P23459

PR
Gene name
HOXD8 (CHOX-M)
Protein name
Homeobox protein Hox-D8
Names
Homeobox protein Hox-M, Chox-M
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:396301
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-188 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P23459

Entry ID Method Resolution Chain Position Source
AF-P23459-F1 Predicted AlphaFoldDB

No variants for P23459

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P23459

No associated diseases with P23459

6 regional properties for P23459

Type Name Position InterPro Accession
conserved_site Helix-turn-helix motif 124 - 149 IPR000047
domain Homeobox domain 93 - 157 IPR001356
conserved_site Homeobox protein, antennapedia type, conserved site 83 - 88 IPR001827
conserved_site Homeobox, conserved site 128 - 151 IPR017970
domain Homeobox domain, metazoa 117 - 128 IPR020479-1
domain Homeobox domain, metazoa 132 - 151 IPR020479-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A2T6Z0 HOXB1 Homeobox protein Hox-B1 Pan troglodytes (Chimpanzee) SS
P10105 lab Homeotic protein labial Drosophila melanogaster (Fruit fly) EV
P31268 HOXA7 Homeobox protein Hox-A7 Homo sapiens (Human) SS
P49639 HOXA1 Homeobox protein Hox-A1 Homo sapiens (Human) SS
P14653 HOXB1 Homeobox protein Hox-B1 Homo sapiens (Human) SS
P09022 Hoxa1 Homeobox protein Hox-A1 Mus musculus (Mouse) SS
O08656 Hoxa1 Homeobox protein Hox-A1 Rattus norvegicus (Rat) SS
A2D649 HOXB1 Homeobox protein Hox-B1 Macaca mulatta (Rhesus macaque) SS
Q28IU6 hoxd1 Homeobox protein Hox-D1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q8JH55 hoxb8b Homeobox protein Hox-B8b Danio rerio (Zebrafish) (Brachydanio rerio) PR
F1Q4R9 meox1 Homeobox protein MOX-1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSSYFVNPLY SKYKAAAAAA AAVAAGEPLP APYYDCHFAP ERQQIFTTQQ EAELVQYPDC
70 80 90 100 110 120
KSSSANIGEE PDHLNQSSSP AQMFPWMRPQ AAPGRRRGRQ TYSRFQTLEL EKEFLFNPYL
130 140 150 160 170 180
TRKRRIEVSH ALGLTERQVK IWFQNRRMKW KKENNKDKFP ASKQEGKEGE AKKETHDLED
DRAESHTN