AiPD: Autoinhibited Protein Database

P25098

Gene name	GRK2
Protein name	Beta-adrenergic receptor kinase 1
Names	Beta-ARK-1, G-protein coupled receptor kinase 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:156
EC number	2.7.11.15: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-68 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-68 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

334-355 (Activation loop from InterPro)

Target domain	191-453 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

21 structures for P25098

Entry ID	Method	Resolution	Chain	Position	Source
1BAK	NMR	-	A	556-670	PDB
3CIK	X-ray	275 A	A	1-689	PDB
3KRW	X-ray	290 A	A	2-689	PDB
3KRX	X-ray	310 A	A	2-689	PDB
3V5W	X-ray	207 A	A	1-689	PDB
4MK0	X-ray	240 A	A	30-668	PDB
4PNK	X-ray	256 A	A	1-689	PDB
5HE1	X-ray	315 A	A	29-670	PDB
5UKK	X-ray	260 A	A	30-671	PDB
5UKL	X-ray	215 A	A	30-671	PDB
5UUU	X-ray	270 A	A	23-538	PDB
5UVC	X-ray	265 A	A	23-538	PDB
5WG3	X-ray	290 A	A	1-689	PDB
5WG4	X-ray	231 A	A	1-689	PDB
5WG5	X-ray	310 A	A	1-689	PDB
6C2Y	X-ray	274 A	A	1-689	PDB
6U7C	X-ray	244 A	A	1-689	PDB
7K7L	X-ray	254 A	A	30-668	PDB
7K7Z	X-ray	261 A	A	30-668	PDB
7PWD	X-ray	260 A	A	1-689	PDB
AF-P25098-F1	Predicted				AlphaFoldDB

