AiPD: Autoinhibited Protein Database

P21709

Gene name	EPHA1 (EPH, EPHT, EPHT1)
Protein name	Ephrin type-A receptor 1
Names	hEpha1 , EC 2.7.10.1 , EPH tyrosine kinase , EPH tyrosine kinase 1 , Erythropoietin-producing hepatoma receptor , Tyrosine-protein kinase receptor EPH
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2041
EC number	2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.

Autoinhibitory domains (AIDs)

598-624 (Juxtamembrane domain) SS

Target domain	624-884 (Protein kinase domain)
Relief mechanism	PTM
Assay

AID

598-624 (Juxtamembrane domain)

Target domain

624-884 (Protein kinase domain)

Relief mechanism

PTM (Phosphorylation of juxtamembrane domain)

Assay

667-679 (αC helix) SS

Target domain	613-880 (Protein kinase domain)
Relief mechanism	Others
Assay

AID

667-679 (αC helix)

Target domain

613-880 (Protein kinase domain)

Relief mechanism

Others (Dissociation of DLG motif within the activation loop from αC helix)

Assay

Accessory elements

No accessory elements

References

Hubbard SR (2004) "Juxtamembrane autoinhibition in receptor tyrosine kinases", Nature reviews. Molecular cell biology, 5, 464-71

Wybenga-Groot LE et al. (2001) "Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region", Cell, 106, 745-57

Artim SC et al. (2012) "Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family", The Biochemical journal, 448, 213-20

Uchikawa E et al. (2019) "Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex", eLife, 8,

Nielsen J et al. (2022) "Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling", Journal of molecular biology, 434, 167458

Chen YS et al. (2021) "Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation", Proceedings of the National Academy of Sciences of the United States of America, 118,

Craddock BP et al. (2007) "Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region", FEBS letters, 581, 3235-40

Autoinhibited structure

Activated structure

5 structures for P21709

Entry ID	Method	Resolution	Chain	Position	Source
2K1K	NMR	-	A/B	536-573	PDB
2K1L	NMR	-	A/B	536-573	PDB
3HIL	X-ray	200 A	A/B	911-974	PDB
3KKA	X-ray	240 A	A/B	911-974	PDB
AF-P21709-F1	Predicted				AlphaFoldDB

