AiPD: Autoinhibited Protein Database

P25490

Gene name	YY1 (INO80S)
Protein name	Transcriptional repressor protein YY1
Names	Delta transcription factor, INO80 complex subunit S, NF-E1, Yin and yang 1, YY-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7528
EC number
Protein Class

Descriptions

YY1 is a multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. This protein possesses intrinsically disordered regions (IDRs) with large negative charge, some of which involve a consecutive sequence of aspartate (D) or glutamate (E) residues, known as D/E repeats. These D/E repeats can cause autoinhibition through intramolecular electrostatic interaction with HMG boxes and modulate binding to DNA. This autoinhibited state can transition into the uninhibited complex with DNA through an electrostatically driven induced-fit process, which accelerates the target DNA search kinetics in the presence of non-functional high-affinity ligands ('decoys').

Autoinhibitory domains (AIDs)

43-53 (D/E repeat) SS

Target domain	296-320 (zinc-finger domain)
Relief mechanism
Assay

AID

43-53 (D/E repeat)

Target domain

296-320 (zinc-finger domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for P25490

Entry ID	Method	Resolution	Chain	Position	Source
1UBD	X-ray	250 A	C	291-414	PDB
1ZNM	NMR	-	A	352-379	PDB
4C5I	X-ray	259 A	C	199-228	PDB
AF-P25490-F1	Predicted				AlphaFoldDB

