Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P23607
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P23607-F1 | Predicted | AlphaFoldDB |
No variants for P23607
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P23607 | |||||
No associated diseases with P23607
15 regional properties for P23607
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Transcriptional activator, Zfx / Zfy domain | 70 - 209 | IPR006794-1 |
| domain | Transcriptional activator, Zfx / Zfy domain | 211 - 347 | IPR006794-2 |
| domain | Zinc finger C2H2-type | 362 - 392 | IPR013087-1 |
| domain | Zinc finger C2H2-type | 393 - 415 | IPR013087-2 |
| domain | Zinc finger C2H2-type | 425 - 447 | IPR013087-3 |
| domain | Zinc finger C2H2-type | 456 - 484 | IPR013087-4 |
| domain | Zinc finger C2H2-type | 485 - 512 | IPR013087-5 |
| domain | Zinc finger C2H2-type | 513 - 541 | IPR013087-6 |
| domain | Zinc finger C2H2-type | 542 - 569 | IPR013087-7 |
| domain | Zinc finger C2H2-type | 570 - 598 | IPR013087-8 |
| domain | Zinc finger C2H2-type | 599 - 626 | IPR013087-9 |
| domain | Zinc finger C2H2-type | 627 - 655 | IPR013087-10 |
| domain | Zinc finger C2H2-type | 656 - 683 | IPR013087-11 |
| domain | Zinc finger C2H2-type | 684 - 712 | IPR013087-12 |
| domain | Zinc finger C2H2-type | 713 - 740 | IPR013087-13 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| metal ion binding | Binding to a metal ion. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P17010 | ZFX | Zinc finger X-chromosomal protein | Homo sapiens (Human) | PR |
| P17012 | Zfx | Zinc finger X-chromosomal protein | Mus musculus (Mouse) | PR |
| P10925 | Zfy1 | Zinc finger Y-chromosomal protein 1 | Mus musculus (Mouse) | PR |
| Q99KZ6 | Znf639 | Zinc finger protein 639 | Mus musculus (Mouse) | PR |
| P20662 | Zfy2 | Zinc finger Y-chromosomal protein 2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKMDLNYNNK | HQTHFLMQQE | LVAPHMDGSQ | IVVEVQETVY | VSDVVDSDII | VHNYVPDDPD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SVVIQDVIED | VVIEDVQCTD | IMDEADVSET | VIIPEQVLNS | DVTEEVSLTH | CTVPDDVLAS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DITSASISMP | KRVLTSESIH | VSDIGHVEHV | VHDSVVEAEI | ITDPLATDVV | SEEVLVADCA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SEAVIDANRI | PVNQQDEEKN | NCEDYLMISC | GTVDIVESEP | ENELGVELLD | PNNSICVPRE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KMVYMAVNNS | QQEEELNVTE | IADEIYMEVI | VGEEDATASE | HEQQVEDNKM | KTFMPIAWEA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AYGNNSDGIE | NRNGTASALL | HIDESAGLGR | LAKQKPKKRR | PDSRQYQTAI | IIGPDGHPLT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VYPCMICGKK | FKSRGFLKRH | MKNHPEHLAK | KKYRCTDCDY | TTNKKISLHN | HLESHKLTSK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AEKAIECDEY | GKHFSHAGAL | FTHKMVHKEK | GANKMHKCKF | CEYETAEQGL | LNRHLLAVHS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KNFPHICVEC | GKGFCHPSEL | KKHMRIHTGE | KPYECQYCEY | RSTDSSNLKT | HVKTKHSKEM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PFKCDICLLT | FSDTKEVQQH | ALVHQESKTH | QCLHCDHKSS | NSSDLKRHII | SVHTKDYPHK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| CDMCDKGFHR | PSELKKHVAA | HKGKKTHQCR | HCDFKIADPF | VLSRHILSVH | TKDLPFRCKR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| CRTRFRQQSE | LKKHMKTHSG | QKVYQCEYCD | YSTTDASGFK | RHVISIHTKD | YPHCCEHCKK |
| 730 | 740 | ||||
| GFRRPSEKNQ | HIMRHHKEVG | LP |