AiPD: Autoinhibited Protein Database

P29320

Gene name	EPHA3 (ETK, ETK1, HEK, TYRO4)
Protein name	Ephrin type-A receptor 3
Names	EPH-like kinase 4, EK4, hEK4, HEK, Human embryo kinase, Tyrosine-protein kinase TYRO4, Tyrosine-protein kinase receptor ETK1, Eph-like tyrosine kinase 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2042
EC number	2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

(Annotation based on sequence homology with P29323)
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.

Autoinhibitory domains (AIDs)

561-634 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

561-634 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

763-789 (Activation loop from InterPro)

Target domain	621-882 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

29 structures for P29320

Entry ID	Method	Resolution	Chain	Position	Source
2GSF	X-ray	177 A	A	577-947	PDB
2QO2	X-ray	160 A	A	577-947	PDB
2QO7	X-ray	160 A	A	577-947	PDB
2QO9	X-ray	155 A	A	577-947	PDB
2QOB	X-ray	165 A	A	609-947	PDB
2QOC	X-ray	125 A	A	609-947	PDB
2QOD	X-ray	115 A	A	577-947	PDB
2QOF	X-ray	120 A	A	577-947	PDB
2QOI	X-ray	125 A	A	577-947	PDB
2QOK	X-ray	120 A	A	577-947	PDB
2QOL	X-ray	107 A	A	577-947	PDB
2QON	X-ray	179 A	A	577-947	PDB
2QOO	X-ray	125 A	A	577-947	PDB
2QOQ	X-ray	160 A	A	577-947	PDB
3DZQ	X-ray	175 A	A	609-947	PDB
3FXX	X-ray	170 A	A	577-947	PDB
3FY2	X-ray	180 A	A	577-947	PDB
4G2F	X-ray	170 A	A	609-947	PDB
4GK2	X-ray	220 A	A	609-947	PDB
4GK3	X-ray	190 A	A	609-947	PDB
4GK4	X-ray	210 A	A	609-947	PDB
4L0P	X-ray	226 A	A	29-201	PDB
4P4C	X-ray	160 A	A	609-947	PDB
4P5Q	X-ray	135 A	A	606-947	PDB
4P5Z	X-ray	200 A	A	606-947	PDB
4TWN	X-ray	171 A	A	609-947	PDB
4TWO	X-ray	205 A	A	609-947	PDB
6IN0	X-ray	150 A	A	612-904	PDB
AF-P29320-F1	Predicted				AlphaFoldDB

