P22056
Gene name |
|
Protein name |
Structural polyprotein |
Names |
p130 [Cleaved into: Capsid protein , EC 3.4.21.90 , Coat protein , C; Precursor of protein E3/E2 , p62 , pE2; Assembly protein E3; Spike glycoprotein E2 , E2 envelope glycoprotein; 6K protein; Spike glycoprotein E1 , E1 envelope glycoprotein] |
Species |
O'nyong-nyong virus (strain Gulu) (ONNV) |
KEGG Pathway |
|
EC number |
3.4.21.90: Serine endopeptidases |
Protein Class |
|
Descriptions
This structural polyprotein forms an icosahedral capsid that binds to the viral RNA genome at a site adjacent to a ribosome binding site for viral genome translation following genome release. Autoinhibition of the suicidal capsid protease (CP) involves the C-terminal tryptophan localizing to the active pocket, effectively deactivating the enzyme. This results in the lack of enzymatic activity, crucial for halting the viral replication cycle as the virus cannot produce infectious progeny.
Autoinhibitory domains (AIDs)
Target domain |
111-260 (Peptidase S3) |
Relief mechanism |
Partner binding |
Assay |
Deletion assay, Structural analysis |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for P22056
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for P22056
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P22056 | |||||
No associated diseases with P22056
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.21.90 | Serine endopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| host cell cytoplasm | The cytoplasm of a host cell. |
| host cell nucleus | A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
| host cell plasma membrane | The plasma membrane surrounding a host cell. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. |
| T=4 icosahedral viral capsid | The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres. |
| virion membrane | The lipid bilayer surrounding a virion. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| serine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| fusion of virus membrane with host endosome membrane | Fusion of a virus membrane with a host endosome membrane. Occurs after internalization of the virus through the endosomal pathway, and results in release of the virus contents into the cell. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| suppression by virus of host toll-like receptor signaling pathway | Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of toll-like receptor (TLR) signaling in the host organism. |
| viral entry into host cell | The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. |
| virion attachment to host cell | The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEFIPAQTYY | NRRYQPRPWT | QRPTIQVIRP | KPRRRRPAGQ | LAQLISAVSR | LALRTVPQKP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RRTRKIKKQK | QVKQEQQSTT | NQKKKAPKQK | QTQKKKRPGR | RERMCMKIEN | DCIFEVRHEG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KVTGYACLVG | DKVMKPAHVK | GTIDNADLAK | LAFKRSSKYD | LECAQIPVHM | KSDASKFTHE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KPEGYYNWHH | GAVQYSGGRF | TIPTGAGKPG | DSGRPIFDNK | GRVVAIVLGG | ANEGTRTALS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VVTWNKDIVT | KITPEGSVEW | SLALPVMCLL | ANTTFPCSQP | PCAPCCYEKK | PEETLRMLED |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NVMQPGYYQL | LDSALACSQR | RQKRNARENF | NVYKVTRPYL | AHCPDCGEGH | SCHSPIALER |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IRSEATDGTL | KIQVSLQIGI | KTDDSHDWTK | LRYMDSHTPV | DADRSGLFVR | TSAPCTITGT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MGHFILARCP | KGETLTVGFV | DSRRISHTCM | HPFRHEPPLI | GREKFHSRPQ | HGKELPCSTY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VHTTAATAEE | IEVHMPPDTP | DYTLMTQQAG | NVKITVDGQT | VRYKCKCDGS | NEGLITADKV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| INNCKVDQCH | TAVTNHKKWQ | YNSPLTPRNS | EQGDRKGKIH | IPFPLVNTTC | RVPKARNPTV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TYGKNRVTLL | LHPDHPTLLS | YRAMGRIPDY | HEEWITNKKE | ISITVPAEGL | EVTWGNNDPY |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KYWPQLSTNG | TAHGHPHEII | LYYYELYPTT | TIAVLAAASI | VITSLVGLSL | GMCICARRRC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ITPYELTPGA | TIPFLLGVLC | CARTAKAASY | YEAATYLWNE | QQPLFWLQLL | IPLSAAIVVC |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NCLKLLPCCC | KTLTFLAVMS | IGARTVTAYE | HATVIPNTVG | VPCKTLVSRP | GYSPMVLEME |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LQSVTLEPAL | SLDYITCEYK | TITPSPYVKC | CGTAECKAKN | LPDYNCKVFT | GVYPFMWGGA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| YCFCDAENTQ | LSEAHVEKSE | SCKTEFASAY | RAHTASVSAK | LRVFYQGNNI | TVSAYANGDH |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AVTVEDAKFV | IGPLSSAWSP | FDNKIVVYKG | EVYNMDYPPF | GAGRPGQFGD | IQSRTPDSKD |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VYANTQLILQ | RPAAGAIHVP | YSQAPSGFKY | WLKEKGASLQ | HTAPFGCQIA | TNPVRAVNCA |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| VGNIPVSIDI | PDAAFTRVTD | APSITDMSCE | VASCTHSSDF | GGAAVIKYTA | SKKGKCAVHS |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| VTNAVTIREP | NVDVKGTAQL | QIAFSTALAS | AEFKVQICST | LVHCSATCHP | PKDHIVNYPS |
| 1210 | 1220 | 1230 | 1240 | ||
| PHTTLGVQDI | STTAMSWVQK | ITGGVGLVVA | IAALILIIVL | CVSFSRH |