P25008

PR
Gene name
CycC (CLND, CG7281)
Protein name
Cyclin-C
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG7281
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P25008

Entry ID Method Resolution Chain Position Source
AF-P25008-F1 Predicted AlphaFoldDB

No variants for P25008

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P25008

No associated diseases with P25008

No regional properties for P25008

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P25008

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

7 GO annotations of biological process

Name Definition
chaeta development The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.
imaginal disc-derived leg segmentation Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint.
positive regulation of autophagy Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
sex comb development The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg.
snRNA 3'-end processing Any process involved in forming the mature 3' end of an snRNA molecule.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P47821 SSN8 RNA polymerase II holoenzyme cyclin-like subunit Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3ZCK5 CCNC Cyclin-C Bos taurus (Bovine) PR
P55168 CCNC Cyclin-C Gallus gallus (Chicken) PR
P24863 CCNC Cyclin-C Homo sapiens (Human) PR
Q62447 Ccnc Cyclin-C Mus musculus (Mouse) PR
P39947 Ccnc Cyclin-C Rattus norvegicus (Rat) PR
Q28F72 ccnc Cyclin-C Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MAGNFWQSSH SQQWILDKPD LLRERQHDLL ALNEDEYQKV FIFFANVIQV LGEQLKLRQQ
70 80 90 100 110 120
VIATATVYFK RFYARNSLKN IDPLLLAPTC ILLASKVEEF GVISNSRLIS ICQSAIKTKF
130 140 150 160 170 180
SYAYAQEFPY RTNHILECEF YLLENLDCCL IVYQPYRPLL QLVQDMGQED QLLTLSWRIV
190 200 210 220 230 240
NDSLRTDVCL LYPPYQIAIA CLQIACVILQ KDATKQWFAE LNVDLDKVQE IVRAIVNLYE
250 260
LWKDWKEKDE IQMLLSKIPK PKPPPQR