P24863
PR
Gene name |
CCNC |
Protein name |
Cyclin-C |
Names |
SRB11 homolog, hSRB11 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:892 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
32 structures for P24863
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3RGF | X-ray | 220 A | B | 1-283 | PDB |
| 4CRL | X-ray | 240 A | B | 1-283 | PDB |
| 4F6S | X-ray | 260 A | B | 1-283 | PDB |
| 4F6U | X-ray | 210 A | B | 1-283 | PDB |
| 4F6W | X-ray | 239 A | B | 1-283 | PDB |
| 4F70 | X-ray | 300 A | B | 1-283 | PDB |
| 4F7J | X-ray | 260 A | B | 1-283 | PDB |
| 4F7L | X-ray | 290 A | B | 1-283 | PDB |
| 4F7N | X-ray | 265 A | B | 1-283 | PDB |
| 4F7S | X-ray | 220 A | B | 1-283 | PDB |
| 4G6L | X-ray | 270 A | B | 1-283 | PDB |
| 5BNJ | X-ray | 264 A | B | 1-283 | PDB |
| 5CEI | X-ray | 224 A | B | 1-283 | PDB |
| 5FGK | X-ray | 236 A | B | 1-264 | PDB |
| 5HBE | X-ray | 238 A | B | 1-264 | PDB |
| 5HBH | X-ray | 250 A | B | 1-264 | PDB |
| 5HBJ | X-ray | 300 A | B | 1-264 | PDB |
| 5HNB | X-ray | 235 A | B | 1-264 | PDB |
| 5HVY | X-ray | 239 A | B | 1-283 | PDB |
| 5I5Z | X-ray | 260 A | B | 1-264 | PDB |
| 5ICP | X-ray | 218 A | B | 1-264 | PDB |
| 5IDN | X-ray | 226 A | B | 1-264 | PDB |
| 5IDP | X-ray | 265 A | B | 1-264 | PDB |
| 5XQX | X-ray | 230 A | B | 2-264 | PDB |
| 5XS2 | X-ray | 204 A | B | 2-264 | PDB |
| 6QTG | X-ray | 270 A | B | 1-283 | PDB |
| 6QTJ | X-ray | 248 A | B | 1-283 | PDB |
| 6R3S | X-ray | 219 A | B | 1-283 | PDB |
| 6T41 | X-ray | 245 A | B | 1-283 | PDB |
| 6TPA | X-ray | 280 A | B | 1-283 | PDB |
| 6Y0A | X-ray | 219 A | B | 1-280 | PDB |
| AF-P24863-F1 | Predicted | AlphaFoldDB |
113 variants for P24863
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA365111885 rs1201923177 |
3 | G>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA143943741 rs79162773 |
4 | N>D | No |
ClinGen Ensembl |
|
| TCGA novel | 14 | W>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA365128364 rs1471940594 |
15 | I>M | No |
ClinGen gnomAD |
|
|
CA143966364 rs745828562 |
15 | I>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1251893221 CA365128324 |
19 | Q>R | No |
ClinGen gnomAD |
|
|
rs772424516 CA3936018 |
20 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs1260195663 CA365128251 |
24 | E>G | No |
ClinGen TOPMed |
|
|
rs1314175799 CA365128236 |
25 | R>C | No |
ClinGen gnomAD |
|
|
COSM3429796 CA3936015 rs755107219 |
25 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs755107219 CA3936016 |
25 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 26 | Q>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA365128115 rs1290270634 |
33 | S>P | No |
ClinGen gnomAD |
|
|
rs796471188 CA143966271 |
37 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1302071936 CA365128041 |
38 | W>R | No |
ClinGen gnomAD |
|
|
CA365127973 rs1156589568 |
43 | F>C | No |
ClinGen gnomAD |
|
|
rs766105726 CA3936010 |
43 | F>L | No |
ClinGen ExAC gnomAD |
|
| rs1456359224 | 44 | F>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA3936009 rs147364472 |
46 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1208140816 CA365127863 |
47 | V>A | No |
ClinGen gnomAD |
|
|
rs764780094 CA3935990 |
48 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA3935989 rs756854853 |
54 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
CA3935986 rs763638199 |
60 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA3935985 rs761299038 |
62 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs776112779 CA3935984 |
63 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs756503282 CA3935983 COSM301894 |
66 | T>M | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA3935980 rs771063204 |
67 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs1369197453 CA365127504 |
70 | K>Q | No |
ClinGen gnomAD |
|
|
rs749471346 CA3935979 |
72 | F>V | No |
ClinGen ExAC gnomAD |
|
|
CA3935977 rs769823983 |
73 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365127422 rs1197099039 |
74 | A>S | No |
ClinGen gnomAD |
|
|
CA365127281 rs1394118423 |
79 | K>R | No |
ClinGen TOPMed |
|
|
rs1201688903 CA365127258 |
80 | S>I | No |
ClinGen gnomAD |
|
|