464 variants for P25098

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA6133819 rs778566509	5	E>Q		No	ClinGen ExAC gnomAD
rs1267341728 CA381525451	6	A>V		No	ClinGen TOPMed
CA224128083 rs867482919	8	L>P		No	ClinGen Ensembl
rs1170445155 CA381525507	11	V>L		No	ClinGen gnomAD
CA381525523 rs1417063134	12	S>I		No	ClinGen gnomAD
CA381525641 rs1223563312	21	K>T		No	ClinGen TOPMed
CA224128095 rs868320916	22	A>D		No	ClinGen Ensembl
rs1323939721 CA381525649	22	A>T		No	ClinGen gnomAD
CA381525665 rs1233371776	23	T>R		No	ClinGen gnomAD
rs1436404023 CA381525678	24	P>L		No	ClinGen TOPMed gnomAD
rs1436404023 CA381525677	24	P>R		No	ClinGen TOPMed gnomAD
rs1337784962 CA381525685	25	A>S		No	ClinGen gnomAD
CA381525681 rs1337784962	25	A>T		No	ClinGen gnomAD
rs1565434525 CA381525691	25	A>V		No	ClinGen Ensembl
CA381525694 rs1291105914	26	A>T		No	ClinGen gnomAD
CA381525700 rs1336459275	26	A>V		No	ClinGen gnomAD
CA381525706 rs1251787046	27	R>C		No	ClinGen gnomAD
rs1251787046 CA381525703	27	R>S		No	ClinGen gnomAD
rs1195166103 CA381525718	28	A>D		No	ClinGen TOPMed gnomAD
rs910121977 CA224128098	28	A>S		No	ClinGen TOPMed gnomAD
rs910121977 CA381525713	28	A>T		No	ClinGen TOPMed gnomAD
rs1195166103 CA381525722	28	A>V		No	ClinGen TOPMed gnomAD
CA381525726 rs1475081359	29	S>G		No	ClinGen gnomAD
rs1163600857 CA381525730	29	S>N		No	ClinGen TOPMed gnomAD
CA381525735 rs1415744110	29	S>R		No	ClinGen gnomAD
CA6133826 rs746094488 COSM3980606	30	K>R	ovary [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1393761312 CA381525782	33	L>M		No	ClinGen gnomAD
rs775578042 CA381525791	34	L>M		No	ClinGen ExAC TOPMed gnomAD
CA381525796 rs1325182225	34	L>P		No	ClinGen gnomAD
rs1357789704 CA381525811	35	P>L		No	ClinGen gnomAD
CA381525805 rs1285119222	35	P>S		No	ClinGen gnomAD
rs1272161822 CA381525816	36	E>K		No	ClinGen gnomAD
rs1281584972 CA381525835	37	P>H		No	ClinGen gnomAD
rs1206374871 CA381525828	37	P>S		No	ClinGen gnomAD
CA381525842 rs1188203755	38	S>G		No	ClinGen gnomAD
CA6133850 rs780233870	40	R>C		No	ClinGen ExAC TOPMed gnomAD
CA381527919 rs1469702901	40	R>H		No	ClinGen TOPMed gnomAD
rs1174739521 CA381527986	44	Q>H		No	ClinGen gnomAD
TCGA novel	45	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768707526 CA224133016	50	R>L		No	ClinGen ExAC gnomAD
CA6133852 rs768707526	50	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA381528062 rs1165911865	50	R>W		No	ClinGen gnomAD
rs1312621144 CA381528080	51	G>D		No	ClinGen TOPMed gnomAD
CA6133853 rs774431677	52	E>K		No	ClinGen ExAC gnomAD
TCGA novel	56	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs190227928 CA6133856	58	I>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	58	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381528209 rs1394048967	60	S>F		No	ClinGen gnomAD
TCGA novel	60	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1195058408 CA381528216	61	Q>E		No	ClinGen TOPMed
rs769702786 CA6133881	66	L>P		No	ClinGen ExAC gnomAD
rs1166669766 CA381528796	67	L>F		No	ClinGen gnomAD
CA381528808 rs1460468596	68	F>L		No	ClinGen gnomAD
rs768317883 CA6133884	69	R>G		No	ClinGen ExAC gnomAD
CA381528839 rs773756280	69	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6133885 rs773756280	69	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs761365631 CA6133887	73	L>V		No	ClinGen ExAC gnomAD
CA6133888 rs556538832	76	L>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs750915028 CA6133890	76	L>P		No	ClinGen ExAC TOPMed gnomAD
CA6133889 rs750915028	76	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA381528934 rs750915028	76	L>R		No	ClinGen ExAC TOPMed gnomAD
rs556538832 CA224133909	76	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381528941 rs1167801468	77	E>D		No	ClinGen TOPMed
rs766734072 CA6133891	78	E>A		No	ClinGen ExAC gnomAD
rs370556389 CA6133892	78	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA6133893 rs574869350	79	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6133894 rs779169761	82	L>S		No	ClinGen ExAC gnomAD
CA224133927 rs201237885	85	F>C		No	ClinGen TOPMed gnomAD
CA381529052 rs1479398275	86	Y>C		No	ClinGen TOPMed
CA381529077 rs1415203161	88	E>Q		No	ClinGen gnomAD
CA381529186 rs1229317062	90	K>N		No	ClinGen TOPMed
CA381529190 rs1379428572	91	K>E		No	ClinGen TOPMed
rs913907517 CA224134019	93	E>K		No	ClinGen TOPMed gnomAD
CA6133915 rs778007364	95	L>V		No	ClinGen ExAC gnomAD
CA6133916 rs751653371	96	E>K		No	ClinGen ExAC gnomAD
CA6133917 rs200019576	97	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381529307 rs200019576	97	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1349201741 CA381529331	99	E>G		No	ClinGen gnomAD
rs367808517 CA6133918	99	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1237196544 CA381529345	100	E>K		No	ClinGen gnomAD
