AiPD: Autoinhibited Protein Database

P23443

EV SS

Gene name	RPS6KB1 (STK14A)
Protein name	Ribosomal protein S6 kinase beta-1
Names	S6K-beta-1, S6K1, 70 kDa ribosomal protein S6 kinase 1, P70S6K1, p70-S6K 1, Ribosomal protein S6 kinase I, Serine/threonine-protein kinase 14A, p70 ribosomal S6 kinase alpha, p70 S6 kinase alpha, p70 S6K-alpha, p70 S6KA
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6198
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class	RIBOSOMAL PROTEIN S6 KINASE (PTHR24351)

Descriptions

Ribosomal protein S6 kinases are proteins playing a crucial role in regulating cellular growth and metabolism through its involvement in the mTOR signaling pathway. S6Ks are activated by a wide variety of growth factor receptors, including receptor tyrosine kinases, G-protein-coupled receptors, and the interleukin-2 receptor.
The activity of S6K protein is regulated by autoinhibitory domains. Phosphorylation of specific serine residues within the N-terminal autoinhibitory domain of S6K by cyclin-dependent kinase 5 (Cdk5) is required for dendritic spine morphogenesis in the neuron. In S6K, the N-terminal region also contains an autoinhibitory domain and its deletion activates S6K.

Autoinhibitory domains (AIDs)

Target domain	91-352 (Protein kinase domain)
Relief mechanism	Partner binding
Assay	Deletion assay

AID

58-77 (Autoinhibitory domain)

Target domain

91-352 (Protein kinase domain)

Relief mechanism

Partner binding (Interaction with insulin)

Assay

Deletion assay

424-525 (Autoinhibitory domain) SS

Target domain	91-352 (Protein kinase domain)
Relief mechanism	PTM
Assay

AID

424-525 (Autoinhibitory domain)

Target domain

91-352 (Protein kinase domain)

Relief mechanism

PTM (Phosphorylation of Ser within this domain stimulated by Cdk5)

Assay

Accessory elements

235-258 (Activation loop from InterPro)

Target domain	91-352 (Protein kinase domain)
Relief mechanism
Assay

References

Lai KO et al. (2015) "Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis", The Journal of biological chemistry, 290, 14637-46

Dennis PB et al. (1998) "Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation", The Journal of biological chemistry, 273, 14845-52

Mahalingam M et al. (1996) "Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains", Molecular and cellular biology, 16, 405-13

Autoinhibited structure

Activated structure

23 structures for P23443

Entry ID	Method	Resolution	Chain	Position	Source
3A60	X-ray	280 A	A/B	75-399	PDB
3A61	X-ray	343 A	A	75-399	PDB
3A62	X-ray	235 A	A	75-399	PDB
3WE4	X-ray	200 A	A	78-399	PDB
3WF5	X-ray	210 A	A	78-399	PDB
3WF6	X-ray	203 A	A	78-399	PDB
3WF7	X-ray	185 A	A	78-399	PDB
3WF8	X-ray	198 A	A	78-399	PDB
3WF9	X-ray	204 A	A	78-399	PDB
4L3J	X-ray	210 A	A	75-375	PDB
4L3L	X-ray	210 A	A	75-375	PDB
4L42	X-ray	280 A	A	75-417	PDB
4L43	X-ray	300 A	A	75-417	PDB
4L44	X-ray	290 A	A	75-417	PDB
4L45	X-ray	290 A	A	75-417	PDB
4L46	X-ray	301 A	A	75-417	PDB
4RLO	X-ray	253 A	A/B	85-372	PDB
4RLP	X-ray	279 A	A	85-372	PDB
5WBH	X-ray	175 A	W	412-437	PDB
5WBK	X-ray	311 A	T	24-37	PDB
7N91	X-ray	300 A	A/B	82-421	PDB
7N93	X-ray	274 A	A/B	82-421	PDB
AF-P23443-F1	Predicted				AlphaFoldDB