rs1471688151 CA569091503 |
80 | S>TIY* | No |
ClinGen gnomAD |
|
|
CA365127149 rs1251149886 |
87 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
CA365127153 rs1251149886 |
87 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1562494037 CA365127133 |
88 | P>S | No |
ClinGen Ensembl |
|
|
CA143965394 TCGA novel rs77717928 |
93 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA143963657 rs376395442 |
100 | F>S | No |
ClinGen ESP |
|
| TCGA novel | 101 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 104 | S>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 107 | R>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1353473261 CA365125877 |
108 | L>S | No |
ClinGen gnomAD |
|
|
rs1562492796 CA365125859 |
109 | I>T | No |
ClinGen Ensembl |
|
|
rs780791977 CA3935941 |
111 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA143963646 rs941457310 |
113 | T>N | No |
ClinGen TOPMed |
|
|
rs766693480 CA3935938 |
115 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs752067009 CA3935939 |
115 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365123905 rs1180711158 |
125 | P>L | No |
ClinGen gnomAD |
|
|
rs1270401879 CA365123915 |
125 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA365123811 rs1482997458 |
129 | P>S | No |
ClinGen gnomAD |
|
|
CA365123728 rs1233851060 |
132 | M>L | No |
ClinGen gnomAD |
|
|
CA143960447 rs1045292995 |
132 | M>T | No |
ClinGen gnomAD |
|
|
rs1562489259 CA365123579 |
135 | I>L | No |
ClinGen Ensembl |
|
|
CA365123556 rs1462789406 |
136 | L>S | No |
ClinGen gnomAD |
|
|
rs910135708 CA143960032 |
137 | E>D | No |
ClinGen TOPMed |
|
|
rs1023945530 CA143960027 |
141 | Y>C | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 150 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA3935872 rs771528577 |
152 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1362091998 CA365123237 |
156 | Y>C | No |
ClinGen gnomAD |
|
|
CA3935871 rs746412454 |
157 | R>K | No |
ClinGen ExAC gnomAD |
|
|
CA143959655 rs926414039 |
158 | P>L | No |
ClinGen TOPMed |
|
|
CA143959651 rs970158250 |
162 | Y>H | No |
ClinGen TOPMed |
|
|
rs779382674 CA3935870 |
163 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA3935868 rs369260892 |
167 | G>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA365123131 rs1263983869 |
171 | M>T | No |
ClinGen gnomAD |
|
|
CA143959209 rs1048560072 |
179 | I>T | No |
ClinGen TOPMed |
|
|
CA365123059 rs1174052252 |
180 | V>M | No |
ClinGen gnomAD |
|
|
CA365123036 rs1480190290 |
183 | T>A | No |
ClinGen gnomAD |
|
|
rs371333092 CA3935855 |
183 | T>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs948885477 CA143959175 |
184 | Y>C | No |
ClinGen TOPMed |
|
| TCGA novel | 184 | Y>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA143959174 rs940563658 |
186 | T>M | No |
ClinGen TOPMed gnomAD |
|
|
CA365123004 rs1221793267 |
188 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
CA365122992 rs1194951623 |
190 | L>I | No |
ClinGen gnomAD |
|
|
rs1470337889 CA365122958 |
195 | F>S | No |
ClinGen TOPMed |
|
|
rs1159479551 CA365122941 |
197 | I>T | No |
ClinGen TOPMed |
|
|
CA365122234 rs1264065358 |
200 | A>G | No |
ClinGen gnomAD |
|
|
CA3935828 rs781634701 |
205 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1478905490 CA365122129 |
206 | C>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1433139486 CA365122032 |
211 | K>N | No |
ClinGen gnomAD |
|
|
rs61753659 CA143957445 |
211 | K>R | No |
ClinGen Ensembl |
|
| TCGA novel | 213 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 221 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs747179991 CA3935826 |
224 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs1165185165 CA365121415 |
233 | V>F | No |
ClinGen TOPMed gnomAD |
|
|
rs777157075 CA3935810 |
234 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1168128649 CA365121193 |
241 | W>L | No |
ClinGen gnomAD |
|
| TCGA novel | 242 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA3935807 rs747673155 |
243 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs374888747 CA3935804 |
245 | D>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs745941649 CA3935805 |
