P24583
SS
Gene name |
PKC1 (HPO2, STT1, YBL105C, YBL0807) |
Protein name |
Protein kinase C-like 1 |
Names |
PKC 1 , EC 2.7.11.13 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YBL105C |
EC number |
2.7.11.13: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
Protein kinase C-like 1 (PKC1) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of PKC1.
Autoinhibitory domains (AIDs)
Accessory elements
966-989 (Activation loop from InterPro)
Target domain |
824-1083 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for P24583
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P24583-F1 | Predicted | AlphaFoldDB |
8 variants for P24583
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s02-16345 | 451 | K>R | No | SGRP | |
| s02-16009 | 563 | Q>P | No | SGRP | |
| s02-15901 | 599 | T>N | No | SGRP | |
| s02-15880 | 606 | G>E | No | SGRP | |
| s02-15830 | 623 | S>P | No | SGRP | |
| s02-15101 | 866 | I>L | No | SGRP | |
| 958 | T>I | cly5; temperature-sensitive mutation that cause cell lysis at high temperature [UniProt] | No | ||
| 1023 | P>S | cly7; temperature-sensitive mutation that cause cell lysis at high temperature [UniProt] | No |
No associated diseases with P24583
6 regional properties for P24583
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pancreatic trypsin inhibitor Kunitz domain | 50 - 104 | IPR002223-1 |
| domain | Pancreatic trypsin inhibitor Kunitz domain | 122 - 175 | IPR002223-2 |
| domain | Pancreatic trypsin inhibitor Kunitz domain | 220 - 273 | IPR002223-3 |
| conserved_site | Proteinase inhibitor I2, Kunitz, conserved site | 81 - 99 | IPR020901-1 |
| conserved_site | Proteinase inhibitor I2, Kunitz, conserved site | 152 - 170 | IPR020901-2 |
| conserved_site | Proteinase inhibitor I2, Kunitz, conserved site | 250 - 268 | IPR020901-3 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.13 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cellular bud neck | The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic stress granule | A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| prospore septin filament array | Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation. |
| site of polarized growth | Any part of a cell where non-isotropic growth takes place. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| diacylglycerol-dependent serine/threonine kinase activity | Catalysis of the reaction |
| metal ion binding | Binding to a metal ion. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular bud neck septin ring organization | Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck. |
| fungal-type cell wall biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| pexophagy | The selective autophagy process in which a peroxisome is degraded by macroautophagy. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of cytoplasmic mRNA processing body assembly | Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. |
| regulation of fungal-type cell wall organization | Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall. |
| regulation of nuclear-transcribed mRNA poly(A) tail shortening | Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| stress granule assembly | The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. |
52 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q03407 | PKH1 | Serine/threonine-protein kinase PKH1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P53894 | CBK1 | Serine/threonine-protein kinase CBK1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| A1A4I4 | PKN1 | Serine/threonine-protein kinase N1 | Bos taurus (Bovine) | SS |
| P04409 | PRKCA | Protein kinase C alpha type | Bos taurus (Bovine) | EV SS |
| P05128 | PRKCG | Protein kinase C gamma type | Bos taurus (Bovine) | SS |
| P05126 | PRKCB | Protein kinase C beta type | Bos taurus (Bovine) | SS |
| A1Z9X0 | aPKC | Atypical protein kinase C | Drosophila melanogaster (Fruit fly) | SS |
| A1Z7T0 | Pkn | Serine/threonine-protein kinase N | Drosophila melanogaster (Fruit fly) | SS |
| P83099 | Pkcdelta | Putative protein kinase C delta type homolog | Drosophila melanogaster (Fruit fly) | PR |
| P13677 | inaC | Protein kinase C, eye isozyme | Drosophila melanogaster (Fruit fly) | SS |
| P05130 | Pkc53E | Protein kinase C, brain isozyme | Drosophila melanogaster (Fruit fly) | SS |
| Q05513 | PRKCZ | Protein kinase C zeta type | Homo sapiens (Human) | SS |
| P41743 | PRKCI | Protein kinase C iota type | Homo sapiens (Human) | EV |
| Q16512 | PKN1 | Serine/threonine-protein kinase N1 | Homo sapiens (Human) | EV |
| Q6P5Z2 | PKN3 | Serine/threonine-protein kinase N3 | Homo sapiens (Human) | SS |
| Q16513 | PKN2 | Serine/threonine-protein kinase N2 | Homo sapiens (Human) | EV |
| P24723 | PRKCH | Protein kinase C eta type | Homo sapiens (Human) | SS |
| Q02156 | PRKCE | Protein kinase C epsilon type | Homo sapiens (Human) | SS |
| Q04759 | PRKCQ | Protein kinase C theta type | Homo sapiens (Human) | PR |
| Q05655 | PRKCD | Protein kinase C delta type | Homo sapiens (Human) | SS |