1164 variants for P21709

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1473690516	1	M>?	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1805636910	3	R>Q		No	TOPMed
rs1805637071	3	R>W		No	TOPMed gnomAD
rs1805636800	4	R>L		No	gnomAD
rs1409667882	5	W>*		No	gnomAD
rs1191226865	5	W>G		No	TOPMed gnomAD
rs2116647507	10	G>V		No	Ensembl
rs2116647488	12	V>L		No	Ensembl
rs1805635665	14	L>P		No	TOPMed
rs1805635582	15	L>V		No	TOPMed gnomAD
rs1343287730	17	A>T		No	TOPMed
rs1805634837	18	P>L		No	Ensembl
rs896909240	18	P>S		No	1000Genomes
rs1462823087	20	P>H		No	TOPMed
rs1462823087	20	P>L		No	TOPMed
rs1805634512	20	P>S		No	TOPMed
rs1805634253	21	P>A		No	TOPMed
rs1805634253	21	P>S		No	TOPMed
rs1038171832	23	A>P		No	TOPMed gnomAD
RCV000950730 rs79587607	24	R>H		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs79587607	24	R>P		No	1000Genomes ExAC TOPMed gnomAD
rs2116647348	24	R>S		No	Ensembl
rs1467190935	25	A>P		No	TOPMed gnomAD
rs1467190935	25	A>S		No	TOPMed gnomAD
rs1273047972	26	K>*		No	TOPMed
rs1273047972	26	K>Q		No	TOPMed
TCGA novel	29	T>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs889892936	30	L>P		No	Ensembl
COSM3922987	31	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1342428064	31	M>T		No	TOPMed gnomAD
rs1050291925	32	D>G		No	TOPMed gnomAD
rs774079359	34	S>N		No	ExAC gnomAD
rs1000636068	35	K>N		No	TOPMed
rs768501447	38	G>R		No	ExAC gnomAD
rs779885990	39	E>D		No	ExAC TOPMed gnomAD
rs934062647	40	L>P		No	Ensembl
rs1805591242	41	G>A		No	gnomAD
rs1389840241	41	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs755797395	45	D>H		No	ExAC TOPMed gnomAD
rs571770871 COSM452536 COSM452537	46	P>S	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1805590949	47	P>R		No	Ensembl
rs1188031745	48	K>N		No	TOPMed
rs1037157442	49	D>G		No	gnomAD
rs780744262	50	G>A		No	ExAC TOPMed gnomAD
rs2116632000	53	E>Q		No	Ensembl
rs1805423738	55	Q>K		No	Ensembl
rs1470179846	56	Q>K		No	gnomAD
rs2116631952	57	I>M		No	Ensembl
rs769627585	57	I>T		No	ExAC TOPMed gnomAD
rs1224513857	60	G>R		No	gnomAD
rs2116631911	61	T>R		No	Ensembl
rs1805422631	61	T>S		No	Ensembl
rs139238731	62	P>S		No	ESP ExAC TOPMed gnomAD
rs139238731	62	P>T		No	ESP ExAC TOPMed gnomAD
rs778371838	63	L>M		No	ExAC TOPMed gnomAD
rs1414693803	64	Y>C		No	Ensembl
rs1319809963	65	M>I		No	gnomAD
rs1805421696	65	M>T		No	Ensembl
rs376995026	65	M>V		No	ESP gnomAD
rs758867460	67	Q>*		No	ExAC gnomAD
COSM1448852	67	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1346434969	68	D>N		No	gnomAD
rs2116631813	68	D>V		No	Ensembl
rs1346434969	68	D>Y		No	gnomAD
TCGA novel	70	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs118129834	71	M>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1805421137	71	M>T		No	TOPMed
rs2116631774	72	Q>*		No	Ensembl
rs1805420933	72	Q>H		No	TOPMed gnomAD
rs2116631764	72	Q>L		No	Ensembl
rs2116631764	72	Q>R		No	Ensembl
rs373319975	73	G>R		No	ESP TOPMed gnomAD
rs755258725	74	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs755258725	74	R>G		No	ExAC gnomAD
rs535622332	74	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs535622332	74	R>L		No	1000Genomes ExAC TOPMed gnomAD
rs1254092990	75	R>K		No	gnomAD
rs766451992	75	R>S		No	ExAC gnomAD
rs1563119657	77	T>A		No	Ensembl
rs760843035	77	T>I		No	ExAC TOPMed gnomAD
rs760843035	77	T>N		No	ExAC TOPMed gnomAD
rs2116631691	80	W>*		No	Ensembl
rs773136368	80	W>*		No	ExAC TOPMed gnomAD
rs74721927 COSM3922983	82	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
COSM4762225 rs1029805928	82	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs1029805928	82	R>L		No	TOPMed
rs1372113896	83	S>T		No	gnomAD
rs1296665931	84	N>D		No	TOPMed gnomAD
rs142191815	84	N>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs961514735	84	N>K		No	gnomAD
rs142191815	84	N>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1364023704	85	W>R		No	gnomAD
rs769720234	85	W>S		No	ExAC gnomAD
rs1805418104	86	I>L		No	TOPMed
rs1478817861	86	I>M		No	TOPMed gnomAD
rs1805418032	86	I>T		No	TOPMed
rs1194676814	87	Y>*		No	TOPMed gnomAD