196 variants for P25490

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV001291657 CA390971162 rs1246486173	68	A>T	Gabriele de Vries syndrome [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
rs76675246 RCV001198476	80	H>missing	Gabriele de Vries syndrome [ClinVar]	Yes	ClinVar dbSNP
rs770164761 RCV002292371 CA7344016	144	D>N	Gabriele de Vries syndrome [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
rs1890695996 RCV001266005 RCV001268245	157	G>missing	Inborn genetic diseases [ClinVar]	Yes	ClinVar dbSNP
rs1890697895 RCV001331054	176	G>D	Gabriele de Vries syndrome [ClinVar]	Yes	ClinVar dbSNP
rs1131692046 RCV000494728 CA390972436	179	K>*	Gabriele de Vries syndrome [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
VAR_079202	179	K>del	GADEVS [UniProt]	Yes	UniProt
RCV001331052 rs1890698987	188	G>S	Gabriele de Vries syndrome [ClinVar]	Yes	ClinVar dbSNP
RCV001266108 rs1891321014	319	T>I	Inborn genetic diseases [ClinVar]	Yes	ClinVar dbSNP
VAR_079203	320	H>Y	GADEVS; unknown pathological significance [UniProt]	Yes	UniProt
RCV000623107 CA390968879 rs1555370868 VAR_079204	339	K>Q	Inborn genetic diseases GADEVS; unknown pathological significance [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
rs1131692045 RCV000494726 CA390968945	344	Q>*	Gabriele de Vries syndrome [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
VAR_079205	344	Q>del	GADEVS [UniProt]	Yes	UniProt
CA390969338 rs1131692163 VAR_079206 RCV000494727	366	L>P	Gabriele de Vries syndrome GADEVS; reduced DNA-binding; reduced transcription regulator activity [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
RCV000494721 VAR_079207 CA390969334 rs1131692044	366	L>V	Gabriele de Vries syndrome GADEVS; unknown pathological significance [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
RCV001254142 rs1891340236	373	H>R	Gabriele de Vries syndrome [ClinVar]	Yes	ClinVar dbSNP
RCV000494725 CA390969516 rs1131692043 VAR_065086	380	D>Y	Gabriele de Vries syndrome GADEVS; reduced DNA-binding; reduced transcription regulator activity [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
rs1891340702 RCV001266764	387	F>missing	Inborn genetic diseases [ClinVar]	Yes	ClinVar dbSNP
VAR_079208	393	K>del	GADEVS; unknown pathological significance [UniProt]	Yes	UniProt
rs1472368019 CA390970735	4	G>R		No	ClinGen gnomAD
CA390970753 rs1415949028	6	T>I		No	ClinGen gnomAD
CA390970764 rs1458971641	8	Y>C		No	ClinGen gnomAD
CA390970761 rs1389479798	8	Y>H		No	ClinGen TOPMed gnomAD
rs552013894 CA7343911	9	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1286455232 CA390970776	10	A>S		No	ClinGen gnomAD
CA390970782 rs1271244582	11	T>S		No	ClinGen TOPMed
rs1329282810 CA390970804	14	S>L		No	ClinGen gnomAD
rs890220415 CA266822582	16	M>I		No	ClinGen TOPMed gnomAD
CA390970848 rs1210643562	20	I>M		No	ClinGen gnomAD
rs1471534078 CA390970861	22	E>D		No	ClinGen gnomAD
CA390970882 rs201492732	25	E>D		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA390970885 rs1171014537	26	I>V		No	ClinGen gnomAD
CA266822588 rs112723009	27	E>G		No	ClinGen Ensembl
rs1367623299 CA390970909	29	E>V		No	ClinGen TOPMed
CA7343917 rs777497914	31	I>V		No	ClinGen ExAC gnomAD
CA390970930 rs770757387	33	V>L		No	ClinGen ExAC TOPMed gnomAD
CA7343919 rs770757387	33	V>M		No	ClinGen ExAC TOPMed gnomAD
rs776452688 CA390970947	35	T>I		No	ClinGen ExAC TOPMed gnomAD
rs776452688 CA7343920	35	T>N		No	ClinGen ExAC TOPMed gnomAD
CA7343923 rs774374231	40	V>L		No	ClinGen ExAC TOPMed gnomAD
CA390970985 rs1595309412	41	V>G		No	ClinGen Ensembl
rs1280409322 CA390970989	42	G>D		No	ClinGen gnomAD
CA390971010 rs1204309662	45	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	46	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761956344 CA7343929	46	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1252510326 CA390971016	46	E>K		No	ClinGen TOPMed gnomAD
CA7343931 rs142619613 RCV000889047	47	E>D		No	ClinGen ClinVar 1000Genomes ESP TOPMed dbSNP
CA7343930 rs767575930	47	E>G		No	ClinGen ExAC gnomAD
rs1478451548 CA390971036	48	D>E		No	ClinGen TOPMed gnomAD
CA390971030 rs1377144885	48	D>N		No	ClinGen gnomAD
rs1388676369 CA390971043	49	D>E		No	ClinGen gnomAD
CA266822673 rs867447858	49	D>G		No	ClinGen Ensembl
rs968693718 CA266822677	50	D>G		No	ClinGen TOPMed gnomAD
rs1452403732 CA390971063	52	E>A		No	ClinGen TOPMed gnomAD