CA6133919 rs564473820	101	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6133920 rs371602631	101	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA6133921 rs371602631	101	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1590851494 CA381529367	102	V>M		No	ClinGen Ensembl
rs747840297 CA6133922	104	R>C		No	ClinGen ExAC TOPMed gnomAD
rs747840297 CA6133923	104	R>G		No	ClinGen ExAC TOPMed gnomAD
rs71640262 COSM690377 CA6133924	104	R>H	lung Variant assessed as Somatic; 9.349e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs71640262 CA6133925	104	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA224134059 rs71640262	104	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201802840 CA224134066	105	S>I		No	ClinGen gnomAD
rs771465253 CA6133926	106	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA381529449 rs1455500216	106	R>W		No	ClinGen TOPMed gnomAD
rs1565066098 CA381529472	107	E>Q		No	ClinGen Ensembl
rs1410379191 CA381529492	108	I>V		No	ClinGen TOPMed gnomAD
CA6133929 rs543696664	109	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA6133930 rs775654396	110	D>N		No	ClinGen ExAC TOPMed gnomAD
rs368707177 CA381529620	113	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA6133931 rs763270677	113	I>V		No	ClinGen ExAC gnomAD
CA6133933 rs751739128	114	M>T		No	ClinGen ExAC gnomAD
CA381529658 rs1371856674	115	K>R		No	ClinGen gnomAD
CA6133934 rs139639168	116	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA381529709 rs1348561442	117	L>Q		No	ClinGen gnomAD
CA6133936 rs753803100	121	S>L		No	ClinGen ExAC TOPMed gnomAD
rs529567037 CA6133938	122	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA6133955 rs754965566	124	F>S		No	ClinGen ExAC gnomAD
CA6133956 rs765062789	125	S>L		No	ClinGen ExAC gnomAD
rs758181077 CA6133958	128	A>V		No	ClinGen ExAC gnomAD
TCGA novel	130	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6133959 rs777457733	131	H>N		No	ClinGen ExAC TOPMed gnomAD
CA6133960 rs751224103	131	H>R		No	ClinGen ExAC gnomAD
rs1401743159 CA381530825	132	V>L		No	ClinGen gnomAD
CA381530865 rs1320861437	134	G>A		No	ClinGen gnomAD
CA381530893 rs1404171042	136	L>Q		No	ClinGen TOPMed
CA6133962 rs780788944	137	G>W		No	ClinGen ExAC
rs745324704 CA6133963	139	K>N		No	ClinGen ExAC TOPMed gnomAD
CA381530933 rs1370953566	139	K>R		No	ClinGen TOPMed
rs770385315 CA6133964	140	Q>K		No	ClinGen ExAC gnomAD
CA381530970 rs1460686367	142	P>L		No	ClinGen TOPMed
CA381530966 rs1356953611	142	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1590851720 CA381530982	143	P>L		No	ClinGen Ensembl
rs772378377 CA6133991	148	P>L		No	ClinGen ExAC gnomAD
rs748500568 CA6133990	148	P>S		No	ClinGen ExAC TOPMed gnomAD
rs760863502 CA6133993	149	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA6133994 rs770926241	150	I>V		No	ClinGen ExAC TOPMed gnomAD
rs771530727 CA224138684	151	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1047485224 CA224138696	152	E>D		No	ClinGen TOPMed
CA381531118 rs1197812109	152	E>K		No	ClinGen gnomAD
CA381531168 rs1454784072	155	Q>E		No	ClinGen TOPMed
TCGA novel	157	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6133996 rs762912207	158	R>Q		No	ClinGen ExAC gnomAD
rs761569320 CA6133999	160	D>G		No	ClinGen ExAC gnomAD
rs377671393 CA6133998	160	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs377671393 CA224138725	160	D>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1157182710 CA381531242	161	V>M		No	ClinGen TOPMed
CA6134001 rs370934447	166	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs753435050 CA6134022	169	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA381531479 rs753435050	169	D>Y		No	ClinGen ExAC gnomAD
CA381531522 rs1397908259	172	T>A		No	ClinGen gnomAD
CA381531555 rs1297416384	174	F>L		No	ClinGen gnomAD
CA381531677 rs1234165276	179	N>S		No	ClinGen gnomAD
CA6134025 rs753269682	183	N>S		No	ClinGen ExAC
rs55696045 CA6134027 VAR_040378	184	I>T		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
CA6134026 rs758872311	184	I>V		No	ClinGen ExAC TOPMed gnomAD
rs747352703	185	H>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs374028985 CA6134049	186	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1207053613 CA381532009	188	M>L		No	ClinGen gnomAD
rs749342499 CA6134051	188	M>T		No	ClinGen ExAC gnomAD
rs1477483736 CA381532076	189	N>S		No	ClinGen TOPMed
CA381532081 rs1477483736	189	N>T		No	ClinGen TOPMed
rs1173761928 CA381532138	192	S>I		No	ClinGen gnomAD
rs200583894 CA381532141	192	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1465763738 CA381532147	193	V>M		No	ClinGen gnomAD
CA381532180 rs1298782790	195	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6134054 rs369743896	197	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs72556394 CA224139572	198	G>V		No	ClinGen Ensembl
rs909327917 CA224139573	199	R>G		No	ClinGen TOPMed