792 variants for P29320

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
COSM1176710 CA353701150 rs770282917 COSM1176711	2	D>N	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA2502189 rs770282917	2	D>Y		No	ClinGen ExAC gnomAD
rs775889890 CA2502190	3	C>S		No	ClinGen ExAC gnomAD
CA2502192 rs764355602	6	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs751989411 CA2502194	7	I>L		No	ClinGen ExAC
TCGA novel	7	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750454214 CA2502197	8	L>F		No	ClinGen ExAC gnomAD
rs771405440 CA2502198	10	L>F		No	ClinGen ExAC TOPMed gnomAD
CA79216396 rs369721497	14	S>F		No	ClinGen ExAC gnomAD
rs780224889 CA2502199	14	S>P		No	ClinGen ExAC gnomAD
rs369721497 CA2502200	14	S>Y		No	ClinGen ExAC gnomAD
rs758417906 CA2502201	15	V>A		No	ClinGen ExAC gnomAD
CA79216397 rs373387079	15	V>F		No	ClinGen Ensembl
rs1194741028 CA353701245	17	D>E		No	ClinGen TOPMed
rs1461534861 CA353701242	17	D>G		No	ClinGen gnomAD
rs201110271 CA2502202	17	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353701246 rs1480670631	18	S>R		No	ClinGen TOPMed
CA353701255 rs1559734115	19	F>L		No	ClinGen Ensembl
CA2502204 rs141456190	21	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353701292 rs1433031247	24	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353701295 rs1236884924	25	Q>K		No	ClinGen TOPMed
CA353701302 rs1341481107	26	P>A		No	ClinGen TOPMed gnomAD
CA353701315 rs1559734152	28	N>D		No	ClinGen Ensembl
CA2502206 rs745339448	28	N>S		No	ClinGen ExAC TOPMed gnomAD
CA353701347 rs1347546355	30	V>A		No	ClinGen gnomAD
rs1157209705 CA353701349	31	N>D		No	ClinGen gnomAD
rs1321323037 COSM1425618 CA353701390 COSM1425619	37	T>A	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
VAR_036086	37	T>K	a colorectal cancer sample; somatic mutation [UniProt]	No	UniProt
rs1295767981 CA353701396	38	I>V		No	ClinGen gnomAD
rs760801471 CA2502232	39	Q>E		No	ClinGen ExAC gnomAD
rs760801471 CA353701401	39	Q>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2502234 rs374211029	41	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA79218120 rs756018331	42	L>P		No	ClinGen Ensembl
rs372273179 CA2502236	43	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs372273179 CA353701427	43	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA79218121 rs368633855	43	G>S		No	ClinGen ESP TOPMed gnomAD
CA2502237 rs139262347	45	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM731481 CA353701448 rs1559743082	46	S>C	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA353701469 rs1559743096	49	S>L		No	ClinGen Ensembl
rs993037877 CA79218123	50	H>N		No	ClinGen TOPMed gnomAD
CA353701473 rs1468754976	50	H>R		No	ClinGen TOPMed
rs750238747 CA2502240	51	G>R		No	ClinGen ExAC gnomAD
TCGA novel	54	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353701773 rs1223603848	56	S>N		No	ClinGen gnomAD
rs753507903 CA2502262	57	G>D		No	ClinGen ExAC gnomAD
CA353701805 rs1359245420	58	V>A		No	ClinGen gnomAD
rs1310714298 CA353701859	61	H>R		No	ClinGen gnomAD
CA353701855 rs1487544308	61	H>Y		No	ClinGen gnomAD
CA353701929 rs1354537650	66	R>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1400426073 CA353701935	67	T>N		No	ClinGen gnomAD
CA353701944 rs1279990429	68	Y>H		No	ClinGen TOPMed gnomAD
CA2502264 rs778392937	72	N>S		No	ClinGen ExAC gnomAD
TCGA novel	73	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752206333 CA2502265	75	D>E		No	ClinGen ExAC TOPMed gnomAD
CA79225393 rs267599943	75	D>N		No	ClinGen Ensembl
CA2502266 rs565897036	76	H>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs778365543 CA2502267	77	S>G		No	ClinGen ExAC gnomAD
TCGA novel	78	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1262037812 CA353702065	79	N>S		No	ClinGen gnomAD
rs1213239892 CA353702100	82	L>M		No	ClinGen TOPMed gnomAD
rs1019076961 CA79225394	83	R>I		No	ClinGen TOPMed gnomAD
VAR_036087	85	N>S	a colorectal cancer sample; somatic mutation [UniProt]	No	UniProt
CA353702169 rs1162117153	87	V>L		No	ClinGen gnomAD
rs1244334822 CA353702194	88	P>L		No	ClinGen gnomAD
rs771292552 CA2502269	88	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2502270 rs142484873	89	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1211863735 CA353702227	90	N>I		No	ClinGen TOPMed
rs539750746 CA2502271	92	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA2502272 rs371194762	93	Q>L		No	ClinGen ESP ExAC gnomAD
COSM280824 COSM280825 rs369150999 CA2502273	94	K>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1165172952 CA353702292	95	I>T		No	ClinGen gnomAD
rs1171325456 CA353702286	95	I>V		No	ClinGen gnomAD
CA2502275 rs771868437	97	V>M	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA353702358 rs1294076209	100	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs753700696 CA2502279	104	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1347519802 CA353702449	107	N>H		No	ClinGen TOPMed gnomAD
rs1365430715 CA353702451	107	N>S		No	ClinGen TOPMed
rs764881139 CA2502281	109	I>F		No	ClinGen ExAC gnomAD
COSM320149 CA2502283 COSM320148 rs757955810	111	L>F	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA2502282 rs561025059	111	L>W		No	ClinGen ExAC gnomAD
TCGA novel	112	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2502285 rs752079301	113	L>F		No	ClinGen ExAC gnomAD
rs537025827 CA2502284	113	L>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2502286 rs200995645	115	T>A		No	ClinGen ExAC TOPMed gnomAD
rs202143347 CA2502290	124	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA2502291 rs749566378	125	M>L		No	ClinGen ExAC gnomAD
CA2502292 rs768759202	125	M>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	126	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs982229155 CA79225398	126	E>Q		No	ClinGen TOPMed gnomAD
CA353702762 rs1168349491	129	D>G		No	ClinGen TOPMed
rs201357801 CA79225399	129	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA
TCGA novel	131	H>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353702789 rs1370363055	131	H>N		No	ClinGen gnomAD
rs1250111431 CA353702796	131	H>R		No	ClinGen TOPMed
CA353702812 rs1281519905	132	G>A		No	ClinGen gnomAD
rs1443135220 CA353702807	132	G>R		No	ClinGen gnomAD
CA2502294 rs746962589	134	K>E		No	ClinGen ExAC gnomAD
TCGA novel	134	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1048851 rs770780950 COSM1048852 CA2502295	136	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs776350196 CA353702870	136	R>L		No	ClinGen ExAC TOPMed gnomAD
rs776350196 CA2502296	136	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs373433238 CA2502297	137	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA79225401 rs577908847	138	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA
CA2502299 rs775092793	141	T>I		No	ClinGen ExAC gnomAD
rs1457847145 CA353702960	142	K>T		No	ClinGen gnomAD
CA353703008 rs1210304482	146	I>V		No	ClinGen TOPMed
CA353703041 rs1230871085	148	A>G		No	ClinGen gnomAD
rs1358372150 CA353703033	148	A>T		No	ClinGen TOPMed
CA353703051 rs1469427775	149	D>G		No	ClinGen gnomAD
CA2502302 rs751094345	150	E>K		No	ClinGen ExAC
CA353703108 rs1249441630	154	Q>E		No	ClinGen TOPMed
CA2502303 rs757714246	155	M>I		No	ClinGen ExAC TOPMed gnomAD
CA79225403 rs866821420	156	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA353703168 rs1342457962	158	G>E		No	ClinGen TOPMed
rs768163795 CA2502304	160	R>C		No	ClinGen ExAC gnomAD
CA2502305 rs750779844	160	R>H		No	ClinGen ExAC TOPMed gnomAD
CA353703202 rs1247330677	161	I>V		No	ClinGen gnomAD
CA353703243 rs1164159108	164	L>F		No	ClinGen gnomAD
TCGA novel	170	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1393773449 CA353703316	170	E>K		No	ClinGen gnomAD
CA2502306 rs141287594	173	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA353703382 rs1334260867	175	N>D		No	ClinGen gnomAD
rs770039696 CA2502308	175	N>K		No	ClinGen ExAC gnomAD
rs755222529 CA2502309	176	K>E		No	ClinGen ExAC gnomAD
CA2502310 rs778986745	177	K>*		No	ClinGen ExAC gnomAD
CA2502312 rs770851201	180	Y>F		No	ClinGen ExAC gnomAD
rs1317973431 CA353703479	181	L>V		No	ClinGen gnomAD
rs1270443958 CA353703491 COSM396051 COSM396050	182	A>S	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA353703488 rs1270443958	182	A>T		No	ClinGen TOPMed gnomAD
rs1559602030 CA353703545	187	G>D		No	ClinGen Ensembl
CA353703553 rs1187836345	188	A>G		No	ClinGen TOPMed gnomAD
CA353703552 rs1187836345	188	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	192	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769554825 CA2502315	195	V>A		No	ClinGen ExAC gnomAD
rs1378343025 CA353703611	197	V>G		No	ClinGen TOPMed
