	X-ray	150 A	B	547-573	PDB
4WJO	X-ray	146 A	B	547-573	PDB
5YUF	X-ray	160 A	A/B/C/D	49-99	PDB
6IMQ	X-ray	206 A	A/B/C/D	120-168	PDB
6UYO	X-ray	164 A	B/D	547-574	PDB
6UYP	X-ray	142 A	B	547-574	PDB
6UYQ	X-ray	150 A	B	547-574	PDB
6UYR	X-ray	130 A	B	547-574	PDB
6UYS	X-ray	159 A	B/D	547-574	PDB
6UYT	X-ray	166 A	B	547-574	PDB
6UYU	X-ray	166 A	B/D	547-574	PDB
6UYV	X-ray	140 A	B	547-574	PDB
8DJH	X-ray	177 A	B	546-573	PDB
8DJI	X-ray	197 A	B	547-574	PDB
8J25	X-ray	260 A	A	183-236	PDB
8J2P	X-ray	209 A	A/E	183-236	PDB
AF-P29590-F1	Predicted				AlphaFoldDB

775 variants for P29590

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA058983 rs780746013 RCV000207284	755	R>P	Ductal breast carcinoma [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs925273078 CA272726353	3	P>T		No	ClinGen Ensembl
CA393114886 rs1450586395	4	A>T		No	ClinGen TOPMed gnomAD
CA393114891 rs1225562023	4	A>V		No	ClinGen gnomAD
rs1257467598 CA393114894	5	P>A		No	ClinGen gnomAD
rs975151127 CA272726361	5	P>H		No	ClinGen Ensembl
rs1482238182 CA393114917	7	R>L		No	ClinGen TOPMed gnomAD
CA7652294 rs542097036	8	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA7652295 rs542097036	8	S>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs1479031859 CA393114926	9	P>A		No	ClinGen TOPMed
CA393114934 rs1429883570	9	P>L		No	ClinGen gnomAD
CA393114939 rs1168158486	10	R>K		No	ClinGen gnomAD
CA393114947 rs1469928575	11	P>S		No	ClinGen TOPMed gnomAD
CA393114969 rs1277045101	13	Q>E		No	ClinGen TOPMed
CA272726374 rs1020660622	15	P>S		No	ClinGen TOPMed
CA272726376 rs886298849	16	A>T		No	ClinGen Ensembl
rs751354376 CA393115010	17	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1273074911 CA393115049	20	E>D		No	ClinGen TOPMed
rs1466002928 CA393115055	21	P>S		No	ClinGen gnomAD
rs1380719368 CA393115080	23	M>I		No	ClinGen TOPMed gnomAD
rs1364577658 CA393115074	23	M>L		No	ClinGen gnomAD
CA393115072 rs1364577658	23	M>V		No	ClinGen gnomAD
CA393115089 rs1595870267	24	P>L		No	ClinGen Ensembl
CA393115088 rs1274872826	24	P>S		No	ClinGen TOPMed
CA272726383 rs376726233	25	P>T		No	ClinGen Ensembl
rs781165510 CA7652299	26	P>H		No	ClinGen ExAC gnomAD
rs781165510 CA7652300	26	P>R		No	ClinGen ExAC gnomAD
CA393115101 rs1346221283	26	P>T		No	ClinGen gnomAD
rs979739048 CA272726401	27	E>D		No	ClinGen TOPMed
CA7652302 rs201524800	28	T>I		No	ClinGen ExAC TOPMed gnomAD
CA7652301 RCV000957320 rs28504405	28	T>P		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs749399804 CA393115125	29	P>A		No	ClinGen ExAC gnomAD
CA272726412 rs959506424	29	P>L		No	ClinGen TOPMed
rs749399804 CA7652303	29	P>S		No	ClinGen ExAC gnomAD
CA393115124 rs749399804	29	P>T		No	ClinGen ExAC gnomAD
rs1369762288 CA393115131	30	S>P		No	ClinGen TOPMed
rs768816135 CA7652304	31	E>K		No	ClinGen ExAC TOPMed gnomAD
CA393115161 rs1191059573	32	G>D		No	ClinGen gnomAD
CA393115165 rs1480567758	33	R>C		No	ClinGen gnomAD
CA393115177 rs1200903609	34	Q>P		No	ClinGen gnomAD
CA393115178 rs1200903609	34	Q>R		No	ClinGen gnomAD
CA393115208 rs1422486859	37	P>T		No	ClinGen gnomAD
CA393115218 rs1595870347	38	S>R		No	ClinGen Ensembl
rs1001161123 CA272726420	38	S>T		No	ClinGen Ensembl
CA393115238 rs1160529595	40	S>G		No	ClinGen gnomAD
rs779135665 CA7652305	41	P>A		No	ClinGen ExAC TOPMed gnomAD
CA7652306 rs748479176	42	T>A		No	ClinGen ExAC TOPMed gnomAD
rs748479176 CA393115258	42	T>P		No	ClinGen ExAC TOPMed gnomAD
rs761685300 CA7652316	44	R>Q		No	ClinGen ExAC gnomAD
CA393115941 rs1321882631	45	A>V		No	ClinGen gnomAD
TCGA novel	47	A>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7652317 rs767279397	47	A>S		No	ClinGen ExAC gnomAD
CA7652318 rs377614337	48	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs780062613 CA7652320	51	E>A		No	ClinGen ExAC TOPMed gnomAD
CA393116002 rs1595875004	51	E>D		No	ClinGen Ensembl
CA272731054 rs951185816	53	Q>R		No	ClinGen TOPMed
rs147696900 CA7652321	56	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	56	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1567115231 COSM3387038 COSM3387036 COSM3387039 CA393116132 COSM3387037 COSM3387040	62	A>V	pancreas Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1359953081 CA393116138	63	E>G		No	ClinGen gnomAD
rs1308225290 CA393116133	63	E>K		No	ClinGen gnomAD
CA272731060 rs963684052	66	C>S		No	ClinGen TOPMed gnomAD
CA7652322 rs755088983	67	P>S		No	ClinGen ExAC gnomAD
CA393116198 rs975077458	69	L>V		No	ClinGen TOPMed gnomAD
CA393116219 rs1456793279	71	P>L		No	ClinGen gnomAD
rs1446894217 CA393116290	78	S>L		No	ClinGen TOPMed gnomAD
CA393116296 rs748429878	79	G>A		No	ClinGen ExAC gnomAD
rs748429878 CA7652324	79	G>E		No	ClinGen ExAC gnomAD
rs28412621 CA272731080	79	G>R		No	ClinGen Ensembl
rs772423497 CA7652325	80	C>G		No	ClinGen ExAC TOPMed gnomAD
CA393116301 rs772423497	80	C>R		No	ClinGen ExAC TOPMed gnomAD
CA7652327 rs752972084	84	S>A		No	ClinGen ExAC TOPMed gnomAD
rs771298279 CA7652328	84	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1450534241 CA393116363	86	M>L		No	ClinGen gnomAD
rs543332226 CA272731092	87	Q>K		No	ClinGen 1000Genomes
CA272731096 rs955683290	89	P>S		No	ClinGen TOPMed
CA272731102 rs977975731	91	C>S		No	ClinGen TOPMed
rs762523424 CA7652330	92	Q>E		No	ClinGen ExAC gnomAD
rs531642849 CA7652332	93	A>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs531642849 CA7652331	93	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs531642849 CA272731122	93	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1355146149 CA393116460	94	P>L		No	ClinGen gnomAD
rs761487093 CA7652333	94	P>S		No	ClinGen ExAC gnomAD
CA393116471 rs767209117	95	W>*		No	ClinGen ExAC TOPMed gnomAD
rs767209117 CA7652334	95	W>C		No	ClinGen ExAC TOPMed gnomAD
CA393116473 rs1274459324 COSM35573	96	P>T	central_nervous_system [Cosmic]	No	ClinGen cosmic curated gnomAD
CA272731130 rs936181106	98	G>A		No	ClinGen TOPMed
rs1173712908 CA393116493	98	G>S		No	ClinGen TOPMed
CA393116498 rs1214444976	99	A>T		No	ClinGen Ensembl
CA7652335 rs772834238	101	T>P		No	ClinGen ExAC gnomAD
CA393116535 rs570405596 COSM555995 COSM555997 COSM555996	103	A>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs570405596 CA272731131	103	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7652336 rs760548118	105	D>A		No	ClinGen ExAC gnomAD
rs372639541 CA272731135	106	N>D		No	ClinGen ESP gnomAD
rs756707115 CA272731139	107	V>A		No	ClinGen Ensembl
CA393116573 rs1251227417	107	V>I		No	ClinGen TOPMed
rs1268652956 CA393116610	110	E>K		No	ClinGen gnomAD
CA393116622 rs1340042373	111	S>N		No	ClinGen gnomAD
rs1237299020 CA393116645	113	Q>R		No	ClinGen gnomAD
CA393116653 rs1475848935	114	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs766194468 CA7652337	115	R>C		No	ClinGen ExAC gnomAD
TCGA novel	118	V>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393116706 rs1204490067	119	Y>*		No	ClinGen TOPMed
CA7652340 rs765368853	119	Y>H		No	ClinGen ExAC gnomAD
CA393116696 rs765368853	119	Y>N		No	ClinGen ExAC gnomAD
rs141544943 CA7652341 COSM1374477 COSM1374478 COSM1374476	120	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA gnomAD
CA393116724 rs1339696841	121	Q>H		No	ClinGen gnomAD
rs758491320 CA7652342	122	I>T		No	ClinGen ExAC gnomAD
rs1430981462 CA393116730	122	I>V		No	ClinGen gnomAD
CA393116752 rs1279833875	124	D>G		No	ClinGen TOPMed gnomAD
CA7652343 rs77069486	125	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1254559908 CA393116761	125	A>S		No	ClinGen TOPMed
CA393116765 rs77069486	125	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA272731157 rs764681333	127	A>T		No	ClinGen Ensembl
rs916000806 CA272731165	128	V>A		No	ClinGen TOPMed
CA393116797 rs1278780676	129	C>G		No	ClinGen gnomAD
rs948690909 CA272731173	130	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA393116808 rs1595875279	130	T>P		No	ClinGen Ensembl
