P27697
Gene name |
COQ8 (ABC1) |
Protein name |
Atypical kinase COQ8, mitochondrial |
Names |
Activity of bc1 complex protein 1, Coenzyme Q protein 8, Ubiquinone biosynthesis protein COQ8 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGL119W |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
153-403 (ADCK3-like domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P27697
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P27697-F1 | Predicted | AlphaFoldDB |
7 variants for P27697
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-284550 | 35 | I>V | No | SGRP | |
| s07-284588 | 47 | K>N | No | SGRP | |
| s07-284596 | 50 | E>A | No | SGRP | |
| s07-284612 | 55 | R>S | No | SGRP | |
| s07-285072 | 209 | S>G | No | SGRP | |
| s07-285259 | 271 | R>K | No | SGRP | |
| s07-285468 | 341 | K>Q | No | SGRP |
No associated diseases with P27697
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| extrinsic component of mitochondrial inner membrane | The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| lipid binding | Binding to a lipid. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| ubiquinone biosynthetic process | The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. |
| ubiquinone-6 biosynthetic process | The chemical reactions and pathways resulting in the formation of ubiquinone-6. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q29RI0 | COQ8A | Atypical kinase COQ8A, mitochondrial | Bos taurus (Bovine) | SS |
| Q96D53 | COQ8B | Atypical kinase COQ8B, mitochondrial | Homo sapiens (Human) | SS |
| Q8NI60 | COQ8A | Atypical kinase COQ8A, mitochondrial | Homo sapiens (Human) | EV |
| Q566J8 | Coq8b | Atypical kinase COQ8B, mitochondrial | Mus musculus (Mouse) | SS |
| Q60936 | Coq8a | Atypical kinase COQ8A, mitochondrial | Mus musculus (Mouse) | SS |
| Q6AY19 | Coq8b | Atypical kinase COQ8B, mitochondrial | Rattus norvegicus (Rat) | SS |
| Q5BJQ0 | Coq8a | Atypical kinase COQ8A, mitochondrial | Rattus norvegicus (Rat) | SS |
| Q18486 | coq-8 | Atypical kinase coq-8, mitochondrial | Caenorhabditis elegans | SS |
| Q9SBB2 | ABC1 | Protein ABC transporter 1, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | SS |
| A3QJU3 | coq8b | Atypical kinase COQ8B, mitochondrial | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5RGU1 | coq8a | Atypical kinase COQ8A, mitochondrial | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVTNMVKLRN | LRRLYCSSRL | LRTIQNGRIS | SVSSISLSKK | YTTKSAKEGE | ENVERKHEEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKDTLKSSSV | PTSRISRLFH | YGSLAAGVGM | NAAAKGISEV | AKGNSPTWKS | LILSDSNIDR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ITNKFSKMRG | VALKIGQLLS | FQDEKVLPKE | LYEILSRVQN | SANHMPQRQL | EKVMAKELGA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NWKTKFSKFD | KIPMAAASIG | QVHAAELPSG | QRVVVKIQYP | GVKESIDSDL | NSLLMLLTAS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLLPKGLFLD | KTIANARTEL | KWECDYNREA | RALQKFEALL | KDDPAFEVPH | VFPEYTTDNI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ITMTRMEGTE | IMKLPKASQE | TKNFISENIM | RLCLEEIATF | KYMQTDPNWA | NFLYNGRTKK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IELLDFGASR | PFAEDFILKY | RKLLTYATLR | DRKGAYEMSV | QLGYLTGLES | QSMKDAHVDS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VLTLGEPFRG | DVDKSFDFKD | QTVSDRIRGN | IGLMLNERLC | PPPEETYSLH | RKFSGIFLLC |
| 490 | 500 | ||||
| ARMGASVHCA | KLFKEIFAYK | V |