rs1187094132 CA353703606	197	V>I		No	ClinGen TOPMed gnomAD
rs1042248812 CA79225405	200	K>R		No	ClinGen TOPMed
CA2502316 rs775318326	201	K>N		No	ClinGen ExAC gnomAD
CA353703657 rs1483221430	204	F>L		No	ClinGen TOPMed
COSM94195 CA353703671 rs1276350997	206	V>L	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
VAR_068853 rs200567888 CA2502319	207	K>N	a pancreatic ductal adenocarcinoma sample; somatic mutation [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2502318 rs763655362	207	K>R		No	ClinGen ExAC gnomAD
TCGA novel	210	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761263727 CA2502320	210	A>V		No	ClinGen ExAC TOPMed gnomAD
COSM1633350 rs1413376820 COSM1633351 CA353703702	211	M>V	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
CA353703722 rs1274968589	213	P>L		No	ClinGen TOPMed
rs1293200426 CA353703719	213	P>S		No	ClinGen gnomAD
CA2502321 rs767180087	215	T>A		No	ClinGen ExAC
rs750948534 COSM74528 CA2502322 COSM1425633	215	T>M	ovary Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA353703737 rs1267843219	216	V>I		No	ClinGen TOPMed gnomAD
CA353703736 rs1267843219	216	V>L		No	ClinGen TOPMed gnomAD
rs1338210929 CA353703741	217	P>S		No	ClinGen TOPMed gnomAD
CA353703743 rs1338210929	217	P>T		No	ClinGen TOPMed gnomAD
rs770106113 CA79225406	218	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA353703749 rs1372738630	218	M>L		No	ClinGen TOPMed
rs1576233343 CA353703751	218	M>R		No	ClinGen Ensembl
COSM1693044 COSM1693043 CA353703781 rs1282065699	222	S>F	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs766846963 CA2502324	222	S>P		No	ClinGen ExAC TOPMed gnomAD
CA2502325 rs754158548	224	V>A		No	ClinGen ExAC gnomAD
CA353703788 rs1209963217	224	V>L		No	ClinGen gnomAD
rs1576233383 CA353703804	226	V>G		No	ClinGen Ensembl
COSM1425636 CA2502326 rs755172206 COSM1425637	226	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA353703812 rs1190951059 CA353703813	228	G>R		No	ClinGen gnomAD
rs1475149451 CA353703819	229	S>A		No	ClinGen gnomAD
VAR_042126	229	S>Y	a lung large cell carcinoma sample; somatic mutation [UniProt]	No	UniProt
TCGA novel	231	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA79225408 rs1018715666	231	V>I		No	ClinGen TOPMed gnomAD
rs748217146 CA2502328	232	N>D		No	ClinGen ExAC gnomAD
TCGA novel	233	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2502329 rs758441001	233	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA353703867 rs1253791217	236	E>*		No	ClinGen TOPMed
CA353703865 rs1253791217	236	E>K		No	ClinGen TOPMed
COSM109237 CA2502330 rs139652107	237	E>K	skin [Cosmic]	No	ClinGen cosmic curated ESP ExAC
CA2502332 rs769787086	238	D>E		No	ClinGen ExAC gnomAD
rs370457091 CA2502333	241	R>T		No	ClinGen ESP ExAC gnomAD
rs995930628 CA79225410	242	M>L		No	ClinGen TOPMed gnomAD
CA353703942 rs1261033710	246	T>I		No	ClinGen gnomAD
CA353703947 rs1203269012	247	E>G		No	ClinGen gnomAD
CA353703956 rs1553665305	248	G>V		No	ClinGen Ensembl
rs773846066 CA2502337 COSM138380	249	E>K	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA353703982 rs1229614068	252	V>A		No	ClinGen TOPMed
CA353703979 rs1194420863	252	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353703986 rs1396970589	253	P>A		No	ClinGen gnomAD
rs761576191 COSM197999 CA2502338	253	P>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA2502340 rs772927622	256	K>E		No	ClinGen ExAC gnomAD
rs1291872386 CA353704007	256	K>T		No	ClinGen TOPMed
TCGA novel	263	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs138376716 CA2502341	265	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2502342 rs138974536	267	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs754184476 CA353704089	268	F>L		No	ClinGen ExAC TOPMed gnomAD
CA2502343 rs754184476	268	F>V		No	ClinGen ExAC TOPMed gnomAD
rs1439645986 CA353704119	271	Q>R		No	ClinGen gnomAD
rs374955351 CA2502345	272	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs559831321 CA79236776	272	A>V		No	ClinGen Ensembl
rs760135022 CA2502361	274	R>*		No	ClinGen ExAC TOPMed gnomAD
CA2502362 rs765502894	274	R>Q		No	ClinGen ExAC gnomAD
CA353701514 rs201468736	275	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201468736 CA2502363	275	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2502364 rs201468736	275	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764312912 CA2502365	276	G>A		No	ClinGen ExAC gnomAD
rs896512954 CA79236778	280	A>V		No	ClinGen TOPMed
CA2502368 CA2502369 rs781383365	282	D>E		No	ClinGen ExAC gnomAD
CA2502370 rs755010537 COSM584811 COSM584810	283	G>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs200484511 CA2502371	284	N>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747973326 CA2502372	285	M>R		No	ClinGen ExAC gnomAD
rs948106621 CA79236779	286	K>Q		No	ClinGen TOPMed
CA2502373 rs758077460	286	K>T		No	ClinGen ExAC gnomAD
CA353701611 rs1259444587	289	K>N		No	ClinGen TOPMed
rs1559653607 CA353701609	289	K>R		No	ClinGen Ensembl
rs1355784567 CA353701625	291	P>L		No	ClinGen gnomAD
CA353701632 rs1559653620	292	P>L		No	ClinGen Ensembl
CA353701656 rs1297280508	296	T>S		No	ClinGen gnomAD
rs142109561 CA2502374	298	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353701689 rs1416437726	300	G>A		No	ClinGen gnomAD
rs1291352437 CA353701718	303	N>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs746697550 CA2502375	305	R>W		No	ClinGen ExAC gnomAD
TCGA novel	307	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs148593404 CA2502377	307	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
COSM94196 rs1381512203 CA353701827	311	F>L	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
CA353701848 COSM1425655 COSM1425654 rs1486190561	312	R>Q	liver large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs746351940 COSM1425652 CA2502378 COSM1425653	312	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA353701872 rs1187636039	314	D>E		No	ClinGen gnomAD
CA353701863 rs1483175958	314	D>N		No	ClinGen TOPMed gnomAD
CA353701877 rs1420974457	315	K>E		No	ClinGen gnomAD
rs1576321571 CA353701898	316	D>A		No	ClinGen Ensembl
CA353701908 rs770338205	316	D>E		No	ClinGen ExAC TOPMed gnomAD
CA353701918 rs1167543166	317	P>H		No	ClinGen gnomAD
rs1231064330 CA353701912	317	P>T		No	ClinGen gnomAD
rs763328423 CA2502381	319	S>C		No	ClinGen ExAC gnomAD
rs564506073 CA2502382	320	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA353701955 rs1420203186	320	M>V		No	ClinGen TOPMed
CA2502386 rs531563474	324	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA353702091 rs1286945505	325	P>A		No	ClinGen gnomAD
CA79236827 rs868816181	326	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA353702113 rs1315586801	327	S>T		No	ClinGen gnomAD
CA353702133 rs1273217724	328	S>L		No	ClinGen gnomAD
CA353702156 COSM1048859 rs1559654048 COSM1048860	330	R>I	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA2502409 rs368542690	336	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA353702246 rs1279441414	338	E>Q		No	ClinGen TOPMed
CA79236828 rs372301564	342	I>L		No	ClinGen ESP gnomAD
rs1405536132 CA353702302	342	I>T		No	ClinGen TOPMed gnomAD
rs372301564 CA353702296	342	I>V		No	ClinGen ESP gnomAD
rs756802617 CA2502411	344	D>G		No	ClinGen ExAC gnomAD
rs374701071 CA2502412	345	W>R		No	ClinGen ESP ExAC TOPMed
rs749859409 CA2502413	346	S>I		No	ClinGen ExAC gnomAD
rs755616509 CA2502414	347	W>L		No	ClinGen ExAC gnomAD
CA353702395 rs1330804725	349	L>P		No	ClinGen TOPMed gnomAD
CA79236829 rs933501529	351	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1281583058 CA353702424	351	T>K		No	ClinGen gnomAD
CA79236830 rs779599137	354	R>G		No	ClinGen ExAC TOPMed gnomAD
CA79236831 rs144727411	354	R>Q		No	ClinGen ESP gnomAD
rs779599137 CA2502415	354	R>W		No	ClinGen ExAC TOPMed gnomAD
CA2502416 rs749793758	355	K>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	356	D>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1195814121 CA353702473	356	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs149937883 CA2502418	357	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA353702539 rs1288697097	361	I>L		No	ClinGen gnomAD
rs1230921861 CA353702559	362	I>M		No	ClinGen gnomAD
rs202046045 CA2502420	362	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs367816678 CA2502419	362	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs773454441 CA2502421	364	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs1197169173 CA353702603	365	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA353702612 rs1188537096	366	C>R		No	ClinGen gnomAD
CA2502422 rs760852634	367	G>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1420005671 CA353702624	367	G>R		No	ClinGen gnomAD