CA393116851 rs1567115705	134	E>K		No	ClinGen Ensembl
CA7652349 rs372931853	135	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	136	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1170797771 CA393116915	139	W>C		No	ClinGen TOPMed gnomAD
CA7652351 rs771584396	140	C>W		No	ClinGen ExAC gnomAD
rs1567115731 COSM416829 COSM416827 COSM416828 CA393116943	142	E>Q	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1437769332 CA393116993	146	L>H		No	ClinGen TOPMed
rs1184287467 CA393116996	147	L>F		No	ClinGen TOPMed
rs1212946978 CA393117004	148	C>R		No	ClinGen gnomAD
CA393117023 rs1262054222	149	A>V		No	ClinGen gnomAD
rs1283335549 CA393117036	150	K>N		No	ClinGen TOPMed gnomAD
rs1399049666 CA393117031	150	K>R		No	ClinGen gnomAD
CA393117069 rs1332371182	153	E>G		No	ClinGen gnomAD
CA272731192 rs943898401	154	A>T		No	ClinGen Ensembl
CA272731195 rs370861713	158	F>L		No	ClinGen ESP gnomAD
CA393117193 rs1488061660	163	A>V		No	ClinGen gnomAD
CA393117200 rs1223553102	164	R>L		No	ClinGen gnomAD
rs1223553102 CA393117197	164	R>Q		No	ClinGen gnomAD
rs759402979 CA7652356	165	P>R		No	ClinGen ExAC gnomAD
CA272731199 rs1047320957	167	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1196661368 CA393117220	167	A>S		No	ClinGen gnomAD
CA7652357 rs565000110	168	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA393117227 rs1376941327	168	E>Q		No	ClinGen gnomAD
CA272731201 rs995136133	170	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA7652358 rs200708179 COSM1736534 COSM1736535 COSM1736536	170	R>H	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs758540569 CA7652359	171	N>H		No	ClinGen ExAC gnomAD
rs764195821 CA7652360	171	N>I		No	ClinGen ExAC gnomAD
TCGA novel	172	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393117293 rs781633419	175	R>H		No	ClinGen ExAC gnomAD
CA7652364 rs781633419	175	R>L		No	ClinGen ExAC gnomAD
CA7652363 rs781633419	175	R>P		No	ClinGen ExAC gnomAD
rs368684793 CA7652365	177	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA393117317 rs1353498874	178	L>V		No	ClinGen gnomAD
CA393117337 rs1267526518	180	G>S		No	ClinGen gnomAD
COSM335029 rs771660433 COSM335030 CA7652369 COSM335028	182	R>C	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA7652368 rs771660433	182	R>G		No	ClinGen ExAC TOPMed gnomAD
CA393117362 rs1251375241	182	R>H		No	ClinGen gnomAD
CA393117374 rs1458135124	183	K>N		No	ClinGen gnomAD
CA272731221 rs200143816	185	N>K		No	ClinGen Ensembl
CA393117393 rs1296376316	185	N>S		No	ClinGen gnomAD
rs996506100 CA272731223	186	N>I		No	ClinGen TOPMed gnomAD
rs373742710 CA7652371	188	F>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs138345086 CA7652372	190	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs759349668 CA393117453	191	N>I		No	ClinGen ExAC TOPMed gnomAD
CA393117456 rs1456081859	191	N>K		No	ClinGen gnomAD
rs759349668 CA7652373	191	N>S		No	ClinGen ExAC TOPMed gnomAD
CA393117465 rs1162081356	192	P>L		No	ClinGen gnomAD
rs551261745 CA7652374	193	N>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7652375 rs775451143	193	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1376622935 CA393117492	195	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs35291318 CA7652377	196	T>N		No	ClinGen ExAC TOPMed gnomAD
CA393117511 rs1244391079	197	P>H		No	ClinGen gnomAD
rs1320170444 CA393117517	198	T>A		No	ClinGen TOPMed gnomAD
CA393117515 rs1320170444	198	T>P		No	ClinGen TOPMed gnomAD
CA393121735 rs1270889485	204	C>R		No	ClinGen TOPMed
CA7652395 rs768489639	205	R>Q		No	ClinGen ExAC gnomAD
rs774435967 CA7652396	207	C>R		No	ClinGen ExAC gnomAD
rs1263370609 CA393121765	207	C>Y		No	ClinGen gnomAD
CA272740575 rs897824788	208	S>C		No	ClinGen TOPMed
CA393121775 rs1595901342	208	S>P		No	ClinGen Ensembl
CA393121802 rs1262797163	210	P>L		No	ClinGen TOPMed
rs1422344468 CA393121799	210	P>S		No	ClinGen gnomAD
CA393121808 rs1178944366	211	L>Q		No	ClinGen gnomAD
rs750722602 CA7652399	214	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1289836458 CA393121883	216	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA393121927 rs1398414369	218	L>P		No	ClinGen gnomAD
CA393121963 rs1297620109	220	S>G		No	ClinGen gnomAD
rs1297620109 CA393121954	220	S>R		No	ClinGen gnomAD
rs1595901403 CA393121968	220	S>T		No	ClinGen Ensembl
CA393122034 rs1303403905	223	S>N		No	ClinGen gnomAD
CA393122029 rs1442033915	223	S>R		No	ClinGen TOPMed
CA272740616 rs17849258	224	E>D		No	ClinGen ExAC gnomAD
CA393122126 rs1567129448	228	D>N		No	ClinGen Ensembl
rs779310039 CA7652404	229	I>M		No	ClinGen ExAC gnomAD
TCGA novel	229	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393122138 rs1232184244	229	I>V		No	ClinGen gnomAD
rs751040865 CA7652405	230	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1214061989 CA393122163	231	A>T		No	ClinGen gnomAD
rs926123422 CA272740626	231	A>V		No	ClinGen Ensembl
rs1261820613 CA393122253	236	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs780804100 CA7652407	237	Q>H		No	ClinGen ExAC gnomAD
CA7652408 rs745581079	239	E>A		No	ClinGen ExAC gnomAD
CA393122314 rs1433142701	240	L>M		No	ClinGen TOPMed gnomAD
rs779837719 CA7652410	241	D>Y		No	ClinGen ExAC gnomAD
rs1297879562 CA393122349	242	A>S		No	ClinGen gnomAD
CA393122383 rs1198521064	243	M>I		No	ClinGen gnomAD
CA393122368 rs1454143397	243	M>V		No	ClinGen TOPMed
rs548755096 CA7652412	244	T>K		No	ClinGen 1000Genomes ExAC
rs548755096 CA272740637	244	T>M		No	ClinGen 1000Genomes ExAC
rs1175324232 CA393122394	245	Q>K		No	ClinGen TOPMed
CA7652414 rs748216366	245	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1409973888 CA393122410	246	A>T		No	ClinGen TOPMed
TCGA novel	248	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393122439 rs1158932968	248	Q>K		No	ClinGen TOPMed
CA393122444 rs1365346638	248	Q>R		No	ClinGen gnomAD
CA7652418 rs766524275	251	D>A		No	ClinGen ExAC gnomAD
rs267604312 CA272740659	251	D>E		No	ClinGen TOPMed
CA393122507 rs766524275	251	D>G		No	ClinGen ExAC gnomAD
rs769861444 CA272740658	251	D>H		No	ClinGen ExAC TOPMed gnomAD
CA7652417 rs769861444	251	D>N		No	ClinGen ExAC TOPMed gnomAD
rs936232769 CA272740663	252	S>G		No	ClinGen gnomAD
rs1223070898 CA393122524	252	S>N		No	ClinGen gnomAD
CA272740666 rs1039943861	256	A>E		No	ClinGen Ensembl
rs765744379 CA7652422	257	V>A		No	ClinGen ExAC
rs1438297871 CA393122646	259	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA393122655 rs1414728269	260	Q>*		No	ClinGen gnomAD
rs1156972442 CA393122676	261	M>T		No	ClinGen TOPMed gnomAD
rs1318964350 CA393122696	262	H>Q		No	ClinGen TOPMed
rs921249769 CA272740671	262	H>Y		No	ClinGen gnomAD
TCGA novel	264	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749942852 CA7652426	265	V>A		No	ClinGen ExAC gnomAD
rs755711851 CA7652427	266	G>R		No	ClinGen ExAC gnomAD
TCGA novel	266	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7652428 rs779600459	267	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1332038475 CA393122765	268	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs369316804 CA7652430	271	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1020491808 CA272740693	272	R>H		No	ClinGen TOPMed gnomAD
rs1020491808 CA393122819	272	R>L		No	ClinGen TOPMed gnomAD
CA272740696 rs887232755	273	A>G		No	ClinGen Ensembl
CA393122844 rs1320649709	274	E>D		No	ClinGen gnomAD
CA7652433 rs772139210	274	E>K		No	ClinGen ExAC TOPMed gnomAD
CA393122853 rs1199813720	275	T>I		No	ClinGen gnomAD
CA393122855 rs1346612667	276	E>K		No	ClinGen TOPMed
CA7652434 rs773369332	280	R>L		No	ClinGen ExAC gnomAD
rs1238444195 CA393122952	282	R>C		No	ClinGen TOPMed gnomAD
CA393122958 rs1473885809	282	R>H		No	ClinGen TOPMed gnomAD
rs1180398219 CA393122965	283	V>M		No	ClinGen gnomAD
rs771145349 CA7652436	284	R>H		No	ClinGen ExAC TOPMed gnomAD