rs750643631 CA7343937	52	E>D		No	ClinGen ExAC gnomAD
rs1309162432 CA390971059	52	E>K		No	ClinGen gnomAD
rs554380259 CA266822685	53	D>E		No	ClinGen Ensembl
rs1320953843 CA390971086	56	G>R		No	ClinGen TOPMed gnomAD
rs1320953843 CA390971085	56	G>S		No	ClinGen TOPMed gnomAD
CA7343941 rs766816538	57	G>D		No	ClinGen ExAC gnomAD
rs1189077917 CA390971100	58	D>G		No	ClinGen TOPMed
rs1467500093 CA390971112	60	G>S		No	ClinGen gnomAD
rs201197093 CA266822708	64	G>D		No	ClinGen 1000Genomes
rs1275256666 CA390971141	65	H>N		No	ClinGen gnomAD
rs376271434 CA7343947	65	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV001227270 rs1275256666 CA390971143	65	H>Y		No	ClinGen ClinVar dbSNP gnomAD
rs1452296158 CA390971155	67	H>D		No	ClinGen gnomAD
CA390971160 rs777217783	67	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA7343950 rs746643331	68	A>G		No	ClinGen ExAC TOPMed gnomAD
CA7343958 rs780916558	70	H>P		No	ClinGen ExAC gnomAD
rs780916558 CA7343959	70	H>R		No	ClinGen ExAC gnomAD
rs1353105136 CA390971202	71	H>R		No	ClinGen Ensembl
CA7343960 rs769652713	72	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1566765700 CA390971243	73	H>Q		No	ClinGen Ensembl
rs1237081802 CA390971261	74	H>Q		No	ClinGen TOPMed
CA266822799 rs1038824676	76	H>D		No	ClinGen TOPMed gnomAD
rs762854228 CA390971319	77	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA390971361 rs1397863470	80	H>P		No	ClinGen TOPMed
rs772186005 CA7343973	80	H>Q		No	ClinGen ExAC gnomAD
rs997054119 CA266822816	81	P>Q		No	ClinGen TOPMed
CA7343974 rs773201959	82	P>S		No	ClinGen ExAC gnomAD
rs760925279 CA7343975	84	I>F		No	ClinGen ExAC gnomAD
rs766727266 CA7343976	84	I>T		No	ClinGen ExAC gnomAD
rs1465323890 CA390971460	88	P>S		No	ClinGen TOPMed
rs765758223 CA390971474	89	L>V		No	ClinGen ExAC gnomAD
rs1160058509 CA390971496	91	T>P		No	ClinGen TOPMed
TCGA novel	94	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390971553 rs1314257490	97	V>M		No	ClinGen gnomAD
rs1422473858 CA390971568	99	H>Y		No	ClinGen gnomAD
CA7343985 rs756864544	101	Q>H		No	ClinGen ExAC gnomAD
rs539908009 CA7343988	109	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs1311918952 CA390971650	111	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1340924267 CA390971653	111	E>V		No	ClinGen gnomAD
rs1328626457 CA390971677	115	G>D		No	ClinGen gnomAD
TCGA novel	117	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA266822931 rs866340291	118	S>*		No	ClinGen Ensembl
rs1208791544 CA390971724	120	G>E		No	ClinGen gnomAD
rs759906771 CA7343997	120	G>R		No	ClinGen ExAC gnomAD
rs1249577058 CA390971735	121	L>R		No	ClinGen gnomAD
CA390971740 rs1180677286	122	R>C		No	ClinGen gnomAD
CA266822950 COSM242295 rs965298843	123	A>T	prostate [Cosmic]	No	ClinGen cosmic curated Ensembl
CA390971813 rs1346667862	127	F>L		No	ClinGen TOPMed gnomAD
rs976835161 CA266822957	127	F>Y		No	ClinGen Ensembl
TCGA novel	128	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1464236898 CA390971817	128	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
RCV001008768 rs1595309671	129	D>missing		No	ClinVar dbSNP
rs1452149800 CA390971833	129	D>N		No	ClinGen gnomAD
rs1306145498 CA390971909	135	V>E		No	ClinGen gnomAD
CA7344003 rs756772698	136	P>H		No	ClinGen ExAC TOPMed gnomAD
CA390971916 rs1229149356	136	P>S		No	ClinGen gnomAD
CA7344004 rs767071328	137	A>V		No	ClinGen ExAC
CA7344005 rs750069951	139	A>P		No	ClinGen ExAC gnomAD
CA7344006 rs755802001	139	A>V		No	ClinGen ExAC TOPMed gnomAD
rs749056291 CA7344008	140	G>A		No	ClinGen ExAC gnomAD
CA390971964 rs749056291	140	G>D		No	ClinGen ExAC gnomAD
CA7344012 COSM2261793 rs748178185	141	G>D	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed
CA7344010 rs139565994	141	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7344014 rs776893346	143	D>E		No	ClinGen ExAC TOPMed gnomAD
CA7344017 rs775885326	144	D>E		No	ClinGen ExAC TOPMed gnomAD
rs770164761 CA390972008	144	D>H		No	ClinGen ExAC gnomAD
CA7344020 rs769149627	145	Y>C		No	ClinGen ExAC gnomAD
rs769149627 CA7344019	145	Y>F		No	ClinGen ExAC gnomAD
rs766981294 CA390972091	150	L>V		No	ClinGen ExAC TOPMed gnomAD
CA7344023 rs749983365	152	T>A		No	ClinGen ExAC gnomAD
rs760269210 CA7344024	153	V>M		No	ClinGen ExAC TOPMed gnomAD
CA7344025 rs765975441	155	A>E		No	ClinGen ExAC gnomAD
CA390972169 rs1226735353	157	G>D		No	ClinGen gnomAD
