Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P23812

Entry ID Method Resolution Chain Position Source
AF-P23812-F1 Predicted AlphaFoldDB

10 variants for P23812

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3391708675 11 Y>F No EVA
rs3388561741 35 Q>* No EVA
rs3388556185 61 A>V No EVA
rs3388554291 81 G>R No EVA
rs3388561765 102 T>M No EVA
rs3388557806 118 P>S No EVA
rs3388549814 146 G>D No EVA
rs3388556187 166 G>C No EVA
rs3388558625 251 R>Q No EVA
rs3388549812 257 R>Q No EVA

No associated diseases with P23812

4 regional properties for P23812

Type Name Position InterPro Accession
domain Homeobox domain 198 - 262 IPR001356
conserved_site Homeobox, conserved site 233 - 256 IPR017970
domain Homeobox domain, metazoa 222 - 233 IPR020479-1
domain Homeobox domain, metazoa 237 - 256 IPR020479-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

3 GO annotations of biological process

Name Definition
embryonic digit morphogenesis The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.
pattern specification process Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
skeletal system development The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P35452 HOXD12 Homeobox protein Hox-D12 Homo sapiens (Human) PR
Q6JIY5 hoxc13a Homeobox protein Hox-C13a Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q9DDU0 hoxa11a Homeobox protein Hox-A11a Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MCERSLYRAG YVGSLLNLQS PDSFYFSNLR ANGSQLAALP PISYPRSALP WATTPASCTP
70 80 90 100 110 120
AQPATASAFG GFSQPYLTGS GPIGLQSPGA KDGPEDQVKF YTPDAPTASE ERSRTRPPFA
130 140 150 160 170 180
PESSLVHSAL KGTKYDYAGV GRTAPGSATL LQGAPCASSF KEDTKGPLNL NMAVQVAGVA
190 200 210 220 230 240
SCLRSSLPDG LPWGAAPGRA RKKRKPYTKQ QIAELENEFL VNEFINRQKR KELSNRLNLS
250 260
DQQVKIWFQN RRMKKKRVVQ REQALALY