P25799

EV
Gene name
Nfkb1
Protein name
Nuclear factor NF-kappa-B p105 subunit [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
Names
DNA-binding factor KBF1, EBP-1, NF-kappa-B1 p84/NF-kappa-B1 p98, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:18033
EC number
Protein Class
NUCLEAR FACTOR NF-KAPPA-B PROTEIN (PTHR24169)

Descriptions

NFκB1 is a nuclear factor NFκB p105 subunit (p50 and its precursor p105), and plays pivotal role in the regulation of the inflammatory response to pathogens, autoimmune diseases, and cancerous cells. The five members of the NF-κB family are normally kept inactive in the cytoplasm by interaction with inhibitors called IκBs or the unprocessed forms of NF-κB1 and NF-κB2. The C-terminal ankyrin repeats of p105 allow it to serve as an IkappaB-like function. The ankyrin repeats interact with and shield the nuclear localization signal located at the end of Rel-homology domain (RHD) domain and DNA binding of Rel/NF-kappaB complexes. RHD domain mediates DNA binding.

Autoinhibitory domains (AIDs)

535-793 (Ankyrin repeat-containing domain) EV

Target domain

37-350 (Rel-homology domain)

Relief mechanism

Cleavage, PTM

Assay

Deletion assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

21 structures for P25799

Entry ID Method Resolution Chain Position Source
1BFS X-ray 220 A A 245-350 PDB
1IKN X-ray 230 A C 245-363 PDB
1LE5 X-ray 275 A B/F 39-350 PDB
1LE9 X-ray 300 A B/F 39-350 PDB
1LEI X-ray 270 A B 39-350 PDB
1NFK X-ray 230 A A/B 39-363 PDB
1OOA X-ray 245 A A/B 39-363 PDB
1U36 X-ray 189 A A 245-350 PDB
1U3J X-ray 190 A A 245-350 PDB
1U3Y X-ray 190 A A 245-350 PDB
1U3Z X-ray 190 A A 245-350 PDB
1U41 X-ray 220 A A/B/C/D 245-350 PDB
1U42 X-ray 270 A A 245-350 PDB
1VKX X-ray 290 A B 39-350 PDB
2I9T X-ray 280 A B 39-350 PDB
2V2T X-ray 305 A B 38-363 PDB
3JV4 X-ray 315 A B/D/F 245-359 PDB
8TKL X-ray 300 A A/B 39-350 PDB
8TKM X-ray 280 A A/B 39-350 PDB
8TKN X-ray 280 A A/B 39-350 PDB
AF-P25799-F1 Predicted AlphaFoldDB

44 variants for P25799

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1133337474 18 A>P No EVA
rs3388665277 46 E>D No EVA
rs3388667079 67 L>F No EVA
rs3388662711 68 P>T No EVA
rs3388667106 70 A>T No EVA
rs3388662742 82 V>I No EVA
rs3388665310 84 I>T No EVA
rs3388660434 92 K>N No EVA
rs232176681 120 V>I No EVA
rs3388665317 126 G>* No EVA
rs3388653075 146 K>T No EVA
rs3388660474 160 I>E No EVA
rs3388660433 176 L>V No EVA
rs3388669918 177 Q>E No EVA
rs3388662237 179 E>D No EVA
rs3388665675 179 E>V No EVA
rs3388653011 261 T>S No EVA
rs3410540297 262 G>E No EVA
rs3388660518 292 W>G No EVA
rs3410332036 297 D>N No EVA
rs3388660476 309 I>L No EVA
rs3388659441 313 T>S No EVA
rs3388666591 343 K>N No EVA
rs3388662657 387 G>A No EVA
rs262241696 405 S>P No EVA
rs234322611 406 N>H No EVA
rs218495059 421 V>A No EVA
rs263027543 450 E>K No EVA
rs3541877264 476 P>S No EVA
rs3388659393 570 I>T No EVA
rs3388666588 581 P>L No EVA
rs3388665280 581 P>T No EVA
rs36503768 596 D>E No EVA
rs3388662663 604 L>Q No EVA
rs3388647956 610 W>S No EVA
rs3388662236 619 A>T No EVA
rs231728937 628 S>G No EVA
rs3388647904 686 H>L No EVA
rs3388660502 706 A>T No EVA
rs3388647983 743 V>* No EVA
rs3388665702 757 E>K No EVA
rs3388669302 821 I>N No EVA
rs3388665293 833 Q>* No EVA
rs3388662129 914 T>S No EVA