179 variants for P23443

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs769786318 CA8682731	2	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1456168166 CA400435358	2	R>W		No	ClinGen gnomAD
CA292159075 rs1007996112	5	R>K		No	ClinGen Ensembl
rs773013562 CA8682732	5	R>S		No	ClinGen ExAC gnomAD
CA8682733 rs762843401	7	R>G		No	ClinGen ExAC gnomAD
rs762843401 CA400435400	7	R>W		No	ClinGen ExAC gnomAD
CA8682735 rs139530428	9	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs201606773 CA292159097	10	F>Y		No	ClinGen Ensembl
CA400435445 rs1598604302	11	Y>S		No	ClinGen Ensembl
CA400435458 rs1421811183	12	P>S		No	ClinGen TOPMed gnomAD
CA400435464 rs1465279456	13	A>T		No	ClinGen gnomAD
CA400435489 rs1404397597	15	D>A		No	ClinGen gnomAD
CA8682736 rs759865603	16	F>C		No	ClinGen ExAC TOPMed gnomAD
rs1231145816 CA400435512	17	R>*		No	ClinGen TOPMed
CA8682738 rs767780996	17	R>P		No	ClinGen ExAC gnomAD
rs767780996 CA8682737	17	R>Q		No	ClinGen ExAC gnomAD
rs756132794 CA8682739	18	D>N		No	ClinGen ExAC gnomAD
CA8682741 rs754270633	20	E>K		No	ClinGen ExAC gnomAD
rs757691849 CA8682742	21	A>V		No	ClinGen ExAC TOPMed gnomAD
CA400435579 rs1443518745	23	D>N		No	ClinGen TOPMed
CA400435610 rs1226172830	25	A>V		No	ClinGen gnomAD
rs1483907789 CA400435625	27	V>G		No	ClinGen gnomAD
rs1488886621 CA400435699	33	D>A		No	ClinGen gnomAD
rs376390460 CA292159142	37	D>E		No	ClinGen ESP TOPMed gnomAD
rs1446143670 CA400435751	37	D>G		No	ClinGen TOPMed
rs142855919 CA8682746	37	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1167359257 CA400435771	39	G>A		No	ClinGen TOPMed
CA8682748 rs769152306	39	G>C		No	ClinGen ExAC gnomAD
rs1464661498 CA400435787	41	E>*		No	ClinGen gnomAD
CA8682749 rs763484257	41	E>D		No	ClinGen ExAC TOPMed gnomAD
CA400435796 rs1374813056	42	D>N		No	ClinGen gnomAD
CA400435818 rs1158964070	43	E>D		No	ClinGen TOPMed
CA400435857 rs1231119934	46	E>D		No	ClinGen TOPMed
CA400435855 rs1231119934	46	E>D		No	ClinGen TOPMed
CA8682769 rs771005046	48	G>C		No	ClinGen ExAC gnomAD
CA400437097 rs1445839180	50	L>F		No	ClinGen TOPMed
CA400437154 rs1238870402	54	M>R		No	ClinGen gnomAD
CA400437173 rs1339950914	55	D>Y		No	ClinGen TOPMed
CA8682770 rs774417798	56	H>D		No	ClinGen ExAC gnomAD
rs1411844093 CA400437192	56	H>R		No	ClinGen TOPMed
CA8682772 rs771959807	57	G>A		No	ClinGen ExAC gnomAD
CA8682771 rs745723563	57	G>R		No	ClinGen ExAC gnomAD
rs775831949 CA8682773	58	G>A		No	ClinGen ExAC gnomAD
rs930082055 CA292170233	58	G>R		No	ClinGen TOPMed gnomAD
CA292170243 rs1047107646	61	P>S		No	ClinGen TOPMed gnomAD
rs1047107646 CA400437238	61	P>T		No	ClinGen TOPMed gnomAD
CA292170245 rs967994179	64	L>I		No	ClinGen TOPMed
rs200282847 CA8682784	65	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA400437416 rs1353369885	66	M>V		No	ClinGen gnomAD
rs369352640 CA8682785	67	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1377606156 CA400437475	72	F>Y		No	ClinGen gnomAD
rs1323291838 CA400437528	78	S>G		No	ClinGen TOPMed
rs756820769 CA8682787	78	S>N		No	ClinGen ExAC gnomAD
rs1320301030 CA400437561	80	N>K		No	ClinGen TOPMed gnomAD
CA292171513 rs758392709	83	P>S		No	ClinGen Ensembl
CA292171519 rs201788760	85	K>N		No	ClinGen Ensembl
rs1160966767 CA400437615	85	K>Q		No	ClinGen TOPMed
rs779032288 CA8682788	86	I>T		No	ClinGen ExAC gnomAD
rs1212484580 CA400437641	87	R>G		No	ClinGen Ensembl
COSM1384928 CA292171534 rs951553081	95	R>W	large_intestine breast [Cosmic]	No	ClinGen cosmic curated Ensembl