rs754738960 CA7344027	157	G>S		No	ClinGen ExAC TOPMed gnomAD
CA7344028 rs778839522	158	K>R		No	ClinGen ExAC gnomAD
rs752652665 CA7344030	159	S>N		No	ClinGen ExAC TOPMed gnomAD
CA390972235 rs576505331	163	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs576505331 CA7344032	163	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745977468 CA7344033	164	S>P		No	ClinGen ExAC TOPMed gnomAD
CA390972267 rs1389336201	165	S>L		No	ClinGen gnomAD
CA390972262 rs1166413085	165	S>P		No	ClinGen gnomAD
TCGA novel	166	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390972292 rs1172486228	167	S>L		No	ClinGen gnomAD
rs1457520050 CA390972311	169	G>D		No	ClinGen gnomAD
CA266823071 rs928224334	170	G>D		No	ClinGen TOPMed gnomAD
CA390972325 rs928224334	170	G>V		No	ClinGen TOPMed gnomAD
rs1169201571 CA390972328	171	R>G		No	ClinGen TOPMed
CA390972333 rs1373381977	171	R>L		No	ClinGen gnomAD
CA7344035 rs780154054	173	K>R		No	ClinGen ExAC gnomAD
CA390972363 rs1247704599	174	K>Q		No	ClinGen TOPMed
rs1199293045 CA390972391	176	G>S		No	ClinGen TOPMed
CA390972412 rs1319394671	177	G>D		No	ClinGen gnomAD
CA390972445 rs1273277003	179	K>N		No	ClinGen gnomAD
CA390972452 rs1469487250	180	S>N		No	ClinGen gnomAD
CA390972467 rs1317050894	181	G>D		No	ClinGen TOPMed
CA390972480 rs1247141189	182	K>R		No	ClinGen gnomAD
rs1555368900 RCV000657546	184	S>missing		No	ClinVar dbSNP
CA390972539 rs1436001778	186	L>F		No	ClinGen gnomAD
CA390972536 rs1436001778	186	L>V		No	ClinGen gnomAD
rs1423177521 CA390972555	187	S>T		No	ClinGen TOPMed gnomAD
CA390972571 rs1299212066	188	G>V		No	ClinGen Ensembl
CA7344043 rs772586727	191	G>A		No	ClinGen ExAC TOPMed gnomAD
rs772586727 CA390972609	191	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1477254750 CA390972615	192	A>T		No	ClinGen TOPMed
rs1566766060 CA390972621	192	A>V		No	ClinGen Ensembl
CA390972649 rs1282942458	195	G>S		No	ClinGen gnomAD
rs1196662677 CA390972716	200	P>L		No	ClinGen TOPMed
CA7344045 rs760179330	201	G>D		No	ClinGen ExAC gnomAD
CA7344046 rs371252181	202	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1375424134 CA390972769	204	K>N		No	ClinGen Ensembl
rs1217595948 CA390972796	206	E>G		No	ClinGen TOPMed gnomAD
rs1595309901 CA390972827	208	K>R		No	ClinGen Ensembl
rs1220415087 CA390972853	210	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1235535640 CA390972887	213	K>Q		No	ClinGen gnomAD
CA390972940 rs1188606390	217	G>S		No	ClinGen gnomAD
CA390973054 rs1409081046	225	S>P		No	ClinGen gnomAD
rs759536629	231	D>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	235	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	244	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs919458830 CA266790387	260	L>I		No	ClinGen gnomAD
rs75348257 CA7344068	270	L>I		No	ClinGen 1000Genomes ExAC gnomAD
CA7344069 rs76852509	270	L>R		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	278	E>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1289426653 CA390967566	280	A>V		No	ClinGen TOPMed
rs1555370811 RCV000498533	287	I>missing		No	ClinVar dbSNP
rs774336349 CA7344091	287	I>L		No	ClinGen ExAC gnomAD
TCGA novel	289	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	292	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390968305 rs1485741517	299	P>A		No	ClinGen gnomAD
CA390968376 rs1311599551	304	T>S		No	ClinGen TOPMed
TCGA novel	314	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	316	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390968710 rs1189366704	327	C>S		No	ClinGen gnomAD
rs1184263696 CA390968861	337	S>R		No	ClinGen gnomAD
TCGA novel	339	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	358	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	363	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	363	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_074172 COSM1717684 rs386834266 CA232225 RCV000122507	372	T>R	adrenal_gland found in patients with late onset insulinomas; alters DNA-binding motif; increases transactivation activity; produces a constitutive activation of cAMP and Ca2+ signaling pathways involved in insulin secretion [Cosmic, UniProt]	No	ClinGen cosmic curated ClinVar UniProt Ensembl dbSNP
TCGA novel	377	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	379	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	411	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