CA2502423 rs771117648	368	W>R		No	ClinGen ExAC gnomAD
rs1317735981 CA353702697	372	Q>E		No	ClinGen TOPMed
CA2502424 rs776913752	374	E>G		No	ClinGen ExAC TOPMed gnomAD
CA79236833 rs371687854	374	E>K		No	ClinGen ESP TOPMed gnomAD
rs200415022 CA2502425	377	S>N	Variant assessed as Somatic; 0.0005543 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	379	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs995238704 CA79236835	381	R>C		No	ClinGen TOPMed gnomAD
COSM198018 CA2502426 rs764139832	381	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA2502428 rs761696838	385	R>G		No	ClinGen ExAC gnomAD
CA2502429 rs767254790	385	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1339518966 CA353702903	388	G>V		No	ClinGen gnomAD
rs1400852070 CA353702910	389	L>F		No	ClinGen TOPMed
CA353702921 rs1215928276	390	T>I		No	ClinGen gnomAD
CA353702925 rs1270503537	391	N>S		No	ClinGen gnomAD
CA353702948 rs1211409809	393	T>M		No	ClinGen gnomAD
CA2502430 rs533112669	393	T>P		No	ClinGen 1000Genomes ExAC gnomAD
CA353702971 rs1234568158	395	T>K		No	ClinGen gnomAD
rs1205132450 CA353702970	395	T>P		No	ClinGen gnomAD
rs1559654273 CA353703013	398	D>V		No	ClinGen Ensembl
CA353703042 rs1367928047	401	A>P		No	ClinGen TOPMed gnomAD
rs1367928047 CA353703044	401	A>S		No	ClinGen TOPMed gnomAD
CA2502433 rs753359922	401	A>V		No	ClinGen ExAC TOPMed gnomAD
CA2502434 rs755432416	402	H>D		No	ClinGen ExAC
rs1169851160 CA353703061	402	H>R		No	ClinGen gnomAD
CA2502436 rs748645303	404	N>Y		No	ClinGen ExAC
rs1313799818 CA353703130	406	T>I		No	ClinGen gnomAD
CA353703162 rs1377674952	408	E>D		No	ClinGen gnomAD
COSM296223 COSM296224 CA2502437 rs772463834	412	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1334127938 CA353703239	414	G>V		No	ClinGen gnomAD
TCGA novel	415	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353703245 rs1432350325	415	V>M		No	ClinGen gnomAD
rs776790513 CA2502441	418	L>R		No	ClinGen ExAC gnomAD
rs1254932287 CA353703301	419	S>G		No	ClinGen TOPMed
CA353703309 rs1282140504	419	S>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA353703334 rs144998277	421	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144998277 CA2502443	421	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2502442 rs759709969	421	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA353703336 rs1178604557	422	P>T		No	ClinGen gnomAD
CA353703345 rs1195505981	423	R>G		No	ClinGen gnomAD
TCGA novel	423	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1013433060 CA79236837	424	Q>E		No	ClinGen TOPMed
CA353703376 rs1246269252	425	F>V		No	ClinGen gnomAD
CA2502445 COSM1205447 rs530556931 COSM1205448	427	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA2502447 rs750191873	429	S>I		No	ClinGen ExAC gnomAD
CA2502448 rs760263242	430	I>V		No	ClinGen ExAC gnomAD
rs1172488603 CA353703438	431	T>P		No	ClinGen gnomAD
CA353703454 rs766046211 COSM731469	432	T>I	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA2502449 rs766046211	432	T>N		No	ClinGen ExAC TOPMed gnomAD
CA353703483 rs1317883302	434	Q>*		No	ClinGen gnomAD
rs754455890 CA353703495	434	Q>H		No	ClinGen ExAC gnomAD
rs571620668 CA79236838	435	A>D		No	ClinGen TOPMed gnomAD
CA2502474 rs751932716	436	A>V		No	ClinGen ExAC TOPMed gnomAD
CA353661248 rs1267303962	439	P>T		No	ClinGen gnomAD
rs757664499 CA2502475	442	T>A		No	ClinGen ExAC gnomAD
rs112239794 CA2502476	442	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353661345 rs1473800664	444	K>M		No	ClinGen TOPMed gnomAD
rs1348993609 COSM1284755 CA353661349 COSM1284754	444	K>N	autonomic_ganglia Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA353661344 rs1473800664	444	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA353661387 rs1180627146	446	D>E		No	ClinGen gnomAD
rs925530491 CA78491616	447	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs780126700 CA2502479	447	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1457055144 CA353661430	448	T>I		No	ClinGen gnomAD
CA2502480 rs372621625	448	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
VAR_042127	449	S>F	a lung neuroendocrine carcinoma sample; somatic mutation [UniProt]	No	UniProt
CA353661435 rs1398335242	449	S>Y		No	ClinGen gnomAD
CA353661444 rs1201275406	450	R>K		No	ClinGen gnomAD
rs747000701 CA2502483	451	N>S		No	ClinGen ExAC gnomAD
rs1392564713 CA353662176	453	I>N		No	ClinGen TOPMed
rs1373094456 CA353662236 COSM1425682 COSM1425683	454	S>F	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA353662579 rs1271844607	461	E>D		No	ClinGen TOPMed
CA2502487 rs764806570	461	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1475098621 CA353662615	462	H>L		No	ClinGen gnomAD
CA2502488 rs775011935	463	P>R		No	ClinGen ExAC gnomAD
CA2502489 rs762400314	464	N>D		No	ClinGen ExAC gnomAD
rs752539520 CA2502490	466	I>F		No	ClinGen ExAC TOPMed gnomAD
CA353662723 rs1203540302	466	I>N		No	ClinGen gnomAD
rs570604469 CA2502492	467	I>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs570604469 CA353662775	467	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2502491 rs752088339	467	I>V		No	ClinGen ExAC gnomAD
CA2502494 rs750832814	468	L>S		No	ClinGen ExAC TOPMed gnomAD
CA2502496 rs780172142	469	D>G		No	ClinGen ExAC gnomAD
CA353662844 rs1391704321	470	Y>H		No	ClinGen gnomAD
rs537923825 CA2502498	471	E>Q		No	ClinGen ExAC gnomAD
rs1375857079 CA353662940	472	V>A		No	ClinGen gnomAD
CA2502499 rs370552845	474	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA353663035 rs1301060598	476	E>K		No	ClinGen TOPMed gnomAD
TCGA novel	478	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353663376 rs1463190446	479	E>G		No	ClinGen gnomAD
CA353663389 rs1409851868	480	Q>R		No	ClinGen TOPMed
rs370986773 CA2502528	482	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA2502529 rs748888287	483	S>C		No	ClinGen ExAC gnomAD
rs374626393 CA78494191	486	I>V		No	ClinGen ESP TOPMed gnomAD
CA353663475 rs1259440529	489	A>T		No	ClinGen TOPMed
rs771749213 CA2502533	490	R>G		No	ClinGen ExAC gnomAD
CA2502534 rs773835698	491	G>D		No	ClinGen ExAC gnomAD
rs766652795 CA2502536	492	T>A		No	ClinGen ExAC gnomAD
CA353663492 rs766652795	492	T>P		No	ClinGen ExAC gnomAD
rs1438893531 CA353663501	493	N>S		No	ClinGen gnomAD
rs1438893531 CA353663500	493	N>T		No	ClinGen gnomAD
TCGA novel	495	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777061580 CA2502537	495	T>P		No	ClinGen ExAC
rs938686751 CA78494233	496	I>L		No	ClinGen TOPMed gnomAD
CA2502538 rs759615049	497	S>G		No	ClinGen ExAC TOPMed gnomAD
rs765462880 CA2502539	497	S>N		No	ClinGen ExAC gnomAD
rs144696297 CA2502540	498	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2502541 rs758438939	499	L>F		No	ClinGen ExAC gnomAD
CA2502542 rs764206594	500	K>Q		No	ClinGen ExAC
CA2502544 rs75391524	502	D>N		No	ClinGen ExAC gnomAD
rs75391524 CA353663561	502	D>Y		No	ClinGen ExAC gnomAD
rs751929427 CA78494293	503	T>S		No	ClinGen Ensembl
rs867131534 CA78494309	504	I>V		No	ClinGen TOPMed gnomAD
CA353663597 rs1245874536	505	Y>H		No	ClinGen gnomAD
rs1381500170 CA353663650	508	Q>K		No	ClinGen TOPMed
rs1184230536 CA353663678	510	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353663702 rs1472226095	512	R>*		No	ClinGen gnomAD
CA2502548 rs778678869	513	T>A		No	ClinGen ExAC TOPMed gnomAD
CA2502550 rs747853999	514	A>T		No	ClinGen ExAC gnomAD
CA353663753 rs1559681526	517	Y>C		No	ClinGen Ensembl
TCGA novel	517	Y>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1362369938 CA353663769	518	G>E		No	ClinGen TOPMed
VAR_042128	518	G>L	a lung squamous cell carcinoma sample; somatic mutation; requires 2 nucleotide substitutions [UniProt]	No	UniProt
CA2502553 COSM1737266 COSM1737265 rs543425684	519	T>M	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1310386960 CA353663793	520	N>T		No	ClinGen gnomAD
rs552884651 CA2502554	521	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA2502555 rs776808297	521	S>R		No	ClinGen ExAC gnomAD
rs759973751 CA2502556	522	R>C		No	ClinGen ExAC gnomAD
rs775665893 CA2502558	522	R>H		No	ClinGen ExAC TOPMed gnomAD
COSM397779 CA2502557 COSM397778 rs759973751	522	R>S	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA353663818 rs1226229275	523	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	523	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1288766137 CA353663834	524	F>S		No	ClinGen gnomAD
CA2502559 rs150469112	525	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2502560 rs764155355	526	F>S		No	ClinGen ExAC gnomAD
CA2502562 rs755956785	527	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA353663917 rs1188603929	528	T>S		No	ClinGen gnomAD