CA400437833 rs1312790624	102	Y>F		No	ClinGen gnomAD
rs1304242590 CA400438106	109	R>Q		No	ClinGen TOPMed
CA400438113 rs1236587996	110	K>R		No	ClinGen TOPMed
CA8682812 rs768495617	114	A>G		No	ClinGen ExAC TOPMed gnomAD
rs377332462 CA8682813	116	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA400438178 rs1159721037	120	F>Y		No	ClinGen gnomAD
CA8682830 rs781068987	129	M>I		No	ClinGen ExAC gnomAD
rs1236732025 CA400439483	131	V>I		No	ClinGen gnomAD
rs747867363 CA8682831	134	A>D		No	ClinGen ExAC gnomAD
CA400439570 rs1256976213	137	T>I		No	ClinGen TOPMed
rs1356718539 CA400439657	144	R>Q		No	ClinGen gnomAD
CA8682833 rs183590386	145	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1467731056 CA400439726	149	E>D		No	ClinGen gnomAD
CA8682834 rs749435991	156	V>A		No	ClinGen ExAC gnomAD
rs1310960425 CA400439815	157	D>N		No	ClinGen TOPMed
CA8682837 rs746408016	163	Q>*		No	ClinGen ExAC gnomAD
rs367762054 CA292179639	166	G>R		No	ClinGen ESP TOPMed gnomAD
rs371239209 CA8682848	189	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA400426318 rs1355015141	207	G>R		No	ClinGen gnomAD
rs1259284409 CA400426544	218	D>N		No	ClinGen gnomAD
CA8682865 rs773920494	229	Q>E		No	ClinGen ExAC gnomAD
CA292150005 rs944521053	240	C>G		No	ClinGen TOPMed
CA400427840 rs1222867548	244	I>V		No	ClinGen TOPMed
rs745629253 CA292150014	248	T>I		No	ClinGen Ensembl
CA400428136 rs1295474347	257	I>V		No	ClinGen TOPMed gnomAD
CA400428331 rs1306881654	264	I>M		No	ClinGen gnomAD
rs1011153223 CA292150107	268	S>G		No	ClinGen TOPMed
rs766645749 CA8682913 VAR_040640	272	R>C		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs201582805 CA292150131	276	W>*		No	ClinGen 1000Genomes
CA8682916 rs147955400	281	A>V		No	ClinGen ESP ExAC gnomAD
rs1418112814 CA400428748	283	M>T		No	ClinGen gnomAD
rs756594255 CA400428781	284	Y>C		No	ClinGen ExAC gnomAD
CA8682918 rs756594255	284	Y>S		No	ClinGen ExAC gnomAD
CA400430270 rs1212126307	293	F>L		No	ClinGen TOPMed
rs769735104 CA8682929	299	K>R		No	ClinGen ExAC gnomAD
CA400430395 rs1568484527	302	I>T		No	ClinGen Ensembl
rs762824413 CA8682931	302	I>V		No	ClinGen ExAC gnomAD
rs1351800084 CA400430427	304	K>N		No	ClinGen TOPMed gnomAD
rs766770547 CA8682932	304	K>R		No	ClinGen ExAC gnomAD
CA8682933 rs774681501	305	I>V		No	ClinGen ExAC gnomAD
rs752780303 CA8682936	307	K>R		No	ClinGen ExAC TOPMed gnomAD
rs752780303 CA8682937	307	K>T		No	ClinGen ExAC TOPMed gnomAD
CA8682940 rs200443093	311	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA400430562 rs1232388015	314	P>L		No	ClinGen gnomAD
CA400430674 rs1228058375	320	A>S		No	ClinGen TOPMed
CA8682942 rs746643734	322	D>V		No	ClinGen ExAC gnomAD
CA400430734 rs1331453119	323	L>V		No	ClinGen TOPMed
rs373201580 CA8682951	328	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA8682952 rs745681533	331	N>H		No	ClinGen ExAC TOPMed gnomAD
rs1223791841 CA400431026	334	S>T		No	ClinGen TOPMed
CA400431050 rs1332846171	335	R>H		No	ClinGen TOPMed
rs1598806787 CA400431093	341	G>A		No	ClinGen Ensembl
CA8682955 rs764576299	343	A>T		No	ClinGen ExAC gnomAD
rs1436560081 CA400431110	344	G>E		No	ClinGen gnomAD
CA400431115 rs1568487397	345	E>*		No	ClinGen Ensembl
rs754312922 CA8682956	346	V>I		No	ClinGen ExAC TOPMed gnomAD
CA400431163 rs1189222736	348	A>S		No	ClinGen TOPMed
CA8682977 rs762342327	349	H>Y		No	ClinGen ExAC gnomAD
rs975291099 COSM1384933 CA292151455	351	F>L	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA400431219 rs1259908500	355	I>F		No	ClinGen TOPMed
