P28708

PR
Gene name
PRR1 (YKL116C, YKL516)
Protein name
Serine/threonine-protein kinase PRR1
Names
Pheromone response regulator 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YKL116C
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-209 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P28708

Entry ID Method Resolution Chain Position Source
AF-P28708-F1 Predicted AlphaFoldDB

13 variants for P28708

Variant ID(s) Position Change Description Diseaes Association Provenance
s11-222439 36 E>K No SGRP
s11-222409 46 S>P No SGRP
s11-222207 113 S>F No SGRP
s11-222196 117 P>S No SGRP
s11-221911 212 M>V No SGRP
s11-221740 269 P>S No SGRP
s11-221686 287 K>E No SGRP
s11-221677 290 C>R No SGRP
s11-221664 294 I>K No SGRP
s11-221595 317 A>V No SGRP
s11-221550 332 Q>R No SGRP
s11-221542 335 F>L No SGRP
s11-221116 477 Y>D No SGRP

No associated diseases with P28708

3 regional properties for P28708

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 260 IPR000719
active_site Serine/threonine-protein kinase, active site 119 - 131 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

5 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of conjugation with cellular fusion Any process that decreases the rate or frequency of conjugation with cellular fusion.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
protein phosphorylation The process of introducing a phosphate group on to a protein.
response to pheromone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P36004 KKQ8 Probable serine/threonine-protein kinase KKQ8 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P47116 PTK2 Serine/threonine-protein kinase PTK2/STK2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P06782 SNF1 Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
Q8AYC9 CHEK1 Serine/threonine-protein kinase Chk1 Gallus gallus (Chicken) PR
O61661 grp Serine/threonine-protein kinase grp Drosophila melanogaster (Fruit fly) SS
O14757 CHEK1 Serine/threonine-protein kinase Chk1 Homo sapiens (Human) EV
O35280 Chek1 Serine/threonine-protein kinase Chk1 Mus musculus (Mouse) PR
Q91ZN7 Chek1 Serine/threonine-protein kinase Chk1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDEYSSIYSQ PKTPRLKQEG FPDSIGDQHE KALIDENGEE DKKMASTEGT TGDSRSTPLT
70 80 90 100 110 120
VSIPTFENVQ ALPTPMTYTP LSPGNLSMSP IDQSSLNIPK RRSHARLLDD MLSVTQPNQR
130 140 150 160 170 180
VVSELIAPAN LSPQRVVSLP TVTEEALVND SVDSDNYTKE PYFPESSSST EKCDDDIFQG
190 200 210 220 230 240
FLLDHWDRPL LWKKVRPIGS GNFSTVLLYE LMDQSNPKLK QVAVKRLKYP EELSNVEQIN
250 260 270 280 290 300
TSLRYKETLS RLENSLTREL QVLKSLNHPC IVKLLGINNP IFVTSKKPLC DLIIKTPRAL
310 320 330 340 350 360
PPCDMIMSYC PAGDLLAAVM ARNGRLEAWL IQRIFTEVVL AVKYLHENSI IHRDLKLENI
370 380 390 400 410 420
LLKYSFDDIN SFRDSPIYCK QNFIELADFG LCKKIENNEM CTARCGSEDY VSPEILMGVP
430 440 450 460 470 480
YDGHLSDTWA LGVILYSLFE DRLPFDPPPN ASARQRSRAT SHRIARFDWR WYRLSDYKTN
490 500 510
VGKQIVENTL TRKNQRWSIN EIYESPFVKT IADTLSFS