P21803

SS
Gene name
Fgfr2 (Bek, Ect1)
Protein name
Fibroblast growth factor receptor 2
Names
FGFR-2 , EC 2.7.10.1 , Keratinocyte growth factor receptor , KGFR , CD antigen CD332
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:14183
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

Fibroblast growth factor receptor 3 (FGFR3) is one of the members of FGFR family belonging to the receptor tyrosine kinases (RTK) in cell proliferation, differentiation, migration, and maintenance of cellular homeostasis. FGFR3 consists of the ligand-binding region (immunoglobulin (Ig) domain 1-like domains) designated D1, D2, and D3, and a kinase domain. The D1 domain and the acid box (AB)-containing linker between D1 and D2 are involved in autoinhibition. Loss of D1 or the linker enhances the affinity of FGFR for FGF and HS and increases the signaling capacity of FGFR. Specifically, the AB region blocks the heparan sulfate (HS)-binding site on the D2 domain in cis to suppress HS-binding affinity of EGFR. D1 is dispensable for autoinhibition but plays a minor role in autoinhibition.

Autoinhibitory domains (AIDs)

469-471 (Helix αN) SS

Target domain

481-762 (Protein kinase domain)

Relief mechanism

Ligand binding, PTM

Assay

522-526 (Autoinhibitory segment) SS

Target domain

481-762 (Protein kinase domain)

Relief mechanism

Ligand binding, PTM

Assay

Accessory elements

643-668 (Activation loop from InterPro)

Target domain

481-770 (Protein kinase domain)

Relief mechanism

Assay

643-668 (Activation loop from InterPro)

Target domain

481-770 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

2 structures for P21803

Entry ID Method Resolution Chain Position Source
4HWU X-ray 290 A A/B 45-127 PDB
AF-P21803-F1 Predicted AlphaFoldDB

No variants for P21803

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P21803

No associated diseases with P21803

15 regional properties for P21803

Type Name Position InterPro Accession
domain Protein kinase domain 481 - 770 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 481 - 757 IPR001245
domain Immunoglobulin subtype 2 53 - 114 IPR003598-1
domain Immunoglobulin subtype 2 170 - 238 IPR003598-2
domain Immunoglobulin subtype 2 269 - 349 IPR003598-3
domain Immunoglobulin subtype 47 - 125 IPR003599-1
domain Immunoglobulin subtype 164 - 249 IPR003599-2
domain Immunoglobulin subtype 263 - 360 IPR003599-3
domain Immunoglobulin-like domain 39 - 125 IPR007110-1
domain Immunoglobulin-like domain 154 - 247 IPR007110-2
domain Immunoglobulin-like domain 256 - 358 IPR007110-3
active_site Tyrosine-protein kinase, active site 622 - 634 IPR008266
domain Immunoglobulin I-set 173 - 248 IPR013098
binding_site Protein kinase, ATP binding site 487 - 517 IPR017441
domain Tyrosine-protein kinase, catalytic domain 481 - 757 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane; Single-pass type I membrane protein
  • Golgi apparatus
  • Cytoplasmic vesicle
  • Detected on osteoblast plasma membrane lipid rafts
  • After ligand binding, the activated receptor is rapidly internalized and degraded (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
excitatory synapse A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibroblast growth factor binding Binding to a fibroblast growth factor.
fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
heparin binding Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