CA393122991 rs771145349	284	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1180210722 CA393122994	285	Q>*		No	ClinGen TOPMed
rs1180210722 CA393122993	285	Q>E		No	ClinGen TOPMed
CA7652437 rs776759306	285	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1478151792 CA393122996	285	Q>R		No	ClinGen gnomAD
rs759926492 CA7652439	286	V>L		No	ClinGen ExAC TOPMed gnomAD
rs759926492 CA7652438	286	V>M		No	ClinGen ExAC TOPMed gnomAD
CA7652440 rs775974503	287	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1294566437 CA393123037	289	H>D		No	ClinGen TOPMed
CA393123044 rs1327908477	289	H>R		No	ClinGen gnomAD
CA7652441 rs763387415	290	V>G		No	ClinGen ExAC gnomAD
rs1247431420 CA393123079	291	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs764605006 CA7652442	292	A>T		No	ClinGen ExAC gnomAD
rs749893395 CA7652443	293	Q>L		No	ClinGen ExAC gnomAD
rs1226139282 CA393123141	295	R>G		No	ClinGen TOPMed
rs755656820 CA7652444	296	E>G		No	ClinGen ExAC TOPMed gnomAD
rs868222335 CA272740738	296	E>K		No	ClinGen TOPMed
rs868222335 CA272740737	296	E>Q		No	ClinGen TOPMed
CA393123200 rs1198615199	299	E>V		No	ClinGen gnomAD
rs1279768942 CA393123220	301	V>M		No	ClinGen gnomAD
CA393123243 rs1444561442	302	D>V		No	ClinGen gnomAD
rs1414305085 CA393123250	303	A>T		No	ClinGen Ensembl
rs754797325 CA7652447	303	A>V		No	ClinGen ExAC gnomAD
CA7652448 rs778503914	304	R>G		No	ClinGen ExAC TOPMed gnomAD
CA7652449 rs778503914	304	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7652450 rs538982599	305	Y>H		No	ClinGen 1000Genomes ExAC gnomAD
COSM1724222 COSM1724221 COSM1724220 CA393123295 rs1195888860	306	Q>*	NS [Cosmic]	No	ClinGen cosmic curated gnomAD
rs140050477 CA7652451	307	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7652452 rs747055654	308	D>N		No	ClinGen ExAC gnomAD
CA272740767 rs1033626602	310	E>D		No	ClinGen Ensembl
CA7652454 rs146344435	310	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs377549937 CA272740766	310	E>V		No	ClinGen ESP TOPMed gnomAD
rs889133403 CA272740768	311	E>A		No	ClinGen TOPMed
CA7652455 rs746145846	313	A>P		No	ClinGen ExAC gnomAD
rs746145846 CA393123411	313	A>S		No	ClinGen ExAC gnomAD
CA7652456 rs139917470	315	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA393123486 rs1299464689	317	G>R		No	ClinGen gnomAD
rs1299464689 CA393123485	317	G>S		No	ClinGen gnomAD
rs1227334631 CA393123510	318	R>H		No	ClinGen gnomAD
rs1337848870 CA393123507	318	R>S		No	ClinGen gnomAD
TCGA novel	319	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393123524 rs1347767687	319	L>R		No	ClinGen gnomAD
CA7652457 rs775778127	319	L>V		No	ClinGen ExAC gnomAD
CA272740773 rs774884695	320	D>G		No	ClinGen ExAC gnomAD
rs774884695 CA7652460	320	D>V		No	ClinGen ExAC gnomAD
rs769118386 CA7652459	320	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA393123562 rs1219129562	321	A>V		No	ClinGen gnomAD
TCGA novel	322	V>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765869727 CA7652462	325	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA272740776 rs966391049	326	I>F		No	ClinGen Ensembl
rs979167489 CA272740777	327	R>C		No	ClinGen gnomAD
rs1218716032 CA393123677	327	R>L		No	ClinGen TOPMed
CA272740781 rs957562720	329	G>S		No	ClinGen Ensembl
CA7652465 rs765004499	331	A>T		No	ClinGen ExAC TOPMed gnomAD
rs752501211 CA7652466	331	A>V		No	ClinGen ExAC gnomAD
CA393123868 rs1381104278	335	R>S		No	ClinGen gnomAD
CA272740792 rs921570606	337	K>R		No	ClinGen gnomAD
rs371084483 CA7652468	338	C>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA7652470 rs199516006	345	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745978140 CA7652472	347	D>G		No	ClinGen ExAC gnomAD
CA393124094 rs1463575722	347	D>N		No	ClinGen TOPMed
rs769864191 CA393124125	348	M>L		No	ClinGen ExAC TOPMed gnomAD
CA393124137 rs1210460728	348	M>T		No	ClinGen gnomAD
rs769864191 CA7652473	348	M>V		No	ClinGen ExAC TOPMed gnomAD
rs749628246 CA393124189	350	G>C		No	ClinGen ExAC gnomAD
CA7652475 rs749628246	350	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1169828822 CA393124227	351	F>C		No	ClinGen TOPMed
rs1163670302 CA393124271	353	R>H		No	ClinGen gnomAD
rs1252142924 CA393124279	354	Q>E		No	ClinGen gnomAD
rs1567130417 CA393124350	358	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA272740841 rs967509295	358	R>H		No	ClinGen TOPMed
CA7652480 rs375594567	360	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA272740849 rs74471420	362	E>G		No	ClinGen ExAC TOPMed gnomAD
rs775954834 CA7652481	362	E>Q		No	ClinGen ExAC gnomAD
rs74471420 CA7652482	362	E>V		No	ClinGen ExAC TOPMed gnomAD
rs1449390274 CA393124456	365	Q>H		No	ClinGen TOPMed gnomAD
rs764951444 CA7652484	368	Q>R		No	ClinGen ExAC gnomAD
CA393124497 rs1267279902	369	A>T		No	ClinGen gnomAD
rs752448206 CA7652485	370	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7652488 rs751376158	371	V>L		No	ClinGen ExAC TOPMed gnomAD
CA272740858 rs773725664	372	R>C		No	ClinGen ExAC gnomAD
rs773725664 CA7652489	372	R>G		No	ClinGen ExAC gnomAD
COSM1517515 CA393124542 COSM1517513 COSM1517514 rs1309900464	372	R>L	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA7652490 rs767515993	373	T>A		No	ClinGen ExAC gnomAD
CA272740861 rs545588296	374	D>G		No	ClinGen TOPMed
CA393124576 rs1418125536	375	G>A		No	ClinGen gnomAD
rs1418125536 CA393124574	375	G>D		No	ClinGen gnomAD
rs780238004 CA7652493	376	F>L		No	ClinGen ExAC gnomAD
CA7652495 rs377747936	377	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	377	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371413149 CA7652496	378	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1358921256 CA393124639	380	K>E		No	ClinGen TOPMed gnomAD
rs937867488 CA393124677	382	R>C		No	ClinGen TOPMed gnomAD
CA7652497 rs149871195	382	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149871195 CA7652498	382	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs937867488 CA272740892	382	R>S		No	ClinGen TOPMed gnomAD
CA393124686 rs1329692309	383	L>R		No	ClinGen gnomAD
CA393124690 rs1203975549	384	Q>K		No	ClinGen TOPMed
rs745349363 CA7652500	385	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1458563717 CA393124711	385	D>N		No	ClinGen TOPMed gnomAD
rs1315028133 CA393124726	386	L>V		No	ClinGen gnomAD
rs369148720 CA272740898	387	S>T		No	ClinGen Ensembl
rs769487892 CA7652501	388	S>C		No	ClinGen ExAC TOPMed gnomAD
CA393124756 rs1317401607	388	S>T		No	ClinGen TOPMed
CA393124775 rs1238028144	389	C>Y		No	ClinGen TOPMed
rs1180638019 CA393124811	391	T>N		No	ClinGen gnomAD
CA7652502 rs775280848	392	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs762629473 CA7652503	392	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA7652504 rs763855841	394	K>T		No	ClinGen ExAC gnomAD
rs867104191 CA272741428	395	D>G		No	ClinGen TOPMed
CA393125483 rs1434304568	397	A>T		No	ClinGen Ensembl
CA393125497 rs1595904100	397	A>V		No	ClinGen Ensembl
rs768386792 CA7652522	402	A>P		No	ClinGen ExAC gnomAD
CA7652523 rs142023780	403	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1457054837 CA393125591	404	P>A		No	ClinGen TOPMed
rs1047960171 CA272741433	404	P>L		No	ClinGen TOPMed gnomAD
CA393125601 rs1047960171	404	P>R		No	ClinGen TOPMed gnomAD
CA7652524 rs761496643	406	A>P		No	ClinGen ExAC gnomAD
rs767411421 CA7652525	408	S>G		No	ClinGen ExAC gnomAD
CA393125645 rs767411421	408	S>R		No	ClinGen ExAC gnomAD
CA7652526 rs772885645	409	T>S		No	ClinGen ExAC gnomAD
TCGA novel	410	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393125724 rs1262379239	412	D>N		No	ClinGen TOPMed
rs766326578 CA393125789	416	V>F		No	ClinGen ExAC TOPMed gnomAD
rs766326578 CA7652528	416	V>I		No	ClinGen ExAC TOPMed gnomAD
