P25390
Gene name |
SSK22 (YCR073C, YCR73C) |
Protein name |
Serine/threonine-protein kinase SSK22 |
Names |
MAP kinase kinase kinase SSK22, Suppressor of sensor kinase 22 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YCR073C |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
1175-1185 (Activation loop from InterPro)
Target domain |
1034-1310 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
1208-1214 (Activation loop from InterPro)
Target domain |
1034-1310 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for P25390
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P25390-F1 | Predicted | AlphaFoldDB |
60 variants for P25390
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s03-246481 | 34 | S>P | No | SGRP | |
| s03-246475 | 36 | H>D | No | SGRP | |
| s03-246429 | 51 | G>D | No | SGRP | |
| s03-246416 | 55 | I>M | No | SGRP | |
| s03-246406 | 59 | P>S | No | SGRP | |
| s03-246274 | 103 | G>S | No | SGRP | |
| s03-246266 | 105 | D>E | No | SGRP | |
| s03-246180 | 134 | R>M | No | SGRP | |
| s03-246168 | 138 | S>L | No | SGRP | |
| s03-245901 | 227 | M>T | No | SGRP | |
| s03-245892 | 230 | Q>R | No | SGRP | |
| s03-245853 | 243 | E>A | No | SGRP | |
| s03-245821 | 254 | H>D | No | SGRP | |
| s03-245759 | 274 | N>K | No | SGRP | |
| s03-245734 | 283 | D>Y | No | SGRP | |
| s03-245718 | 288 | W>L | No | SGRP | |
| s03-245649 | 311 | P>L | No | SGRP | |
| s03-245628 | 318 | C>F | No | SGRP | |
| s03-245584 | 333 | K>E | No | SGRP | |
| s03-245461 | 374 | T>A | No | SGRP | |
| s03-245460 | 374 | T>I | No | SGRP | |
| s03-245431 | 384 | Y>H | No | SGRP | |
| s03-245362 | 407 | S>T | No | SGRP | |
| s03-245296 | 429 | A>S | No | SGRP | |
| s03-245235 | 449 | P>Q | No | SGRP | |
| s03-245032 | 517 | L>V | No | SGRP | |
| s03-244983 | 533 | K>R | No | SGRP | |
| s03-244918 | 555 | F>L | No | SGRP | |
| s03-244885 | 566 | N>D | No | SGRP | |
| s03-244879 | 568 | F>L | No | SGRP | |
| s03-244728 | 618 | A>V | No | SGRP | |
| s03-244423 | 720 | E>Q | No | SGRP | |
| s03-244369 | 738 | E>K | No | SGRP | |
| s03-244300 | 761 | D>N | No | SGRP | |
| s03-244293 | 763 | G>E | No | SGRP | |
| s03-244282 | 767 | N>H | No | SGRP | |
| s03-244278 | 768 | P>Q | No | SGRP | |
| s03-244171 | 804 | C>S | No | SGRP | |
| s03-244164 | 806 | L>P | No | SGRP | |
| s03-244070 | 837 | S>R | No | SGRP | |
| s03-243977 | 868 | F>L | No | SGRP | |
| s03-243925 | 886 | N>Y | No | SGRP | |
| s03-243894 | 896 | D>V | No | SGRP | |
| s03-243777 | 935 | E>G | No | SGRP | |
| s03-243684 | 966 | R>K | No | SGRP | |
| s03-243561 | 1007 | G>D | No | SGRP | |
| s03-243450 | 1044 | T>I | No | SGRP | |
| s03-243435 | 1049 | Y>C | No | SGRP | |
| s03-243409 | 1058 | E>K | No | SGRP | |
| s03-243318 | 1088 | E>G | No | SGRP | |
| s03-243256 | 1109 | N>D | No | SGRP | |
| s03-243221 | 1120 | L>F | No | SGRP | |
| s03-243216 | 1122 | S>L | No | SGRP | |
| s03-243181 | 1134 | V>I | No | SGRP | |
| s03-243141 | 1147 | A>V | No | SGRP | |
| s03-243139 | 1148 | Y>H | No | SGRP | |
| s03-242914 | 1223 | G>S | No | SGRP | |
| s03-242883 | 1233 | D>G | No | SGRP | |
| s03-242677 | 1302 | V>M | No | SGRP | |
| s03-242601 | 1327 | P>L | No | SGRP |
No associated diseases with P25390
