P23812
Gene name |
Hoxd12 (Hox-4.7, Hoxd-12) |
Protein name |
Homeobox protein Hox-D12 |
Names |
Homeobox protein Hox-4.7, Homeobox protein Hox-5.6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:15432 |
EC number |
|
Protein Class |
|

Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure

Activated structure

1 structures for P23812
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-P23812-F1 | Predicted | AlphaFoldDB |
10 variants for P23812
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
rs3391708675 | 11 | Y>F | No | EVA | |
rs3388561741 | 35 | Q>* | No | EVA | |
rs3388556185 | 61 | A>V | No | EVA | |
rs3388554291 | 81 | G>R | No | EVA | |
rs3388561765 | 102 | T>M | No | EVA | |
rs3388557806 | 118 | P>S | No | EVA | |
rs3388549814 | 146 | G>D | No | EVA | |
rs3388556187 | 166 | G>C | No | EVA | |
rs3388558625 | 251 | R>Q | No | EVA | |
rs3388549812 | 257 | R>Q | No | EVA |
No associated diseases with P23812
4 regional properties for P23812
Type | Name | Position | InterPro Accession |
---|---|---|---|
domain | Homeobox domain | 198 - 262 | IPR001356 |
conserved_site | Homeobox, conserved site | 233 - 256 | IPR017970 |
domain | Homeobox domain, metazoa | 222 - 233 | IPR020479-1 |
domain | Homeobox domain, metazoa | 237 - 256 | IPR020479-2 |
2 GO annotations of cellular component
Name | Definition |
---|---|
nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
transcription regulator complex | A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. |
2 GO annotations of molecular function
Name | Definition |
---|---|
DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
3 GO annotations of biological process
Name | Definition |
---|---|
embryonic digit morphogenesis | The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. |
pattern specification process | Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. |
skeletal system development | The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). |
3 homologous proteins in AiPD
10 | 20 | 30 | 40 | 50 | 60 |
MCERSLYRAG | YVGSLLNLQS | PDSFYFSNLR | ANGSQLAALP | PISYPRSALP | WATTPASCTP |
70 | 80 | 90 | 100 | 110 | 120 |
AQPATASAFG | GFSQPYLTGS | GPIGLQSPGA | KDGPEDQVKF | YTPDAPTASE | ERSRTRPPFA |
130 | 140 | 150 | 160 | 170 | 180 |
PESSLVHSAL | KGTKYDYAGV | GRTAPGSATL | LQGAPCASSF | KEDTKGPLNL | NMAVQVAGVA |
190 | 200 | 210 | 220 | 230 | 240 |
SCLRSSLPDG | LPWGAAPGRA | RKKRKPYTKQ | QIAELENEFL | VNEFINRQKR | KELSNRLNLS |
250 | 260 | ||||
DQQVKIWFQN | RRMKKKRVVQ | REQALALY |