| P17252 | PRKCA | Protein kinase C alpha type | Homo sapiens (Human) | EV |
| P05129 | PRKCG | Protein kinase C gamma type | Homo sapiens (Human) | SS |
| P05771 | PRKCB | Protein kinase C beta type | Homo sapiens (Human) | SS |
| Q02956 | Prkcz | Protein kinase C zeta type | Mus musculus (Mouse) | SS |
| Q62074 | Prkci | Protein kinase C iota type | Mus musculus (Mouse) | SS |
| P70268 | Pkn1 | Serine/threonine-protein kinase N1 | Mus musculus (Mouse) | SS |
| Q8K045 | Pkn3 | Serine/threonine-protein kinase N3 | Mus musculus (Mouse) | SS |
| Q8BWW9 | Pkn2 | Serine/threonine-protein kinase N2 | Mus musculus (Mouse) | SS |
| P23298 | Prkch | Protein kinase C eta type | Mus musculus (Mouse) | PR |
| P16054 | Prkce | Protein kinase C epsilon type | Mus musculus (Mouse) | PR |
| Q02111 | Prkcq | Protein kinase C theta type | Mus musculus (Mouse) | PR |
| P28867 | Prkcd | Protein kinase C delta type | Mus musculus (Mouse) | PR |
| P20444 | Prkca | Protein kinase C alpha type | Mus musculus (Mouse) | SS |
| P63318 | Prkcg | Protein kinase C gamma type | Mus musculus (Mouse) | SS |
| P68404 | Prkcb | Protein kinase C beta type | Mus musculus (Mouse) | SS |
| P09217 | Prkcz | Protein kinase C zeta type | Rattus norvegicus (Rat) | SS |
| F1M7Y5 | Prkci | Protein kinase C iota type | Rattus norvegicus (Rat) | SS |
| Q63433 | Pkn1 | Serine/threonine-protein kinase N1 | Rattus norvegicus (Rat) | SS |
| O08874 | Pkn2 | Serine/threonine-protein kinase N2 | Rattus norvegicus (Rat) | SS |
| Q64617 | Prkch | Protein kinase C eta type | Rattus norvegicus (Rat) | PR |
| P09216 | Prkce | Protein kinase C epsilon type | Rattus norvegicus (Rat) | PR |
| P09215 | Prkcd | Protein kinase C delta type | Rattus norvegicus (Rat) | PR |
| P05696 | Prkca | Protein kinase C alpha type | Rattus norvegicus (Rat) | SS |
| P63319 | Prkcg | Protein kinase C gamma type | Rattus norvegicus (Rat) | SS |
| P68403 | Prkcb | Protein kinase C beta type | Rattus norvegicus (Rat) | SS |
| Q19266 | pkc-3 | Protein kinase C-like 3 | Caenorhabditis elegans | SS |
| P34722 | tpa-1 | Protein kinase C-like 1 | Caenorhabditis elegans | PR |
| P90980 | pkc-2 | Protein kinase C-like 2 | Caenorhabditis elegans | SS |
| A8KBH6 | prkcb | Protein kinase C beta type | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q90XF2 | prkci | Protein kinase C iota type | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A7MBL8 | pkn2 | Serine/threonine-protein kinase N2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SY24 | prkcbb | Protein kinase C beta type | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFSQLEQNI | KKKIAVEENI | IRGASALKKK | TSNVMVIQKC | NTNIREARQN | LEYLEDSLKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LRLKTAQQSQ | GENGSEDNER | CNSKEYGFLS | TKSPNEHIFS | RLDLVKYDCP | SLAQRIQYML |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QQLEFKLQVE | KQYQEANTKL | TKLYQIDGDQ | RSSSAAEGGA | MESKYRIQML | NKALKKYQAI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NVDFDQFKHQ | PNDIMDNQQP | KFRRKQLTGV | LTIGITAARD | VDHIQSPMFA | RKPESYVTIK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IDDTIKARTK | PSRNDRWSED | FQIPVEKGNE | IEITVYDKVN | DSLIPVAIMW | LLLSDIAEEI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RKKKAGQTNE | QQGWVNASNI | NGGSSLASEE | GSTLTSTYSN | SAIQSTSAKN | VQGENTSTSQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ISTNSWFVLE | PSGQILLTLG | FHKSSQIERK | QLMGGLHRHG | AIINRKEEIF | EQHGHHFVQK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SFYNIMCCAY | CGDFLRYTGF | QCQDCKFLCH | KKCYTNVVTK | CIAKTSTDTD | PDEAKLNHRI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PHRFLPTSNR | GTKWCCHCGY | ILPWGRHKVR | KCSECGIMCH | AQCAHLVPDF | CGMSMEMANK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ILKTIQDTKR | NQEKKKRTVP | SAQLGSSIGT | ANGSDLSPSK | LAERANAPLP | PQPRKHDKTP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SPQKVGRDSP | TKQHDPIIDK | RISLQTHGRE | KLNKFIDENE | AYLNFTEGAQ | QTAEFSSPEK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TLDPTSNRRS | LGLTDLSIEH | SQTWESKDDL | MRDELELWKA | QREEMELEIK | QDSGEIQEDL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EVDHIDLETK | QKLDWENKND | FREADLTIDS | THTNPFRDMN | SETFQIEQDH | ASKEVLQETV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SLAPTSTHAS | RTTDQQSPQK | SQTSTSAKHK | KRAAKRRKVS | LDNFVLLKVL | GKGNFGKVIL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SKSKNTDRLC | AIKVLKKDNI | IQNHDIESAR | AEKKVFLLAT | KTKHPFLTNL | YCSFQTENRI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| YFAMEFIGGG | DLMWHVQNQR | LSVRRAKFYA | AEVLLALKYF | HDNGVIYRDL | KLENILLTPE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GHIKIADYGL | CKDEMWYGNR | TSTFCGTPEF | MAPEILKEQE | YTKAVDWWAF | GVLLYQMLLC |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| QSPFSGDDED | EVFNAILTDE | PLYPIDMAGE | IVQIFQGLLT | KDPEKRLGAG | PRDADEVMEE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| PFFRNINFDD | ILNLRVKPPY | IPEIKSPEDT | SYFEQEFTSA | PPTLTPLPSV | LTTSQQEEFR |
| 1150 | |||||
| GFSFMPDDLD | L |