1 associated diseases with P25490

[MIM: 617557]: Gabriele-de Vries syndrome (GADEVS)

An autosomal dominant neurodevelopmental disorder characterized by delayed psychomotor development and intellectual disability. Most patients have behavioral and feeding problems, movement abnormalities, mild distal skeletal anomalies, and dysmorphic facial features. . Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

An autosomal dominant neurodevelopmental disorder characterized by delayed psychomotor development and intellectual disability. Most patients have behavioral and feeding problems, movement abnormalities, mild distal skeletal anomalies, and dysmorphic facial features. . Note=The disease is caused by variants affecting the gene represented in this entry.

3 regional properties for P25490

Type	Name	Position	InterPro Accession
conserved_site	14-3-3 protein, conserved site	45 - 55	IPR023409-1
conserved_site	14-3-3 protein, conserved site	217 - 236	IPR023409-2
domain	14-3-3 domain	7 - 248	IPR023410

Functions

		Description
EC Number
Subcellular Localization	Nucleus matrix	Associated with the nuclear matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
chromatin silencing complex	Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.
Ino80 complex	A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity.
nuclear matrix	The dense fibrillar network lying on the inner side of the nuclear membrane.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
PcG protein complex	A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
transcription regulator complex	A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

15 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor binding	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
DNA-binding transcription repressor activity	A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
DNA-binding transcription repressor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
four-way junction DNA binding	Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
metal ion binding	Binding to a metal ion.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
SMAD binding	Binding to a SMAD signaling protein.
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

31 GO annotations of biological process

Name	Definition
anterior/posterior pattern specification	The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
B cell differentiation	The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
camera-type eye morphogenesis	The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
cellular response to interleukin-1	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
cellular response to UV	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
chromatin remodeling	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
DNA damage response	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
double-strand break repair via homologous recombination	The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
immunoglobulin heavy chain V-D-J recombination	The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
negative regulation of cell growth involved in cardiac muscle cell development	Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of interferon-beta production	Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production.
negative regulation of miRNA transcription	Any process that stops, prevents or reduces the frequency, rate or extent of microRNA (miRNA) gene transcription.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of DNA repair	Any process that activates or increases the frequency, rate or extent of DNA repair.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of telomere maintenance in response to DNA damage	Any process that activates or increases the frequency, rate or extent of telomere maintenance in response to DNA damage.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.
regulation of chromosome organization	Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.
regulation of DNA repair	Any process that modulates the frequency, rate or extent of DNA repair.
regulation of DNA replication	Any process that modulates the frequency, rate or extent of DNA replication.
regulation of DNA strand elongation	Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand.
regulation of embryonic development	Any process that modulates the frequency, rate or extent of embryonic development.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to prostaglandin F	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus.
response to UV-C	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm.
RNA localization	A process in which RNA is transported to, or maintained in, a specific location.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
telomere maintenance	Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

