P25867

PR
Gene name
eff (UbcD1, CG7425)
Protein name
Ubiquitin-conjugating enzyme E2-17 kDa
Names
E2 ubiquitin-conjugating enzyme D1, Protein effete, Ubiquitin carrier protein, Ubiquitin-protein ligase
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG7425
EC number
2.3.2.23: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P25867

Entry ID Method Resolution Chain Position Source
AF-P25867-F1 Predicted AlphaFoldDB

No variants for P25867

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P25867

No associated diseases with P25867

2 regional properties for P25867

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 1 - 147 IPR000608
active_site Ubiquitin-conjugating enzyme, active site 74 - 89 IPR023313

Functions

Description
EC Number 2.3.2.23 Aminoacyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

17 GO annotations of biological process

Name Definition
anaphase-promoting complex-dependent catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.
chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
compound eye morphogenesis The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
compound eye photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.
female germ-line stem cell asymmetric division The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes.
germ-line stem cell population maintenance Any process by which an organism or tissue maintains a population of germ-line stem cells.
male meiotic nuclear division A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
negative regulation of smoothened signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
neuron remodeling The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
peptidoglycan recognition protein signaling pathway The series of molecular signals initiated by binding of peptidoglycan to a receptor and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides.
protein linear polyubiquitination A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
regulation of protein stability Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
regulation of R7 cell differentiation Any process that modulates the frequency, rate or extent of R7 differentiation.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32LD2 UBE2T Ubiquitin-conjugating enzyme E2 T Bos taurus (Bovine) PR
Q5ZJJ5 AKTIP AKT-interacting protein Gallus gallus (Chicken) PR
P35128 ben Ubiquitin-conjugating enzyme E2 N Drosophila melanogaster (Fruit fly) PR
P52486 Ubc4 Ubiquitin-conjugating enzyme E2-22 kDa Drosophila melanogaster (Fruit fly) PR
P52487 Ubc84D Ubiquitin-conjugating enzyme E2-18 kDa Drosophila melanogaster (Fruit fly) PR
Q9VX25 CG8188 Ubiquitin-conjugating enzyme E2 S Drosophila melanogaster (Fruit fly) SS
Q9NPD8 UBE2T Ubiquitin-conjugating enzyme E2 T Homo sapiens (Human) PR
Q96LR5 UBE2E2 Ubiquitin-conjugating enzyme E2 E2 Homo sapiens (Human) PR
Q969T4 UBE2E3 Ubiquitin-conjugating enzyme E2 E3 Homo sapiens (Human) PR
Q9H8T0 AKTIP AKT-interacting protein Homo sapiens (Human) PR
Q9CQ37 Ube2t Ubiquitin-conjugating enzyme E2 T Mus musculus (Mouse) PR
P52483 Ube2e3 Ubiquitin-conjugating enzyme E2 E3 Mus musculus (Mouse) PR
P61079 Ube2d3 Ubiquitin-conjugating enzyme E2 D3 Mus musculus (Mouse) PR
Q64362 Aktip AKT-interacting protein Mus musculus (Mouse) PR
Q5FVH4 Aktip AKT-interacting protein Rattus norvegicus (Rat) PR
P35129 let-70 Ubiquitin-conjugating enzyme E2 2 Caenorhabditis elegans PR
Q9LJD7 COP10 Constitutive photomorphogenesis protein 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8X7 UBC31 Probable ubiquitin-conjugating enzyme E2 31 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SLE4 UBC29 Ubiquitin-conjugating enzyme E2 29 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MALKRINKEL QDLGRDPPAQ CSAGPVGDDL FHWQATIMGP PDSPYQGGVF FLTIHFPTDY
70 80 90 100 110 120
PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV
130 140
PEIARIYKTD REKYNELARE WTRKYAM