Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

8 structures for P27348

Entry ID Method Resolution Chain Position Source
2BTP X-ray 280 A A/B 1-234 PDB
5IQP X-ray 260 A A/B 1-245 PDB
6BCR X-ray 199 A A/B/E/F 1-245 PDB
6BD2 X-ray 290 A A/B 1-245 PDB
6BQT X-ray 280 A A/B/D/E/G/H/J/K 1-245 PDB
6KZG X-ray 200 A A/B 2-234 PDB
6KZH X-ray 265 A A/B 2-234 PDB
AF-P27348-F1 Predicted AlphaFoldDB

135 variants for P27348

Variant ID(s) Position Change Description Diseaes Association Provenance
CA345870533
rs1201939077
2 E>D No ClinGen
gnomAD
CA345870526
rs1347601492
3 K>N No ClinGen
gnomAD
rs1161896547
CA345870527
3 K>R No ClinGen
TOPMed
rs1390448720
CA345870524
4 T>A No ClinGen
TOPMed
rs1256912617
CA345870520
4 T>S No ClinGen
gnomAD
CA345870511
rs761020810
5 E>D Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs1227391131
CA345870514
5 E>G No ClinGen
TOPMed
gnomAD
rs1333653992
CA345870497
8 Q>E No ClinGen
TOPMed
CA345870484
rs1365202009
9 K>N No ClinGen
TOPMed
gnomAD
rs776134213
CA1524093
10 A>G No ClinGen
ExAC
TOPMed
gnomAD
CA345870482
rs1335699369
10 A>T No ClinGen
gnomAD
rs776134213
CA345870479
10 A>V No ClinGen
ExAC
TOPMed
gnomAD
rs1404137243
CA345870476
11 K>E No ClinGen
TOPMed
gnomAD
rs1404137243
CA345870477
11 K>Q No ClinGen
TOPMed
gnomAD
rs1218968603
CA345870445
15 Q>L No ClinGen
TOPMed
CA345870437
rs1573011079
16 A>V No ClinGen
Ensembl
CA345870436
rs1388248788
17 E>* No ClinGen
gnomAD
TCGA novel 19 Y>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA1524089
rs770667690
20 D>E No ClinGen
ExAC
gnomAD
rs774114759
CA1524091
20 D>H No ClinGen
ExAC
gnomAD
rs774114759
CA1524090
20 D>N No ClinGen
ExAC
gnomAD
CA345870408
rs1257357675
21 D>N No ClinGen
gnomAD
CA42693525
rs1020766289
24 T>I No ClinGen
TOPMed
gnomAD
rs1277401819
CA345870364
27 K>Q No ClinGen
gnomAD
CA1524086
rs769631927
27 K>R No ClinGen
ExAC
gnomAD
rs1167518482
CA345870354
28 A>V Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs1186066024
CA345870348
29 V>E No ClinGen
TOPMed
rs141887759
CA345870350
29 V>L No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs141887759
CA1524084
29 V>M No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1445424650
CA345870346
30 T>A No ClinGen
gnomAD
rs758380692
CA1524083
31 E>Q No ClinGen
ExAC
gnomAD
CA1524082
rs750464603
33 G>S No ClinGen
ExAC
TOPMed
gnomAD
CA1524081
rs778991719
33 G>V No ClinGen
ExAC
gnomAD
CA1524080
rs757416206
34 A>P No ClinGen
ExAC
gnomAD
rs1558553670
CA345870318
34 A>V No ClinGen
Ensembl
CA345870316
rs1173245074
35 E>K Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
CA1524077
rs756561669
38 N>T No ClinGen
ExAC
gnomAD
CA1524074
rs760149820
42 N>S No ClinGen
ExAC
TOPMed
gnomAD
rs1254370439
CA345870254
44 L>F No ClinGen
gnomAD
CA345870207
rs1404463545
51 V>M No ClinGen
TOPMed
rs1394300626
CA345870202
52 V>I No ClinGen
TOPMed
rs1332147491