107 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
axonogenesis De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
bone development The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
bone mineralization The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
bone morphogenesis The process in which bones are generated and organized.
branch elongation involved in salivary gland morphogenesis The differential growth of the salivary branches along their axis, resulting in the growth of a branch.
branching involved in labyrinthine layer morphogenesis The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer.
branching involved in prostate gland morphogenesis The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.
branching involved in salivary gland morphogenesis The process in which the branching structure of the salivary gland is generated and organized.
branching morphogenesis of a nerve The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).
bud elongation involved in lung branching The process in which a bud in the lung grows out from the point where it is formed.
canonical Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
cardiac muscle cell proliferation The expansion of a cardiac muscle cell population by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cell fate commitment The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate.
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cell-cell signaling Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
cellular response to fibroblast growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
coronal suture morphogenesis The process in which the coronal suture is generated and organized.
digestive tract development The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
embryonic digestive tract morphogenesis The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.
embryonic organ development Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
embryonic organ morphogenesis Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
embryonic pattern specification The process that results in the patterns of cell differentiation that will arise in an embryo.
endodermal digestive tract morphogenesis The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm.
epidermis morphogenesis The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
epithelial cell proliferation The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.
epithelial cell proliferation involved in salivary gland morphogenesis The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland.
epithelial to mesenchymal transition A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
epithelial tube branching involved in lung morphogenesis The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
ERK1 and ERK2 cascade An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier
fibroblast growth factor receptor apoptotic signaling pathway An apoptotic signaling pathway that starts with a ligand binding to, or being withdrawn from, a fibroblast growth factor receptor (FGFR).
fibroblast growth factor receptor signaling pathway The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
fibroblast growth factor receptor signaling pathway involved in hemopoiesis The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis.
fibroblast growth factor receptor signaling pathway involved in mammary gland specification The series of molecular signals initiated by binding of a fibroblast growth factor to its receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes.
fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow.
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state.
fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow.
gland morphogenesis The process in which the anatomical structures of a gland are generated and organized.
hair follicle morphogenesis The process in which the anatomical structures of the hair follicle are generated and organized.
in utero embryonic development The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
inner ear morphogenesis The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
lacrimal gland development The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye.
lateral sprouting from an epithelium The process in which a branch forms along the side of an epithelium.
lens fiber cell development The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
limb bud formation The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable.
lung alveolus development The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
lung development The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
lung lobe morphogenesis The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung.
lung-associated mesenchyme development The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung.
mammary gland bud formation The morphogenetic process in which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis.
membranous septum morphogenesis The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.
mesenchymal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.
mesenchymal cell differentiation involved in lung development The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.
mesenchymal cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
mesenchymal cell proliferation involved in lung development The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
midbrain development The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
mitotic nuclear division A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
morphogenesis of embryonic epithelium The process in which the anatomical structures of embryonic epithelia are generated and organized.
negative regulation of epithelial cell proliferation Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
negative regulation of mitotic nuclear division Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
neuromuscular junction development A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
odontogenesis The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
orbitofrontal cortex development The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe.
organ growth The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.
otic vesicle formation The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear.
outflow tract septum morphogenesis The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of canonical Wnt signaling pathway Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of cardiac muscle cell proliferation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
positive regulation of cell cycle Any process that activates or increases the rate or extent of progression through the cell cycle.
positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of epithelial cell proliferation Any process that activates or increases the rate or extent of epithelial cell proliferation.
positive regulation of epithelial cell proliferation involved in lung morphogenesis Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.
positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of mesenchymal cell proliferation The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.
positive regulation of stem cell proliferation Any process that activates or increases the frequency, rate or extent of stem cell proliferation.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of urothelial cell proliferation Any process that activates or increases the rate or extent of urothelial cell proliferation.
positive regulation of vascular associated smooth muscle cell proliferation Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.
positive regulation of Wnt signaling pathway Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
post-embryonic development The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini.
prostate epithelial cord elongation The developmental growth process in which solid chords of prostate epithelium increase in length.
prostate gland morphogenesis The process in which the anatomical structures of a prostate gland are generated and organized.
pyramidal neuron development The progression of a pyramidal neuron from its initial formation to its mature state.
regulation of epithelial cell proliferation Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
regulation of ERK1 and ERK2 cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
regulation of morphogenesis of a branching structure Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized.
regulation of osteoblast proliferation Any process that modulates the frequency, rate or extent of osteoblast proliferation.
regulation of smooth muscle cell differentiation Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation.
regulation of smoothened signaling pathway Any process that modulates the frequency, rate or extent of smoothened signaling.
reproductive structure development The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate.
stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
stem cell proliferation The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
synaptic vesicle transport The directed movement of synaptic vesicles.
ureteric bud development The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
urothelial cell proliferation The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria.
vasculogenesis involved in coronary vascular morphogenesis The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes.
ventricular cardiac muscle tissue morphogenesis The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.
ventricular zone neuroblast division The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially.