rs145863996 CA7652529	417	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs543631733	419	P>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs866169120 CA393108518	419	P>L		No	ClinGen gnomAD
rs866169120 CA272722049	419	P>R		No	ClinGen gnomAD
rs763180010 CA7652553	420	E>A		No	ClinGen ExAC
rs565219584 CA7652552	420	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764247291 CA7652554	422	A>T		No	ClinGen ExAC TOPMed gnomAD
rs867206689 CA272722075	423	E>G		No	ClinGen Ensembl
CA393108547 rs1480851109	424	R>K		No	ClinGen TOPMed
CA7652555 rs751936860	424	R>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	425	V>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746160914 CA272722078	427	A>T		No	ClinGen gnomAD
CA393108588 rs1219908926	430	Q>R		No	ClinGen TOPMed
rs751033700 CA7652558	431	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1567135316 CA393108596	431	A>V		No	ClinGen Ensembl
rs778426636 CA7652560	433	G>E		No	ClinGen ExAC TOPMed gnomAD
CA272722087 rs758611701	434	L>M		No	ClinGen Ensembl
rs747633287 CA7652561	437	A>V		No	ClinGen ExAC TOPMed gnomAD
rs771715585 CA7652562	438	Q>R		No	ClinGen ExAC gnomAD
rs772181249 CA272722102	440	M>V		No	ClinGen TOPMed gnomAD
rs866380391 CA272722118	441	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1595913715 CA393108659	442	V>G		No	ClinGen Ensembl
CA393108667 rs1595913719	443	V>G		No	ClinGen Ensembl
rs777441794 CA7652563 CA393108694	448	G>R		No	ClinGen ExAC TOPMed gnomAD
rs746784735 CA7652564	449	A>V		No	ClinGen ExAC gnomAD
rs1273869549 CA393108709	450	H>L		No	ClinGen TOPMed
TCGA novel	452	V>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1256891305 CA393108722	452	V>E		No	ClinGen gnomAD
COSM964735 rs759404689 CA7652567 COSM964736 COSM964733	452	V>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA393108730 rs1488618225	454	V>L		No	ClinGen gnomAD
rs1488618225 CA393108729	454	V>M		No	ClinGen gnomAD
CA7652568 rs769635059	455	Y>N		No	ClinGen ExAC gnomAD
rs11555843 CA7652570	456	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA272722146 rs143771296	458	S>F		No	ClinGen ESP TOPMed
CA7652571 rs148158604	461	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA393108779 rs148158604	461	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1398970294 CA393108785	462	P>L		No	ClinGen gnomAD
CA393108791 rs1436188555	463	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1298048139 CA393108796	464	Y>C		No	ClinGen TOPMed gnomAD
CA272722152 rs1008530876	465	G>E		No	ClinGen Ensembl
CA7652572 rs774767661	466	E>D		No	ClinGen ExAC TOPMed gnomAD
rs769734938 CA7652586	470	N>S		No	ClinGen ExAC TOPMed gnomAD
CA7652588 rs200123201	472	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA393108874 rs1294097306	475	Q>K		No	ClinGen Ensembl
rs774573419 CA7652590	478	K>R		No	ClinGen ExAC gnomAD
CA393108901 rs774573419	478	K>T		No	ClinGen ExAC gnomAD
CA7652591 rs762065759	479	C>S		No	ClinGen ExAC gnomAD
rs773669860 CA7652593	480	S>R		No	ClinGen ExAC gnomAD
CA393108916 rs1264097177	480	S>T		No	ClinGen gnomAD
CA393108931 rs1252189977	482	T>I		No	ClinGen TOPMed gnomAD
rs760985638 CA7652594	483	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA7652595 rs766886570	485	P>L		No	ClinGen ExAC gnomAD
rs1163353594 COSM1608663 CA393108974 COSM3706723 COSM1608661 COSM1608662	487	K>N	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1420597564 CA393109020	491	M>L		No	ClinGen gnomAD
TCGA novel	494	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393109106 rs1460372560	496	G>V		No	ClinGen gnomAD
CA272722432 rs1040029293	499	A>G		No	ClinGen gnomAD
CA393109144 rs1325628964	499	A>S		No	ClinGen gnomAD
CA393109140 rs1325628964	499	A>T		No	ClinGen gnomAD
CA393109147 rs1040029293	499	A>V		No	ClinGen gnomAD
CA272722437 rs897508286	502	A>S		No	ClinGen TOPMed gnomAD
CA7652599 rs751085157	503	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7652598 rs763529879	503	R>W		No	ClinGen ExAC TOPMed gnomAD
rs756856518 CA7652600	505	S>F		No	ClinGen ExAC gnomAD
CA393109193 rs1206488056	506	P>A		No	ClinGen TOPMed
CA7652601 rs202019975	506	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA393109229 rs1217033720	509	P>S		No	ClinGen TOPMed
CA393109251 rs1595914612	510	R>S		No	ClinGen Ensembl
rs1595914627 CA393109285	513	T>P		No	ClinGen Ensembl
CA7652605 rs749109993	515	K>R		No	ClinGen ExAC gnomAD
CA393109332 rs768725303	517	V>F		No	ClinGen ExAC TOPMed gnomAD
CA7652606 rs768725303	517	V>I		No	ClinGen ExAC TOPMed gnomAD
rs886310440 CA272722482	519	P>A		No	ClinGen TOPMed
rs772391650 CA7652609	520	P>L		No	ClinGen ExAC gnomAD
CA7652608 rs748267579	520	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1463802797 CA393109369	521	H>D		No	ClinGen TOPMed gnomAD
CA393109373 rs1166540601	521	H>P		No	ClinGen TOPMed gnomAD
CA393109371 rs1463802797	521	H>Y		No	ClinGen TOPMed gnomAD
CA393109385 rs1395992192	522	L>Q		No	ClinGen gnomAD
CA393109400 rs1462902978	523	D>E		No	ClinGen TOPMed
rs370723883 CA7652610	525	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA7652612 rs771267596	526	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1292537881 CA393109462	528	P>H		No	ClinGen gnomAD
CA7652614 rs759979414	530	S>I		No	ClinGen ExAC gnomAD
rs146047180 CA7652615	532	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA393109519 rs1211232615	533	I>T		No	ClinGen gnomAD
CA393109514 rs1264938598	533	I>V		No	ClinGen TOPMed
rs761356725 CA7652617	536	E>A		No	ClinGen ExAC gnomAD
CA7652618 rs767138681	537	V>I		No	ClinGen ExAC gnomAD
rs779652279 CA7652621	543	N>K		No	ClinGen ExAC gnomAD
TCGA novel	544	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA272722529 rs867299859	545	V>M		No	ClinGen TOPMed gnomAD
CA393109731 rs1175685867	547	S>R		No	ClinGen gnomAD
CA393109743 rs1292101503	548	G>D		No	ClinGen gnomAD
CA7652624 rs11855663 RCV000880310	549	A>T		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7652627 rs146326362	550	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs374199653 CA7652626	550	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1325735061	551	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771198810 CA7652629	552	A>T		No	ClinGen ExAC gnomAD
rs1325710733 CA393109795	553	E>K		No	ClinGen gnomAD
CA393111203 rs1567136651	554	E>V		No	ClinGen Ensembl
CA393111213 rs1237579574	555	R>C		No	ClinGen TOPMed
CA7652672 rs200546578	555	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs746515572 CA7652675	556	V>F		No	ClinGen ExAC TOPMed gnomAD
rs746515572 CA7652674	556	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA393111307 rs1312140456	561	S>T		No	ClinGen TOPMed
CA272723175 rs375611361	564	D>N		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs764959569 CA7652678	565	S>T		No	ClinGen ExAC
CA393111381 rs1309299270	566	D>E		No	ClinGen Ensembl
CA7652682 rs371956504	567	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA7652680 rs762767132	567	A>T		No	ClinGen ExAC
rs371956504 CA7652681	567	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
COSM964746 rs1026561797 CA272723187 COSM964749 COSM964748	568	E>K	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs767645907 CA7652684	569	N>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	570	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765859108 CA7652957	571	S>F		No	ClinGen ExAC gnomAD
CA7652960 rs778493023	573	R>*		No	ClinGen ExAC gnomAD
CA7652961 rs752502722	573	R>Q		No	ClinGen ExAC gnomAD
COSM1608664 rs746979292 CA7652964	579	S>I	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs200104189 CA7652965	580	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1399653982 CA393118029	582	S>F		No	ClinGen TOPMed
CA272727987 rs958002310	582	S>T		No	ClinGen TOPMed
CA393118036 rs1257908951	583	S>G		No	ClinGen TOPMed gnomAD
CA7652966 rs148332748	583	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA393118057 rs1458109267	584	D>E		No	ClinGen gnomAD