CA345870186
54 G>A No ClinGen
TOPMed
rs1284443542
CA345870181
55 R>H No ClinGen
TOPMed
gnomAD
CA345870179
rs1284443542
55 R>L No ClinGen
TOPMed
gnomAD
TCGA novel 56 R>M Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs776325430
CA1524067
58 A>S No ClinGen
ExAC
TOPMed
gnomAD
CA345870159
rs1309583828
59 W>R No ClinGen
gnomAD
rs1410406554
CA345870151
60 R>G No ClinGen
gnomAD
rs960357310
CA42693522
61 V>I No ClinGen
Ensembl
rs746966183
CA1524065
64 S>G No ClinGen
ExAC
TOPMed
gnomAD
CA42693521
rs982921555
66 E>Q No ClinGen
Ensembl
rs778901859
CA1524064
67 Q>R No ClinGen
ExAC
gnomAD
rs749499495
CA1524062
71 T>A No ClinGen
ExAC
gnomAD
CA345870072
rs1183336588
71 T>I Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
rs11544465
CA42693520
73 D>N No ClinGen
Ensembl
rs756400871
COSM1532907
CA1524060
74 K>R lung [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
rs1256127421
CA345870050
75 K>E No ClinGen
TOPMed
rs1452859677
CA345870032
77 Q>R No ClinGen
gnomAD
CA1524058
rs199958721
80 K>R No ClinGen
1000Genomes
ExAC
gnomAD
rs1027369792
CA345870003
81 D>E No ClinGen
gnomAD
CA1524056
rs752112912
82 Y>C No ClinGen
ExAC
gnomAD
TCGA novel 83 R>Q Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1573010858
CA345869981
85 K>Q No ClinGen
Ensembl
CA1524055
rs774239040
85 K>R No ClinGen
ExAC
TOPMed
gnomAD
rs1228772598
CA345869955
88 S>F No ClinGen
gnomAD
CA42693517
rs1037601336
92 S>F No ClinGen
TOPMed
gnomAD
CA1524053
rs369852702
93 I>F No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1455899719
CA345869918
94 C>S No ClinGen
gnomAD
rs761396781
CA1524051
95 T>N No ClinGen
ExAC
TOPMed
gnomAD
rs1558541411
CA345871885
99 E>Q No ClinGen
Ensembl
CA345871820
rs1304828875
108 N>D Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
rs775375833
CA1524026
108 N>S No ClinGen
ExAC
TOPMed
gnomAD
rs185211853
CA1524025
110 T>A No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1043933165
CA42688730
110 T>I No ClinGen
gnomAD
rs1305026555
CA345871792
112 P>L No ClinGen
gnomAD
rs892847212
CA42688728
112 P>T No ClinGen
Ensembl
TCGA novel 113 E>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1353639482
CA345871671
129 L>V No ClinGen
gnomAD
rs1306741559
CA345871641
133 A>V No ClinGen
TOPMed
gnomAD
CA345871622
rs1391534106
136 D>G No ClinGen
gnomAD
CA345871608
rs1168659382
138 R>Q Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA1524022
rs769768341
140 Q>* No ClinGen
ExAC
gnomAD
CA345871297
rs1286254245
140 Q>H No ClinGen
TOPMed
TCGA novel 140 Q>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs767312364
CA1524006
141 T>M No ClinGen
ExAC
gnomAD
CA1524005
rs759450776
142 I>V No ClinGen
ExAC
gnomAD
rs1052123960
CA42688372
147 G>E Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
CA1524004
rs774221614
147 G>R No ClinGen
ExAC
gnomAD
CA1524003
rs769900540
148 A>T No ClinGen
ExAC
gnomAD
rs371354151
