P26044

SS
Gene name
RDX
Protein name
Radixin
Names
Moesin-B
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:494457
EC number
Protein Class

Descriptions

MSN is a moesin protein and belongs to the ezrin-radixin-moesin (ERM) protein family, directly involved in the cytoskeleton-membrane crosslinking. Functional N-terminal FERM domain of ERM attaches to the membrane by binding specific membrane proteins while the last 34 residues of the C-terminal tail domain bind actin filaments. The autoinhibitory domain is positions at the C-terminal tail domain of ERM, where FERM domain of ERM is bound tightly via phosphotyrosine binding (PTB), pleckstrin homology (PH), and Enabled/VASP Homology 1 (EVH1) domains, thus masking the binding sites for other molecules. ERM is activated through phosphorylation at Thr558 weakening the FERM/tail binding and, unmasks the binding sites of membrane protein and actin filaments in the presence of phospholipids.

Autoinhibitory domains (AIDs)

467-583 (Tail domain) SS

Target domain

5-295 (FERM domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P26044

Entry ID Method Resolution Chain Position Source
AF-P26044-F1 Predicted AlphaFoldDB

No variants for P26044

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P26044

No associated diseases with P26044

4 regional properties for P26044

Type Name Position InterPro Accession
domain SNF2, N-terminal 506 - 807 IPR000330
domain Helicase, C-terminal domain-like 839 - 998 IPR001650
domain Helicase superfamily 1/2, ATP-binding domain 499 - 699 IPR014001
domain SNF2/RAD5-like, C-terminal helicase domain 834 - 959 IPR049730

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane; Peripheral membrane protein; Cytoplasmic side
  • Cytoplasm, cytoskeleton
  • Cleavage furrow
  • Cell projection, microvillus
  • Cell projection, stereocilium
  • Enriched at the stereocilium base with very low levels in the shaft of stereociliary bundles (By similarity)
  • Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
adherens junction A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
apical part of cell The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
cleavage furrow The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
microvillus Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
stereocilium base The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium.

2 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
cell adhesion molecule binding Binding to a cell adhesion molecule.

5 GO annotations of biological process

Name Definition
actin filament capping The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
positive regulation of early endosome to late endosome transport Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport.
positive regulation of protein localization to early endosome Any process that activates or increases the frequency, rate or extent of protein localization to early endosome.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of organelle assembly Any process that modulates the frequency, rate or extent of organelle assembly.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P31976 EZR Ezrin Bos taurus (Bovine) PR
Q2HJ49 MSN Moesin Bos taurus (Bovine) PR
Q32LP2 RDX Radixin Bos taurus (Bovine) SS
Q9PU45 RDX Radixin Gallus gallus (Chicken) PR
Q24564 Mer Moesin/ezrin/radixin homolog 2 Drosophila melanogaster (Fruit fly) SS
P46150 Moe Moesin/ezrin/radixin homolog 1 Drosophila melanogaster (Fruit fly) SS
P35240 NF2 Merlin Homo sapiens (Human) EV
P26038 MSN Moesin Homo sapiens (Human) EV
P15311 EZR Ezrin Homo sapiens (Human) EV
Q3KP66 INAVA Innate immunity activator protein Homo sapiens (Human) PR
P35241 RDX Radixin Homo sapiens (Human) SS
A2AD83 Frmd7 FERM domain-containing protein 7 Mus musculus (Mouse) PR
P26040 Ezr Ezrin Mus musculus (Mouse) SS
P46662 Nf2 Merlin Mus musculus (Mouse) SS
P26041 Msn Moesin Mus musculus (Mouse) SS
P26043 Rdx Radixin Mus musculus (Mouse) SS
P26042 MSN Moesin Sus scrofa (Pig) PR
Q63648 Nf2 Merlin Rattus norvegicus (Rat) SS
P31977 Ezr Ezrin Rattus norvegicus (Rat) SS
O35763 Msn Moesin Rattus norvegicus (Rat) SS
Q6Q413 nf2b NF2, moesin-ezrin-radixin-like Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTVGLR EVWFFGLQYV DSKGYSTWLK
70 80 90 100 110 120
LNKKVTQQDV KKENPLQFKF RAKFFPEDVS EELIQEITQR LFFLQVKEAI LNDEIYCPPE
130 140 150 160 170 180
TAVLLASYAV QAKYGDYNKE IHKPGYLAND RLLPQRVLEQ HKLTKEQWEE RIQNWHEEHR
190 200 210 220 230 240
GMLREDSIME YLKIAQDLEM YGVNYFEIKN KKGTELWLGV DALGLNIYEH DDKLTPKIGF
250 260 270 280 290 300
PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI
310 320 330 340 350 360
EVQQMKAQAR EEKHQKQLER AQLENEKKKR EIAEKEKERI EREKEELMER LRQIEEQTMK
370 380 390 400 410 420
AQKELEEQTR KALELDQERK RAKEEAERLE KERRAAEEAK SAIAKQAADQ MKNQEQLAAE
430 440 450 460 470 480
LAEFTAKIAL LEEAKKKKEE EATEWQHKAF AAQEDLEKTK EELKTVMSAP PPPPPPPVVP
490 500 510 520 530 540
PTENEHDEHD ENNAEASAEL SNDGVMNHRS EEERVTETQK NERVNKQLQA LSSELAQARD
550 560 570 580
ETKKTQNDVL HAENVKAGRD KYKTLRQIRQ GNTKQRIDEF EAM