CA393118136 rs1481001295	590	P>L		No	ClinGen gnomAD
CA7652968 rs770162831	591	S>R		No	ClinGen ExAC
TCGA novel	593	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7652970 rs775792287 CA7652969	594	R>S		No	ClinGen ExAC gnomAD
rs1275457313 CA393118189	595	V>A		No	ClinGen TOPMed gnomAD
rs11272 CA272728023	598	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs143616011 CA7652974	598	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs11272 CA7652973	598	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs371806874 CA7652975	599	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA7652976 rs758989714	600	L>I		No	ClinGen ExAC gnomAD
CA272728034 rs995252356	601	A>P		No	ClinGen Ensembl
CA7652978 rs368061525	602	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7652979 rs758035628	603	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1246714490 CA393118284	603	P>S		No	ClinGen gnomAD
rs1246714490 CA393118280	603	P>T		No	ClinGen gnomAD
rs751337106 CA7652981	607	D>N		No	ClinGen ExAC gnomAD
CA393118339 rs371624259	608	R>*		No	ClinGen ESP TOPMed
CA272728055 rs371624259	608	R>G		No	ClinGen ESP TOPMed
rs757172711 CA7652982	609	P>L		No	ClinGen ExAC TOPMed gnomAD
rs757172711 CA393118359	609	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1161773321 CA393118369	610	L>P		No	ClinGen gnomAD
rs781134737 CA393118479	616	K>E		No	ClinGen ExAC gnomAD
CA7652983 rs781134737	616	K>Q		No	ClinGen ExAC gnomAD
CA393118507 rs1400277229	617	I>T		No	ClinGen gnomAD
rs745955110 CA7652984	619	N>S		No	ClinGen ExAC TOPMed gnomAD
CA393118570 rs1434374702	620	E>A		No	ClinGen gnomAD
rs762475037 CA7653015	621	T>N		No	ClinGen ExAC gnomAD
TCGA novel	622	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1248855090 CA393120297	622	Q>R		No	ClinGen gnomAD
CA272728483 rs924871120	623	K>R		No	ClinGen TOPMed
rs773983495 CA7653018	624	I>V		No	ClinGen ExAC TOPMed gnomAD
CA393120336 rs1186703766	625	S>N		No	ClinGen gnomAD
CA7653019 rs761363933	626	Q>E		No	ClinGen ExAC gnomAD
CA7653020 rs147197708	626	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs140558473 CA7653022	627	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA393120380 rs1404163177	629	A>S		No	ClinGen gnomAD
rs1468020613 CA393120382	629	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA272728489 rs373236341	631	N>S		No	ClinGen Ensembl
CA7653025 rs574698430	632	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs142900813 CA7653024	632	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7653026 rs772041580	634	S>N		No	ClinGen ExAC gnomAD
rs1595923646 CA393120471	636	F>S		No	ClinGen Ensembl
rs753021611 CA393120481	637	R>C		No	ClinGen ExAC TOPMed gnomAD
rs753021611 CA7653027	637	R>G		No	ClinGen ExAC TOPMed gnomAD
CA393120485 rs1234689753	637	R>H		No	ClinGen gnomAD
rs778153703 CA7653029	638	V>M		No	ClinGen ExAC gnomAD
CA7653031 rs747332047	642	P>A		No	ClinGen ExAC TOPMed gnomAD
rs747332047 CA393120541	642	P>S		No	ClinGen ExAC TOPMed gnomAD
CA7653033 rs781620616	643	E>K		No	ClinGen ExAC gnomAD
rs768274916 CA7653035	645	F>C		No	ClinGen ExAC gnomAD
rs5742915 VAR_052090 CA7653034	645	F>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA393120578 rs5742915	645	F>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA393120659 rs1474850595	651	K>E		No	ClinGen TOPMed
rs761108099 CA272728543	653	V>A		No	ClinGen gnomAD
rs761108099 CA393120686	653	V>E		No	ClinGen gnomAD
CA7653038 rs771816629	653	V>L		No	ClinGen ExAC TOPMed gnomAD
CA393120682 rs771816629	653	V>M		No	ClinGen ExAC TOPMed gnomAD
rs773166495 CA7653039	654	S>C		No	ClinGen ExAC gnomAD
rs1252366505 CA393120689	654	S>T		No	ClinGen TOPMed
rs773166495 CA7653040	654	S>Y		No	ClinGen ExAC gnomAD
rs1304100114 CA393120718	656	E>A		No	ClinGen TOPMed gnomAD
CA7653041 rs766424051	658	G>R		No	ClinGen ExAC gnomAD
CA7653043 rs759381921	660	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA393120784 rs758676057	661	H>Q		No	ClinGen ExAC gnomAD
CA7653045 rs752691619	661	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs777920303 COSM471044 CA7653047	662	F>L	kidney [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA393120877 rs1270993926	667	S>N		No	ClinGen gnomAD
CA7653048 rs751931798	669	M>L		No	ClinGen ExAC gnomAD
rs1412523768 CA393120900	669	M>T		No	ClinGen gnomAD
CA7653049 COSM1374492 rs202099881	670	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs781533017 CA7653050	670	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7653051 rs746444712	671	R>C		No	ClinGen ExAC TOPMed gnomAD
rs149885467 CA7653052	671	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	672	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs367820386 CA7653054	673	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA7653053 rs367820386	673	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA7653055 rs534126343	675	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1309165417 CA393120996	677	Y>H		No	ClinGen gnomAD
CA393121025 rs1409016428	678	K>N		No	ClinGen TOPMed
rs760399378 CA7653057	679	L>P		No	ClinGen ExAC TOPMed gnomAD
CA272728576 rs1029424334	680	W>*		No	ClinGen TOPMed gnomAD
CA393121047 rs1567141785	680	W>C		No	ClinGen Ensembl
rs770911206 CA7653058	681	G>E		No	ClinGen ExAC TOPMed gnomAD
CA393121053 rs1306604077	681	G>R		No	ClinGen gnomAD
rs952161997 CA272728585	684	L>F		No	ClinGen Ensembl
CA7653061 rs765048167	685	P>L		No	ClinGen ExAC gnomAD
rs752841570 CA7653062	686	N>H		No	ClinGen ExAC TOPMed gnomAD
rs752841570 CA393121104	686	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs1252422504 CA393121141	688	F>L		No	ClinGen gnomAD
rs764300823 CA7653064	689	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7653063 rs762959382	689	R>W		No	ClinGen ExAC TOPMed gnomAD
CA7653065 rs751842032	690	A>T		No	ClinGen ExAC TOPMed gnomAD
rs757456915 CA7653066	690	A>V		No	ClinGen ExAC gnomAD
TCGA novel	696	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1169830713 CA393121238	696	R>T		No	ClinGen gnomAD
CA393121253 rs1356752075	697	L>R		No	ClinGen gnomAD
CA393121323 rs780369568	702	E>K		No	ClinGen ExAC TOPMed gnomAD
rs780369568 CA7653070	702	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs916147857 CA272728619	702	E>V		No	ClinGen Ensembl
rs758050411 CA7653072	705	S>A		No	ClinGen ExAC gnomAD
rs376941681 CA7653073	705	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs376941681 CA393121371	705	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	706	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1314377363 CA393121376	706	G>S		No	ClinGen TOPMed
rs573612912 CA7653074	708	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA7653075 rs372005113	709	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs776522964 CA7653076	710	A>S		No	ClinGen ExAC gnomAD
rs745598226 CA7653077	713	L>V		No	ClinGen ExAC TOPMed gnomAD
rs934681999 CA272728650	714	I>T		No	ClinGen Ensembl
CA7653079 rs769781945	715	R>G		No	ClinGen ExAC TOPMed gnomAD
rs762869380 CA7653080	715	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7653078 rs769781945	715	R>W		No	ClinGen ExAC TOPMed gnomAD
rs367988522 CA272728654	717	R>C		No	ClinGen ESP TOPMed gnomAD
rs367988522 CA393121494	717	R>G		No	ClinGen ESP TOPMed gnomAD
CA393121500 rs1185108539	717	R>H		No	ClinGen TOPMed gnomAD
CA393121497 rs1185108539	717	R>L		No	ClinGen TOPMed gnomAD
rs764216789 CA7653081	719	P>H		No	ClinGen ExAC gnomAD
TCGA novel	719	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7653083 rs762061870	720	G>R		No	ClinGen ExAC TOPMed gnomAD
CA272728695 rs559192849	721	A>T		No	ClinGen Ensembl
CA393121525 rs1408649253	722	S>N		No	ClinGen gnomAD
CA7653084 rs767593867	724	F>L		No	ClinGen ExAC gnomAD
CA7653085 rs111398700	725	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA393121572 rs1595923777	728	N>K		No	ClinGen Ensembl