CA381532221 rs1246290647	199	R>H		No	ClinGen TOPMed
rs1221281854 CA381532297	204	E>K		No	ClinGen gnomAD
rs1256258635 CA381532316	205	V>F		No	ClinGen TOPMed
CA381532325 rs1590853081	205	V>G		No	ClinGen Ensembl
rs768813349 CA224139591	206	Y>C		No	ClinGen gnomAD
rs759292676 CA6134057	206	Y>N		No	ClinGen ExAC gnomAD
COSM1244560 CA6134059 rs774914090	209	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA224139606 rs868480523	209	R>W		No	ClinGen gnomAD
rs940768002 CA224139628	210	K>E		No	ClinGen TOPMed
CA224139635 rs1009944	211	A>G		No	ClinGen Ensembl
CA224139632 rs1009943	211	A>P		No	ClinGen Ensembl
CA6134090 rs755089226	218	A>T		No	ClinGen ExAC gnomAD
rs765388264 CA6134091	219	M>I		No	ClinGen ExAC gnomAD
CA381532667 rs1226475013	223	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	225	K>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1704278 CA6134094 rs781246400	226	R>C	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA381532722 rs1487408087	226	R>L		No	ClinGen gnomAD
CA6134095 rs745725870	228	K>R		No	ClinGen ExAC gnomAD
CA6134096 rs755961102	229	M>I		No	ClinGen ExAC gnomAD
CA381532867 rs1477157873	236	A>S		No	ClinGen TOPMed
CA381532931 rs1200682182	240	R>C		No	ClinGen TOPMed
rs768156866 CA6134099	241	I>V		No	ClinGen ExAC TOPMed gnomAD
CA381532956 rs145638181	242	M>L		No	ClinGen ESP TOPMed gnomAD
CA6134100 rs773936786	242	M>T		No	ClinGen ExAC TOPMed gnomAD
CA224139924 rs145638181	242	M>V		No	ClinGen ESP TOPMed gnomAD
rs1160780700 CA381532999	245	L>F		No	ClinGen TOPMed gnomAD
rs1160780700 CA381532997	245	L>V		No	ClinGen TOPMed gnomAD
CA6134104 rs770458416	246	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA224139936 rs368479232	248	T>I		No	ClinGen ESP TOPMed gnomAD
CA6134135 rs751653503	250	D>G		No	ClinGen ExAC TOPMed gnomAD
CA381534096 rs1199989759	251	C>S		No	ClinGen gnomAD
rs1476809971 CA381534143	254	I>V		No	ClinGen gnomAD
CA381534176 rs1400659757	258	S>L		No	ClinGen gnomAD
rs760688917 CA6134136	259	Y>H		No	ClinGen ExAC gnomAD
rs753710294 CA6134138	260	A>S		No	ClinGen ExAC TOPMed gnomAD
CA6134139 rs753710294	260	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1399412951 CA381534187	260	A>V		No	ClinGen TOPMed gnomAD
CA6134142 rs758003046	261	F>L		No	ClinGen ExAC gnomAD
CA6134143 rs777286637	262	H>Y		No	ClinGen ExAC gnomAD
rs543467610 CA224140107	263	T>M		No	ClinGen 1000Genomes gnomAD
rs781544095 CA6134146	265	D>E		No	ClinGen ExAC gnomAD
CA381534214 rs1379183136	265	D>N		No	ClinGen TOPMed
TCGA novel	270	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	272	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1457680258 CA381534278	274	M>V		No	ClinGen gnomAD
rs1362243970 CA381534309	276	G>D		No	ClinGen gnomAD
CA381534351 rs1402018551	282	H>R		No	ClinGen gnomAD
rs1364360150 CA381534409	291	E>K		No	ClinGen gnomAD
CA381534421 rs1342751351	292	A>G		No	ClinGen TOPMed
rs1219808769 CA381534417	292	A>T		No	ClinGen TOPMed
rs202054233 CA6134179	293	D>N		No	ClinGen 1000Genomes ExAC
CA6134181 rs756869266	294	M>T		No	ClinGen ExAC gnomAD
CA6134180 rs751186389	294	M>V		No	ClinGen ExAC gnomAD
CA6134182 rs142106623	295	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6134183 rs374978008	295	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs142106623 CA381534437	295	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA381534452 rs780679941	297	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA6134185 rs780679941	297	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs756737110 CA6134184	297	Y>H		No	ClinGen ExAC gnomAD
rs755384357 CA6134187	298	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA381534460 rs1381865613	299	A>T		No	ClinGen gnomAD
rs1417630605 CA381534466	300	E>K		No	ClinGen gnomAD
CA224140371 rs895639184	308	M>T		No	ClinGen TOPMed
CA6134193 rs769787472	310	N>D		No	ClinGen ExAC TOPMed gnomAD
CA6134194 rs775391882	310	N>S		No	ClinGen ExAC gnomAD
CA6134195 rs61891564	311	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1477610425 CA381534544	311	R>H		No	ClinGen TOPMed
rs1310622815 CA381534551	312	F>S		No	ClinGen gnomAD
rs763883122 CA6134196	314	V>I		No	ClinGen ExAC gnomAD
rs528538949 CA6134198	316	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6134197 rs528538949	316	R>W	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA381534656 rs1400246915	327	E>K		No	ClinGen gnomAD
rs751785033 CA6134227	331	V>M		No	ClinGen ExAC gnomAD
CA224140814 rs868706705	342	F>L		No	ClinGen Ensembl
rs745926852 CA6134230	343	S>Y		No	ClinGen ExAC gnomAD
CA6134231 rs768518674	344	K>R		No	ClinGen ExAC gnomAD
CA6134232 rs778907356	346	K>Q		No	ClinGen ExAC gnomAD
TCGA novel	349	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	352	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381534840 rs1385231599	352	G>V		No	ClinGen gnomAD
