P22209

PR
Gene name
KIN3 (NPK1, YAR018C, FUN52)
Protein name
Serine/threonine-protein kinase KIN3
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YAR018C
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

230-253 (Activation loop from InterPro)

Target domain

25-343 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P22209

Entry ID Method Resolution Chain Position Source
AF-P22209-F1 Predicted AlphaFoldDB

2 variants for P22209

Variant ID(s) Position Change Description Diseaes Association Provenance
s01-171680 7 F>L No SGRP
s01-171128 191 I>V No SGRP

No associated diseases with P22209

3 regional properties for P22209

Type Name Position InterPro Accession
domain Protein kinase domain 25 - 343 IPR000719
active_site Serine/threonine-protein kinase, active site 170 - 182 IPR008271
binding_site Protein kinase, ATP binding site 31 - 54 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
protein phosphorylation The process of introducing a phosphate group on to a protein.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P51955 NEK2 Serine/threonine-protein kinase Nek2 Homo sapiens (Human) EV
O35942 Nek2 Serine/threonine-protein kinase Nek2 Mus musculus (Mouse) PR
Q6ZEZ5 NEK3 Serine/threonine-protein kinase Nek3 Oryza sativa subsp japonica (Rice) PR
Q10GB1 NEK1 Serine/threonine-protein kinase Nek1 Oryza sativa subsp japonica (Rice) PR
Q9SLI2 NEK1 Serine/threonine-protein kinase Nek1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RXT4 NEK4 Serine/threonine-protein kinase Nek4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LT35 NEK6 Serine/threonine-protein kinase Nek6 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MHRRQFFQEY RSPQQQQGHP PRSEYQVLEE IGRGSFGSVR KVIHIPTKKL LVRKDIKYGH
70 80 90 100 110 120
MNSKERQQLI AECSILSQLK HENIVEFYNW DFDEQKEVLY LYMEYCSRGD LSQMIKHYKQ
130 140 150 160 170 180
EHKYIPEKIV WGILAQLLTA LYKCHYGVEL PTLTTIYDRM KPPVKGKNIV IHRDLKPGNI
190 200 210 220 230 240
FLSYDDSDYN INEQVDGHEE VNSNYYRDHR VNSGKRGSPM DYSQVVVKLG DFGLAKSLET
250 260 270 280 290 300
SIQFATTYVG TPYYMSPEVL MDQPYSPLSD IWSLGCVIFE MCSLHPPFQA KNYLELQTKI
310 320 330 340 350 360
KNGKCDTVPE YYSRGLNAII HSMIDVNLRT RPSTFELLQD IQIRTARKSL QLERFERKLL
370 380 390 400 410 420
DYENELTNIE KILEKQAIEY ERELSQLKEQ FTQAVEERAR EVISGKKVGK VPESINGYYG
430
KKFAKPAYHW QTRYR