No associated diseases with P25799

2 regional properties for P25799

Type Name Position InterPro Accession
domain Sec7 domain 54 - 243 IPR000904
domain Pleckstrin homology domain 259 - 378 IPR001849

Functions

Description
EC Number
Subcellular Localization
  • [Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm
  • ;
PANTHER Family PTHR24169 NUCLEAR FACTOR NF-KAPPA-B PROTEIN
PANTHER Subfamily PTHR24169:SF9 NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT
PANTHER Protein Class DNA-binding transcription factor
Rel homology transcription factor
immunoglobulin fold transcription factor
PANTHER Pathway Category Inflammation mediated by chemokine and cytokine signaling pathway
NFkappaB
B cell activation
NFkappaB
T cell activation
NFkappaB
Toll receptor signaling pathway
NFkappaB
Apoptosis signaling pathway
NFkappaB

8 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
NF-kappaB complex A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

19 GO annotations of molecular function

Name Definition
actinin binding Binding to actinin, any member of a family of proteins that crosslink F-actin.
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription repressor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
double-stranded DNA binding Binding to double-stranded DNA.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
heat shock protein binding Binding to a heat shock protein, a protein synthesized or activated in response to heat shock.
identical protein binding Binding to an identical protein or proteins.
protein-containing complex binding Binding to a macromolecular complex.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
transcription coactivator binding Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

