P26361
PR
Gene name |
Cftr (Abcc7) |
Protein name |
Cystic fibrosis transmembrane conductance regulator |
Names |
CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, cAMP-dependent chloride channel |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12638 |
EC number |
5.6.1.6: Enzymes altering polypeptide conformation or assembly |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
10 structures for P26361
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1Q3H | X-ray | 250 A | A/B/C/D | 389-673 | PDB |
| 1R0W | X-ray | 220 A | A/B/C/D | 389-673 | PDB |
| 1R0X | X-ray | 220 A | A/B/C/D | 389-673 | PDB |
| 1R0Y | X-ray | 255 A | A/B/C/D | 389-673 | PDB |
| 1R0Z | X-ray | 235 A | A/B/C/D | 389-673 | PDB |
| 1R10 | X-ray | 300 A | A/B | 389-673 | PDB |
| 1XF9 | X-ray | 270 A | A/B/C/D | 389-670 | PDB |
| 1XFA | X-ray | 310 A | A/B | 389-670 | PDB |
| 3SI7 | X-ray | 225 A | A/B/C/D | 389-673 | PDB |
| AF-P26361-F1 | Predicted | AlphaFoldDB |
57 variants for P26361
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs46436804 | 20 | T>S | No | EVA | |
| rs47945703 | 22 | P>A | No | EVA | |
| rs50179807 | 30 | H>Q | No | EVA | |
| rs3388806354 | 42 | S>F | No | EVA | |
| rs1131830369 | 55 | R>T | No | EVA | |
| rs48887458 | 119 | I>L | No | EVA | |
| rs3388816848 | 124 | G>D | No | EVA | |
| rs3388819624 | 152 | M>I | No | EVA | |
| rs3388812176 | 162 | K>M | No | EVA | |
| rs3396110422 | 358 | V>* | No | EVA | |
| rs3396110422 | 359 | Q>* | No | EVA | |
| rs3396527400 | 359 | Q>L | No | EVA | |
| rs3388785437 | 382 | V>A | No | EVA | |
| rs217403988 | 382 | V>I | No | EVA | |
| rs3388806300 | 402 | E>D | No | EVA | |
| rs48026769 | 423 | S>N | No | EVA | |
| rs3388803762 | 504 | E>A | No | EVA | |
| rs3395776809 | 506 | I>* | No | EVA | |
| rs3396500424 | 506 | I>S | No | EVA | |
| rs3412781077 | 577 | Y>* | No | EVA | |
| rs3388817123 | 620 | H>Y | No | EVA | |
| rs3388823404 | 649 | T>S | No | EVA | |
| rs3388785461 | 653 | F>C | No | EVA | |
| rs3388801363 | 657 | R>K | No | EVA | |
| rs260343458 | 679 | S>N | No | EVA | |
| rs240861972 | 691 | V>L | No | EVA | |
| rs264806007 | 719 | I>M | No | EVA | |
| rs3388811687 | 722 | E>K | No | EVA | |
| rs3388801369 | 738 | E>D | No | EVA | |
| rs3388814602 | 748 | N>I | No | EVA | |
| rs3388814602 | 748 | N>S | No | EVA | |
| rs257571969 | 749 | M>V | No | EVA | |
| rs236351621 | 778 | N>S | No | EVA | |
| rs3388819643 | 849 | T>I | No | EVA | |
| rs3388810315 | 856 | L>I | No | EVA | |
| rs3388816174 | 893 | I>T | No | EVA | |
| rs3388806376 | 927 | F>V | No | EVA | |
| rs3388816163 | 948 | L>S | No | EVA | |
| rs3388823476 | 950 | S>T | No | EVA | |
| rs218543945 | 997 | I>V | No | EVA | |
| rs240740917 | 999 | A>T | No | EVA | |
| rs3388811611 | 1045 | P>L | No | EVA | |
| rs3388817394 | 1054 | L>F | No | EVA | |
| rs3388816843 | 1063 | F>S | No | EVA | |
| rs3388819708 | 1065 | R>H | No | EVA | |
| rs30074415 | 1175 | I>M | No | EVA | |
| rs3388816889 | 1179 | P>L | No | EVA | |
| rs256882852 | 1180 | R>K | No | EVA | |
| rs3388817350 | 1231 | S>G | No | EVA | |
| rs3396580887 | 1251 | S>* | No | EVA | |
| rs3396576751 | 1251 | S>T | No | EVA | |
| rs3388785436 | 1303 | N>H | No | EVA | |
| rs3388817191 | 1303 | N>S | No | EVA | |
| rs3388806330 | 1324 | I>T | No | EVA | |
| rs3396438601 | 1378 | Q>H | No | EVA | |
| rs3396119755 | 1379 | V>I | No | EVA | |
| rs3388810246 | 1400 | I>L | No | EVA |
No associated diseases with P26361
9 regional properties for P26361
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 423 - 646 | IPR003439-1 |
| domain | ABC transporter-like, ATP-binding domain | 1208 - 1439 | IPR003439-2 |
| domain | AAA+ ATPase domain | 450 - 623 | IPR003593-1 |
| domain | AAA+ ATPase domain | 1232 - 1414 | IPR003593-2 |
| domain | ABC transporter type 1, transmembrane domain | 82 - 350 | IPR011527-1 |
| domain | ABC transporter type 1, transmembrane domain | 855 - 1153 | IPR011527-2 |
| conserved_site | ABC transporter-like, conserved site | 548 - 562 | IPR017871 |
| domain | CFTR regulator domain | 639 - 844 | IPR025837 |
| domain | Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1 | 389 - 670 | IPR047082 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.6.1.6 | Enzymes altering polypeptide conformation or assembly |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
21 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic vesicle membrane | The lipid bilayer surrounding a cytoplasmic vesicle. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| microvillus | Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| recycling endosome | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. |
| recycling endosome membrane | The lipid bilayer surrounding a recycling endosome. |
14 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type transporter activity | Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATPase-coupled transmembrane transporter activity | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. |