112 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43481 KIT Mast/stem cell growth factor receptor Kit Bos taurus (Bovine) SS
Q06805 TIE1 Tyrosine-protein kinase receptor Tie-1 Bos taurus (Bovine) PR
Q06807 TEK Angiopoietin-1 receptor Bos taurus (Bovine) SS
Q28889 KIT Mast/stem cell growth factor receptor Kit Felis catus (Cat) (Felis silvestris catus) SS
P13369 CSF1R Macrophage colony-stimulating factor 1 receptor Felis catus (Cat) (Felis silvestris catus) SS
P18460 FGFR3 Fibroblast growth factor receptor 3 Gallus gallus (Chicken) SS
P21804 FGFR1 Fibroblast growth factor receptor 1 Gallus gallus (Chicken) SS
Q9PUF6 PDGFRA Platelet-derived growth factor receptor alpha Gallus gallus (Chicken) SS
Q08156 KIT Mast/stem cell growth factor receptor Kit Gallus gallus (Chicken) SS
Q8QHL3 FLT1 Vascular endothelial growth factor receptor 1 Gallus gallus (Chicken) SS
P18461 FGFR2 Fibroblast growth factor receptor 2 Gallus gallus (Chicken) SS
Q07407 htl Fibroblast growth factor receptor homolog 1 Drosophila melanogaster (Fruit fly) PR
Q6J9G0 STYK1 Tyrosine-protein kinase STYK1 Homo sapiens (Human) PR
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens (Human) EV
P16234 PDGFRA Platelet-derived growth factor receptor alpha Homo sapiens (Human) EV
P09619 PDGFRB Platelet-derived growth factor receptor beta Homo sapiens (Human) EV
P35916 FLT4 Vascular endothelial growth factor receptor 3 Homo sapiens (Human) SS
P35968 KDR Vascular endothelial growth factor receptor 2 Homo sapiens (Human) EV
P17948 FLT1 Vascular endothelial growth factor receptor 1 Homo sapiens (Human) SS
P07333 CSF1R Macrophage colony-stimulating factor 1 receptor Homo sapiens (Human) SS
P10721 KIT Mast/stem cell growth factor receptor Kit Homo sapiens (Human) EV
P22455 FGFR4 Fibroblast growth factor receptor 4 Homo sapiens (Human) SS
P22607 FGFR3 Fibroblast growth factor receptor 3 Homo sapiens (Human) EV
P07949 RET Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens (Human) EV
P35590 TIE1 Tyrosine-protein kinase receptor Tie-1 Homo sapiens (Human) PR
Q02763 TEK Angiopoietin-1 receptor Homo sapiens (Human) SS
P11362 FGFR1 Fibroblast growth factor receptor 1 Homo sapiens (Human) EV
P21802 FGFR2 Fibroblast growth factor receptor 2 Homo sapiens (Human) EV
Q91V87 Fgfrl1 Fibroblast growth factor receptor-like 1 Mus musculus (Mouse) PR
Q6J9G1 Styk1 Tyrosine-protein kinase STYK1 Mus musculus (Mouse) PR
P35546 Ret Proto-oncogene tyrosine-protein kinase receptor Ret Mus musculus (Mouse) SS
Q61006 Musk Muscle, skeletal receptor tyrosine-protein kinase Mus musculus (Mouse) SS
Q9Z138 Ror2 Tyrosine-protein kinase transmembrane receptor ROR2 Mus musculus (Mouse) SS
Q9Z139 Ror1 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Mus musculus (Mouse) PR
Q62371 Ddr2 Discoidin domain-containing receptor 2 Mus musculus (Mouse) SS
Q03146 Ddr1 Epithelial discoidin domain-containing receptor 1 Mus musculus (Mouse) SS
P15209 Ntrk2 BDNF/NT-3 growth factors receptor Mus musculus (Mouse) SS
Q3UFB7 Ntrk1 High affinity nerve growth factor receptor Mus musculus (Mouse) SS
Q6VNS1 Ntrk3 NT-3 growth factor receptor Mus musculus (Mouse) SS
P35917 Flt4 Vascular endothelial growth factor receptor 3 Mus musculus (Mouse) SS
P35969 Flt1 Vascular endothelial growth factor receptor 1 Mus musculus (Mouse) SS
P35918 Kdr Vascular endothelial growth factor receptor 2 Mus musculus (Mouse) PR
Q03145 Epha2 Ephrin type-A receptor 2 Mus musculus (Mouse) PR