rs2116631573	87	Y>F		No	Ensembl
rs759350123	88	R>C		No	ExAC gnomAD
rs148653512	88	R>H		No	ESP ExAC TOPMed gnomAD
rs148653512	88	R>L		No	ESP ExAC TOPMed gnomAD
TCGA novel	88	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs772621246	89	G>E		No	ExAC gnomAD
rs144146635	89	G>R		No	ESP ExAC TOPMed gnomAD
rs144146635	89	G>W		No	ESP ExAC TOPMed gnomAD
rs1805416951	90	E>K		No	TOPMed
rs1486155232	91	E>D		No	Ensembl
rs748648935	91	E>K		No	ExAC TOPMed gnomAD
rs1805416620	92	A>T		No	TOPMed
rs2116631473	92	A>V		No	Ensembl
COSM5406845	93	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2116631453	93	S>P		No	Ensembl
COSM4587212 rs755348512	94	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs755348512	94	R>G		No	ExAC TOPMed gnomAD
rs45447297	94	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs45447297	94	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs201228574	95	V>I		No	1000Genomes ExAC TOPMed gnomAD
rs201228574	95	V>L		No	1000Genomes ExAC TOPMed gnomAD
rs752699309	97	V>A		No	ExAC TOPMed gnomAD
rs761922296	97	V>L		No	ExAC gnomAD
rs761922296	97	V>M		No	ExAC gnomAD
rs147254019	99	L>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs143810053	100	Q>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs924106822	100	Q>P		No	Ensembl
rs1805414436	102	T>N		No	TOPMed
rs760227816	103	V>L		No	ExAC TOPMed gnomAD
rs760227816 COSM1205425 COSM1205426	103	V>M	large_intestine [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs369887921	104	R>L		No	ESP ExAC TOPMed gnomAD
rs369887921	104	R>Q		No	ESP ExAC TOPMed gnomAD
rs201546539	104	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1805413410	105	D>E		No	Ensembl
rs1460792502	105	D>G		No	gnomAD
rs2116631238	106	C>Y		No	Ensembl
rs749711811	107	K>E		No	ExAC TOPMed gnomAD
rs780269428	107	K>N		No	ExAC TOPMed gnomAD
rs1053367957	109	F>S		No	TOPMed
COSM3635281	110	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs756424890	111	G>E		No	ExAC TOPMed gnomAD
COSM94193 rs1805412828	111	G>R	lung [Cosmic]	No	cosmic curated TOPMed gnomAD
COSM362590 rs756424890 COSM362591	111	G>V	lung [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
COSM3635279 rs781509885	112	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1475628798	113	A>S		No	gnomAD
rs1475628798	113	A>T		No	gnomAD
rs2116631153	113	A>V		No	Ensembl
rs530283884	114	G>R		No	1000Genomes ExAC TOPMed gnomAD
rs759367292	115	P>S		No	ExAC TOPMed gnomAD
rs1563119463	116	L>P		No	Ensembl
rs972897874	117	G>R		No	TOPMed gnomAD
rs972897874	117	G>S		No	TOPMed gnomAD
rs1233382933	118	C>Y		No	TOPMed gnomAD
rs961153147	119	K>R		No	TOPMed
rs1349425480	120	E>K		No	gnomAD
rs760451814	121	T>N		No	ExAC gnomAD
rs772864439	122	F>I		No	ExAC gnomAD
rs764543064	123	N>T		No	Ensembl
rs1375957847	124	L>F		No	TOPMed gnomAD
rs1299141462	125	L>P		No	TOPMed gnomAD
rs1299141462	125	L>Q		No	TOPMed gnomAD
rs1392943742	126	Y>C		No	TOPMed gnomAD
rs1392943742	126	Y>F		No	TOPMed gnomAD
COSM3635277 rs111858878	127	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
rs767106252	127	M>L		No	ExAC TOPMed gnomAD
rs767106252	127	M>V		No	ExAC TOPMed gnomAD
rs761342435	128	E>A		No	ExAC gnomAD
rs1586585702	130	D>N		No	Ensembl
rs1287337651	133	V>G		No	gnomAD
COSM745160	133	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs773830927	133	V>M		No	ExAC TOPMed gnomAD
rs1158975064	135	I>L		No	Ensembl
rs1805408917	137	L>F		No	Ensembl
rs1421157458 COSM3411731 COSM3411732	138	R>*	Variant assessed as Somatic; HIGH impact. central_nervous_system [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
COSM1448849 COSM1448850 rs190437539	138	R>Q	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
COSM6176849	139	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs770072024	139	R>P		No	ExAC gnomAD
rs770072024 COSM175453 COSM5074994	139	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs551009816	139	R>W		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	140	P>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	142	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs746261846	145	V>A		No	ExAC TOPMed gnomAD
