P29311

PR
Gene name
BMH1 (YER177W)
Protein name
Protein BMH1
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YER177W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

38-108 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P29311

Entry ID Method Resolution Chain Position Source
5N6N X-ray 229 A A/B 1-236 PDB
6QK8 X-ray 292 A A/B/C/D 1-236 PDB
AF-P29311-F1 Predicted AlphaFoldDB

3 variants for P29311

Variant ID(s) Position Change Description Diseaes Association Provenance
s05-545858 85 C>R No SGRP
s05-546324 240 S>F No SGRP
s05-546387 261 A>G No SGRP

No associated diseases with P29311

3 regional properties for P29311

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 255 IPR000719
active_site Serine/threonine-protein kinase, active site 120 - 132 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
DNA replication origin binding Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
enzyme activator activity Binds to and increases the activity of an enzyme.
phosphoserine residue binding Binding to a phosphorylated serine residue within a protein.
RNA polymerase II-specific DNA-binding transcription factor binding Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.

15 GO annotations of biological process

Name Definition
aggresome assembly The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein.
ascospore formation The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).
DNA damage checkpoint signaling A signal transduction process that contributes to a DNA damage checkpoint.
fungal-type cell wall chitin biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of fungal cells.
mitotic spindle orientation checkpoint signaling A signaling process that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of ubiquitin protein ligase activity Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
pseudohyphal growth The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli.
Ras protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
regulation of glycogen metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen.
regulation of mitotic cell cycle Any process that modulates the rate or extent of progress through the mitotic cell cycle.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
signal transduction involved in filamentous growth Relaying of environmental signals promoting filamentous growth.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P34730 BMH2 Protein BMH2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9S9Z8 GRF11 14-3-3-like protein GF14 omicron Arabidopsis thaliana (Mouse-ear cress) PR
Q9C5W6 GRF12 14-3-3-like protein GF14 iota Arabidopsis thaliana (Mouse-ear cress) PR
P93212 TFT7 14-3-3 protein 7 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MSTSREDSVY LAKLAEQAER YEEMVENMKT VASSGQELSV EERNLLSVAY KNVIGARRAS
70 80 90 100 110 120
WRIVSSIEQK EESKEKSEHQ VELICSYRSK IETELTKISD DILSVLDSHL IPSATTGESK
130 140 150 160 170 180
VFYYKMKGDY HRYLAEFSSG DAREKATNAS LEAYKTASEI ATTELPPTHP IRLGLALNFS
190 200 210 220 230 240
VFYYEIQNSP DKACHLAKQA FDDAIAELDT LSEESYKDST LIMQLLRDNL TLWTSDMSES
250 260
GQAEDQQQQQ QHQQQQPPAA AEGEAPK