P28033
SS
Gene name |
Cebpb |
Protein name |
CCAAT/enhancer-binding protein beta |
Names |
C/EBP beta , AGP/EBP , Interleukin-6-dependent-binding protein , IL-6DBP , Liver-enriched transcriptional activator , LAP |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12608 |
EC number |
|
Protein Class |
|
Descriptions
CEBPB is a transcription factor that regulates oncogenic H-RasV12-induced senescence and growth arrest. Three distinct N-terminal sequences that are predicted to form secondary structures inhibit CEBPB DNA binding. These include the autoinhibitory domain, which is located within CR5, and two LX motifs (LX1 and LX2). CEBPB is autoinhibited by these multiple elements, which also play a role in mediating interactions with coactivators. The autoinhibitory region physically interacts with the basic region within the DNA-binding domain to achieve autoinhibition.Truncation of the autoinhibitory domain, LX1, and/or LX2 recovered CEBPB DNA binding activity
Autoinhibitory domains (AIDs)
Target domain |
220-285 (DNA-binding domain (bZIP region)) |
Relief mechanism |
Partner binding, PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P28033
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1CI6 | X-ray | 260 A | B | 224-285 | PDB |
| AF-P28033-F1 | Predicted | AlphaFoldDB |
1 variants for P28033
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1131747235 | 208 | A>V | No | EVA |
No associated diseases with P28033
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| C/EBP complex | A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-TNNGNAA-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities. |
| CHOP-C/EBP complex | A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors. |
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| condensed chromosome, centromeric region | The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear matrix | The dense fibrillar network lying on the inner side of the nuclear membrane. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RNA polymerase II transcription regulator complex | A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. |
21 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| chromatin DNA binding | Binding to DNA that is assembled into chromatin. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor binding | Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. |
| DNA-binding transcription repressor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. |
| histone acetyltransferase binding | Binding to an histone acetyltransferase. |
| histone deacetylase binding | Binding to histone deacetylase. |
| identical protein binding | Binding to an identical protein or proteins. |
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| nuclear glucocorticoid receptor binding | Binding to a nuclear glucocorticoid receptor. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| RNA polymerase II core promoter sequence-specific DNA binding | Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
| RNA polymerase II-specific DNA-binding transcription factor binding | Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
| ubiquitin-like protein ligase binding | Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase. |
41 GO annotations of biological process
| Name | Definition |
|---|---|
| brown fat cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. |
| cellular response to amino acid stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. |
| cellular response to interleukin-1 | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. |
| cellular response to lipopolysaccharide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| embryonic placenta development | The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. |
| fat cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. |
| granuloma formation | The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic. |
| hepatocyte proliferation | The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. |
| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. |
| liver regeneration | The regrowth of lost or destroyed liver. |
| mammary gland epithelial cell differentiation | The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland. |
| mammary gland epithelial cell proliferation | The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. |
| myeloid cell development | The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of neuron apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. |
| negative regulation of T cell proliferation | Any process that stops, prevents or reduces the rate or extent of T cell proliferation. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| ovarian follicle development | The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. |
| positive regulation of biomineral tissue development | Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. |
| positive regulation of cold-induced thermogenesis | Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of fat cell differentiation | Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of inflammatory response | Any process that activates or increases the frequency, rate or extent of the inflammatory response. |
| positive regulation of interleukin-4 production | Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. |
| positive regulation of osteoblast differentiation | Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. |
| positive regulation of sodium-dependent phosphate transport | Any process that activates or increases the frequency, rate or extent of sodium-dependent phosphate transport. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of cell differentiation | Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. |
| regulation of dendritic cell differentiation | Any process that modulates the frequency, rate or extent of dendritic cell differentiation. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of interleukin-6 production | Any process that modulates the frequency, rate, or extent of interleukin-6 production. |
| regulation of odontoblast differentiation | Any process that modulates the frequency, rate or extent of odontoblast differentiation. |
| regulation of osteoclast differentiation | Any process that modulates the frequency, rate or extent of osteoclast differentiation. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| response to endoplasmic reticulum stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. |
| response to lipopolysaccharide | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| T-helper 1 cell activation | The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
| transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O02755 | CEBPB | CCAAT/enhancer-binding protein beta | Bos taurus (Bovine) | SS |
| Q90Z72 | NFIL3 | Nuclear factor interleukin-3-regulated protein | Gallus gallus (Chicken) | PR |
| Q16649 | NFIL3 | Nuclear factor interleukin-3-regulated protein | Homo sapiens (Human) | PR |
| P17676 | CEBPB | CCAAT/enhancer-binding protein beta | Homo sapiens (Human) | EV |
| O08750 | Nfil3 | Nuclear factor interleukin-3-regulated protein | Mus musculus (Mouse) | PR |
| Q6IMZ0 | Nfil3 | Nuclear factor interleukin-3-regulated protein | Rattus norvegicus (Rat) | PR |
| P21272 | Cebpb | CCAAT/enhancer-binding protein beta | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHRLLAWDAA | CLPPPPAAFR | PMEVANFYYE | PDCLAYGAKA | ARAAPRAPAA | EPAIGEHERA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IDFSPYLEPL | APAADFAAPA | PAHHDFLSDL | FADDYGAKPS | KKPADYGYVS | LGRAGAKAAP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PACFPPPPPA | ALKAEPGFEP | ADCKRADDAP | AMAAGFPFAL | RAYLGYQATP | SGSSGSLSTS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSSSPPGTPS | PADAKAAPAA | CFAGPPAAPA | KAKAKKTVDK | LSDEYKMRRE | RNNIAVRKSR |
| 250 | 260 | 270 | 280 | 290 | |
| DKAKMRNLET | QHKVLELTAE | NERLQKKVEQ | LSRELSTLRN | LFKQLPEPLL | ASAGHC |