P27639
Gene name |
inf-1 (F57B9.6) |
Protein name |
Eukaryotic initiation factor 4A |
Names |
eIF-4A, ATP-dependent RNA helicase eIF4A, Initiation factor 1 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F57B9.6 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P27639
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P27639-F1 | Predicted | AlphaFoldDB |
No variants for P27639
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P27639 | |||||
No associated diseases with P27639
6 regional properties for P27639
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 176 - 184 | IPR000629 |
| domain | Helicase, C-terminal | 241 - 402 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 54 - 217 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 48 - 245 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 29 - 57 | IPR014014 |
| domain | ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain | 31 - 231 | IPR044728 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| P granule | A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoplasmic translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
21 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41378 | Eukaryotic initiation factor 4A | Triticum aestivum (Wheat) | PR | |
| P10081 | TIF2 | ATP-dependent RNA helicase eIF4A | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3SZ65 | EIF4A2 | Eukaryotic initiation factor 4A-II | Bos taurus (Bovine) | PR |
| Q3SZ54 | EIF4A1 | Eukaryotic initiation factor 4A-I | Bos taurus (Bovine) | PR |
| Q8JFP1 | EIF4A2 | Eukaryotic initiation factor 4A-II | Gallus gallus (Chicken) | PR |
| A5A6N4 | EIF4A1 | Eukaryotic initiation factor 4A-I | Pan troglodytes (Chimpanzee) | PR |
| Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | Homo sapiens (Human) | PR |
| P60842 | EIF4A1 | Eukaryotic initiation factor 4A-I | Homo sapiens (Human) | PR |
| Q41741 | Eukaryotic initiation factor 4A | Zea mays (Maize) | PR | |
| P60843 | Eif4a1 | Eukaryotic initiation factor 4A-I | Mus musculus (Mouse) | PR |
| P10630 | Eif4a2 | Eukaryotic initiation factor 4A-II | Mus musculus (Mouse) | PR |
| Q5RKI1 | Eif4a2 | Eukaryotic initiation factor 4A-II | Rattus norvegicus (Rat) | PR |
| P35683 | Os06g0701100 | Eukaryotic initiation factor 4A-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z2Z4 | Os02g0146600 | Eukaryotic initiation factor 4A-3 | Oryza sativa subsp japonica (Rice) | PR |
| P34580 | T26G10.1 | Putative ATP-dependent RNA helicase T26G10.1 | Caenorhabditis elegans | PR |
| P34640 | ZK512.2 | Probable ATP-dependent RNA helicase DDX55 homolog | Caenorhabditis elegans | PR |
| P34668 | ZK686.2 | Putative ATP-dependent RNA helicase ZK686.2 | Caenorhabditis elegans | PR |
| Q3E9C3 | RH58 | DEAD-box ATP-dependent RNA helicase 58, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CAI7 | TIF4A-3 | Eukaryotic initiation factor 4A-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41377 | TIF4A-2 | Eukaryotic initiation factor 4A-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41376 | EIF4A1 | Eukaryotic initiation factor 4A-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTDVKNDVNV | SSVVDADGLI | EGNYDQVVES | FDDMELKEEL | LRGIYGFGFE | KPSAIQKRAI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VPCTTGKDVI | AQAQSGTGKT | ATFSVSILQR | IDHEDPHVQA | LVMAPTRELA | QQIQKVMSAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GEYLNVNILP | CIGGTSVRDD | QRKLEAGIHV | VVGTPGRVGD | MINRNALDTS | RIKMFVLDEA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DEMLSRGFKD | QIYEVFRSMP | QDVQVVLLSA | TMPSEVLDVT | NRFMRNPIRI | LVKKDELTLE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GIRQFYINVQ | KDEWKFDCLC | DLYNVVNVTQ | AVIFCNTRRK | VDTLTEKMTE | NQFTVSCLHG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DMDQAERDTI | MREFRSGSSR | VLITTDILAR | GIDVQQVSLV | INYDLPSNRE | NYIHRIGRSG |
| 370 | 380 | 390 | 400 | ||
| RFGRKGVAIN | FVTENDARQL | KEIESYYTTQ | IEEMPESIAD | LI |