CA353663956 rs1161663372	531	D>N		No	ClinGen gnomAD
CA353663965 rs1413432309	532	S>A		No	ClinGen TOPMed gnomAD
CA353665623 rs1233786675	534	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1257548456 CA353665639	535	I>M		No	ClinGen gnomAD
CA2502587 rs777508142	536	S>C		No	ClinGen ExAC gnomAD
rs777508142 CA2502588	536	S>F		No	ClinGen ExAC gnomAD
rs756765228 CA2502589	537	G>A		No	ClinGen ExAC gnomAD
CA78499790 rs371787296	537	G>S		No	ClinGen ESP TOPMed
CA353665678 rs1200731184	539	S>G		No	ClinGen TOPMed
COSM1048873 CA78499800 rs964408959	539	S>N	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA2502591 rs149643424	541	Q>H		No	ClinGen ESP ExAC gnomAD
rs780337925 CA2502593	542	V>A		No	ClinGen ExAC gnomAD
rs377041029 CA2502592	542	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2502595 rs768941729	543	V>L		No	ClinGen ExAC gnomAD
TCGA novel	544	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774612991 CA2502596	545	I>N		No	ClinGen ExAC TOPMed gnomAD
rs774612991 CA353665772	545	I>T		No	ClinGen ExAC TOPMed gnomAD
CA353665784 rs1221318412	546	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1172547285 CA353665800	547	I>T		No	ClinGen gnomAD
CA353665816 rs1386464909	548	S>L		No	ClinGen gnomAD
COSM4155081 CA2502598 rs147450955	549	A>V	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA2502600 rs371462790	550	A>P		No	ClinGen ExAC
rs983187598 CA78499893	551	V>A		No	ClinGen TOPMed gnomAD
CA2502601 rs142865154	552	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA353665884 rs1387008905	554	I>V		No	ClinGen TOPMed gnomAD
rs752322107 CA78499904	555	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1356072262 CA353665909	556	L>F		No	ClinGen TOPMed
CA2502603 rs752497107	557	T>I		No	ClinGen ExAC gnomAD
rs762801053 CA2502604	558	V>A		No	ClinGen ExAC gnomAD
rs374460085 CA353665970	560	I>F		No	ClinGen ESP TOPMed gnomAD
CA2502606 rs751208279	560	I>T		No	ClinGen ExAC TOPMed gnomAD
rs374460085 CA78499938	560	I>V		No	ClinGen ESP TOPMed gnomAD
CA2502607 rs139544432	561	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA353665989 rs1322202080	561	Y>H		No	ClinGen gnomAD
CA353666011 rs1210690957	562	V>L		No	ClinGen gnomAD
CA2502609 rs536008328	564	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
VAR_042129 CA2502608 rs55712516	564	I>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs756564447 CA2502610	566	R>K		No	ClinGen ExAC gnomAD
rs56077781 CA2502627	568	C>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
VAR_042130 rs56077781 CA2502626	568	C>S		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1372209561 CA353666619	569	G>V		No	ClinGen gnomAD
CA2502629 rs370678502	570	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1384402151 CA353666670	572	S>T		No	ClinGen TOPMed
rs913193328 CA353666698	573	K>I		No	ClinGen TOPMed gnomAD
rs1372684890 CA353666701	573	K>N		No	ClinGen gnomAD
rs913193328 CA78500464	573	K>R		No	ClinGen TOPMed gnomAD
CA78500476 rs372943443	575	G>A		No	ClinGen ESP TOPMed
CA78500484 rs745973705	576	A>V		No	ClinGen Ensembl
rs1278755088 COSM1048874 CA353666803	578	E>D	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs867835679 CA78500485	578	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA2502631 rs779282250	580	R>I		No	ClinGen ExAC TOPMed gnomAD
rs748487754 CA2502632	580	R>S		No	ClinGen ExAC gnomAD
CA353666892 rs1351210663	583	F>S		No	ClinGen gnomAD
CA2502633 rs758610779	584	G>V		No	ClinGen ExAC gnomAD
CA353666930 rs1203604011	585	N>S		No	ClinGen gnomAD
CA2502635 rs778106353	586	G>A		No	ClinGen ExAC TOPMed gnomAD
CA2502636 rs778106353	586	G>E		No	ClinGen ExAC TOPMed gnomAD
CA78500523 rs533770865	586	G>R		No	ClinGen Ensembl
rs778106353 CA2502634	586	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1183034828 CA353666971	587	H>P		No	ClinGen gnomAD
CA2502661 rs771851703	588	L>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2502662 rs772998374	589	K>E		No	ClinGen ExAC gnomAD
rs1450215218 CA353667961	589	K>I		No	ClinGen TOPMed
rs567496673 CA2502663	590	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
VAR_042131 CA78504003 rs56081642	590	L>P		No	ClinGen UniProt dbSNP gnomAD
CA353668007 rs1463230067	592	G>C		No	ClinGen gnomAD
rs534679111 CA2502664	592	G>D		No	ClinGen 1000Genomes ExAC gnomAD
rs776171101 CA2502665	593	L>R		No	ClinGen ExAC gnomAD
rs758942025 CA2502666	594	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1189384773 CA353668039	595	T>I		No	ClinGen gnomAD
CA353668045 rs1472882999	596	Y>H		No	ClinGen gnomAD
CA2502667 rs61733120 RCV000881117	597	V>I		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2502669 rs763618226	598	D>G		No	ClinGen ExAC gnomAD
rs753127242 COSM1048876 CA2502668	598	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	599	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353668109 rs1488450493	601	T>A		No	ClinGen TOPMed
CA2502671 rs751984150	601	T>I		No	ClinGen ExAC gnomAD
rs1301680905 CA353668157	605	P>L		No	ClinGen gnomAD
COSM584782 CA353668154 rs1439127416	605	P>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs577668720 CA2502674	606	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353668168 rs1289635005	606	T>I		No	ClinGen gnomAD
CA353668181 rs1339615261	607	Q>H		No	ClinGen TOPMed
rs1326510338 CA353668177	607	Q>P		No	ClinGen gnomAD
CA78504127 rs776181530	608	A>G		No	ClinGen Ensembl
CA78504126 rs17855794	608	A>T		No	ClinGen Ensembl
CA2502675 rs756134991	609	V>I		No	ClinGen ExAC gnomAD
rs1323282781 CA353668240	613	A>T		No	ClinGen gnomAD
rs772013090 CA2502678	614	K>E		No	ClinGen ExAC TOPMed gnomAD
CA78504145 rs866025221	615	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs374235660 CA2502680	617	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs374235660 CA2502681 COSM584781	617	D>Y	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	618	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759287229 CA2502683	619	T>N		No	ClinGen ExAC gnomAD
rs1414714315 VAR_036088 CA353668334 COSM33004	621	I>L	large_intestine a colorectal cancer sample; somatic mutation [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt dbSNP gnomAD
rs545022458 CA2502685	622	S>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353668373 rs1162005172	624	D>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1468797697 CA353668372	624	D>G		No	ClinGen gnomAD
CA353668381 rs1365375680	625	K>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1430916797 CA353668396	626	V>A		No	ClinGen gnomAD
CA353668409 rs1310443133	628	G>E		No	ClinGen gnomAD
CA2502709 rs767708554	631	E>A		No	ClinGen ExAC
CA2502710 rs773640458	631	E>D		No	ClinGen ExAC gnomAD
rs867931903 CA78507376	631	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA353669169 rs1242840680 COSM98892	636	C>F	stomach [Cosmic]	No	ClinGen cosmic curated gnomAD
CA78507384 rs375432691	637	S>G		No	ClinGen ESP gnomAD
rs375432691 CA353669174	637	S>R		No	ClinGen ESP gnomAD
CA2502713 rs754102338	639	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2502714 rs570346631 COSM1633353	639	R>H	Variant assessed as Somatic; 0.0 impact. liver [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
RCV001293546 CA353669192 rs754102338	639	R>S		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs549882703 CA78507386	640	L>V		No	ClinGen 1000Genomes
CA353669232 rs1553692173	642	L>F		No	ClinGen Ensembl
rs146728702 CA2502715	643	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs146728702 CA2502716	643	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA353669254 rs1576368494	644	S>L		No	ClinGen Ensembl
rs1335496435 CA353669259	645	K>T		No	ClinGen gnomAD
rs201062946 CA78507389	647	E>D		No	ClinGen 1000Genomes TOPMed gnomAD
rs1467832547	647	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1325678893 CA353669342	649	S>*		No	ClinGen gnomAD
COSM198046 rs1559689115 CA353669361	651	A>T	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1276606795 COSM1048878 CA353669380	651	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1262606547 CA353669398	652	I>M		No	ClinGen gnomAD
CA2502721 rs779822883	652	I>V		No	ClinGen ExAC gnomAD
rs1465477687 COSM1538626 CA353669411	653	K>R	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA2502722 rs748999069	657	V>F		No	ClinGen ExAC TOPMed gnomAD
rs748999069 CA78507447	657	V>I		No	ClinGen ExAC TOPMed gnomAD
VAR_065831	660	T>K	a lung carcinoma sample; somatic mutation [UniProt]	No	UniProt
TCGA novel	662	K>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1446838360 CA545016768	664	R>N		No	ClinGen gnomAD
rs1248892878 CA353669664	665	R>I		No	ClinGen gnomAD