177 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q08DS3	OSR1	Protein odd-skipped-related 1	Bos taurus (Bovine)	PR
Q2VWH6	FEZF2	Fez family zinc finger protein 2	Bos taurus (Bovine)	PR
A6QNZ0	ZSCAN26	Zinc finger and SCAN domain-containing protein 26	Bos taurus (Bovine)	PR
A7MBI1	ZFP69	Zinc finger protein 69 homolog	Bos taurus (Bovine)	PR
Q08705	CTCF	Transcriptional repressor CTCF	Gallus gallus (Chicken)	PR
O42409	GFI1B	Zinc finger protein Gfi-1b	Gallus gallus (Chicken)	PR
A2T6W2	ZNF449	Zinc finger protein 449	Pan troglodytes (Chimpanzee)	PR
Q9U405	grau	Transcription factor grauzone	Drosophila melanogaster (Fruit fly)	PR
Q7K0S9	sug	Zinc finger protein GLIS2 homolog	Drosophila melanogaster (Fruit fly)	PR
P20385	Cf2	Chorion transcription factor Cf2	Drosophila melanogaster (Fruit fly)	PR
Q86P48	ATbp	AT-rich binding protein	Drosophila melanogaster (Fruit fly)	PR
P28698	MZF1	Myeloid zinc finger 1	Homo sapiens (Human)	PR
Q9NTW7	ZFP64	Zinc finger protein 64	Homo sapiens (Human)	PR
O14978	ZNF263	Zinc finger protein 263	Homo sapiens (Human)	PR
O60304	ZNF500	Zinc finger protein 500	Homo sapiens (Human)	PR
P08151	GLI1	Zinc finger protein GLI1	Homo sapiens (Human)	PR
Q9UFB7	ZBTB47	Zinc finger and BTB domain-containing protein 47	Homo sapiens (Human)	PR
P18146	EGR1	Early growth response protein 1	Homo sapiens (Human)	PR
Q9Y5W3	KLF2	Krueppel-like factor 2	Homo sapiens (Human)	PR
Q9UNY5	ZNF232	Zinc finger protein 232	Homo sapiens (Human)	PR
Q96SZ4	ZSCAN10	Zinc finger and SCAN domain-containing protein 10	Homo sapiens (Human)	PR
P17028	ZNF24	Zinc finger protein 24	Homo sapiens (Human)	PR
P57682	KLF3	Krueppel-like factor 3	Homo sapiens (Human)	PR
O43296	ZNF264	Zinc finger protein 264	Homo sapiens (Human)	PR
P49711	CTCF	Transcriptional repressor CTCF	Homo sapiens (Human)	PR
Q9NQX1	PRDM5	PR domain zinc finger protein 5	Homo sapiens (Human)	PR
Q9HBE1	PATZ1	POZ-, AT hook-, and zinc finger-containing protein 1	Homo sapiens (Human)	PR
Q8TAX0	OSR1	Protein odd-skipped-related 1	Homo sapiens (Human)	PR
Q9UL58	ZNF215	Zinc finger protein 215	Homo sapiens (Human)	PR
Q8TBJ5	FEZF2	Fez family zinc finger protein 2	Homo sapiens (Human)	PR
Q96SR6	ZNF382	Zinc finger protein 382	Homo sapiens (Human)	PR
Q96IT1	ZNF496	Zinc finger protein 496	Homo sapiens (Human)	PR
Q96N95	ZNF396	Zinc finger protein 396	Homo sapiens (Human)	PR
Q9ULJ3	ZBTB21	Zinc finger and BTB domain-containing protein 21	Homo sapiens (Human)	PR
O75840	KLF7	Krueppel-like factor 7	Homo sapiens (Human)	PR
Q9H9D4	ZNF408	Zinc finger protein 408	Homo sapiens (Human)	PR
Q13127	REST	RE1-silencing transcription factor	Homo sapiens (Human)	PR
Q8IZM8	ZNF654	Zinc finger protein 654	Homo sapiens (Human)	PR
Q14526	HIC1	Hypermethylated in cancer 1 protein	Homo sapiens (Human)	PR
P17022	ZNF18	Zinc finger protein 18	Homo sapiens (Human)	PR
Q86XF7	ZNF575	Zinc finger protein 575	Homo sapiens (Human)	PR
Q06889	EGR3	Early growth response protein 3	Homo sapiens (Human)	PR
Q8NAM6	ZSCAN4	Zinc finger and SCAN domain-containing protein 4	Homo sapiens (Human)	PR
Q08ER8	ZNF543	Zinc finger protein 543	Homo sapiens (Human)	PR
P17029	ZKSCAN1	Zinc finger protein with KRAB and SCAN domains 1	Homo sapiens (Human)	PR
Q8N680	ZBTB2	Zinc finger and BTB domain-containing protein 2	Homo sapiens (Human)	PR
O95625	ZBTB11	Zinc finger and BTB domain-containing protein 11	Homo sapiens (Human)	PR
Q9NPC7	MYNN	Myoneurin	Homo sapiens (Human)	PR
Q96BV0	ZNF775	Zinc finger protein 775	Homo sapiens (Human)	PR
Q8NF99	ZNF397	Zinc finger protein 397	Homo sapiens (Human)	PR
Q63HK3	ZKSCAN2	Zinc finger protein with KRAB and SCAN domains 2	Homo sapiens (Human)	PR
Q5FWF6	ZNF789	Zinc finger protein 789	Homo sapiens (Human)	PR
Q15776	ZKSCAN8	Zinc finger protein with KRAB and SCAN domains 8	Homo sapiens (Human)	PR
Q53GI3	ZNF394	Zinc finger protein 394	Homo sapiens (Human)	PR
O95125	ZNF202	Zinc finger protein 202	Homo sapiens (Human)	PR
Q05516	ZBTB16	Zinc finger and BTB domain-containing protein 16	Homo sapiens (Human)	PR
Q9H116	GZF1	GDNF-inducible zinc finger protein 1	Homo sapiens (Human)	PR
Q8N0Y2	ZNF444	Zinc finger protein 444	Homo sapiens (Human)	PR
Q6P9G9	ZNF449	Zinc finger protein 449	Homo sapiens (Human)	PR
Q8IW36	ZNF695	Zinc finger protein 695	Homo sapiens (Human)	PR
Q5VTD9	GFI1B	Zinc finger protein Gfi-1b	Homo sapiens (Human)	PR
Q6PG37	ZNF790	Zinc finger protein 790	Homo sapiens (Human)	PR
Q9NQV6	PRDM10	PR domain zinc finger protein 10	Homo sapiens (Human)	PR