CA381534904 rs1590854258	361	V>G		No	ClinGen Ensembl
rs1185607871 CA381534910	362	L>P		No	ClinGen TOPMed
CA381534942 rs1590854269	366	V>G		No	ClinGen Ensembl
CA381534939 rs1445646235	366	V>M		No	ClinGen TOPMed gnomAD
rs138698093 CA6134253	367	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6134255 rs770771786 COSM931026	369	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA381534964 rs1306863401	370	S>G		No	ClinGen gnomAD
CA381534966 rs1348743840	370	S>N		No	ClinGen gnomAD
TCGA novel	374	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381535014 rs1279335956	376	S>C		No	ClinGen gnomAD
CA224140980 rs750744453	378	G>A		No	ClinGen gnomAD
rs915582205 CA224140998	380	M>L		No	ClinGen Ensembl
rs774824024 CA6134259	386	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM308967 CA381535077 rs1275870858	386	R>W	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA381535136 rs1175039905	389	S>I		No	ClinGen gnomAD
CA381535132 rs1175039905	389	S>N		No	ClinGen gnomAD
CA6134275 rs745565697	392	R>W		No	ClinGen ExAC gnomAD
CA381535174 rs1477974154	393	Q>*		No	ClinGen gnomAD
CA381535195 rs375195634	394	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6134279 rs565263383	398	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6134281 rs367821561	403	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA224141248 rs367821561	403	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs767877179 CA6134282	404	R>C		No	ClinGen ExAC gnomAD
rs868080683 CA224141265	404	R>H	Variant assessed as Somatic; 5.105e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs773412797 CA6134283	405	M>L		No	ClinGen ExAC gnomAD
rs773412797 CA224141269	405	M>V		No	ClinGen ExAC gnomAD
CA6134284 COSM1475804 rs761003605	406	T>M	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs754014639 CA6134286	408	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1381279717	410	A>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1317758016 CA381535543	410	A>V		No	ClinGen gnomAD
CA6134309 rs761891768	411	V>M		No	ClinGen ExAC gnomAD
CA6134311 rs750300020	414	P>S		No	ClinGen ExAC gnomAD
rs781191950	417	F>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs753496595 CA6134315	417	F>S		No	ClinGen ExAC gnomAD
CA224141735 rs866486684 COSM1684899	418	S>F	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs374934278 CA224141744	419	P>S		No	ClinGen ESP TOPMed gnomAD
CA381535706 rs1460848733	420	E>D		No	ClinGen gnomAD
rs778421554 CA6134317	420	E>K		No	ClinGen ExAC gnomAD
rs778421554 CA224141750	420	E>Q		No	ClinGen ExAC gnomAD
CA6134319 rs772629678	422	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1051180 CA6134320	422	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs973091689 CA381535733	423	S>A		No	ClinGen Ensembl
CA381535737 rs1363496728	423	S>C		No	ClinGen TOPMed gnomAD
CA381535735 rs1363496728	423	S>F		No	ClinGen TOPMed gnomAD
rs973091689 CA224141792	423	S>P		No	ClinGen Ensembl
CA381535789 rs1338822294	427	G>A		No	ClinGen gnomAD
rs1472920694 CA381535783	427	G>R		No	ClinGen gnomAD
rs1181588575 CA381535792	428	L>V		No	ClinGen gnomAD
rs759859470 CA6134324	430	Q>E		No	ClinGen ExAC gnomAD
rs950389043 CA224141840	432	D>N		No	ClinGen Ensembl
rs144705095 CA6134326	432	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1222491412 CA381535878	433	V>G		No	ClinGen gnomAD
CA381535881 rs1442154190	434	N>H		No	ClinGen TOPMed
CA6134327 rs763121919	434	N>K		No	ClinGen ExAC gnomAD
rs773040164 CA6134329	435	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs542501875 CA6134328	435	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs561062604 CA6134330	439	C>S		No	ClinGen 1000Genomes ExAC gnomAD
CA381535968 rs1322672208	440	L>M		No	ClinGen gnomAD
rs148084953 CA6134331	441	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs148084953 CA6134332	441	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1240019144 CA381535986	442	R>*		No	ClinGen TOPMed gnomAD
rs1240019144 CA381535987	442	R>G		No	ClinGen TOPMed gnomAD
rs372392743 CA6134333	442	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1302111063 CA381535996	443	G>R		No	ClinGen TOPMed
CA381537160 rs1309787074	444	A>S		No	ClinGen TOPMed
CA381537165 rs1408747889	444	A>V		No	ClinGen gnomAD
rs573018580 CA6134360	449	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1208435182 CA381537348	454	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1208435182 CA381537349	454	R>G		No	ClinGen TOPMed gnomAD
CA6134362 COSM931030 rs746293222	454	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs746293222 CA6134361	454	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1344526772 CA381537364	455	S>F		No	ClinGen gnomAD
CA6134363 rs780501966	456	L>V		No	ClinGen ExAC gnomAD
rs142713432 CA224142495	457	D>E		No	ClinGen ESP TOPMed