245 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA143956652 rs745941649 |
245 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 250 | M>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1202801256 CA365120928 |
252 | T>A | No |
ClinGen gnomAD |
|
|
rs1319094771 CA365120926 |
252 | T>N | No |
ClinGen TOPMed |
|
|
rs781010184 CA3935801 |
253 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs748037864 CA3935802 |
253 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA365120863 rs1208527532 |
256 | K>R | No |
ClinGen TOPMed |
|
|
CA365120835 rs1257397839 |
257 | M>T | No |
ClinGen TOPMed |
|
|
rs781390814 CA143956630 |
260 | P>S | No |
ClinGen Ensembl |
|
|
CA365120725 rs1222846498 |
262 | P>S | No |
ClinGen gnomAD |
|
|
CA365120697 rs1316505751 |
263 | P>L | No |
ClinGen gnomAD |
|
|
rs1346004412 CA365120660 |
265 | N>D | No |
ClinGen TOPMed gnomAD |
|
|
rs1346004412 CA365120662 |
265 | N>H | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 269 | E>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA3935778 rs779837777 |
270 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA3935776 rs750048355 |
273 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs1353652632 CA365119693 |
275 | S>T | No |
ClinGen TOPMed |
|
|
CA365119614 rs1266323637 |
279 | S>T | No |
ClinGen TOPMed |
|
|
rs1380766885 CA365119583 |
281 | S>G | No |
ClinGen gnomAD |
|
|
rs1358174702 CA365119577 |
281 | S>T | No |
ClinGen TOPMed |
|
|
rs754453163 CA3935773 |
283 | S>P | No |
ClinGen ExAC gnomAD |
No associated diseases with P24863
12 regional properties for P24863
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | B-box-type zinc finger | 181 - 230 | IPR000315-1 |
| domain | B-box-type zinc finger | 260 - 301 | IPR000315-2 |
| repeat | NHL repeat | 580 - 623 | IPR001258-1 |
| repeat | NHL repeat | 627 - 670 | IPR001258-2 |
| repeat | NHL repeat | 674 - 717 | IPR001258-3 |
| repeat | NHL repeat | 721 - 764 | IPR001258-4 |
| repeat | NHL repeat | 768 - 811 | IPR001258-5 |
| repeat | NHL repeat | 815 - 855 | IPR001258-6 |
| repeat | Filamin/ABP280 repeat | 470 - 570 | IPR001298 |
| domain | Zinc finger, RING-type | 12 - 94 | IPR001841 |
| repeat | Filamin/ABP280 repeat-like | 466 - 567 | IPR017868 |
| conserved_site | Zinc finger, RING-type, conserved site | 60 - 69 | IPR017907 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cyclin-dependent protein kinase holoenzyme complex | Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. |
| mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
| identical protein binding | Binding to an identical protein or proteins. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| G0 to G1 transition | The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression. |
| negative regulation of Notch signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P47821 | SSN8 | RNA polymerase II holoenzyme cyclin-like subunit | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3ZCK5 | CCNC | Cyclin-C | Bos taurus (Bovine) | PR |
| P55168 | CCNC | Cyclin-C | Gallus gallus (Chicken) | PR |
| P25008 | CycC | Cyclin-C | Drosophila melanogaster (Fruit fly) | PR |
| P51946 | CCNH | Cyclin-H | Homo sapiens (Human) | PR |
| O60563 | CCNT1 | Cyclin-T1 | Homo sapiens (Human) | EV |
| O75909 | CCNK | Cyclin-K | Homo sapiens (Human) | PR |
| Q8N1B3 | CCNQ | Cyclin-Q | Homo sapiens (Human) | PR |
| Q62447 | Ccnc | Cyclin-C | Mus musculus (Mouse) | PR |
| P39947 | Ccnc | Cyclin-C | Rattus norvegicus (Rat) | PR |
| Q28F72 | ccnc | Cyclin-C | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGNFWQSSH | YLQWILDKQD | LLKERQKDLK | FLSEEEYWKL | QIFFTNVIQA | LGEHLKLRQQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VIATATVYFK | RFYARYSLKS | IDPVLMAPTC | VFLASKVEEF | GVVSNTRLIA | AATSVLKTRF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SYAFPKEFPY | RMNHILECEF | YLLELMDCCL | IVYHPYRPLL | QYVQDMGQED | MLLPLAWRIV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NDTYRTDLCL | LYPPFMIALA | CLHVACVVQQ | KDARQWFAEL | SVDMEKILEI | IRVILKLYEQ |
| 250 | 260 | 270 | 280 | ||
| WKNFDERKEM | ATILSKMPKP | KPPPNSEGEQ | GPNGSQNSSY | SQS |