Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

7 structures for P23439

Entry ID Method Resolution Chain Position Source
6MZB EM 340 A B 1-853 PDB
7JSN EM 320 A B 1-853 PDB
8UFI EM 310 A B 1-853 PDB
8UGB EM 300 A B 1-853 PDB
8UGS EM 320 A B 1-853 PDB
8ULG EM 320 A B 1-853 PDB
AF-P23439-F1 Predicted AlphaFoldDB

No variants for P23439

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P23439

No associated diseases with P23439

5 regional properties for P23439

Type Name Position InterPro Accession
domain 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 481 - 814 IPR002073
domain GAF domain 71 - 230 IPR003018-1
domain GAF domain 252 - 439 IPR003018-2
domain HD/PDEase domain 554 - 741 IPR003607
conserved_site 3'5'-cyclic nucleotide phosphodiesterase, conserved site 597 - 608 IPR023174

Functions

Description
EC Number 3.1.4.35 Phosphoric diester hydrolases
Subcellular Localization
  • Membrane ; Lipid-anchor
  • Cell projection, cilium, photoreceptor outer segment
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
photoreceptor disc membrane Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
photoreceptor outer segment membrane The membrane surrounding the outer segment of a vertebrate photoreceptor.

3 GO annotations of molecular function

Name Definition
3',5'-cyclic-GMP phosphodiesterase activity Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+.
3',5'-cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate.
metal ion binding Binding to a metal ion.

4 GO annotations of biological process

Name Definition
entrainment of circadian clock by photoperiod The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
retina development in camera-type eye The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

34 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P14100 PDE1A Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Bos taurus (Bovine) PR
Q28156 PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase Bos taurus (Bovine) SS
P52731 PDE6C Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Gallus gallus (Chicken) PR
H2QL32 PDE9A High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Pan troglodytes (Chimpanzee) PR
P33726 PDE6B Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Canis lupus familiaris (Dog) (Canis familiaris) PR
Q9W4T4 dnc 3',5'-cyclic-AMP phosphodiesterase, isoform I Drosophila melanogaster (Fruit fly) SS
Q9VJ79 Pde11 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 Drosophila melanogaster (Fruit fly) SS
Q9HCR9 PDE11A Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Homo sapiens (Human) SS
O76083 PDE9A High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens (Human) PR
Q07343 PDE4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B Homo sapiens (Human) EV SS
Q08499 PDE4D cAMP-specific 3',5'-cyclic phosphodiesterase 4D Homo sapiens (Human) EV
O76074 PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase Homo sapiens (Human) EV
Q08493 PDE4C cAMP-specific 3',5'-cyclic phosphodiesterase 4C Homo sapiens (Human) EV SS
P51160 PDE6C Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Homo sapiens (Human) PR
P27815 PDE4A cAMP-specific 3',5'-cyclic phosphodiesterase 4A Homo sapiens (Human) EV SS
Q9Y233 PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Homo sapiens (Human) PR
P35913 PDE6B Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Homo sapiens (Human) PR
O89084 Pde4a 3',5'-cyclic-AMP phosphodiesterase 4A Mus musculus (Mouse) SS
O70628 Pde9a High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Mus musculus (Mouse) PR
Q8CG03 Pde5a cGMP-specific 3',5'-cyclic phosphodiesterase Mus musculus (Mouse) SS
Q8CA95 Pde10a cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Mus musculus (Mouse) PR
P0C1Q2 Pde11a Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Mus musculus (Mouse) SS
Q3UEI1 Pde4c cAMP-specific 3',5'-cyclic phosphodiesterase 4C Mus musculus (Mouse) PR
Q01063 Pde4d 3',5'-cyclic-AMP phosphodiesterase 4D Mus musculus (Mouse) SS
P23440 Pde6b Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Mus musculus (Mouse) PR
Q8QZV1 Pde9a High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Rattus norvegicus (Rat) PR
P14646 Pde4b cAMP-specific 3',5'-cyclic phosphodiesterase 4B Rattus norvegicus (Rat) SS
Q8VID6 Pde11a Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Rattus norvegicus (Rat) SS
O54735 Pde5a cGMP-specific 3',5'-cyclic phosphodiesterase Rattus norvegicus (Rat) SS
P14644 Pde4c cAMP-specific 3',5'-cyclic phosphodiesterase 4C Rattus norvegicus (Rat) PR
P54748 Pde4a 3',5'-cyclic-AMP phosphodiesterase 4A Rattus norvegicus (Rat) SS
Q9QYJ6 Pde10a cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Rattus norvegicus (Rat) PR
P14270 Pde4d cAMP-specific 3',5'-cyclic phosphodiesterase 4D Rattus norvegicus (Rat) PR
Q22000 pde-4 Probable 3',5'-cyclic phosphodiesterase pde-4 Caenorhabditis elegans PR
10 20 30 40 50 60
MSLSEGQVHR FLDQNPGFAD QYFGRKLSPE DVANACEDGC PEGCTSFREL CQVEESAALF
70 80 90 100 110 120
ELVQDMQENV NMERVVFKIL RRLCSILHAD RCSLFMYRQR NGVAELATRL FSVQPDSVLE
130 140 150 160 170 180
DCLVPPDSEI VFPLDIGVVG HVAQTKKMVN VQDVMECPHF SSFADELTDY VTRNILATPI
190 200 210 220 230 240
MNGKDVVAVI MAVNKLDGPC FTSEDEDVFL KYLNFGTLNL KIYHLSYLHN CETRRGQVLL
250 260 270 280 290 300
WSANKVFEEL TDIERQFHKA FYTVRAYLNC DRYSVGLLDM TKEKEFFDVW PVLMGEAQAY
310 320 330 340 350 360
SGPRTPDGRE ILFYKVIDYI LHGKEDIKVI PSPPADHWAL ASGLPTYVAE SGFICNIMNA
370 380 390 400 410 420
PADEMFNFQE GPLDDSGWIV KNVLSMPIVN KKEEIVGVAT FYNRKDGKPF DEQDEVLMES
430 440 450 460 470 480
LTQFLGWSVL NTDTYDKMNK LENRKDIAQD MVLYHVRCDR EEIQLILPTR ERLGKEPADC
490 500 510 520 530 540
EEDELGKILK EVLPGPAKFD IYEFHFSDLE CTELELVKCG IQMYYELGVV RKFQIPQEVL
550 560 570 580 590 600
VRFLFSVSKG YRRITYHNWR HGFNVAQTMF TLLMTGKLKS YYTDLEAFAM VTAGLCHDID
610 620 630 640 650 660
HRGTNNLYQM KSQNPLAKLH GSSILERHHL EFGKFLLSEE TLNIYQNLNR RQHEHVIHLM
670 680 690 700 710 720
DIAIIATDLA LYFKKRTMFQ KIVDESKNYE DRKSWVEYLS LETTRKEIVM AMMMTACDLS
730 740 750 760 770 780
AITKPWEVQS KVALLVAAEF WEQGDLERTV LDQQPIPMMD RNKAAELPKL QVGFIDFVCT
790 800 810 820 830 840
FVYKEFSRFH EEILPMFDRL QNNRKEWKAL ADEYEAKVKA LEEDQKKETT AKKVGTEICN
850
GGPAPRSSTC RIL