TCGA novel	666	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774002419 CA2502724	667	F>S		No	ClinGen ExAC gnomAD
rs748606864 CA2502725	668	L>P		No	ClinGen ExAC gnomAD
rs772653743 CA2502726	672	S>G		No	ClinGen ExAC gnomAD
CA353669800 rs1156495695	672	S>R		No	ClinGen gnomAD
rs1378861144 CA353669850	675	G>R		No	ClinGen gnomAD
CA2502727 rs773406696	678	D>N		No	ClinGen ExAC gnomAD
CA2502728 rs202059523	679	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1343504201 CA353669966	681	N>S		No	ClinGen gnomAD
rs1453560937 CA353670043	684	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs372257039 COSM122864 CA2502730	684	R>Q	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs200071736 CA2502731	685	L>P		No	ClinGen ExAC TOPMed gnomAD
CA353670118 rs1489618254	688	V>I		No	ClinGen TOPMed
CA2502733 rs139451236	689	V>A		No	ClinGen ESP ExAC gnomAD
CA353670177 rs1350231020	691	K>R		No	ClinGen TOPMed gnomAD
CA353656152 rs1460422282	692	S>I		No	ClinGen TOPMed gnomAD
CA353656148 rs1460422282	692	S>N		No	ClinGen TOPMed gnomAD
rs760534439 CA2502759	695	V>L		No	ClinGen ExAC gnomAD
CA353656202 rs1225397244	696	M>T		No	ClinGen gnomAD
TCGA novel	697	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	698	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766217704 CA2502760	702	M>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA353656281 rs1251195512	702	M>T		No	ClinGen gnomAD
TCGA novel	703	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353656301 rs1317503899	703	E>Q		No	ClinGen TOPMed gnomAD
rs1381031176 CA353656313	704	N>D		No	ClinGen gnomAD
rs753707496 CA2502761	704	N>S		No	ClinGen ExAC TOPMed gnomAD
rs754635213 CA2502762	705	G>A		No	ClinGen ExAC gnomAD
CA2502763 rs754635213	705	G>V		No	ClinGen ExAC gnomAD
TCGA novel	706	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754774164 CA78480983	706	S>F		No	ClinGen Ensembl
rs1390521043 CA353656364	708	D>G		No	ClinGen TOPMed
rs777211567 CA2502766	712	R>C		No	ClinGen ExAC TOPMed gnomAD
rs575730567 CA2502767	712	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777211567 CA353656413	712	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs757725021 CA2502786	713	K>E		No	ClinGen ExAC gnomAD
CA2502787 rs199630398	713	K>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1368854829 CA353656587	714	H>R		No	ClinGen gnomAD
rs1280769530 CA353656608	715	D>G		No	ClinGen gnomAD
CA2502789 rs568185407	720	V>D		No	ClinGen 1000Genomes ExAC gnomAD
CA2502788 rs200791821	720	V>I		No	ClinGen 1000Genomes ExAC TOPMed
rs200791821 CA353656684	720	V>L		No	ClinGen 1000Genomes ExAC TOPMed
CA2502790 rs375846678	723	L>V		No	ClinGen ESP ExAC gnomAD
rs1285991622 CA353656745	724	V>A		No	ClinGen gnomAD
CA2502791 rs749469241	725	G>A		No	ClinGen ExAC gnomAD
rs749469241 CA353656754	725	G>E		No	ClinGen ExAC gnomAD
CA2502792 rs768782109	726	M>I		No	ClinGen ExAC gnomAD
TCGA novel	726	M>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353656769 rs1161653294	726	M>V		No	ClinGen gnomAD
CA2502793 rs774448099	728	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs748206093 CA2502794	728	R>Q		No	ClinGen ExAC gnomAD
CA353656830 rs1197239588	731	A>S		No	ClinGen gnomAD
CA2502795 rs772325232	731	A>V		No	ClinGen ExAC gnomAD
rs1559693939 CA353656855	733	G>C		No	ClinGen Ensembl
TCGA novel	733	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA78482271 rs773348056	739	D>E		No	ClinGen Ensembl
rs762621864 CA2502800	740	M>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA353657025 rs762621864	740	M>V		No	ClinGen ExAC TOPMed gnomAD
rs763688148 CA2502801	741	G>C		No	ClinGen ExAC TOPMed gnomAD
CA353657041 rs763688148	741	G>S		No	ClinGen ExAC TOPMed gnomAD
CA78482289 rs925330811	742	Y>F		No	ClinGen TOPMed gnomAD
rs369276620 CA2502802	745	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA2502803 rs756739935	745	R>Q	Variant assessed as Somatic; 4.623e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs149696182 CA2502804	746	D>A		No	ClinGen ESP ExAC TOPMed
CA353657140 rs1288096834	746	D>E		No	ClinGen TOPMed
rs1383248514 CA353657172 COSM1205449	748	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
CA2502807 rs780417089 COSM198048	750	R>Q	large_intestine endometrium Variant assessed as Somatic; 4.622e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs749646074 CA2502808	751	N>D		No	ClinGen ExAC gnomAD
rs755409303 CA2502809	754	I>N		No	ClinGen ExAC gnomAD
CA353657402 rs1483346637	757	N>D		No	ClinGen TOPMed gnomAD
CA353657422 rs1316383286	758	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
COSM731462 rs146856660 CA353657440 CA2502811	759	V>L	Variant assessed as Somatic; 0.0 impact. lung [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA2502810 rs146856660	759	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	763	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1161010949 CA353657543	764	D>G		No	ClinGen TOPMed
VAR_042132	766	G>E	a lung adenocarcinoma sample; somatic mutation [UniProt]	No	UniProt
rs1366099808 COSM1567106 CA353657594	766	G>V	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA353657629 rs1386233725	768	S>A		No	ClinGen gnomAD
CA353657631 rs1446890859	768	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353657627 rs1386233725	768	S>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	771	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353657696 rs1411035734	772	E>Q		No	ClinGen TOPMed gnomAD
CA2502815 rs769645193	773	D>H		No	ClinGen ExAC gnomAD
CA2502816 rs775319034	775	P>T		No	ClinGen ExAC
rs34437982 CA353657785	777	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_042133 CA2502817 RCV000910618 rs34437982	777	A>G		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2502818 rs34437982	777	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	778	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2502819 rs773980261	779	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1290414327 CA353657815	780	T>I		No	ClinGen TOPMed
rs866959883 CA78495038	784	G>E		No	ClinGen Ensembl
CA353660579 rs1195951459	786	I>F		No	ClinGen gnomAD
CA353660601 rs1240798724	788	I>V		No	ClinGen gnomAD
rs1484689450 CA353660612	789	R>K		No	ClinGen TOPMed gnomAD
CA2502834 rs749306993	792	S>P		No	ClinGen ExAC gnomAD
CA353660707 rs1263058019	797	A>V		No	ClinGen TOPMed
CA353660726 rs1203973847	799	R>C		No	ClinGen TOPMed gnomAD
rs1203973847 CA353660725	799	R>G		No	ClinGen TOPMed gnomAD
rs1176464192 CA353660731	799	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2502837 rs73139269	801	F>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2502836 rs73139269	801	F>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs369423490 CA78495067	802	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs369423490 CA2502838	802	T>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
COSM731460 CA2502840 rs760079016	803	S>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	803	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765969815 CA2502841	805	S>N		No	ClinGen ExAC gnomAD
VAR_036089	806	D>N	a colorectal cancer sample; somatic mutation [UniProt]	No	UniProt
rs760090119 CA2502843	806	D>V		No	ClinGen ExAC gnomAD
rs1283969718 CA353660857	810	Y>H		No	ClinGen gnomAD
CA353660944 rs753130827	817	V>L		No	ClinGen ExAC gnomAD
rs753130827 CA2502845	817	V>M		No	ClinGen ExAC gnomAD
rs1351681711 CA353660971	818	M>I		No	ClinGen gnomAD
rs1438673642 CA353660966	818	M>T		No	ClinGen TOPMed
CA353661012 rs1207208621	820	Y>C		No	ClinGen gnomAD
rs150609332 CA78495167	820	Y>H		No	ClinGen ESP
rs758657242 CA2502846	821	G>R		No	ClinGen ExAC gnomAD
rs370863541 CA2502847	822	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs757274748 CA2502849	824	P>S		No	ClinGen ExAC
CA78495182 rs374248537	827	E>D		No	ClinGen ESP
CA2502851 rs749114470	831	Q>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA353661250 rs1198065404	831	Q>R		No	ClinGen gnomAD
rs756225530 CA2502873	836	A>T		No	ClinGen ExAC gnomAD
TCGA novel	836	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1293054659 CA353661496	837	V>I		No	ClinGen gnomAD
CA353661539 rs1397249221	839	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs556754042 CA353661565	840	G>D		No	ClinGen 1000Genomes ExAC gnomAD
rs556754042 CA2502875	840	G>V		No	ClinGen 1000Genomes ExAC gnomAD
rs758183213 CA2502876	842	R>Q		No	ClinGen ExAC gnomAD
rs572288873 CA2502877	845	P>H		No	ClinGen ExAC TOPMed gnomAD
rs572288873 CA353661667	845	P>L		No	ClinGen ExAC TOPMed gnomAD
CA353661664 rs572288873	845	P>R		No	ClinGen ExAC TOPMed gnomAD