| bicarbonate transmembrane transporter activity | Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. |
| chaperone binding | Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. |
| chloride channel activity | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| chloride channel inhibitor activity | Binds to and stops, prevents, or reduces the activity of a chloride channel. |
| chloride transmembrane transporter activity | Enables the transfer of chloride ions from one side of a membrane to the other. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| intracellularly ATP-gated chloride channel activity | Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. |
| isomerase activity | Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. |
| PDZ domain binding | Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. |
| Sec61 translocon complex binding | Binding to a Sec61 translocon complex. |
34 GO annotations of biological process
| Name | Definition |
|---|---|
| amelogenesis | The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. |
| bicarbonate transport | The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| cellular response to cAMP | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. |
| cellular response to forskolin | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus. |
| chloride transmembrane transport | The process in which chloride is transported across a membrane. |
| chloride transport | The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| cholesterol biosynthetic process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| cholesterol transport | The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| enamel mineralization | The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| intracellular pH elevation | Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| lung development | The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. |
| membrane hyperpolarization | The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential. |
| multicellular organismal water homeostasis | Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism. |
| negative regulation of type B pancreatic cell development | Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development. |
| negative regulation of vascular associated smooth muscle cell apoptotic process | Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. |
| positive regulation of cyclic nucleotide-gated ion channel activity | Any process that activates or increases the frequency, rate or extent of cyclic nucleotide-gated ion channel activity. |
| positive regulation of enamel mineralization | Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel. |
| positive regulation of establishment of Sertoli cell barrier | Any process that activates or increases the frequency, rate or extent of establishment of Sertoli cell barrier. |
| positive regulation of exocytosis | Any process that activates or increases the frequency, rate or extent of exocytosis. |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus | Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. |
| positive regulation of mast cell activation | Any process that activates or increases the frequency, rate, or extent of mast cell activation. |
| positive regulation of voltage-gated chloride channel activity | Any process that activates or increases the frequency, rate or extent of voltage-gated chloride channel activity. |
| response to amiloride | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus. |
| response to endoplasmic reticulum stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| sperm capacitation | A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. |
| transepithelial chloride transport | The directed movement of chloride ions from one side of an epithelium to the other. |
| transepithelial water transport | The directed movement of water (H2O) from one side of an epithelium to the other. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
| vasodilation | An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure. |
| vesicle docking involved in exocytosis | The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. |
| water transport | The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
26 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8HXQ5 | ABCC1 | Multidrug resistance-associated protein 1 | Bos taurus (Bovine) | PR |
| Q2QLE5 | CFTR | Cystic fibrosis transmembrane conductance regulator | Pan troglodytes (Chimpanzee) | PR |
| Q5U820 | CFTR | Cystic fibrosis transmembrane conductance regulator | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P91660 | Rh5 | Probable multidrug resistance-associated protein lethal(2)03659 | Drosophila melanogaster (Fruit fly) | PR |
| Q2QLA3 | CFTR | Cystic fibrosis transmembrane conductance regulator | Equus caballus (Horse) | PR |
| O95255 | ABCC6 | ATP-binding cassette sub-family C member 6 | Homo sapiens (Human) | PR |
| O15438 | ABCC3 | ATP-binding cassette sub-family C member 3 | Homo sapiens (Human) | PR |