CA272728697 rs1047741654	730	A>S		No	ClinGen TOPMed gnomAD
rs1047741654 CA393121580	730	A>T		No	ClinGen TOPMed gnomAD
CA393121588 rs1335019509	731	Q>R		No	ClinGen gnomAD
CA7653086 rs140696630	732	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA393121609 rs1435933113	734	L>P		No	ClinGen gnomAD
rs755524243 CA7653089	735	A>V		No	ClinGen ExAC TOPMed gnomAD
rs777469680 CA7653090	736	R>*		No	ClinGen ExAC gnomAD
CA7653092 rs577626364	738	M>T		No	ClinGen 1000Genomes ExAC gnomAD
rs746481117 CA7653091	738	M>V		No	ClinGen ExAC gnomAD
rs780649478 CA393121637	739	S>G		No	ClinGen ExAC gnomAD
CA7653093 rs780649478	739	S>R		No	ClinGen ExAC gnomAD
rs1460558038 CA393121639	739	S>T		No	ClinGen gnomAD
CA7653094 rs745678082	740	E>K		No	ClinGen ExAC gnomAD
rs745678082 CA393121643	740	E>Q		No	ClinGen ExAC gnomAD
CA7653096 rs769540520	741	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs369136208 CA7653097	741	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA7653095 rs769540520	741	R>S		No	ClinGen ExAC TOPMed gnomAD
CA393121662 rs566939707	743	A>S		No	ClinGen ExAC TOPMed gnomAD
rs566939707 CA7653099	743	A>T		No	ClinGen ExAC TOPMed gnomAD
CA393121669 rs1174666365	744	M>K		No	ClinGen TOPMed gnomAD
rs1174666365 CA393121670	744	M>T		No	ClinGen TOPMed gnomAD
rs767787538 CA7653101	747	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1430073273 CA393121700	748	L>R		No	ClinGen gnomAD
rs867495375 CA272728785	749	A>T		No	ClinGen TOPMed gnomAD
CA7653104 rs766703777	749	A>V		No	ClinGen ExAC gnomAD
CA7653105 rs754228130	750	M>T		No	ClinGen ExAC gnomAD
CA393121716 rs1225133713	750	M>V		No	ClinGen gnomAD
rs760154145 CA7653106	751	R>C	Variant assessed as Somatic; 5.762e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs760154145 CA272728789	751	R>G		No	ClinGen ExAC TOPMed gnomAD
rs545201747 CA7653107	751	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs760154145 CA393121734	751	R>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	752	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA272728792 rs995197860	752	D>H		No	ClinGen Ensembl
CA7653108 rs751125523	753	L>V		No	ClinGen ExAC gnomAD
rs1307900203 CA393121769	754	C>S		No	ClinGen gnomAD
rs756651718 CA7653109	755	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7653110 rs780746013	755	R>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	757	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755769375 CA7653112	758	E>K		No	ClinGen ExAC gnomAD
TCGA novel	758	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7653113 rs755769375	758	E>Q		No	ClinGen ExAC gnomAD
rs768601255 CA393121855	759	V>F		No	ClinGen ExAC gnomAD
TCGA novel	759	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768601255 CA7653115	759	V>L		No	ClinGen ExAC gnomAD
CA272728840 rs959133455	760	S>F		No	ClinGen TOPMed
rs200757566 CA7653117	761	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7653118 rs748074472	761	P>L		No	ClinGen ExAC TOPMed gnomAD
CA393121876 rs748074472	761	P>R		No	ClinGen ExAC TOPMed gnomAD
CA7653120 rs140925157	762	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs140925157 CA393121895	762	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1012203019 CA272728849	763	P>L		No	ClinGen TOPMed gnomAD
CA7653122 rs771147774	767	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	770	Y>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1023224519 CA272728880	773	S>I		No	ClinGen TOPMed gnomAD
CA393122080 rs1220973529	774	S>G		No	ClinGen TOPMed gnomAD
rs924896245 CA272728883	777	C>R		No	ClinGen Ensembl
rs765841772 CA7653125	777	C>W		No	ClinGen ExAC gnomAD
rs1231412287 CA393122188	779	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1429292269 CA393122218	781	L>P		No	ClinGen TOPMed
CA393122273 rs1387227893	785	V>M		No	ClinGen gnomAD
CA393122290 rs1261515211	786	Q>*		No	ClinGen TOPMed
CA393122293 rs1261515211	786	Q>K		No	ClinGen TOPMed
rs1422798425 CA393122326	787	A>V		No	ClinGen TOPMed gnomAD
rs1409624673 CA393122336	788	A>D		No	ClinGen TOPMed gnomAD
rs766980954 CA7653128	791	P>H		No	ClinGen ExAC gnomAD
CA393122372 rs1410347513	791	P>S		No	ClinGen gnomAD
CA7653132 rs374210403	792	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs374210403 CA7653131	792	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7653130 rs61751125	792	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1384418899 CA393122443	795	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs754836240 CA7653133 COSM3771884	796	R>C	Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs188674537 CA7653134	796	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs565387284 CA7653136	797	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs1271413648 CA393122481	798	L>P		No	ClinGen TOPMed gnomAD
rs1271413648 CA393122482	798	L>R		No	ClinGen TOPMed gnomAD
CA393122486 rs1437601990	799	A>T		No	ClinGen TOPMed gnomAD
CA7653139 rs202062354	803	V>L		No	ClinGen 1000Genomes ExAC
CA7653140 rs202062354	803	V>M		No	ClinGen 1000Genomes ExAC
CA393122571 rs1328069485	804	S>N		No	ClinGen TOPMed gnomAD
CA7653141 rs776923981	804	S>R		No	ClinGen ExAC gnomAD
rs1299927443 CA393122662	808	L>P		No	ClinGen TOPMed
CA7653144 rs770336594	810	S>I		No	ClinGen ExAC gnomAD
CA7653143 rs770336594	810	S>N		No	ClinGen ExAC gnomAD
rs763409135 CA7653145	811	A>T		No	ClinGen ExAC gnomAD
CA393122724 rs1169575330	811	A>V		No	ClinGen gnomAD
CA393122743 rs1441478097	812	H>R		No	ClinGen gnomAD
rs1037329656 CA272728957	813	R>C		No	ClinGen gnomAD
CA393122751 rs1037329656	813	R>G		No	ClinGen gnomAD
CA7653146 rs566711622	813	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7653147 rs772617875	814	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7653148 rs200577511	814	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs138772531 CA7653149	816	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs201288185 CA272728965	816	R>W		No	ClinGen gnomAD
rs1326505687 CA393122845	817	Q>H		No	ClinGen gnomAD
rs753549555 CA7653151	817	Q>L		No	ClinGen ExAC
CA7653154 rs752500365	818	G>E		No	ClinGen ExAC
CA393122850 rs754603424 CA7653152	818	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7653153 rs754603424	818	G>W		No	ClinGen ExAC TOPMed gnomAD
CA393122867 rs1339183772	819	G>R		No	ClinGen TOPMed gnomAD
rs1339183772 CA393122864	819	G>S		No	ClinGen TOPMed gnomAD
CA393122874 rs1453073399	819	G>V		No	ClinGen TOPMed
CA393122889 rs1595923967	820	L>P		No	ClinGen Ensembl
CA393122896 rs1595923968	821	K>E		No	ClinGen Ensembl
rs758294457 CA7653155	821	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	824	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393122986 rs1196974578	825	R>H		No	ClinGen TOPMed
CA7653157 rs373296015	826	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs373296015 CA393123008	826	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7653158 rs757475807	827	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA393123103 rs1202551662	831	T>N		No	ClinGen TOPMed
CA393123126 rs1371232169	832	T>I		No	ClinGen gnomAD
rs1473024247 CA393123130	833	T>A		No	ClinGen TOPMed
CA7653160 rs746137264	833	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	836	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749615160 CA7653164	836	P>S		No	ClinGen ExAC gnomAD
CA7653165 rs141646523	837	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs112105465 CA272729008	838	Q>H		No	ClinGen Ensembl
CA7653167 rs762214399	839	P>A		No	ClinGen ExAC TOPMed gnomAD
CA393123251 rs1306454478	839	P>L		No	ClinGen TOPMed
CA393123242 rs762214399	839	P>S		No	ClinGen ExAC TOPMed gnomAD
rs762214399 CA393123239	839	P>T		No	ClinGen ExAC TOPMed gnomAD
