P25977

PR
Gene name
Ubtf (Tcfubf, Ubf-1)
Protein name
Nucleolar transcription factor 1
Names
Upstream-binding factor 1, UBF-1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:25574
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-764 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P25977

Entry ID Method Resolution Chain Position Source
AF-P25977-F1 Predicted AlphaFoldDB

No variants for P25977

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P25977

No associated diseases with P25977

7 regional properties for P25977

Type Name Position InterPro Accession
domain High mobility group box domain 111 - 181 IPR009071-1
domain High mobility group box domain 195 - 265 IPR009071-2
domain High mobility group box domain 297 - 363 IPR009071-3
domain High mobility group box domain 406 - 476 IPR009071-4
domain High mobility group box domain 481 - 550 IPR009071-5
domain High mobility group box domain 567 - 635 IPR009071-6
domain High mobility group box domain 5 479 - 563 IPR029215

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
fibrillar center A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
RNA polymerase I cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element).
RNA polymerase I core promoter sequence-specific DNA binding Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.
RNA polymerase I general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs.
scaffold protein binding Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.

5 GO annotations of biological process

Name Definition
cellular response to leukemia inhibitory factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
positive regulation of transcription by RNA polymerase I Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
transcription by RNA polymerase I The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.
transcription elongation by RNA polymerase I The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.
transcription initiation at RNA polymerase I promoter A transcription initiation process that takes place at a RNA polymerase I gene promoter. Ribosomal RNAs (rRNA) genes are transcribed by RNA polymerase I.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32L34 HMGB4 High mobility group protein B4 Bos taurus (Bovine) PR
Q0II87 TFAM Transcription factor A, mitochondrial Bos taurus (Bovine) PR
Q00059 TFAM Transcription factor A, mitochondrial Homo sapiens (Human) PR
P17480 UBTF Nucleolar transcription factor 1 Homo sapiens (Human) EV
P40630 Tfam Transcription factor A, mitochondrial Mus musculus (Mouse) PR
Q3USZ2 Ubtfl1 Upstream-binding factor 1-like protein 1 Mus musculus (Mouse) PR
P25976 Ubtf Nucleolar transcription factor 1 Mus musculus (Mouse) PR
Q5D144 TFAM Transcription factor A, mitochondrial Sus scrofa (Pig) PR
Q9T012 HMGB13 High mobility group B protein 13 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SUP7 HMGB6 High mobility group B protein 6 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNGEADCPTD LEMAAPKGQD RWSQEDMLTL LECMKNNLPS NDSSKFKTTE SHMDWEKVAF
70 80 90 100 110 120
KDFSGDMCKL KWVEISNEVR KFRTLTELIL DAQEHVKNPY KGKKLKKHPD FPKKPLTPYF
130 140 150 160 170 180
RFFMEKRAKY AKLHPEMSNL DLTKILSKKY KELPEKKKMK YIQDFQREKQ EFERNLARFR
190 200 210 220 230 240
EDHPDLIQNA KKSDIPEKPK TPQQLWYTHE KKVYLKVRPD ATTKEVKDSL GKQWSQLSDK
250 260 270 280 290 300
KRLKWIHKAL EQRKEYEEIM RDYIQKHPEL NISEEGITKS TLTKAERQLK DKFDGRPTKP
310 320 330 340 350 360
PPNSYSLYCA ELMANMKDVP STERMVLCSQ QWKLLSQKEK DAYHKKCDQK KKDYEVELLR
370 380 390 400 410 420
FLESLPEEEQ QRVLGEEKML NINKKQTTSP ASKKPSQEGG KGGSEKPKRP VSAMFIFSEE
430 440 450 460 470 480
KRRQLQEERP ELSESELTRL LARMWNDLSE KKKAKYKARE AALKAQSERK PGGEREDRGK
490 500 510 520 530 540
LPESPKRAEE IWQQSVIGDY LARFKNDRVK ALKAMEMTWN NMEKKEKLMW IKKAAEDQKR
550 560 570 580 590 600
YERELSEMRA PPAATNSSKK MKFQGEPKKP PMNGYQKFSQ ELLSNGELNH LPLKERMVEI
610 620 630 640 650 660
GSRWQRISQS QKEHYKKLAE EQQRQYKVHL DLWVKSLSPQ DRAAYKEYIS NKRKNMTKLR
670 680 690 700 710 720
GPNPKSSRTT LQSKSESEED DDEEDDDDDD EEEEEDDENG DSSEDGGDSS ESSSEDESED
730 740 750 760
GDENEDDDDD EDDDEDDDED EDNESEGSSS SSSSSGDSSD SDSN