rs1977983 CA381537401	457	D>G		No	ClinGen gnomAD
CA224142488 rs1977983	457	D>V		No	ClinGen gnomAD
CA224142507 rs1573538	458	W>*		No	ClinGen Ensembl
rs749506738 CA6134364	459	Q>*		No	ClinGen ExAC gnomAD
rs768877784 CA6134365	460	M>T		No	ClinGen ExAC gnomAD
CA6134366 rs774347169	462	F>L		No	ClinGen ExAC gnomAD
CA224142537 rs1977982	465	K>M		No	ClinGen Ensembl
rs1376740220 CA381537542	465	K>Q		No	ClinGen TOPMed
rs1590855401 CA381537632	466	Y>S		No	ClinGen Ensembl
TCGA novel	467	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6134383 rs754212842	469	P>A		No	ClinGen ExAC TOPMed gnomAD
CA224142655 rs950025242	471	I>M		No	ClinGen gnomAD
CA381537743 rs1224558827	473	P>L		No	ClinGen TOPMed gnomAD
rs1224558827 CA381537746	473	P>Q		No	ClinGen TOPMed gnomAD
CA381537744 rs1224558827	473	P>R		No	ClinGen TOPMed gnomAD
rs779178115 CA6134385	474	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	478	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381537806 rs1590855449	478	N>T		No	ClinGen Ensembl
CA6134387 rs544703775	479	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA224142712 rs775188106	481	D>E		No	ClinGen ExAC TOPMed gnomAD
rs769695885 CA6134390	481	D>N		No	ClinGen ExAC gnomAD
CA381537849 rs1447636353	482	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA381537879 rs766786545	483	F>L		No	ClinGen ExAC TOPMed gnomAD
rs753731501 CA6134393	484	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1008088029 CA224142721	485	I>T		No	ClinGen TOPMed
CA381537937 rs1377372044	489	D>N		No	ClinGen gnomAD
CA6134396 rs377477573	490	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA381538210 rs1179224114	501	S>G		No	ClinGen TOPMed
TCGA novel	504	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	505	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6134417 rs760244097	507	R>C		No	ClinGen ExAC TOPMed gnomAD
rs765925133 CA6134418	507	R>H		No	ClinGen ExAC TOPMed gnomAD
CA6134420 rs759915131	510	P>A		No	ClinGen ExAC gnomAD
TCGA novel	511	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381538399 rs1345158398	513	I>V		No	ClinGen TOPMed
rs765668445 CA6134421	514	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1277772249 CA381538426	515	E>D		No	ClinGen TOPMed
CA6134422 rs752975715	516	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA381538440 rs1425138914	517	W>G		No	ClinGen gnomAD
rs892190905 CA224143047	519	Q>R		No	ClinGen TOPMed
rs1590855812 CA381538488	521	V>G		No	ClinGen Ensembl
CA381538484 rs1277612071	521	V>M		No	ClinGen TOPMed
rs758669214 CA6134423	522	A>V		No	ClinGen ExAC gnomAD
rs370321276 CA6134424	523	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA381538529 rs1230280834	525	V>A		No	ClinGen gnomAD
CA381538527 rs1356261466	525	V>F		No	ClinGen TOPMed
rs565139423 CA224143062	526	F>L		No	ClinGen Ensembl
rs781074663 CA6134427	527	D>N	Variant assessed as Somatic; 9.243e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA381538570 rs1449906556	528	T>I		No	ClinGen gnomAD
CA381538562 rs1412955054	528	T>S		No	ClinGen TOPMed
CA381538573 rs1358703028	529	I>V		No	ClinGen TOPMed
CA381538581 rs1388252136	530	N>D		No	ClinGen TOPMed gnomAD
rs1467094087 CA381538584	530	N>S		No	ClinGen gnomAD
rs139609139 CA6134429	531	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA6134431 rs373590067	535	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA381538653 rs1158818904	535	R>W		No	ClinGen TOPMed
rs771904461 CA381538696	538	A>G		No	ClinGen ExAC gnomAD
rs771904461 CA6134432	538	A>V		No	ClinGen ExAC gnomAD
CA6134433 rs773007307	539	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	539	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	543	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381538824 rs1257730692	547	L>P		No	ClinGen TOPMed
rs770499734 CA6134435	548	G>C		No	ClinGen ExAC gnomAD
rs1241275567 CA381539001	554	A>T		No	ClinGen TOPMed gnomAD
CA381539072 rs1455421102	559	C>Y		No	ClinGen TOPMed
rs1177623092 CA381539087	560	I>V		No	ClinGen gnomAD
CA381539105 rs1251480558	561	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA381539157 rs1421145445	563	G>S		No	ClinGen gnomAD
rs775980850 CA6134460	564	Y>C		No	ClinGen ExAC gnomAD
rs763393507 CA381539185	565	M>L		No	ClinGen ExAC gnomAD
rs763393507 CA6134461	565	M>V		No	ClinGen ExAC gnomAD
CA381539231 rs1590856345	570	N>T		No	ClinGen Ensembl
rs892374367 CA224143395	574	T>I		No	ClinGen Ensembl
VAR_040379	578	R>Q	a colorectal adenocarcinoma sample; somatic mutation [UniProt]	No	UniProt
rs140057016 CA6134465	579	R>Q		No	ClinGen ESP ExAC gnomAD
CA6134464 rs762133593	579	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	582	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381539368 rs1590856380	582	Y>S		No	ClinGen Ensembl
rs1590856388 CA381539416	586	N>T		No	ClinGen Ensembl