rs527883108 CA8682979	363	R>*		No	ClinGen 1000Genomes ExAC gnomAD
CA8682980 rs763367511	363	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA400431390 rs1598808033	365	V>G		No	ClinGen Ensembl
rs767111740 CA8682981	367	P>T		No	ClinGen ExAC gnomAD
CA400431468 rs1310819944	370	K>R		No	ClinGen gnomAD
rs1181565268 CA400432487	388	R>H		No	ClinGen TOPMed
rs760407176 CA8683002	399	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1328723452 CA400432663	400	L>I		No	ClinGen gnomAD
CA400432676 rs1220336638	401	S>G		No	ClinGen TOPMed
rs774803147 CA8683022	424	E>G		No	ClinGen ExAC gnomAD
CA400433509 rs1419564659	433	R>Q		No	ClinGen gnomAD
CA400433540 rs1342376918	438	F>S		No	ClinGen Ensembl
CA400433546 rs1307279204	439	I>F		No	ClinGen TOPMed
CA400433559 rs1355645776	441	S>C		No	ClinGen gnomAD
rs776419041 CA8683025	441	S>N		No	ClinGen ExAC gnomAD
CA400433563 rs1598844554	441	S>R		No	ClinGen Ensembl
rs761466990 CA8683026	443	R>*		No	ClinGen ExAC gnomAD
rs1415771859 CA400433571	443	R>Q		No	ClinGen gnomAD
rs201316437 CA8683027	445	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs146927684 CA8683028	446	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs146927684 CA292155680	446	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1295366485 CA400433721	450	K>R		No	ClinGen gnomAD
CA8683046 rs535213123	453	P>R		No	ClinGen 1000Genomes ExAC gnomAD
rs932504496 CA292156209	453	P>S		No	ClinGen TOPMed
rs1234773348 CA400433796	454	G>E		No	ClinGen gnomAD
rs1341855672 CA400433810	455	D>G		No	ClinGen TOPMed
CA8683048 rs769289034	456	F>S		No	ClinGen ExAC gnomAD
CA8683049 rs772798588	458	G>R		No	ClinGen ExAC gnomAD
CA400433930 rs1242329117	461	A>T		No	ClinGen gnomAD
rs762344908 CA8683050	461	A>V		No	ClinGen ExAC gnomAD
CA8683052 rs751489954	462	S>L		No	ClinGen ExAC gnomAD
CA8683053 rs759415083	472	V>G		No	ClinGen ExAC gnomAD
rs1423417423 CA400434204	475	P>L		No	ClinGen gnomAD
CA400434216 rs1278779632	476	M>T		No	ClinGen TOPMed gnomAD
rs1414134583 CA400434209	476	M>V		No	ClinGen gnomAD
rs137873345 CA292156248	484	M>V		No	ClinGen ESP TOPMed gnomAD
CA8683057 rs201664077	488	M>V		No	ClinGen ExAC TOPMed gnomAD
CA400434321 rs1598848397	489	S>R		No	ClinGen Ensembl
COSM192063 rs1410557496 CA400434348	494	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA400434378 rs1568519206	498	I>M		No	ClinGen Ensembl
rs149039467 CA292156277	499	R>*		No	ClinGen ESP TOPMed
CA292156279 rs774592527	499	R>Q		No	ClinGen gnomAD
CA292156280 rs561028562	500	Q>P		No	ClinGen gnomAD
CA8683060 rs779532384	501	P>L		No	ClinGen ExAC gnomAD
CA8683062 rs578242191	502	N>H		No	ClinGen 1000Genomes ExAC gnomAD
rs760585468 CA8683064	503	S>C		No	ClinGen ExAC gnomAD
CA8683063 rs780595729	503	S>P		No	ClinGen ExAC gnomAD
CA292156311 rs1040429813	504	G>A		No	ClinGen TOPMed
CA8683068 rs770364465	507	K>I		No	ClinGen ExAC gnomAD
rs770364465 CA8683069	507	K>R		No	ClinGen ExAC gnomAD
rs796087301 CA292156319	512	P>S		No	ClinGen Ensembl
rs1482169997 CA400434466	513	M>V		No	ClinGen TOPMed
CA8683070 rs759504757	516	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1455802572 CA400434495	517	R>Q		No	ClinGen gnomAD
CA292156359 rs1033258409	517	R>W		No	ClinGen TOPMed
rs1395231513 CA400434528	522	R>H		No	ClinGen gnomAD
CA400434538 rs1463062966	523	M>I		No	ClinGen gnomAD
CA400434542 rs1255679788	524	N>H		No	ClinGen TOPMed
CA400434551 rs1346438176	525	L>P		No	ClinGen gnomAD