Q60750 Epha1 Ephrin type-A receptor 1 Mus musculus (Mouse) SS
P54761 Ephb4 Ephrin type-B receptor 4 Mus musculus (Mouse) PR
Q60629 Epha5 Ephrin type-A receptor 5 Mus musculus (Mouse) SS
P97793 Alk ALK tyrosine kinase receptor Mus musculus (Mouse) SS
Q9WTL4 Insrr Insulin receptor-related protein Mus musculus (Mouse) SS
Q60751 Igf1r Insulin-like growth factor 1 receptor Mus musculus (Mouse) SS
P15208 Insr Insulin receptor Mus musculus (Mouse) SS
P16092 Fgfr1 Fibroblast growth factor receptor 1 Mus musculus (Mouse) SS
Q03142 Fgfr4 Fibroblast growth factor receptor 4 Mus musculus (Mouse) PR
Q60805 Mertk Tyrosine-protein kinase Mer Mus musculus (Mouse) SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
Q00993 Axl Tyrosine-protein kinase receptor UFO Mus musculus (Mouse) PR
P55144 Tyro3 Tyrosine-protein kinase receptor TYRO3 Mus musculus (Mouse) SS
P70424 Erbb2 Receptor tyrosine-protein kinase erbB-2 Mus musculus (Mouse) SS
Q61527 Erbb4 Receptor tyrosine-protein kinase erbB-4 Mus musculus (Mouse) SS
Q61526 Erbb3 Receptor tyrosine-protein kinase erbB-3 Mus musculus (Mouse) SS
Q01279 Egfr Epidermal growth factor receptor Mus musculus (Mouse) SS
Q01887 Ryk Tyrosine-protein kinase RYK Mus musculus (Mouse) PR
Q02858 Tek Angiopoietin-1 receptor Mus musculus (Mouse) SS
Q06806 Tie1 Tyrosine-protein kinase receptor Tie-1 Mus musculus (Mouse) SS
P05532 Kit Mast/stem cell growth factor receptor Kit Mus musculus (Mouse) PR
P05622 Pdgfrb Platelet-derived growth factor receptor beta Mus musculus (Mouse) SS
P09581 Csf1r Macrophage colony-stimulating factor 1 receptor Mus musculus (Mouse) SS
P26618 Pdgfra Platelet-derived growth factor receptor alpha Mus musculus (Mouse) SS
Q00342 Flt3 Receptor-type tyrosine-protein kinase FLT3 Mus musculus (Mouse) SS
Q61851 Fgfr3 Fibroblast growth factor receptor 3 Mus musculus (Mouse) PR
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
Q2HWD6 KIT Mast/stem cell growth factor receptor Kit Sus scrofa (Pig) SS
Q7TQM3 Fgfrl1 Fibroblast growth factor receptor-like 1 Rattus norvegicus (Rat) PR
P53767 Flt1 Vascular endothelial growth factor receptor 1 Rattus norvegicus (Rat) PR
P20786 Pdgfra Platelet-derived growth factor receptor alpha Rattus norvegicus (Rat) SS
Q91ZT1 Flt4 Vascular endothelial growth factor receptor 3 Rattus norvegicus (Rat) SS
Q04589 Fgfr1 Fibroblast growth factor receptor 1 Rattus norvegicus (Rat) SS
G3V9H8 Ret Proto-oncogene tyrosine-protein kinase receptor Ret Rattus norvegicus (Rat) SS
Q498D6 Fgfr4 Fibroblast growth factor receptor 4 Rattus norvegicus (Rat) PR
Q05030 Pdgfrb Platelet-derived growth factor receptor beta Rattus norvegicus (Rat) SS
O08775 Kdr Vascular endothelial growth factor receptor 2 Rattus norvegicus (Rat) SS
Q17833 old-1 Tyrosine-protein kinase receptor old-1 Caenorhabditis elegans PR
Q19238 F09A5.2 Putative tyrosine-protein kinase F09A5.2 Caenorhabditis elegans SS
P34892 kin-16 Receptor-like tyrosine-protein kinase kin-16 Caenorhabditis elegans PR
G5ED65 ver-1 Protein ver-1 Caenorhabditis elegans PR
Q10656 egl-15 Myoblast growth factor receptor egl-15 Caenorhabditis elegans PR
O64556 At2g19230 Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGI2 At1g67720 Probable LRR receptor-like serine/threonine-protein kinase At1g67720 Arabidopsis thaliana (Mouse-ear cress) PR