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase kinase kinase activity | Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| osmosensory signaling MAPK cascade | The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal, containing at least a Hog1/Sty1 family MAPK, a Pbs2/Wis1 family MAPKK and a Ssk2/Win1 family MAP3K. |
| p38MAPK cascade | An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41279 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Homo sapiens (Human) | EV |
| Q07174 | Map3k8 | Mitogen-activated protein kinase kinase kinase 8 | Mus musculus (Mouse) | SS |
| Q63562 | Map3k8 | Mitogen-activated protein kinase kinase kinase 8 | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMMDILNTQQ | QKAAEGGRVL | APHTISSKLV | KRLSSHSSHK | LSRSDLKALG | GSETISDGPS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLTFKDRYVF | NESLYLKKLK | KTALDDYYTR | GIKLTNRYEE | DDGDDEIIRL | SNGDRIDEDL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HSGVKFFSTT | PYCRKMRSDS | DELAWNEIAT | ERFKWQSMLA | RVLKGDIVKG | EKTRIANQVK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KPGLNKELSD | EIWLELKAWL | NGRTMQEMEQ | SLTYLRDSSD | SVFEEIMKFQ | IPQGKILSLD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ALEAILQDLM | NRYHSVVSYW | PNLKKMYKDK | PITNTAEFTA | RIDVMNSWLN | FKTNLTLRRQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ELDDWINRFS | PISSSDNCQE | DFDGVPQWNC | KMKILAEQLM | KEKNIESIFQ | KKIFYPLSPW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MFKLKLHFIV | YRETLTKMNI | KYPYERLRSL | LAFPVYLIKE | VILTRLSYAR | KLKNPTMMMI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DQMIDDFNAF | IRLSVQLKYT | LTKYCSNLPF | DVDFDPTFEN | TVIEAIRYLF | FLLNLKLIDS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SKQNFKAPDL | LLKYWDHLKN | TGHYINGAET | VIPNEFLKLT | LRLVHKLQFY | LLKQQNFPPT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FANASEAEKW | LSSIFENLGA | MKRKLNRFSN | ILVKAFQNSA | VYQINHNAQL | VKKLKDAHYF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LVYSGNTFES | SGVYMFAAPE | LLGCDNDTIL | RILRNKSIGC | DLVPKLDIGN | NLNVYDITTK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ETDLNILVSK | GEDSKGIPYY | RVVANSSSDL | DRHAHQSKKK | NFSTDPFDQH | LDEKNNEVFE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LEVALSSLGA | LVVLYPGEPV | VWDGPVYKLP | GNNLFASNEM | DLGKIGNPNT | LILLNQGSNY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ALTYQIDKFN | QTVGDSVSFI | EKRCSLNSIE | SSLQKINKAY | YKLTYTVLNN | YKGILGSFMK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| QCPGNELLNS | IFMFGRDFGR | SFLKYNAFSS | KRKYVIIFLM | VKLGMNWLKF | LVEECDPTDQ |
| 910 | 920 | 930 | 940 | 950 | 960 |
| RTFRWCVLAM | DFAMQMTSGY | NILALNVKQF | QELKERVSVC | MSLLISHFDV | MGARATEAEN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GMQQARLNID | TEENIDEEAT | LEINSRLRLE | AIKTLEKTMK | RNPRQMGKVL | DATDQGNKYL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LSLASSLSNV | SMRWQKRSFI | GGGTFGQVYS | AINLENGEIL | AVKEIKIHDT | TTMKKIFPLI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KEEMTVLEML | NHPNIVQYYG | VEVHRDKVNI | FMEYCEGGSL | ASLLDHGRIE | DEMVTQVYTF |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| ELLEGLAYLH | QSGVVHRDIK | PENILLDFNG | IIKYVDFGTA | RTVVGSRTRT | VRNAAVQDFG |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| VETKSLNEMM | GTPMYMAPET | ISGSAVKGKL | GADDVWALGC | VVLEMATGRR | PWSNLDNEWA |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| IMYHVAAGRI | PQLPNRDEMT | AAGRAFLERC | LVQDPTMRAT | AVELLIDPWM | IQIREIAFGN |
| 1330 | |||||
| SEKDQVPILS | S |