P25623
PR
Gene name |
SYP1 (YCR030C, YCR30C/YCR29C) |
Protein name |
Suppressor of yeast profilin deletion |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YCR030C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P25623
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3G9G | X-ray | 240 A | A | 1-264 | PDB |
| 3G9H | X-ray | 280 A | A | 566-870 | PDB |
| AF-P25623-F1 | Predicted | AlphaFoldDB |
15 variants for P25623
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s03-176364 | 24 | T>I | No | SGRP | |
| s03-175324 | 371 | S>P | No | SGRP | |
| s03-175135 | 434 | A>T | No | SGRP | |
| s03-175092 | 448 | P>L | No | SGRP | |
| s03-175034 | 467 | N>K | No | SGRP | |
| s03-174999 | 479 | P>L | No | SGRP | |
| s03-174939 | 499 | I>N | No | SGRP | |
| s03-174910 | 509 | Q>E | No | SGRP | |
| s03-174793 | 548 | N>H | No | SGRP | |
| s03-174778 | 553 | A>P | No | SGRP | |
| s03-174729 | 569 | V>A | No | SGRP | |
| s03-174357 | 693 | S>F | No | SGRP | |
| s03-174185 | 750 | F>L | No | SGRP | |
| s03-174076 | 787 | T>P | No | SGRP | |
| s03-173964 | 824 | V>A | No | SGRP |
No associated diseases with P25623
Functions
12 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell division site | The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. |
| cellular bud neck | The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. |
| cellular bud neck septin ring | A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange. |
| cellular bud tip | The end of a cellular bud distal to the site of attachment to the mother cell. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endocytic patch | The part of the cell cortex consisting of an aggregation of proteins that will give rise to an endocytic vesicle. |
| endocytic vesicle | A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. |
| mating projection base | The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone. |
| mating projection tip | The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| prospore membrane | The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe. |
| Syp1 complex | A protein complex that contributes to the endocytic process and bud growth in yeast. It is involved in the precise timing of actin assembly during endocytosis. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| enzyme inhibitor activity | Binds to and stops, prevents or reduces the activity of an enzyme. |
| identical protein binding | Binding to an identical protein or proteins. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cortical patch assembly | Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells. |
| budding cell bud growth | The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. |
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| negative regulation of catalytic activity | Any process that stops or reduces the activity of an enzyme. |
| positive regulation of endocytosis | Any process that activates or increases the frequency, rate or extent of endocytosis. |
| septin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins. |
| unidimensional cell growth | The process in which a cell irreversibly increases in size in one |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05080 | HOF1 | Cytokinesis protein 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| A7MBI0 | PACSIN1 | Protein kinase C and casein kinase substrate in neurons protein 1 | Bos taurus (Bovine) | SS |
| O13154 | PACSIN2 | Protein kinase C and casein kinase substrate in neurons protein 2 | Gallus gallus (Chicken) | SS |
| Q9UKS6 | PACSIN3 | Protein kinase C and casein kinase substrate in neurons protein 3 | Homo sapiens (Human) | SS |
| Q9BY11 | PACSIN1 | Protein kinase C and casein kinase substrate in neurons protein 1 | Homo sapiens (Human) | EV |
| Q9UNF0 | PACSIN2 | Protein kinase C and casein kinase substrate in neurons protein 2 | Homo sapiens (Human) | EV |
| O60861 | GAS7 | Growth arrest-specific protein 7 | Homo sapiens (Human) | PR |
| Q99JB8 | Pacsin3 | Protein kinase C and casein kinase II substrate protein 3 | Mus musculus (Mouse) | SS |
| Q61644 | Pacsin1 | Protein kinase C and casein kinase substrate in neurons protein 1 | Mus musculus (Mouse) | EV |
| Q9WVE8 | Pacsin2 | Protein kinase C and casein kinase substrate in neurons protein 2 | Mus musculus (Mouse) | EV |
| Q60780 | Gas7 | Growth arrest-specific protein 7 | Mus musculus (Mouse) | PR |
| Q9Z0W5 | Pacsin1 | Protein kinase C and casein kinase substrate in neurons protein 1 | Rattus norvegicus (Rat) | SS |
| Q9QY17 | Pacsin2 | Protein kinase C and casein kinase substrate in neurons 2 protein | Rattus norvegicus (Rat) | SS |
| Q4V920 | pacsin1b | Protein kinase C and casein kinase substrate in neurons protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTEQRTKYAD | SILTTKSPYE | ATETIRIRLS | QVKLLNKDFY | LLFKELANLK | RNYAQQLRKI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IAENEDITKI | LNAQMIESNV | LTPQEMSAFR | FNSLGELRNV | WDTVIEELKS | DLKSSTEYYN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TLDQQVVREL | KESVENNTSW | RESKDLHSKL | SKNAASIEHY | SKNNENSSHL | EEARRQWDQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SPYLFELFET | IDYNRLDTLK | NCMLRFQTSF | SDYLLNTTKE | CETVMTKFLA | FEPQSEIDRF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AKDASQYNFQ | LSSSSKEVVP | NNASPASATG | ARPVSVSNGA | ANTEREKKSP | QKDKRKSAFG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NIGHRLASAS | SSLTHNDLMN | NEFSDSTNNS | SLKSKKSSHT | LRSKVGSIFG | RNKTKNKRQQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QSSSNSHIQA | SITETPNNSS | TRVSSTATSS | IYQKQRRPTY | SSSKSNNWTP | GEASDTPPLP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PHATPKNVDA | PVTADTPPAQ | TFTPSEVPPS | TPQQSSPPTA | KEPDSSNLPK | TVPISISQPP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LQPQSKTKPL | PVEPASPSIS | LPTATVDNQP | SGQVDSRPLH | IRAPALPPSR | KQNFIHNRDS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QLYDSLPNHG | SGATPTSSSL | SSIPQERPVS | TLSSQITGEL | RELNPQATGS | STSLVGQSLF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QHSSLDTSQF | GLNASIAEVL | NASFKDGMLQ | NSQLIGEIAL | NYLPNSVMNS | PLPIGINLRI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NNGAKFEKVI | LNQAFIERVA | PEEFKVNPSF | IDSRTLGAIK | YSIKEPIAPI | VIHPVWRFES |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HQASVVLTVK | MSPSLPDEIS | QIVIEDLVVF | VNIDGANATS | ALSKPQGSFS | KEKKRITWRF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KEPVVLTRNG | EGQRLIARFI | TDGLAHESAK | GVITKFTISE | TDNVALPHSG | AGSGITLTCQ |
| 850 | 860 | ||||
| ELDENNPFGG | EWLDVNTKRT | LTTGNYHGLA |