Q6XAT2 ERL2 LRR receptor-like serine/threonine-protein kinase ERL2 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E991 PRK6 Pollen receptor-like kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q94C77 At4g34220 Receptor protein kinase-like protein At4g34220 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AG2 SERK1 Somatic embryogenesis receptor kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9XIC7 SERK2 Somatic embryogenesis receptor kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGJ1 At1g74360 Probable LRR receptor-like serine/threonine-protein kinase At1g74360 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZS4 NIK3 Protein NSP-INTERACTING KINASE 3 Arabidopsis thaliana (Mouse-ear cress) PR
P43298 TMK1 Receptor protein kinase TMK1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGQ4 MDIS2 Protein MALE DISCOVERER 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LFG1 At3g53590 Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At3g53590 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WR59 At5g10020 Probable inactive receptor kinase At5g10020 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGX1 At5g65240 Probable LRR receptor-like serine/threonine-protein kinase At5g65240 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FXF2 RKF1 Probable LRR receptor-like serine/threonine-protein kinase RFK1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8AXB3 kdrl Vascular endothelial growth factor receptor kdr-like Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5GIT4 kdr Vascular endothelial growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
O73791 tek Angiopoietin-1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90Z00 fgfr1a Fibroblast growth factor receptor 1-A Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9I8N6 csf1r Macrophage colony-stimulating factor 1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90413 fgfr4 Fibroblast growth factor receptor 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9DE49 pdgfra Platelet-derived growth factor receptor alpha Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8JFR5 kita Mast/stem cell growth factor receptor kita Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5MD89 flt4 Vascular endothelial growth factor receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8JG38 fgfr2 Fibroblast growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MVSWGRFICL VLVTMATLSL ARPSFSLVED TTLEPEEPPT KYQISQPEAY VVAPGESLEL
70 80 90 100 110 120
QCMLKDAAVI SWTKDGVHLG PNNRTVLIGE YLQIKGATPR DSGLYACTAA RTVDSETWIF
130 140 150 160 170 180
MVNVTDAISS GDDEDDTDSS EDVVSENRSN QRAPYWTNTE KMEKRLHACP AANTVKFRCP
190 200 210 220 230 240
AGGNPTSTMR WLKNGKEFKQ EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CLVENEYGSI
250 260 270 280 290 300
NHTYHLDVVE RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK
310 320 330 340 350 360
NGPDGLPYLK VLKAAGVNTT DKEIEVLYIR NVTFEDAGEY TCLAGNSIGI SFHSAWLTVL
370 380 390 400 410 420
PAPVREKEIT ASPDYLEIAI YCIGVFLIAC MVVTVIFCRM KTTTKKPDFS SQPAVHKLTK
430 440 450 460 470 480
RIPLRRQVTV SAESSSSMNS NTPLVRITTR LSSTADTPML AGVSEYELPE DPKWEFPRDK
490 500 510 520 530 540
LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM
550 560 570 580 590 600
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF
610 620 630 640 650 660
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT
670 680 690 700 710 720
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH
730 740 750 760 770 780
RMDKPTNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDLDRI LTLTTNEEYL DLTQPLEQYS
790 800 810 820
PSYPDTSSSC SSGDDSVFSP DPMPYEPCLP QYPHINGSVK T