CA2502878 rs142030914	846	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353661684 rs1315283374	846	P>R		No	ClinGen gnomAD
CA2502880 rs142030914	846	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2502879 rs142030914	846	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	847	M>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745355919 CA2502881	847	M>T		No	ClinGen ExAC TOPMed gnomAD
CA353661690 rs1315561019	847	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1317589623	847	M>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	849	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1461478295 CA353661794	850	P>L		No	ClinGen gnomAD
rs535947136 CA78495945	851	A>T		No	ClinGen 1000Genomes gnomAD
rs763624373 CA2502884	852	A>D		No	ClinGen ExAC gnomAD
TCGA novel	853	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1423203141 CA353661861	854	Y>H		No	ClinGen gnomAD
rs767812508 CA2502888	857	M>I		No	ClinGen ExAC gnomAD
rs761893191 CA353661927 CA2502887	857	M>L		No	ClinGen ExAC TOPMed gnomAD
rs1389159811 CA353661965	858	L>Q		No	ClinGen TOPMed
CA353661987 rs1399907898	859	D>G		No	ClinGen TOPMed gnomAD
TCGA novel	865	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353662255 rs1380975088	868	R>S		No	ClinGen gnomAD
rs1424411876 CA353662260	869	P>S		No	ClinGen TOPMed
CA353662318 rs1296838201	870	K>R		No	ClinGen gnomAD
CA353662433 rs1309775529	873	Q>H		No	ClinGen gnomAD
rs1242408900 CA353662453	874	I>T		No	ClinGen gnomAD
rs1256842246 CA353662478	876	S>R		No	ClinGen gnomAD
CA353662506 rs1323859567	878	L>M		No	ClinGen gnomAD
rs766511234 CA2502891 COSM389456	881	L>I	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1258333739 CA353662661	882	I>V		No	ClinGen TOPMed
CA2502892 rs752560194	883	R>G		No	ClinGen ExAC TOPMed gnomAD
COSM272641 rs758342526 CA2502893	883	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs752560194 CA78496029	883	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1210916543 CA353662747	884	N>K		No	ClinGen TOPMed
CA353662764 rs1426641543	885	P>A		No	ClinGen TOPMed gnomAD
CA353662763 rs1426641543	885	P>S		No	ClinGen TOPMed gnomAD
CA353662760 rs1426641543	885	P>T		No	ClinGen TOPMed gnomAD
rs373736475 CA2502897	886	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs373736475 CA353662778	886	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs745567462 CA2502898	887	S>I		No	ClinGen ExAC gnomAD
rs559771730 CA2502900	888	L>V		No	ClinGen 1000Genomes ExAC
CA2502901 rs749757419	890	I>V		No	ClinGen ExAC gnomAD
rs367573076 CA2502902	891	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1576384940 CA353662963	892	T>P		No	ClinGen Ensembl
rs1434347368 CA353663001	894	A>T		No	ClinGen TOPMed
CA2502903 rs774540195	894	A>V		No	ClinGen ExAC gnomAD
rs141716319 CA78496168	895	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1029253151 CA78496153	895	A>T		No	ClinGen TOPMed
rs141716319 CA2502904	895	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs773476878 CA2502906	896	A>P		No	ClinGen ExAC gnomAD
CA78496201 rs773476878	896	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2502907 rs760890688	896	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1427078839 CA353666604	900	N>D		No	ClinGen gnomAD
rs1321050276 CA353666629	901	L>I		No	ClinGen gnomAD
CA2502929 rs771171216	902	L>F		No	ClinGen ExAC gnomAD
CA353666693 rs776875895	905	Q>E		No	ClinGen ExAC gnomAD
CA2502930 rs776875895	905	Q>K		No	ClinGen ExAC gnomAD
CA2502931 rs759593006	905	Q>P		No	ClinGen ExAC gnomAD
CA2502932 rs759593006	905	Q>R		No	ClinGen ExAC gnomAD
rs73846185 CA2502934	907	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2502935 rs374961385	909	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA353666771 rs374961385	909	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs750266508 CA2502936	911	T>N		No	ClinGen ExAC TOPMed gnomAD
rs531837299 CA2502938 COSM1425706	912	T>A	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
TCGA novel	912	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs531837299 CA78509005	912	T>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA78509019 rs904397974	913	F>C		No	ClinGen TOPMed
CA2502939 rs549868478	914	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
VAR_027919 rs17801309 CA2502940	914	R>H		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs17801309 CA78509085	914	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs17801309 CA2502941	914	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2502942 rs748629890 COSM380994	915	T>A	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1447002695 CA353666900	915	T>R		No	ClinGen gnomAD
COSM402322 rs758848156 CA2502943	916	T>I	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1312335539 CA353666932	917	G>D		No	ClinGen TOPMed gnomAD
rs1312335539 CA353666940	917	G>V		No	ClinGen TOPMed gnomAD
rs1412450341 CA353666959	918	D>V		No	ClinGen gnomAD
rs998163895 CA78509098	919	W>C		No	ClinGen TOPMed
rs778067909 CA2502944	919	W>L		No	ClinGen ExAC gnomAD
TCGA novel	919	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1328672204 CA353667028	922	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1410875132 CA353667031	922	G>D		No	ClinGen TOPMed
rs150555764 CA2502946	924	W>*		No	ClinGen ESP ExAC TOPMed gnomAD
VAR_042134 rs35124509 CA2502945 CA353667067	924	W>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2502947 rs776824087	926	A>S		No	ClinGen ExAC gnomAD
CA78509162 rs767429462	928	C>F		No	ClinGen Ensembl
CA353667111 rs1231154967	928	C>S		No	ClinGen gnomAD
CA2502948 rs746145854	932	F>L		No	ClinGen ExAC gnomAD
rs372594677 CA2502949	933	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
VAR_065832 rs372594677 CA2502950	933	T>M	Variant assessed as Somatic; 0.0 impact. a lung carcinoma sample; somatic mutation [NCI-TCGA, UniProt]	No	ClinGen UniProt ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs767387399 CA2502952 COSM1693052	934	G>S	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA2502954 rs760525872	935	V>A		No	ClinGen ExAC gnomAD
rs1275174664 CA353667205	935	V>M		No	ClinGen TOPMed gnomAD
rs961598471 CA78509191	936	E>G		No	ClinGen TOPMed
CA78509189 rs369167718	936	E>K		No	ClinGen ESP TOPMed gnomAD
CA2502957 rs754599782	938	S>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1237470958 CA353667252	939	S>Y		No	ClinGen gnomAD
rs764752292 CA2502958	943	I>V		No	ClinGen ExAC gnomAD
CA2502959 rs752176493	946	I>S		No	ClinGen ExAC TOPMed gnomAD
CA2502960 rs752176493	946	I>T		No	ClinGen ExAC TOPMed gnomAD
CA2502962 rs747575749	947	S>A		No	ClinGen ExAC gnomAD
CA2502963 rs192800580	947	S>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1553697265 CA353667396	949	D>Y		No	ClinGen Ensembl
rs1471077698 CA353668772	950	D>E		No	ClinGen gnomAD
TCGA novel	950	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1156599993 CA353668800	952	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353668805 rs1379670186	952	K>I		No	ClinGen gnomAD
rs1379670186 CA353668807	952	K>R		No	ClinGen gnomAD
CA2502997 rs776665976	954	V>F		No	ClinGen ExAC gnomAD
CA2502999 rs769685099	954	V>G		No	ClinGen ExAC gnomAD
CA2502998 rs776665976	954	V>I		No	ClinGen ExAC gnomAD
CA353668849 rs1464031640	955	G>V		No	ClinGen TOPMed
CA78513465 rs1038500327	956	V>I		No	ClinGen TOPMed
rs762601076 CA353668872	958	V>L		No	ClinGen ExAC TOPMed gnomAD
rs762601076 COSM1318640 CA2503001	958	V>M	Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA353668883 rs1336569315	959	V>F		No	ClinGen gnomAD
rs763540505 CA2503003	962	Q>R		No	ClinGen ExAC gnomAD
CA2503006 rs762268874	968	S>N		No	ClinGen ExAC gnomAD
CA2503007 rs767981365	969	I>V		No	ClinGen ExAC TOPMed gnomAD
rs750990530 CA2503008	970	K>N		No	ClinGen ExAC gnomAD
rs756422951 CA2503009	971	A>T		No	ClinGen ExAC gnomAD
rs1250867520 CA353669026	972	L>V		No	ClinGen gnomAD
rs780470195 CA2503010	974	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA353669058 rs1237297238	975	Q>*		No	ClinGen TOPMed gnomAD
CA353669059 rs1237297238	975	Q>K		No	ClinGen TOPMed gnomAD
rs755942381 CA2503012	975	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs779095614 CA2503013	979	G>S		No	ClinGen ExAC gnomAD
CA2503014 rs748204014	980	P>A		No	ClinGen ExAC TOPMed gnomAD
CA353669097 rs1456511809	980	P>L		No	ClinGen gnomAD
CA353669108 rs1449229684	982	P>H		No	ClinGen gnomAD
CA2503015 rs147992008	982	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1453994370 CA353669113	983	V>G		No	ClinGen gnomAD
CA353669109 rs536144760	983	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM198058 rs536144760 CA2503018	983	V>M	lung Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD

1 associated diseases with P29320

[MIM: 114500]: Colorectal cancer (CRC)

A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269|PubMed:12738854}. Note=The gene represented in this entry may be involved in disease pathogenesis.

Without disease ID

A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269|PubMed:12738854}. Note=The gene represented in this entry may be involved in disease pathogenesis.

3 regional properties for P29320

Type	Name	Position	InterPro Accession
domain	C2 domain	406 - 539	IPR000008
domain	Phosphatidylinositol-specific phospholipase C, X domain	106 - 250	IPR000909
domain	Phospholipase C, phosphatidylinositol-specific, Y domain	295 - 412	IPR001711

Functions

		Description
EC Number	2.7.10.1	Protein-tyrosine kinases
Subcellular Localization	[Isoform 1]: Cell membrane ; Single-pass type I membrane protein ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

5 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ephrin receptor activity	Combining with an ephrin receptor ligand to initiate a change in cell activity.
GPI-linked ephrin receptor activity	Combining with a GPI-anchored ephrin to initiate a change in cell activity.
transmembrane receptor protein tyrosine kinase activity	Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
transmembrane-ephrin receptor activity	Combining with a transmembrane ephrin to initiate a change in cell activity.

18 GO annotations of biological process

Name	Definition
axon guidance	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cellular response to retinoic acid	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
ephrin receptor signaling pathway	The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
fasciculation of motor neuron axon	The collection of motor neuron axons into a bundle of rods, known as a fascicle.
fasciculation of sensory neuron axon	The collection of sensory neuron axons into a bundle of rods, known as a fascicle.
negative regulation of endocytosis	Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.
peptidyl-tyrosine phosphorylation	The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
positive regulation of kinase activity	Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
positive regulation of neuron projection development	Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of protein localization to plasma membrane	Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
regulation of actin cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of epithelial to mesenchymal transition	Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
regulation of focal adhesion assembly	Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.
regulation of GTPase activity	Any process that modulates the rate of GTP hydrolysis by a GTPase.
regulation of microtubule cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
transmembrane receptor protein tyrosine kinase signaling pathway	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

49 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P28693	EPHB2	Ephrin type-B receptor 2	Gallus gallus (Chicken)	PR
Q07496	EPHA4	Ephrin type-A receptor 4	Gallus gallus (Chicken)	SS
Q07494	EPHB1	Ephrin type-B receptor 1	Gallus gallus (Chicken)	SS
Q07497	EPHB5	Ephrin type-B receptor 5	Gallus gallus (Chicken)	PR
O42422	EPHA7	Ephrin type-A receptor 7	Gallus gallus (Chicken)	SS
P54755	EPHA5	Ephrin type-A receptor 5	Gallus gallus (Chicken)	SS
Q07498	EPHB3	Ephrin type-B receptor 3	Gallus gallus (Chicken)	SS
P29318	EPHA3	Ephrin type-A receptor 3	Gallus gallus (Chicken)	SS
P0C0K6	EPHB6	Ephrin type-B receptor 6	Pan troglodytes (Chimpanzee)	SS
P21709	EPHA1	Ephrin type-A receptor 1	Homo sapiens (Human)	SS
P54760	EPHB4	Ephrin type-B receptor 4	Homo sapiens (Human)	SS
P29317	EPHA2	Ephrin type-A receptor 2	Homo sapiens (Human)	SS
Q15375	EPHA7	Ephrin type-A receptor 7	Homo sapiens (Human)	SS
P54756	EPHA5	Ephrin type-A receptor 5	Homo sapiens (Human)	SS
Q9UF33	EPHA6	Ephrin type-A receptor 6	Homo sapiens (Human)	SS
P54762	EPHB1	Ephrin type-B receptor 1	Homo sapiens (Human)	SS
P29322	EPHA8	Ephrin type-A receptor 8	Homo sapiens (Human)	SS
P54764	EPHA4	Ephrin type-A receptor 4	Homo sapiens (Human)	SS
P54753	EPHB3	Ephrin type-B receptor 3	Homo sapiens (Human)	SS
Q5JZY3	EPHA10	Ephrin type-A receptor 10	Homo sapiens (Human)	SS
O15197	EPHB6	Ephrin type-B receptor 6	Homo sapiens (Human)	SS
P29323	EPHB2	Ephrin type-B receptor 2	Homo sapiens (Human)	EV
P54754	Ephb3	Ephrin type-B receptor 3	Mus musculus (Mouse)	SS
Q03145	Epha2	Ephrin type-A receptor 2	Mus musculus (Mouse)	PR
Q03137	Epha4	Ephrin type-A receptor 4	Mus musculus (Mouse)	SS
Q61772	Epha7	Ephrin type-A receptor 7	Mus musculus (Mouse)	SS
O09127	Epha8	Ephrin type-A receptor 8	Mus musculus (Mouse)	SS
Q8CBF3	Ephb1	Ephrin type-B receptor 1	Mus musculus (Mouse)	SS
Q8BYG9	Epha10	Ephrin type-A receptor 10	Mus musculus (Mouse)	SS
Q60629	Epha5	Ephrin type-A receptor 5	Mus musculus (Mouse)	SS
Q62413	Epha6	Ephrin type-A receptor 6	Mus musculus (Mouse)	SS
Q60750	Epha1	Ephrin type-A receptor 1	Mus musculus (Mouse)	SS
P54763	Ephb2	Ephrin type-B receptor 2	Mus musculus (Mouse)	SS
P54761	Ephb4	Ephrin type-B receptor 4	Mus musculus (Mouse)	PR
O08644	Ephb6	Ephrin type-B receptor 6	Mus musculus (Mouse)	PR
P29319	Epha3	Ephrin type-A receptor 3	Mus musculus (Mouse)	SS
P54757	Epha5	Ephrin type-A receptor 5	Rattus norvegicus (Rat)	SS
P54759	Epha7	Ephrin type-A receptor 7	Rattus norvegicus (Rat)	SS
P09759	Ephb1	Ephrin type-B receptor 1	Rattus norvegicus (Rat)	SS
P0C0K7	Ephb6	Ephrin type-B receptor 6	Rattus norvegicus (Rat)	SS
O08680	Epha3	Ephrin type-A receptor 3	Rattus norvegicus (Rat)	SS
O61460	vab-1	Ephrin receptor 1	Caenorhabditis elegans	SS
Q8RWZ5	SD25	G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q94AG2	SERK1	Somatic embryogenesis receptor kinase 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q3E991	PRK6	Pollen receptor-like kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FXF2	RKF1	Probable LRR receptor-like serine/threonine-protein kinase RFK1	Arabidopsis thaliana (Mouse-ear cress)	PR
O13147	ephb3	Ephrin type-B receptor 3	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
O73878	ephb4b	Ephrin type-B receptor 4b	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
O13146	epha3	Ephrin type-A receptor 3	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MDCQLSILLL	LSCSVLDSFG	ELIPQPSNEV	NLLDSKTIQG	ELGWISYPSH	GWEEISGVDE
70	80	90	100	110	120
HYTPIRTYQV	CNVMDHSQNN	WLRTNWVPRN	SAQKIYVELK	FTLRDCNSIP	LVLGTCKETF
130	140	150	160	170	180
NLYYMESDDD	HGVKFREHQF	TKIDTIAADE	SFTQMDLGDR	ILKLNTEIRE	VGPVNKKGFY
190	200	210	220	230	240
LAFQDVGACV	ALVSVRVYFK	KCPFTVKNLA	MFPDTVPMDS	QSLVEVRGSC	VNNSKEEDPP
250	260	270	280	290	300
RMYCSTEGEW	LVPIGKCSCN	AGYEERGFMC	QACRPGFYKA	LDGNMKCAKC	PPHSSTQEDG
310	320	330	340	350	360
SMNCRCENNY	FRADKDPPSM	ACTRPPSSPR	NVISNINETS	VILDWSWPLD	TGGRKDVTFN
370	380	390	400	410	420
IICKKCGWNI	KQCEPCSPNV	RFLPRQFGLT	NTTVTVTDLL	AHTNYTFEID	AVNGVSELSS
430	440	450	460	470	480
PPRQFAAVSI	TTNQAAPSPV	LTIKKDRTSR	NSISLSWQEP	EHPNGIILDY	EVKYYEKQEQ
490	500	510	520	530	540
ETSYTILRAR	GTNVTISSLK	PDTIYVFQIR	ARTAAGYGTN	SRKFEFETSP	DSFSISGESS
550	560	570	580	590	600
QVVMIAISAA	VAIILLTVVI	YVLIGRFCGY	KSKHGADEKR	LHFGNGHLKL	PGLRTYVDPH
610	620	630	640	650	660
TYEDPTQAVH	EFAKELDATN	ISIDKVVGAG	EFGEVCSGRL	KLPSKKEISV	AIKTLKVGYT
670	680	690	700	710	720
EKQRRDFLGE	ASIMGQFDHP	NIIRLEGVVT	KSKPVMIVTE	YMENGSLDSF	LRKHDAQFTV
730	740	750	760	770	780
IQLVGMLRGI	ASGMKYLSDM	GYVHRDLAAR	NILINSNLVC	KVSDFGLSRV	LEDDPEAAYT
790	800	810	820	830	840
TRGGKIPIRW	TSPEAIAYRK	FTSASDVWSY	GIVLWEVMSY	GERPYWEMSN	QDVIKAVDEG
850	860	870	880	890	900
YRLPPPMDCP	AALYQLMLDC	WQKDRNNRPK	FEQIVSILDK	LIRNPGSLKI	ITSAAARPSN
910	920	930	940	950	960
LLLDQSNVDI	TTFRTTGDWL	NGVWTAHCKE	IFTGVEYSSC	DTIAKISTDD	MKKVGVTVVG
970	980
PQKKIISSIK	ALETQSKNGP	VPV