No associated diseases with P23443

5 regional properties for P23443

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	91 - 352	IPR000719
domain	AGC-kinase, C-terminal	353 - 423	IPR000961
active_site	Serine/threonine-protein kinase, active site	214 - 226	IPR008271
binding_site	Protein kinase, ATP binding site	97 - 123	IPR017441
domain	Protein kinase, C-terminal	374 - 413	IPR017892

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Synapse, synaptosome Mitochondrion outer membrane Mitochondrion	Colocalizes with URI1 at mitochondrion
PANTHER Family	PTHR24351	RIBOSOMAL PROTEIN S6 KINASE
PANTHER Subfamily	PTHR24351:SF48	RIBOSOMAL PROTEIN S6 KINASE BETA-1
PANTHER Protein Class	protein modifying enzyme
PANTHER Pathway Category	CCKR signaling map p70S6K1 p53 pathway by glucose deprivation S6K PI3 kinase pathway S6K Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade P90 RSK PDGF signaling pathway p90RSK

10 GO annotations of cellular component

Name	Definition
cell surface	The external part of the cell wall and/or plasma membrane.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial outer membrane	The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

10 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding	Binding to an identical protein or proteins.
PDZ domain binding	Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
peptide binding	Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein phosphatase 2A binding	Binding to protein phosphatase 2A.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
ribosomal protein S6 kinase activity	Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.

44 GO annotations of biological process

Name	Definition
aging	A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
behavioral fear response	An acute behavioral change resulting from a perceived external threat.
cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cellular response to dexamethasone stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
cellular response to growth factor stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
cellular response to insulin stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
cellular response to interferon-gamma	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
G1/S transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
germ cell development	The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
long-chain fatty acid import into cell	The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
long-term memory	The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of extrinsic apoptotic signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
negative regulation of insulin receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
phosphatidylinositol-mediated signaling	The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
positive regulation of mitotic cell cycle	Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
positive regulation of skeletal muscle tissue growth	Any process that activates, maintains or increases the rate of skeletal muscle growth.
positive regulation of smooth muscle cell migration	Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
positive regulation of smooth muscle cell proliferation	Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
positive regulation of translation	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
positive regulation of translational initiation	Any process that activates or increases the frequency, rate or extent of translational initiation.
protein kinase B signaling	A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
regulation of glucose import	Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
response to electrical stimulus involved in regulation of muscle adaptation	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation.
response to ethanol	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
response to glucagon	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.
response to glucose	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
response to heat	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
response to leucine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus.
response to lipopolysaccharide	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
response to mechanical stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
response to nutrient	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
response to nutrient levels	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
response to testosterone	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
response to toxic substance	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
response to tumor necrosis factor	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
response to wounding	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
skeletal muscle atrophy	A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.
skeletal muscle contraction	A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.
TOR signaling	The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.