50 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
B cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
cellular response to angiotensin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.
cellular response to brain-derived neurotrophic factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus.
cellular response to carbohydrate stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.
cellular response to cytokine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
cellular response to diterpene Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diterpene stimulus.
cellular response to dsRNA Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus.
cellular response to glucoside Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus.
cellular response to interleukin-1 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
cellular response to interleukin-17 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus.
cellular response to interleukin-6 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to mechanical stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
cellular response to nicotine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
cellular response to organic cyclic compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
cellular response to peptide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.
cellular response to tumor necrosis factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
cellular response to virus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
gene expression The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes.
I-kappaB kinase/NF-kappaB signaling The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
JNK cascade An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier
lymph node development The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes.
mammary gland involution The tissue remodeling that removes differentiated mammary epithelia during weaning.
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of calcidiol 1-monooxygenase activity Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction
negative regulation of cytokine production Any process that stops, prevents, or reduces the rate of production of a cytokine.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of inflammatory response Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
negative regulation of interleukin-12 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
NIK/NF-kappaB signaling The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
positive regulation of canonical Wnt signaling pathway Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of hyaluronan biosynthetic process Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process.
positive regulation of miRNA metabolic process Any process that activates or increases the frequency, rate or extent of miRNA metabolic process.
positive regulation of miRNA transcription Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription.
positive regulation of miRNA-mediated gene silencing A process that activates or increases the frequency, rate or extent of gene silencing by a microRNA (miRNA).
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of transcription initiation by RNA polymerase II Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to cytokine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
response to muscle stretch Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.
response to organic cyclic compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P98150 NFKB2 Nuclear factor NF-kappa-B p100 subunit Gallus gallus (Chicken) SS
Q04861 NFKB1 Nuclear factor NF-kappa-B p105 subunit Gallus gallus (Chicken) SS
Q6F3J0 NFKB1 Nuclear factor NF-kappa-B p105 subunit Canis lupus familiaris (Dog) (Canis familiaris) SS
Q94527 Rel Nuclear factor NF-kappa-B p110 subunit Drosophila melanogaster (Fruit fly) EV
Q99549 MPHOSPH8 M-phase phosphoprotein 8 Homo sapiens (Human) PR
Q8N9B4 ANKRD42 Ankyrin repeat domain-containing protein 42 Homo sapiens (Human) PR
Q6ZVZ8 ASB18 Ankyrin repeat and SOCS box protein 18 Homo sapiens (Human) PR
Q00653 NFKB2 Nuclear factor NF-kappa-B p100 subunit Homo sapiens (Human) SS
P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit Homo sapiens (Human) SS
Q04206 RELA Transcription factor p65 Homo sapiens (Human) EV
Q9CZK6 Anks3 Ankyrin repeat and SAM domain-containing protein 3 Mus musculus (Mouse) PR
Q8VHA6 Asb18 Ankyrin repeat and SOCS box protein 18 Mus musculus (Mouse) PR
Q04207 Rela Transcription factor p65 Mus musculus (Mouse) SS
Q9WTK5 Nfkb2 Nuclear factor NF-kappa-B p100 subunit [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] Mus musculus (Mouse) EV
Q9TZM3 lrk-1 Leucine-rich repeat serine/threonine-protein kinase 1 Caenorhabditis elegans SS
O22265 CAO Signal recognition particle 43 kDa protein, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q9SZI3 NPR2 Regulatory protein NPR2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MADDDPYGTG QMFHLNTALT HSIFNAELYS PEIPLSTDGP YLQILEQPKQ RGFRFRYVCE
70 80 90 100 110 120
GPSHGGLPGA SSEKNKKSYP QVKICNYVGP AKVIVQLVTN GKNIHLHAHS LVGKHCEDGV
130 140 150 160 170 180
CTVTAGPKDM VVGFANLGIL HVTKKKVFET LEARMTEACI RGYNPGLLVH SDLAYLQAEG
190 200 210 220 230 240
GGDRQLTDRE KEIIRQAAVQ QTKEMDLSVV RLMFTAFLPD STGSFTRRLE PVVSDAIYDS
250 260 270 280 290 300
KAPNASNLKI VRMDRTAGCV TGGEEIYLLC DKVQKDDIQI RFYEEEENGG VWEGFGDFSP
310 320 330 340 350 360
TDVHRQFAIV FKTPKYKDVN ITKPASVFVQ LRRKSDLETS EPKPFLYYPE IKDKEEVQRK
370 380 390 400 410 420
RQKLMPNFSD SFGGGSGAGA GGGGMFGSGG GGGSTGSPGP GYGYSNYGFP PYGGITFHPG
430 440 450 460 470 480
VTKSNAGVTH GTINTKFKNG PKDCAKSDDE ESLTLPEKET EGEGPSLPMA CTKTEPIALA
490 500 510 520 530 540
STMEDKEQDM GFQDNLFLEK ALQLARRHAN ALFDYAVTGD VKMLLAVQRH LTAVQDENGD
550 560 570 580 590 600
SVLHLAIIHL HAQLVRDLLE VTSGLISDDI INMRNDLYQT PLHLAVITKQ EDVVEDLLRV
610 620 630 640 650 660
GADLSLLDRW GNSVLHLAAK EGHDRILSIL LKSRKAAPLI DHPNGEGLNA IHIAVMSNSL
670 680 690 700 710 720
PCLLLLVAAG AEVNAQEQKS GRTALHLAVE YDNISLAGCL LLEGDAHVDS TTYDGTTPLH
730 740 750 760 770 780
IAAGRGSTRL AALLKAAGAD PLVENFEPLY DLDDSWEKAG EDEGVVPGTT PLDMAANWQV
790 800 810 820 830 840
FDILNGKPYE PVFTSDDILP QGDMKQLTED TRLQLCKLLE IPDPDKNWAT LAQKLGLGIL
850 860 870 880 890 900
NNAFRLSPAP SKTLMDNYEV SGGTIKELME ALQQMGYTEA IEVIQAAFRT PATTASSPVT
910 920 930 940 950 960
TAQVHCLPLS SSSTRQHIDE LRDSDSVCDS GVETSFRKLS FTESLTGDSP LLSLNKMPHG
970
YGQEGPIEGK I