Q9Y2D9	ZNF652	Zinc finger protein 652	Homo sapiens (Human)	PR
Q5TC79	ZBTB37	Zinc finger and BTB domain-containing protein 37	Homo sapiens (Human)	PR
Q9Y4E5	ZNF451	E3 SUMO-protein ligase ZNF451	Homo sapiens (Human)	PR
Q8ND82	ZNF280C	Zinc finger protein 280C	Homo sapiens (Human)	PR
Q49AA0	ZFP69	Zinc finger protein 69 homolog	Homo sapiens (Human)	PR
O43298	ZBTB43	Zinc finger and BTB domain-containing protein 43	Homo sapiens (Human)	PR
Q9Y330	ZBTB12	Zinc finger and BTB domain-containing protein 12	Homo sapiens (Human)	PR
Q13105	ZBTB17	Zinc finger and BTB domain-containing protein 17	Homo sapiens (Human)	PR
P51508	ZNF81	Zinc finger protein 81	Homo sapiens (Human)	PR
Q5JNZ3	ZNF311	Zinc finger protein 311	Homo sapiens (Human)	PR
Q9BRR0	ZKSCAN3	Zinc finger protein with KRAB and SCAN domains 3	Homo sapiens (Human)	PR
Q969J2	ZKSCAN4	Zinc finger protein with KRAB and SCAN domains 4	Homo sapiens (Human)	PR
P49910	ZNF165	Zinc finger protein 165	Homo sapiens (Human)	PR
Q9Y4X4	KLF12	Krueppel-like factor 12	Homo sapiens (Human)	PR
P10074	ZBTB48	Telomere zinc finger-associated protein	Homo sapiens (Human)	PR
P17010	ZFX	Zinc finger X-chromosomal protein	Homo sapiens (Human)	PR
Q9H5H4	ZNF768	Zinc finger protein 768	Homo sapiens (Human)	PR
Q6NSZ9	ZSCAN25	Zinc finger and SCAN domain-containing protein 25	Homo sapiens (Human)	PR
Q9Y2L8	ZKSCAN5	Zinc finger protein with KRAB and SCAN domains 5	Homo sapiens (Human)	PR
Q86UZ6	ZBTB46	Zinc finger and BTB domain-containing protein 46	Homo sapiens (Human)	PR
Q9NX65	ZSCAN32	Zinc finger and SCAN domain-containing protein 32	Homo sapiens (Human)	PR
O14771	ZNF213	Zinc finger protein 213	Homo sapiens (Human)	PR
Q8IWY8	ZSCAN29	Zinc finger and SCAN domain-containing protein 29	Homo sapiens (Human)	PR
Q8NCP5	ZBTB44	Zinc finger and BTB domain-containing protein 44	Homo sapiens (Human)	PR
P41182	BCL6	B-cell lymphoma 6 protein	Homo sapiens (Human)	PR
Q9NQX0	PRDM6	Putative histone-lysine N-methyltransferase PRDM6	Homo sapiens (Human)	PR
Q9BU19	ZNF692	Zinc finger protein 692	Homo sapiens (Human)	PR
Q08AG5	ZNF844	Zinc finger protein 844	Homo sapiens (Human)	PR
Q6R2W3	ZBED9	SCAN domain-containing protein 3	Homo sapiens (Human)	PR
P98182	ZNF200	Zinc finger protein 200	Homo sapiens (Human)	PR
Q9UK11	ZNF223	Zinc finger protein 223	Homo sapiens (Human)	PR
O15156	ZBTB7B	Zinc finger and BTB domain-containing protein 7B	Homo sapiens (Human)	PR
Q6ZMS7	ZNF783	Zinc finger protein 783	Homo sapiens (Human)	PR
P59923	ZNF445	Zinc finger protein 445	Homo sapiens (Human)	PR
Q8N859	ZNF713	Zinc finger protein 713	Homo sapiens (Human)	PR
Q99612	KLF6	Krueppel-like factor 6	Homo sapiens (Human)	PR
Q8TD17	ZNF398	Zinc finger protein 398	Homo sapiens (Human)	PR
P52739	ZNF131	Zinc finger protein 131	Homo sapiens (Human)	PR
A6NGD5	ZSCAN5C	Zinc finger and SCAN domain-containing protein 5C	Homo sapiens (Human)	PR
Q05215	EGR4	Early growth response protein 4	Homo sapiens (Human)	PR
Q7Z398	ZNF550	Zinc finger protein 550	Homo sapiens (Human)	PR
Q9Y2K1	ZBTB1	Zinc finger and BTB domain-containing protein 1	Homo sapiens (Human)	PR
Q96N20	ZNF75A	Zinc finger protein 75A	Homo sapiens (Human)	PR
A6NJL1	ZSCAN5B	Zinc finger and SCAN domain-containing protein 5B	Homo sapiens (Human)	PR
A1YPR0	ZBTB7C	Zinc finger and BTB domain-containing protein 7C	Homo sapiens (Human)	PR
Q9NWS9	ZNF446	Zinc finger protein 446	Homo sapiens (Human)	PR
P24278	ZBTB25	Zinc finger and BTB domain-containing protein 25	Homo sapiens (Human)	PR
Q96N38	ZNF714	Zinc finger protein 714	Homo sapiens (Human)	PR
Q86YH2	ZNF280B	Zinc finger protein 280B	Homo sapiens (Human)	PR
O08584	Klf6	Krueppel-like factor 6	Mus musculus (Mouse)	PR
Q61164	Ctcf	Transcriptional repressor CTCF	Mus musculus (Mouse)	PR
Q810A1	Znf18	Zinc finger protein 18	Mus musculus (Mouse)	PR
Q8BGS3	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Mus musculus (Mouse)	PR
P41183	Bcl6	B-cell lymphoma 6 protein homolog	Mus musculus (Mouse)	PR
Q9DAI4	Zbtb43	Zinc finger and BTB domain-containing protein 43	Mus musculus (Mouse)	PR
O70237	Gfi1b	Zinc finger protein Gfi-1b	Mus musculus (Mouse)	PR
Q99KZ6	Znf639	Zinc finger protein 639	Mus musculus (Mouse)	PR
Q9Z1D9	Znf394	Zinc finger protein 394	Mus musculus (Mouse)	PR
Q9CXE0	Prdm5	PR domain zinc finger protein 5	Mus musculus (Mouse)	PR
P43300	Egr3	Early growth response protein 3	Mus musculus (Mouse)	PR
Q9DAU9	Znf654	Zinc finger protein 654	Mus musculus (Mouse)	PR
Q9R1Y5	Hic1	Hypermethylated in cancer 1 protein	Mus musculus (Mouse)	PR