17 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6TJY3	RPS6KB1	Ribosomal protein S6 kinase beta-1	Bos taurus (Bovine)	SS
Q9HBY8	SGK2	Serine/threonine-protein kinase Sgk2	Homo sapiens (Human)	SS
O00141	SGK1	Serine/threonine-protein kinase Sgk1	Homo sapiens (Human)	PR
Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	Homo sapiens (Human)	SS
Q15349	RPS6KA2	Ribosomal protein S6 kinase alpha-2	Homo sapiens (Human)	SS
Q15418	RPS6KA1	Ribosomal protein S6 kinase alpha-1	Homo sapiens (Human)	EV
Q9UK32	RPS6KA6	Ribosomal protein S6 kinase alpha-6	Homo sapiens (Human)	SS
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Homo sapiens (Human)	EV
O75676	RPS6KA4	Ribosomal protein S6 kinase alpha-4	Homo sapiens (Human)	SS
O75582	RPS6KA5	Ribosomal protein S6 kinase alpha-5	Homo sapiens (Human)	SS
Q9UBS0	RPS6KB2	Ribosomal protein S6 kinase beta-2	Homo sapiens (Human)	PR
Q8QZV4	Stk32c	Serine/threonine-protein kinase 32C	Mus musculus (Mouse)	PR
Q9Z1M4	Rps6kb2	Ribosomal protein S6 kinase beta-2	Mus musculus (Mouse)	SS
Q9ERE3	Sgk3	Serine/threonine-protein kinase Sgk3	Mus musculus (Mouse)	PR
Q8BSK8	Rps6kb1	Ribosomal protein S6 kinase beta-1	Mus musculus (Mouse)	SS
P67999	Rps6kb1	Ribosomal protein S6 kinase beta-1	Rattus norvegicus (Rat)	EV SS
Q5BKK4	sgk1	Serine/threonine-protein kinase Sgk1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MRRRRRRDGF	YPAPDFRDRE	AEDMAGVFDI	DLDQPEDAGS	EDELEEGGQL	NESMDHGGVG
70	80	90	100	110	120
PYELGMEHCE	KFEISETSVN	RGPEKIRPEC	FELLRVLGKG	GYGKVFQVRK	VTGANTGKIF
130	140	150	160	170	180
AMKVLKKAMI	VRNAKDTAHT	KAERNILEEV	KHPFIVDLIY	AFQTGGKLYL	ILEYLSGGEL
190	200	210	220	230	240
FMQLEREGIF	MEDTACFYLA	EISMALGHLH	QKGIIYRDLK	PENIMLNHQG	HVKLTDFGLC
250	260	270	280	290	300
KESIHDGTVT	HTFCGTIEYM	APEILMRSGH	NRAVDWWSLG	ALMYDMLTGA	PPFTGENRKK
310	320	330	340	350	360
TIDKILKCKL	NLPPYLTQEA	RDLLKKLLKR	NAASRLGAGP	GDAGEVQAHP	FFRHINWEEL
370	380	390	400	410	420
LARKVEPPFK	PLLQSEEDVS	QFDSKFTRQT	PVDSPDDSTL	SESANQVFLG	FTYVAPSVLE
430	440	450	460	470	480
SVKEKFSFEP	KIRSPRRFIG	SPRTPVSPVK	FSPGDFWGRG	ASASTANPQT	PVEYPMETSG
490	500	510	520
IEQMDVTMSG	EASAPLPIRQ	PNSGPYKKQA	FPMISKRPEH	LRMNL