CA1524001
152 A>S Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ESP
ExAC
NCI-TCGA
gnomAD
CA345871221
rs371354151
152 A>T No ClinGen
ESP
ExAC
gnomAD
rs1266699218
CA345871214
153 F>V No ClinGen
gnomAD
rs1351421945
CA345871195
155 I>M No ClinGen
gnomAD
rs768956586
CA1524000
155 I>T No ClinGen
ExAC
TOPMed
gnomAD
CA345871180
rs201487177
157 K>N Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
1000Genomes
NCI-TCGA
TOPMed
rs199515928
CA42688370
158 K>E No ClinGen
1000Genomes
rs927603470
TCGA novel
CA42688368
159 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
TOPMed
NCI-TCGA
CA345871154
rs1452635609
161 Q>E No ClinGen
TOPMed
rs780502121
CA1523999
161 Q>H No ClinGen
ExAC
TOPMed
gnomAD
rs772387887
CA1523997
162 P>S No ClinGen
ExAC
gnomAD
rs1461697218
CA345871133
164 H>R No ClinGen
gnomAD
rs200884745
CA1523995
166 I>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1000606168
CA42688367
167 R>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA1523993
rs367832498
167 R>H Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs367832498
CA1523994
167 R>L No ClinGen
ESP
ExAC
TOPMed
gnomAD
COSM95553
rs1464445429
CA345871038
179 Y>C breast [Cosmic] No ClinGen
cosmic curated
gnomAD
TCGA novel 184 N>K Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1210769232
CA345870996
185 P>S No ClinGen
TOPMed
gnomAD
rs1210769232
CA345870994
185 P>T No ClinGen
TOPMed
gnomAD
rs1255736501
CA345870986
186 E>G No ClinGen
gnomAD
CA1523986
rs150523147
190 T>M No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1441015148
CA345870950
192 A>S No ClinGen
gnomAD
CA1523984
rs776796788
193 K>R No ClinGen
ExAC
gnomAD
rs377175915
CA1523960
195 A>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1388450246
CA345870886
199 A>V No ClinGen
gnomAD
rs1410576904
CA345870880
200 I>M No ClinGen
TOPMed
rs774523757
CA1523959
200 I>V No ClinGen
ExAC
gnomAD
CA1523957
rs749789995
205 T>I No ClinGen
ExAC
gnomAD
CA1523958
rs749789995
205 T>K No ClinGen
ExAC
gnomAD
rs1185622539
CA345870844
206 L>P No ClinGen
gnomAD
rs1444517962
CA345870824
209 D>Y No ClinGen
gnomAD
CA1523956
rs773765562
211 Y>F No ClinGen
ExAC
CA1523955
rs769267624
215 T>I No ClinGen
ExAC
gnomAD
TCGA novel 217 I>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs896145482
CA42688300
221 L>F No ClinGen
Ensembl
rs747693562
CA1523954
224 N>D No ClinGen
ExAC
gnomAD
CA1523933
rs762328022
232 S>T No ClinGen
ExAC
TOPMed
gnomAD
CA345870630
rs1321647925
235 E>K No ClinGen
gnomAD
CA1523929
rs746631800
237 C>G No ClinGen
ExAC
gnomAD
rs1455995513
CA345870604
238 D>E No ClinGen
gnomAD
rs779806817
CA1523928
238 D>V No ClinGen
ExAC
gnomAD
rs200376025
CA1523927
239 A>G No ClinGen
ExAC
gnomAD
CA1523926
rs200376025
239 A>V No ClinGen
ExAC
gnomAD
rs757206430
CA1523924
242 G>R No ClinGen
ExAC
TOPMed
gnomAD
CA1523923
rs753821484
243 A>V No ClinGen
ExAC
gnomAD