CA381539432 rs1261156029	587	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs760663193 CA6134467	588	L>F		No	ClinGen ExAC gnomAD
TCGA novel	590	W>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381539497 rs1175693753	591	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA381539542 rs1201746376	593	E>G		No	ClinGen gnomAD
CA381539562 rs1427757064	594	G>V		No	ClinGen gnomAD
rs1171484396 CA381539580	595	E>G		No	ClinGen gnomAD
rs1429231630 CA381539590	596	A>S		No	ClinGen TOPMed
COSM1736397 rs1046223737 CA224143472	597	P>L	central_nervous_system [Cosmic]	No	ClinGen cosmic curated Ensembl
TCGA novel	597	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748617781 CA6134500	598	Q>E		No	ClinGen ExAC gnomAD
rs545841183 CA224143544	599	S>N		No	ClinGen Ensembl
CA381539761 rs1287273601	602	T>I		No	ClinGen TOPMed
rs772349105 CA6134501	603	M>T		No	ClinGen ExAC gnomAD
CA6134502 rs773591029	606	I>M		No	ClinGen ExAC gnomAD
rs1329353654 CA381539841	607	Q>*		No	ClinGen gnomAD
rs747238775 CA6134503	608	S>L		No	ClinGen ExAC gnomAD
rs1337382095 CA381539865	609	V>A		No	ClinGen Ensembl
CA381539869 rs1208908569	610	E>K		No	ClinGen TOPMed
rs374955195 CA6134505	612	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA381539911 rs1188278348	613	Q>E		No	ClinGen gnomAD
CA381539933 rs1244131139	614	I>M		No	ClinGen gnomAD
rs1446888542 CA381539935	615	K>Q		No	ClinGen gnomAD
rs1046543666 CA224143559	617	R>C		No	ClinGen TOPMed
rs765341702 CA224143562	617	R>H		No	ClinGen ExAC
rs765341702 CA6134507	617	R>L		No	ClinGen ExAC
rs1364285412 CA381540010	622	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA6134508 rs774169368	625	R>C		No	ClinGen ExAC gnomAD
rs1434289352 CA381540045	625	R>H		No	ClinGen gnomAD
CA6134510 rs548308441	626	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs755811948 CA6134512	627	G>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	627	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1327614984 CA381540098	630	F>L		No	ClinGen gnomAD
CA381540111 rs1264382181	631	I>M		No	ClinGen TOPMed gnomAD
rs1208659582 CA381540103	631	I>V		No	ClinGen TOPMed gnomAD
rs758888904	636	S>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA381540198 rs1336709306	636	S>G		No	ClinGen TOPMed
rs778340869 CA6134538	637	D>N		No	ClinGen ExAC gnomAD
CA6134541 rs781649971	641	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1471378419 CA381540289	644	K>E		No	ClinGen TOPMed
CA6134542 rs61763969	645	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6134543 rs770109747	646	E>*		No	ClinGen ExAC
rs780044736 CA6134544	646	E>V		No	ClinGen ExAC
rs1198059585 CA381540315	648	R>C		No	ClinGen gnomAD
CA6134545 rs749373224	648	R>H		No	ClinGen ExAC TOPMed gnomAD
CA381540325 rs773202529	649	D>E		No	ClinGen ExAC TOPMed gnomAD
CA224143677 rs1001981416	649	D>N		No	ClinGen gnomAD
rs1440574399 CA381540326	650	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA381540336 rs1277841517	651	Y>C		No	ClinGen TOPMed
CA6134548 rs149954659	652	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs921263753 CA224143697	652	R>H		No	ClinGen TOPMed gnomAD
CA381540342 rs921263753	652	R>L		No	ClinGen TOPMed gnomAD
CA6134549 rs149954659	652	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	660	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764931970 CA6134552 COSM1676220	660	R>W	ovary [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1289041369 CA381540453	665	K>N		No	ClinGen TOPMed gnomAD
CA6134553 rs752219530	668	P>L		No	ClinGen ExAC TOPMed gnomAD
rs752219530 CA6134554	668	P>R		No	ClinGen ExAC TOPMed gnomAD
rs763457854 CA6134555	669	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1353635469 CA381540511	670	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1323227874 CA381540520	671	P>S		No	ClinGen gnomAD
CA6134559 rs61763970	672	V>M	Variant assessed as Somatic; 4.966e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs756347417 CA6134560	674	E>*		No	ClinGen ExAC gnomAD
rs1247198778 CA381540555	675	L>P		No	ClinGen gnomAD
rs749400608 CA6134562	676	S>C		No	ClinGen ExAC gnomAD
rs768791963 CA6134563	676	S>N		No	ClinGen ExAC gnomAD
CA6134564 rs373199503	679	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1590856975 CA381540618	681	V>I		No	ClinGen Ensembl
CA224143754 rs897804760	682	Q>H		No	ClinGen Ensembl
rs1318881207 CA381540669	684	G>D		No	ClinGen gnomAD
COSM238717 CA224143760 rs1030574788	684	G>S	prostate [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs759325066 CA6134568	687	N>S		No	ClinGen ExAC gnomAD
CA6134570 rs375875634	688	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs200632343 CA6134572	689	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381540746 rs200632343	689	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD

No associated diseases with P25098

3 regional properties for P25098

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	43 - 209	IPR000719
active_site	Serine/threonine-protein kinase, active site	162 - 174	IPR008271
binding_site	Protein kinase, ATP binding site	49 - 72	IPR017441

Functions

		Description
EC Number	2.7.11.15	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Cell membrane Postsynapse Presynapse
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cilium	A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynapse	The part of a synapse that is part of the post-synaptic cell.
presynapse	The part of a synapse that is part of the presynaptic cell.

7 GO annotations of molecular function

Name	Definition
alpha-2A adrenergic receptor binding	Binding to an alpha-2A adrenergic receptor.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
beta-adrenergic receptor kinase activity	Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor.
Edg-2 lysophosphatidic acid receptor binding	Binding to an Edg-2 lysophosphatidic acid receptor.
G protein-coupled receptor binding	Binding to a G protein-coupled receptor.
G protein-coupled receptor kinase activity	Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

18 GO annotations of biological process

Name	Definition
cardiac muscle contraction	Muscle contraction of cardiac muscle tissue.
desensitization of G protein-coupled receptor signaling pathway	The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
G protein-coupled acetylcholine receptor signaling pathway	A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription.
G protein-coupled receptor signaling pathway	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
heart development	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
negative regulation of relaxation of smooth muscle	Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of smooth muscle.
negative regulation of striated muscle contraction	Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.
negative regulation of the force of heart contraction by chemical signal	Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of catecholamine secretion	Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
receptor internalization	A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
regulation of signal transduction	Any process that modulates the frequency, rate or extent of signal transduction.
regulation of the force of heart contraction	Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
tachykinin receptor signaling pathway	A G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. Tachykinin is a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2).
viral entry into host cell	The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
viral genome replication	Any process involved directly in viral genome replication, including viral nucleotide metabolism.

20 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P26818	GRK3	Beta-adrenergic receptor kinase 2	Bos taurus (Bovine)	PR
P43249	GRK5	G protein-coupled receptor kinase 5	Bos taurus (Bovine)	SS
P21146	GRK2	Beta-adrenergic receptor kinase 1	Bos taurus (Bovine)	PR
P32865	Gprk1	G protein-coupled receptor kinase 1	Drosophila melanogaster (Fruit fly)	PR
P34947	GRK5	G protein-coupled receptor kinase 5	Homo sapiens (Human)	EV
P35626	GRK3	Beta-adrenergic receptor kinase 2	Homo sapiens (Human)	PR
Q15835	GRK1	Rhodopsin kinase GRK1	Homo sapiens (Human)	PR
Q96LW2	RSKR	Ribosomal protein S6 kinase-related protein	Homo sapiens (Human)	PR
P32298	GRK4	G protein-coupled receptor kinase 4	Homo sapiens (Human)	SS
P43250	GRK6	G protein-coupled receptor kinase 6	Homo sapiens (Human)	EV
O70293	Grk6	G protein-coupled receptor kinase 6	Mus musculus (Mouse)	SS
Q8VEB1	Grk5	G protein-coupled receptor kinase 5	Mus musculus (Mouse)	SS
Q9WVL4	Grk1	Rhodopsin kinase GRK1	Mus musculus (Mouse)	PR
Q3UYH7	Adrbk2	Beta-adrenergic receptor kinase 2	Mus musculus (Mouse)	PR
Q99MK8	Grk2	Beta-adrenergic receptor kinase 1	Mus musculus (Mouse)	PR
Q62833	Grk5	G protein-coupled receptor kinase 5	Rattus norvegicus (Rat)	SS
P97711	Grk6	G protein-coupled receptor kinase 6	Rattus norvegicus (Rat)	SS
P26817	Grk2	Beta-adrenergic receptor kinase 1	Rattus norvegicus (Rat)	PR
Q09639	grk-2	G protein-coupled receptor kinase 2	Caenorhabditis elegans	PR
O48963	PHOT1	Phototropin-1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MADLEAVLAD	VSYLMAMEKS	KATPAARASK	KILLPEPSIR	SVMQKYLEDR	GEVTFEKIFS
70	80	90	100	110	120
QKLGYLLFRD	FCLNHLEEAR	PLVEFYEEIK	KYEKLETEEE	RVARSREIFD	SYIMKELLAC
130	140	150	160	170	180
SHPFSKSATE	HVQGHLGKKQ	VPPDLFQPYI	EEICQNLRGD	VFQKFIESDK	FTRFCQWKNV
190	200	210	220	230	240
ELNIHLTMND	FSVHRIIGRG	GFGEVYGCRK	ADTGKMYAMK	CLDKKRIKMK	QGETLALNER
250	260	270	280	290	300
IMLSLVSTGD	CPFIVCMSYA	FHTPDKLSFI	LDLMNGGDLH	YHLSQHGVFS	EADMRFYAAE
310	320	330	340	350	360
IILGLEHMHN	RFVVYRDLKP	ANILLDEHGH	VRISDLGLAC	DFSKKKPHAS	VGTHGYMAPE
370	380	390	400	410	420
VLQKGVAYDS	SADWFSLGCM	LFKLLRGHSP	FRQHKTKDKH	EIDRMTLTMA	VELPDSFSPE
430	440	450	460	470	480
LRSLLEGLLQ	RDVNRRLGCL	GRGAQEVKES	PFFRSLDWQM	VFLQKYPPPL	IPPRGEVNAA
490	500	510	520	530	540
DAFDIGSFDE	EDTKGIKLLD	SDQELYRNFP	LTISERWQQE	VAETVFDTIN	AETDRLEARK
550	560	570	580	590	600
KAKNKQLGHE	EDYALGKDCI	MHGYMSKMGN	PFLTQWQRRY	FYLFPNRLEW	RGEGEAPQSL
610	620	630	640	650	660
LTMEEIQSVE	ETQIKERKCL	LLKIRGGKQF	ILQCDSDPEL	VQWKKELRDA	YREAQQLVQR
670	680
VPKMKNKPRS	PVVELSKVPL	VQRGSANGL