Q8R0T2	Znf768	Zinc finger protein 768	Mus musculus (Mouse)	PR
Q9WVG7	Osr1	Protein odd-skipped-related 1	Mus musculus (Mouse)	PR
Q8BI73	Znf775	Zinc finger protein 775	Mus musculus (Mouse)	PR
Q8VCZ7	Zbtb7c	Zinc finger and BTB domain-containing protein 7C	Mus musculus (Mouse)	PR
Q91VN1	Znf24	Zinc finger protein 24	Mus musculus (Mouse)	PR
Q9DB38	Znf580	Zinc finger protein 580	Mus musculus (Mouse)	PR
A7KBS4	Zscan4d	Zinc finger and SCAN domain containing protein 4D	Mus musculus (Mouse)	PR
Q91VW9	Zkscan3	Zinc finger protein with KRAB and SCAN domains 3	Mus musculus (Mouse)	PR
P10925	Zfy1	Zinc finger Y-chromosomal protein 1	Mus musculus (Mouse)	PR
P08046	Egr1	Early growth response protein 1	Mus musculus (Mouse)	PR
Q3UTQ7	Prdm10	PR domain zinc finger protein 10	Mus musculus (Mouse)	PR
Q6P3Y5	Znf280c	Zinc finger protein 280C	Mus musculus (Mouse)	PR
Q9ERU3	Znf22	Zinc finger protein 22	Mus musculus (Mouse)	PR
Q8VIG1	Rest	RE1-silencing transcription factor	Mus musculus (Mouse)	PR
Q9Z1D8	Zkscan5	Zinc finger protein with KRAB and SCAN domains 5	Mus musculus (Mouse)	PR
Q8BID6	Zbtb46	Zinc finger and BTB domain-containing protein 46	Mus musculus (Mouse)	PR
P17012	Zfx	Zinc finger X-chromosomal protein	Mus musculus (Mouse)	PR
Q9WUK6	Zbtb18	Zinc finger and BTB domain-containing protein 18	Mus musculus (Mouse)	PR
O35738	Klf12	Krueppel-like factor 12	Mus musculus (Mouse)	PR
B2RXC5	Znf382	Zinc finger protein 382	Mus musculus (Mouse)	PR
O08900	Ikzf3	Zinc finger protein Aiolos	Mus musculus (Mouse)	PR
Q5DU09	Znf652	Zinc finger protein 652	Mus musculus (Mouse)	PR
Q5RJ54	Zscan26	Zinc finger and SCAN domain-containing protein 26	Mus musculus (Mouse)	PR
Q8BLM0	Klf8	Krueppel-like factor 8	Mus musculus (Mouse)	PR
Q99JB0	Klf7	Krueppel-like factor 7	Mus musculus (Mouse)	PR
Q8R0A2	Zbtb44	Zinc finger and BTB domain-containing protein 44	Mus musculus (Mouse)	PR
P20662	Zfy2	Zinc finger Y-chromosomal protein 2	Mus musculus (Mouse)	PR
Q80VJ6	Zscan4c	Zinc finger and SCAN domain containing protein 4C	Mus musculus (Mouse)	PR
Q3URS2	Zscan4f	Zinc finger and SCAN domain containing protein 4F	Mus musculus (Mouse)	PR
Q60980	Klf3	Krueppel-like factor 3	Mus musculus (Mouse)	PR
Q8K3J5	Znf131	Zinc finger protein 131	Mus musculus (Mouse)	PR
Q00899	Yy1	Transcriptional repressor protein YY1	Mus musculus (Mouse)	PR
Q3TTC2	Yy2	Transcription factor YY2	Mus musculus (Mouse)	PR
Q9Z2K3	Znf394	Zinc finger protein 394	Rattus norvegicus (Rat)	PR
Q642B9	Znf18	Zinc finger protein 18	Rattus norvegicus (Rat)	PR
B0K011	Osr1	Protein odd-skipped-related 1	Rattus norvegicus (Rat)	PR
D3ZUU2	Gzf1	GDNF-inducible zinc finger protein 1	Rattus norvegicus (Rat)	PR
B1WBU4	Zbtb8a	Zinc finger and BTB domain-containing protein 8A	Rattus norvegicus (Rat)	PR
Q7TNK3	Znf24	Zinc finger protein 24	Rattus norvegicus (Rat)	PR
O35819	Klf6	Krueppel-like factor 6	Rattus norvegicus (Rat)	PR
Q9R1D1	Ctcf	Transcriptional repressor CTCF	Rattus norvegicus (Rat)	PR
P43301	Egr3	Early growth response protein 3	Rattus norvegicus (Rat)	PR
P08154	Egr1	Early growth response protein 1	Rattus norvegicus (Rat)	PR
A0JPL0	Znf382	Zinc finger protein 382	Rattus norvegicus (Rat)	PR
Q4KLI1	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Rattus norvegicus (Rat)	PR
A1L1J6	Znf652	Zinc finger protein 652	Rattus norvegicus (Rat)	PR
Q9SHD0	ZAT4	Zinc finger protein ZAT4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0P4X6	zbtb44	Zinc finger and BTB domain-containing protein 44	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
A4II20	egr1	Early growth response protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6P882	zbtb8a.2	Zinc finger and BTB domain-containing protein 8A.2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q567C6	znf367	Zinc finger protein 367	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
A7Y7X5	znf711	Zinc finger protein 711	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MASGDTLYIA	TDGSEMPAEI	VELHEIEVET	IPVETIETTV	VGEEEEEDDD	DEDGGGGDHG
70	80	90	100	110	120
GGGGHGHAGH	HHHHHHHHHH	PPMIALQPLV	TDDPTQVHHH	QEVILVQTRE	EVVGGDDSDG
130	140	150	160	170	180
LRAEDGFEDQ	ILIPVPAPAG	GDDDYIEQTL	VTVAAAGKSG	GGGSSSSGGG	RVKKGGGKKS
190	200	210	220	230	240
GKKSYLSGGA	GAAGGGGADP	GNKKWEQKQV	QIKTLEGEFS	VTMWSSDEKK	DIDHETVVEE
250	260	270	280	290	300
QIIGENSPPD	YSEYMTGKKL	PPGGIPGIDL	SDPKQLAEFA	RMKPRKIKED	DAPRTIACPH
310	320	330	340	350	360
KGCTKMFRDN	SAMRKHLHTH	GPRVHVCAEC	GKAFVESSKL	KRHQLVHTGE	KPFQCTFEGC
370	380	390	400	410
GKRFSLDFNL	RTHVRIHTGD	RPYVCPFDGC	NKKFAQSTNL	KSHILTHAKA	KNNQ