rs770297450	145	V>I		No	ExAC TOPMed gnomAD
rs776751373	146	T>N		No	ExAC gnomAD
rs542068127	147	T>M		No	1000Genomes ExAC TOPMed gnomAD
rs542068127	147	T>R		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	148	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1805377471	148	V>G		No	Ensembl
rs1181973754	148	V>M		No	TOPMed
TCGA novel	149	A>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1365141935	149	A>T		No	gnomAD
rs1316251675	152	Q>*		No	gnomAD
rs1362684299	152	Q>H		No	TOPMed gnomAD
rs1384001533	153	S>N		No	gnomAD
rs372053514	154	F>S		No	ESP ExAC TOPMed gnomAD
rs150426007	155	T>A		No	ESP ExAC TOPMed gnomAD
rs1805376601	156	I>V		No	TOPMed
COSM5079469 rs141528182	157	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs779885233	157	R>P		No	ExAC TOPMed gnomAD
rs779885233	157	R>Q		No	ExAC TOPMed gnomAD
rs1805376267	158	D>E		No	Ensembl
rs1174065751	158	D>Y		No	gnomAD
rs966013135	159	L>F		No	TOPMed gnomAD
rs4725617 VAR_028265	160	V>A		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs4725617	160	V>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs4725617	160	V>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1008484548	161	S>C		No	TOPMed
rs1805375532	162	G>S		No	gnomAD
rs1194610095	162	G>V		No	gnomAD
TCGA novel	163	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs751226403	164	V>A		No	ExAC TOPMed gnomAD
rs143405612	164	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs143405612	164	V>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs982934449	166	L>P		No	TOPMed gnomAD
rs763757809	167	N>H		No	ExAC gnomAD
rs762406186	167	N>K		No	ExAC gnomAD
rs1805374686	169	E>D		No	TOPMed
rs373364271	169	E>K		No	ESP ExAC gnomAD
COSM3258329 rs199931138	170	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs199931138	170	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs777199962	170	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs199931138	170	R>S		No	1000Genomes ExAC TOPMed gnomAD
rs141275729	171	C>W		No	1000Genomes ExAC TOPMed gnomAD
rs2116628550	172	S>C		No	Ensembl
rs1586584699	173	L>R		No	Ensembl
rs1377529661	175	R>C		No	TOPMed gnomAD
rs760180128	175	R>H		No	ExAC TOPMed gnomAD
rs760180128	175	R>P		No	ExAC TOPMed gnomAD
rs779038165	176	L>V		No	ExAC gnomAD
rs769688423	177	T>P		No	ExAC gnomAD
COSM3878973 rs745810214	178	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs141392438	178	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs141392438	178	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs540355150	179	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs572755645	179	R>H		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	179	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs540355150	179	R>S		No	1000Genomes ExAC TOPMed gnomAD
rs1475956163	181	L>F		No	gnomAD
rs752203488	182	Y>C		No	ExAC gnomAD
rs1437597746	183	L>P		No	gnomAD
COSM3411729 COSM3411730 rs1805372916	184	A>T	Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic TOPMed gnomAD
rs1805372845	184	A>V		No	gnomAD
rs1805372781	185	F>L		No	Ensembl
rs1198043030	187	N>S		No	gnomAD
rs766943140	188	P>L		No	ExAC TOPMed gnomAD
rs766943140	188	P>Q		No	ExAC TOPMed gnomAD
rs375516618	189	G>A		No	1000Genomes ESP TOPMed gnomAD
rs375516618	189	G>D		No	1000Genomes ESP TOPMed gnomAD
rs1294128583	190	A>D		No	gnomAD
rs1423610614	191	C>Y		No	gnomAD
rs1441823997	192	V>A		No	gnomAD
rs1441823997	192	V>G		No	gnomAD
COSM5123474	193	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1805371888	194	L>P		No	gnomAD
rs774371662	195	V>A		No	ExAC TOPMed gnomAD
rs1162100202	197	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs781143121	198	R>Q		No	ExAC gnomAD
rs749318217	198	R>W		No	ExAC TOPMed gnomAD
rs2116628305	199	V>G		No	Ensembl
rs1805371266	199	V>I		No	TOPMed
rs1805371207	200	F>S		No	gnomAD
rs1231495693	201	Y>*		No	TOPMed gnomAD
rs557273137	201	Y>C		No	1000Genomes ExAC TOPMed gnomAD
rs557273137	201	Y>S		No	1000Genomes ExAC TOPMed gnomAD
rs1212476853	202	Q>L		No	TOPMed
rs746832004	203	R>C		No	ExAC gnomAD