| Q92887 | ABCC2 | ATP-binding cassette sub-family C member 2 | Homo sapiens (Human) | SS |
| O15439 | ABCC4 | ATP-binding cassette sub-family C member 4 | Homo sapiens (Human) | PR |
| Q96J66 | ABCC11 | ATP-binding cassette sub-family C member 11 | Homo sapiens (Human) | PR |
| P33527 | ABCC1 | Multidrug resistance-associated protein 1 | Homo sapiens (Human) | PR |
| P13569 | CFTR | Cystic fibrosis transmembrane conductance regulator | Homo sapiens (Human) | PR |
| B2RX12 | Abcc3 | ATP-binding cassette sub-family C member 3 | Mus musculus (Mouse) | PR |
| Q8VI47 | Abcc2 | ATP-binding cassette sub-family C member 2 | Mus musculus (Mouse) | SS |
| O35379 | Abcc1 | Multidrug resistance-associated protein 1 | Mus musculus (Mouse) | PR |
| Q80WJ6 | Abcc12 | ATP-binding cassette sub-family C member 12 | Mus musculus (Mouse) | PR |
| Q6PQZ2 | CFTR | Cystic fibrosis transmembrane conductance regulator | Sus scrofa (Pig) | PR |
| Q6Y306 | Abcc12 | ATP-binding cassette sub-family C member 12 | Rattus norvegicus (Rat) | PR |
| Q8CG09 | Abcc1 | Multidrug resistance-associated protein 1 | Rattus norvegicus (Rat) | PR |
| Q63120 | Abcc2 | ATP-binding cassette sub-family C member 2 | Rattus norvegicus (Rat) | EV |
| Q00553 | CFTR | Cystic fibrosis transmembrane conductance regulator | Macaca mulatta (Rhesus macaque) | PR |
| Q9C8G9 | ABCC1 | ABC transporter C family member 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C8H0 | ABCC12 | ABC transporter C family member 12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SKX0 | ABCC13 | ABC transporter C family member 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZZ4 | ABCC6 | ABC transporter C family member 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1C7 | ABCC9 | ABC transporter C family member 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQKSPLEKAS | FISKLFFSWT | TPILRKGYRH | HLELSDIYQA | PSADSADHLS | EKLEREWDRE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QASKKNPQLI | HALRRCFFWR | FLFYGILLYL | GEVTKAVQPV | LLGRIIASYD | PENKVERSIA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IYLGIGLCLL | FIVRTLLLHP | AIFGLHRIGM | QMRTAMFSLI | YKKTLKLSSR | VLDKISIGQL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VSLLSNNLNK | FDEGLALAHF | IWIAPLQVTL | LMGLLWDLLQ | FSAFCGLGLL | IILVIFQAIL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GKMMVKYRDQ | RAAKINERLV | ITSEIIDNIY | SVKAYCWESA | MEKMIENLRE | VELKMTRKAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YMRFFTSSAF | FFSGFFVVFL | SVLPYTVING | IVLRKIFTTI | SFCIVLRMSV | TRQFPTAVQI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WYDSFGMIRK | IQDFLQKQEY | KVLEYNLMTT | GIIMENVTAF | WEEGFGELLE | KVQQSNGDRK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HSSDENNVSF | SHLCLVGNPV | LKNINLNIEK | GEMLAITGST | GSGKTSLLML | ILGELEASEG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IIKHSGRVSF | CSQFSWIMPG | TIKENIIFGV | SYDEYRYKSV | VKACQLQQDI | TKFAEQDNTV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LGEGGVTLSG | GQRARISLAR | AVYKDADLYL | LDSPFGYLDV | FTEEQVFESC | VCKLMANKTR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ILVTSKMEHL | RKADKILILH | QGSSYFYGTF | SELQSLRPDF | SSKLMGYDTF | DQFTEERRSS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ILTETLRRFS | VDDSSAPWSK | PKQSFRQTGE | VGEKRKNSIL | NSFSSVRKIS | IVQKTPLCID |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GESDDLQEKR | LSLVPDSEQG | EAALPRSNMI | ATGPTFPGRR | RQSVLDLMTF | TPNSGSSNLQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RTRTSIRKIS | LVPQISLNEV | DVYSRRLSQD | STLNITEEIN | EEDLKECFLD | DVIKIPPVTT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| WNTYLRYFTL | HKGLLLVLIW | CVLVFLVEVA | ASLFVLWLLK | NNPVNSGNNG | TKISNSSYVV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| IITSTSFYYI | FYIYVGVADT | LLALSLFRGL | PLVHTLITAS | KILHRKMLHS | ILHAPMSTIS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KLKAGGILNR | FSKDIAILDD | FLPLTIFDFI | QLVFIVIGAI | IVVSALQPYI | FLATVPGLVV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| FILLRAYFLH | TAQQLKQLES | EGRSPIFTHL | VTSLKGLWTL | RAFRRQTYFE | TLFHKALNLH |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| TANWFMYLAT | LRWFQMRIDM | IFVLFFIVVT | FISILTTGEG | EGTAGIILTL | AMNIMSTLQW |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| AVNSSIDTDS | LMRSVSRVFK | FIDIQTEESM | YTQIIKELPR | EGSSDVLVIK | NEHVKKSDIW |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| PSGGEMVVKD | LTVKYMDDGN | AVLENISFSI | SPGQRVGLLG | RTGSGKSTLL | SAFLRMLNIK |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| GDIEIDGVSW | NSVTLQEWRK | AFGVITQKVF | IFSGTFRQNL | DPNGKWKDEE | IWKVADEVGL |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| KSVIEQFPGQ | LNFTLVDGGY | VLSHGHKQLM | CLARSVLSKA | KIILLDEPSA | HLDPITYQVI |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| RRVLKQAFAG | CTVILCEHRI | EAMLDCQRFL | VIEESNVWQY | DSLQALLSEK | SIFQQAISSS |
| 1450 | 1460 | 1470 | |||
| EKMRFFQGRH | SSKHKPRTQI | TALKEETEEE | VQETRL |