CA7653168 rs200030114	840	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA393123330 rs1285510885	844	Q>R		No	ClinGen gnomAD
CA393123344 rs1223190247	845	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs759218798 CA7653170	845	A>V		No	ClinGen ExAC gnomAD
CA393123384 rs1486910944	847	G>D		No	ClinGen gnomAD
TCGA novel	847	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	848	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7653171 rs764824094	850	F>L		No	ClinGen ExAC gnomAD
rs752452667 CA7653172	851	E>D		No	ClinGen ExAC gnomAD
CA7653174 rs763790024	852	G>V		No	ClinGen ExAC gnomAD
TCGA novel	854	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745901836 CA7653178	856	G>S		No	ClinGen ExAC TOPMed gnomAD
CA7653179 COSM555984 rs756426423	857	P>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA393123607 rs1156244389	857	P>T		No	ClinGen gnomAD
CA7653181 rs79562667	858	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7653184 rs748693881	859	L>M		No	ClinGen ExAC
rs753052629 CA272729045	860	A>G		No	ClinGen Ensembl
rs370339805 CA393123705	861	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA7653186 rs370339805	861	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs138817062 CA7653185	861	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA393123712 rs1567142187	862	A>T		No	ClinGen Ensembl
rs1236987495 CA393123767	863	E>A		No	ClinGen gnomAD
CA393123768 rs1236987495	863	E>G		No	ClinGen gnomAD
rs769338190 CA7653189	868	P>S		No	ClinGen ExAC gnomAD
CA7653190 rs775282344	870	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1567142199 CA393123952	871	G>V		No	ClinGen Ensembl
CA7653191 rs762496523	872	R>C		No	ClinGen ExAC TOPMed gnomAD
rs762496523 CA393123965	872	R>G		No	ClinGen ExAC TOPMed gnomAD
COSM1221319 rs199966678 CA7653192	872	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs538388118 CA7653193	873	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA393124109 rs1595924064	877	R>T		No	ClinGen Ensembl
CA393124126 rs1420438059	878	A>V		No	ClinGen gnomAD
CA393124190 rs1379215863	881	Q>*		No	ClinGen gnomAD
rs750544529 CA7653196	883	S>W		No	ClinGen ExAC TOPMed gnomAD

1 associated diseases with P29590

Without disease ID

7 regional properties for P29590

Type	Name	Position	InterPro Accession
domain	AAA+ ATPase domain	159 - 295	IPR003593
domain	ATPase, AAA-type, core	163 - 293	IPR003959
conserved_site	ATPase, AAA-type, conserved site	265 - 284	IPR003960
domain	MIT domain	2 - 80	IPR007330
domain	Spastin/Vps4, C-terminal	374 - 434	IPR015415
domain	AAA ATPase, AAA+ lid domain	316 - 350	IPR041569
domain	Vacuolar protein sorting-associated protein 4, MIT domain	4 - 79	IPR045253

Functions

		Description
EC Number
Subcellular Localization	Nucleus Nucleus, nucleoplasm Cytoplasm Nucleus, PML body Nucleus, nucleolus Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side Early endosome membrane; Peripheral membrane protein; Cytoplasmic side	Isoform PML-1 can shuttle between the nucleus and cytoplasm Isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6 are nuclear isoforms whereas isoform PML-7 and isoform PML-14 lacking the nuclear localization signal are cytoplasmic isoforms Detected in the nucleolus after DNA damage Acetylation at Lys-487 is essential for its nuclear localization Within the nucleus, most of PML is expressed in the diffuse nuclear fraction of the nucleoplasm and only a small fraction is found in the matrix-associated nuclear bodies (PML-NBs) The transfer of PML from the nucleoplasm to PML-NBs depends on its phosphorylation and sumoylation The B1 box and the RING finger are also required for the localization in PML-NBs Also found in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria Sequestered in the cytoplasm by interaction with rabies virus phosphoprotein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

13 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
chromosome, telomeric region	The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome membrane	The lipid bilayer surrounding an early endosome.
extrinsic component of endoplasmic reticulum membrane	The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
heterochromatin	A compact and highly condensed form of chromatin that is refractory to transcription.
nuclear matrix	The dense fibrillar network lying on the inner side of the nuclear membrane.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
PML body	A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.

13 GO annotations of molecular function

Name	Definition
cobalt ion binding	Binding to a cobalt ion (Co).
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
identical protein binding	Binding to an identical protein or proteins.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
SMAD binding	Binding to a SMAD signaling protein.
SUMO binding	Binding to the small ubiquitin-like protein SUMO.
SUMO transferase activity	Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages.
sumo-dependent protein binding	Binding to a protein upon sumoylation of the target protein.
transcription coactivator activity	A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.
ubiquitin-protein transferase activity	Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
zinc ion binding	Binding to a zinc ion (Zn).

62 GO annotations of biological process

Name	Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
branching involved in mammary gland duct morphogenesis	The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
cell fate commitment	The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
cellular response to interleukin-4	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.
cellular response to leukemia inhibitory factor	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
cellular senescence	A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
circadian regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
common-partner SMAD protein phosphorylation	The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus.
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
endoplasmic reticulum calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings.
entrainment of circadian clock by photoperiod	The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
extrinsic apoptotic signaling pathway	The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
fibroblast migration	Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
intrinsic apoptotic signaling pathway in response to DNA damage	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
intrinsic apoptotic signaling pathway in response to oxidative stress	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
maintenance of protein location in nucleus	Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus.
myeloid cell differentiation	The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
negative regulation of angiogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
negative regulation of cell growth	Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of interleukin-1 beta production	Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
negative regulation of mitotic cell cycle	Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
negative regulation of telomerase activity	Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
negative regulation of telomere maintenance via telomerase	Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
negative regulation of translation in response to oxidative stress	Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
negative regulation of ubiquitin-dependent protein catabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
oncogene-induced cell senescence	A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family.