No associated diseases with P27348

3 regional properties for P27348

Type Name Position InterPro Accession
conserved_site 14-3-3 protein, conserved site 41 - 51 IPR023409-1
conserved_site 14-3-3 protein, conserved site 211 - 230 IPR023409-2
domain 14-3-3 domain 3 - 242 IPR023410

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • In neurons, axonally transported to the nerve terminals
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

3 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
protein domain specific binding Binding to a specific domain of a protein.
protein N-terminus binding Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.

6 GO annotations of biological process

Name Definition
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.
substantia nigra development The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis).

37 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P61981 YWHAG 14-3-3 protein gamma Homo sapiens (Human) PR
Q04917 YWHAH 14-3-3 protein eta Homo sapiens (Human) PR
P63104 YWHAZ 14-3-3 protein zeta/delta Homo sapiens (Human) PR
P31946 YWHAB 14-3-3 protein beta/alpha Homo sapiens (Human) PR
P49106 GRF1 14-3-3-like protein GF14-6 Zea mays (Maize) PR
P68510 Ywhah 14-3-3 protein eta Mus musculus (Mouse) PR
P63101 Ywhaz 14-3-3 protein zeta/delta Mus musculus (Mouse) PR
P93784 HOX 14-3-3-like protein 16R Solanum tuberosum (Potato) PR
Q41418 14-3-3-like protein Solanum tuberosum (Potato) PR
P63102 Ywhaz 14-3-3 protein zeta/delta Rattus norvegicus (Rat) PR
Q6EUP4 GF14E 14-3-3-like protein GF14-E Oryza sativa subsp japonica (Rice) PR
Q06967 GF14F 14-3-3-like protein GF14-F Oryza sativa subsp japonica (Rice) PR
Q7XTE8 GF14B 14-3-3-like protein GF14-B Oryza sativa subsp japonica (Rice) PR
Q6ZKC0 GF14C 14-3-3-like protein GF14-C Oryza sativa subsp japonica (Rice) PR
Q84J55 GF14A 14-3-3-like protein GF14-A Oryza sativa subsp japonica (Rice) PR
Q2R2W2 GF14D 14-3-3-like protein GF14-D Oryza sativa subsp japonica (Rice) PR
Q2R1D5 GF14H Putative 14-3-3-like protein GF14-H Oryza sativa subsp japonica (Rice) PR
Q96450 GF14A 14-3-3-like protein A Glycine max (Soybean) (Glycine hispida) PR
Q96453 GF14D 14-3-3-like protein D Glycine max (Soybean) (Glycine hispida) PR
Q96452 GF14C 14-3-3-like protein C Glycine max (Soybean) (Glycine hispida) PR
Q9C5W6 GRF12 14-3-3-like protein GF14 iota Arabidopsis thaliana (Mouse-ear cress) PR
Q9S9Z8 GRF11 14-3-3-like protein GF14 omicron Arabidopsis thaliana (Mouse-ear cress) PR
P46077 GRF4 14-3-3-like protein GF14 phi Arabidopsis thaliana (Mouse-ear cress) PR
Q01525 GRF2 14-3-3-like protein GF14 omega Arabidopsis thaliana (Mouse-ear cress) PR
Q96300 GRF7 14-3-3-like protein GF14 nu Arabidopsis thaliana (Mouse-ear cress) PR
P42645 GRF5 14-3-3-like protein GF14 upsilon Arabidopsis thaliana (Mouse-ear cress) PR
P42644 GRF3 14-3-3-like protein GF14 psi Arabidopsis thaliana (Mouse-ear cress) PR
Q96299 GRF9 14-3-3-like protein GF14 mu Arabidopsis thaliana (Mouse-ear cress) PR
P42652 TFT4 14-3-3 protein 4 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93212 TFT7 14-3-3 protein 7 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93209 TFT3 14-3-3 protein 3 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93207 TFT10 14-3-3 protein 10 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93211 TFT6 14-3-3 protein 6 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93206 TFT1 14-3-3 protein 1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93208 TFT2 14-3-3 protein 2 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93213 TFT8 14-3-3 protein 8 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
P93214 TFT9 14-3-3 protein 9 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN VVGGRRSAWR
70 80 90 100 110 120
VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL LDKYLIANAT NPESKVFYLK
130 140 150 160 170 180
MKGDYFRYLA EVACGDDRKQ TIDNSQGAYQ EAFDISKKEM QPTHPIRLGL ALNFSVFYYE
190 200 210 220 230 240
ILNNPELACT LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA
EGAEN