PML body organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia).
positive regulation of apoptotic process involved in mammary gland involution	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process of mammary epithelial cells during mammary gland involution.
positive regulation of defense response to virus by host	Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of extrinsic apoptotic signaling pathway	Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.
positive regulation of fibroblast proliferation	Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
positive regulation of histone deacetylation	Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.
positive regulation of peptidyl-lysine acetylation	Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation.
positive regulation of protein localization to chromosome, telomeric region	Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region.
positive regulation of signal transduction by p53 class mediator	Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator.
positive regulation of telomere maintenance	Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein import into nucleus	The directed movement of a protein from the cytoplasm to the nucleus.
protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
protein targeting	The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
protein-containing complex assembly	The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
protein-containing complex localization	A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.
regulation of calcium ion transport into cytosol	Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
regulation of cell adhesion	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.
regulation of circadian rhythm	Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of double-strand break repair	Any process that modulates the frequency, rate or extent of double-strand break repair.
response to cytokine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
response to gamma radiation	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
response to hypoxia	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to UV	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
retinoic acid receptor signaling pathway	The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands.
suppression of viral release by host	A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells.
transforming growth factor beta receptor signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

46 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5E9G4	TRIM10	Tripartite motif-containing protein 10	Bos taurus (Bovine)	PR
Q2T9Z0	TRIM17	E3 ubiquitin-protein ligase TRIM17	Bos taurus (Bovine)	PR
E1BJS7	TRIM71	E3 ubiquitin-protein ligase TRIM71	Bos taurus (Bovine)	PR
Q7YRV4	TRIM21	E3 ubiquitin-protein ligase TRIM21	Bos taurus (Bovine)	PR
Q1PRL4	TRIM71	E3 ubiquitin-protein ligase TRIM71	Gallus gallus (Chicken)	PR
Q7YR32	TRIM10	Tripartite motif-containing protein 10	Pan troglodytes (Chimpanzee)	PR
O15553	MEFV	Pyrin	Homo sapiens (Human)	SS
Q9BTV5	FSD1	Fibronectin type III and SPRY domain-containing protein 1	Homo sapiens (Human)	PR
Q9H2S5	RNF39	RING finger protein 39	Homo sapiens (Human)	PR
P19474	TRIM21	E3 ubiquitin-protein ligase TRIM21	Homo sapiens (Human)	PR
Q9UJV3	MID2	Probable E3 ubiquitin-protein ligase MID2	Homo sapiens (Human)	PR
Q9C029	TRIM7	E3 ubiquitin-protein ligase TRIM7	Homo sapiens (Human)	PR
Q9NQ86	TRIM36	E3 ubiquitin-protein ligase TRIM36	Homo sapiens (Human)	PR
Q86UV6	TRIM74	Tripartite motif-containing protein 74	Homo sapiens (Human)	PR
Q9UPQ4	TRIM35	E3 ubiquitin-protein ligase TRIM35	Homo sapiens (Human)	PR
Q6ZMU5	TRIM72	Tripartite motif-containing protein 72	Homo sapiens (Human)	PR
Q86UV7	TRIM73	Tripartite motif-containing protein 73	Homo sapiens (Human)	PR
Q8N9V2	TRIML1	Probable E3 ubiquitin-protein ligase TRIML1	Homo sapiens (Human)	PR
Q86XT4	TRIM50	E3 ubiquitin-protein ligase TRIM50	Homo sapiens (Human)	PR
Q5EBN2	TRIM61	Putative tripartite motif-containing protein 61	Homo sapiens (Human)	PR
Q9BZY9	TRIM31	E3 ubiquitin-protein ligase TRIM31	Homo sapiens (Human)	PR
Q2Q1W2	TRIM71	E3 ubiquitin-protein ligase TRIM71	Homo sapiens (Human)	PR
Q9BXM9	FSD1L	FSD1-like protein	Homo sapiens (Human)	PR
Q9WUH5	Trim10	Tripartite motif-containing protein 10	Mus musculus (Mouse)	PR
Q8BZT2	Sh3rf2	E3 ubiquitin-protein ligase SH3RF2	Mus musculus (Mouse)	PR
Q7TPM3	Trim17	E3 ubiquitin-protein ligase TRIM17	Mus musculus (Mouse)	PR
Q1XH17	Trim72	Tripartite motif-containing protein 72	Mus musculus (Mouse)	PR
Q9JJ26	Mefv	Pyrin	Mus musculus (Mouse)	SS
Q99PQ1	Trim12a	Tripartite motif-containing protein 12A	Mus musculus (Mouse)	PR
Q61510	Trim25	E3 ubiquitin/ISG15 ligase TRIM25	Mus musculus (Mouse)	PR
Q810I2	Trim50	E3 ubiquitin-protein ligase TRIM50	Mus musculus (Mouse)	PR
Q1PSW8	Trim71	E3 ubiquitin-protein ligase TRIM71	Mus musculus (Mouse)	PR
Q3TL54	Trim43a	Tripartite motif-containing protein 43A	Mus musculus (Mouse)	PR
P86449	Trim43c	Tripartite motif-containing protein 43C	Mus musculus (Mouse)	PR
Q60953	Pml	Protein PML	Mus musculus (Mouse)	PR
O77666	TRIM26	Tripartite motif-containing protein 26	Sus scrofa (Pig)	PR
O19085	TRIM10	Tripartite motif-containing protein 10	Sus scrofa (Pig)	PR
Q865W2	TRIM50	E3 ubiquitin-protein ligase TRIM50	Sus scrofa (Pig)	PR
Q920M2	Rnf39	RING finger protein 39	Rattus norvegicus (Rat)	PR
Q9JJ25	Mefv	Pyrin	Rattus norvegicus (Rat)	SS
A0JPQ4	Trim72	Tripartite motif-containing protein 72	Rattus norvegicus (Rat)	PR
Q810I1	Trim50	E3 ubiquitin-protein ligase TRIM50	Rattus norvegicus (Rat)	PR
D3ZVM4	Trim71	E3 ubiquitin-protein ligase TRIM71	Rattus norvegicus (Rat)	PR
F6QEU4	trim71	E3 ubiquitin-protein ligase TRIM71	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q640S6	trim72	Tripartite motif-containing protein 72	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
E7FAM5	trim71	E3 ubiquitin-protein ligase TRIM71	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MEPAPARSPR	PQQDPARPQE	PTMPPPETPS	EGRQPSPSPS	PTERAPASEE	EFQFLRCQQC
70	80	90	100	110	120
QAEAKCPKLL	PCLHTLCSGC	LEASGMQCPI	CQAPWPLGAD	TPALDNVFFE	SLQRRLSVYR
130	140	150	160	170	180
QIVDAQAVCT	RCKESADFWC	FECEQLLCAK	CFEAHQWFLK	HEARPLAELR	NQSVREFLDG
190	200	210	220	230	240
TRKTNNIFCS	NPNHRTPTLT	SIYCRGCSKP	LCCSCALLDS	SHSELKCDIS	AEIQQRQEEL
250	260	270	280	290	300
DAMTQALQEQ	DSAFGAVHAQ	MHAAVGQLGR	ARAETEELIR	ERVRQVVAHV	RAQERELLEA
310	320	330	340	350	360
VDARYQRDYE	EMASRLGRLD	AVLQRIRTGS	ALVQRMKCYA	SDQEVLDMHG	FLRQALCRLR
370	380	390	400	410	420
QEEPQSLQAA	VRTDGFDEFK	VRLQDLSSCI	TQGKDAAVSK	KASPEAASTP	RDPIDVDLPE
430	440	450	460	470	480
EAERVKAQVQ	ALGLAEAQPM	AVVQSVPGAH	PVPVYAFSIK	GPSYGEDVSN	TTTAQKRKCS
490	500	510	520	530	540
QTQCPRKVIK	MESEEGKEAR	LARSSPEQPR	PSTSKAVSPP	HLDGPPSPRS	PVIGSEVFLP
550	560	570	580	590	600
NSNHVASGAG	EAEERVVVIS	SSEDSDAENS	SSRELDDSSS	ESSDLQLEGP	STLRVLDENL
610	620	630	640	650	660
ADPQAEDRPL	VFFDLKIDNE	TQKISQLAAV	NRESKFRVVI	QPEAFFSIYS	KAVSLEVGLQ
670	680	690	700	710	720
HFLSFLSSMR	RPILACYKLW	GPGLPNFFRA	LEDINRLWEF	QEAISGFLAA	LPLIRERVPG
730	740	750	760	770	780
ASSFKLKNLA	QTYLARNMSE	RSAMAAVLAM	RDLCRLLEVS	PGPQLAQHVY	PFSSLQCFAS
790	800	810	820	830	840
LQPLVQAAVL	PRAEARLLAL	HNVSFMELLS	AHRRDRQGGL	KKYSRYLSLQ	TTTLPPAQPA
850	860	870	880
FNLQALGTYF	EGLLEGPALA	RAEGVSTPLA	GRGLAERASQ	QS