rs373761584	203	R>H		No	ESP ExAC TOPMed gnomAD
rs746832004	203	R>S		No	ExAC gnomAD
rs1805370683	206	E>*		No	TOPMed gnomAD
rs1805370683	206	E>K		No	TOPMed gnomAD
rs1337019566	209	N>Y		No	gnomAD
rs1805370142	210	G>A		No	Ensembl
rs201944315	210	G>S		No	1000Genomes ExAC TOPMed gnomAD
rs778367248	212	A>S		No	ExAC TOPMed gnomAD
rs1281021546	212	A>V		No	TOPMed gnomAD
rs931862837	213	Q>P		No	Ensembl
rs754557302	216	D>H		No	ExAC gnomAD
rs754557302	216	D>N		No	ExAC gnomAD
rs1421420411	218	L>P		No	TOPMed gnomAD
rs1323793671	219	P>S		No	gnomAD
TCGA novel	221	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs753358941	221	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs756665403	222	A>S		No	ExAC TOPMed gnomAD
rs756665403 COSM5176742	222	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1805369232	223	G>E		No	TOPMed
rs1563118730	226	E>A		No	gnomAD
rs921315527	226	E>D		No	Ensembl
rs1563118730	226	E>V		No	gnomAD
rs1398546577	227	V>A		No	gnomAD
rs1314564039	227	V>M		No	TOPMed gnomAD
rs1409728916	228	A>S		No	gnomAD
rs750821899	228	A>V		No	ExAC TOPMed gnomAD
rs762026258	229	G>E		No	ExAC gnomAD
rs199988413	230	T>A		No	ExAC gnomAD
rs199988413	230	T>P		No	ExAC gnomAD
rs780968060	233	P>T		No	Ensembl
rs1215181856	234	H>N		No	gnomAD
rs1445436832	234	H>P		No	gnomAD
rs200473622	234	H>Q		No	1000Genomes ExAC TOPMed gnomAD
rs1215181856	234	H>Y		No	gnomAD
rs770915770	235	A>E		No	ExAC TOPMed gnomAD
rs3812408	235	A>P		No	TOPMed gnomAD
rs3812408	235	A>T		No	TOPMed gnomAD
COSM3635275 rs770915770	235	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs747845357	236	R>P		No	ExAC TOPMed gnomAD
rs747845357	236	R>Q		No	ExAC TOPMed gnomAD
rs201188496	236	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1586584398	237	A>P		No	Ensembl
rs754645542	239	P>A		No	ExAC TOPMed gnomAD
rs1805367092	239	P>L		No	TOPMed gnomAD
rs1805366945	241	P>S		No	Ensembl
rs779696210	242	S>A		No	ExAC gnomAD
rs912785967	243	G>A		No	TOPMed gnomAD
rs912785967	243	G>D		No	TOPMed gnomAD
rs912785967	243	G>V		No	TOPMed gnomAD
rs369211431	245	P>H		No	ESP TOPMed gnomAD
rs776794841	246	R>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1455925427	246	R>C		No	TOPMed gnomAD
COSM3878971 rs200235266	246	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs200235266	246	R>L		No	TOPMed gnomAD
rs1455925427	246	R>S		No	TOPMed gnomAD
COSM1645247 COSM1645248 rs750956234	247	M>I	large_intestine [Cosmic]	No	cosmic curated ExAC gnomAD
rs1412768892	249	C>R		No	TOPMed gnomAD
rs751843044	252	D>E		No	ExAC TOPMed gnomAD
rs763151811	253	G>A		No	ExAC gnomAD
rs763151811	253	G>V		No	ExAC gnomAD
rs549085590	254	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs963454089	255	W>C		No	TOPMed gnomAD
rs1805364365	255	W>R		No	TOPMed
rs201380861	257	V>G		No	ExAC gnomAD
rs771860596	258	P>A		No	ExAC gnomAD
rs1805363595	258	P>R		No	Ensembl
rs771860596	258	P>S		No	ExAC gnomAD
rs748014434	259	V>G		No	ExAC
rs1805363372	259	V>I		No	TOPMed
rs1390169786	260	G>E		No	TOPMed gnomAD
COSM6176851	261	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs201209720	261	R>P		No	1000Genomes TOPMed gnomAD
rs201209720	261	R>Q		No	1000Genomes TOPMed gnomAD
rs140233341 COSM3878969	261	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs1586584265	262	C>G		No	gnomAD
rs1586584265	262	C>R		No	gnomAD
rs1270306538	263	H>Q		No	gnomAD
rs1805362436	263	H>R		No	Ensembl
rs1266044572	265	E>G		No	TOPMed gnomAD
rs1353200268	265	E>K		No	gnomAD
rs748954306	266	P>L		No	ExAC TOPMed
rs768480626	266	P>S		No	ExAC TOPMed gnomAD
rs779796093	267	G>D		No	ExAC TOPMed gnomAD
rs1805361597	267	G>S		No	TOPMed
rs755673712	268	Y>D		No	ExAC gnomAD
rs1450812457	269	E>G		No	TOPMed gnomAD
rs1189757406	269	E>K		No	gnomAD
rs1450812457	269	E>V		No	TOPMed gnomAD
COSM3635273 rs745331095	270	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1264578895	271	G>D		No	gnomAD
rs781744273	272	G>D		No	ExAC gnomAD
rs757685325	274	G>S		No	ExAC TOPMed gnomAD
COSM4681248 rs778110783	275	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs2116627508	276	A>G		No	Ensembl
rs1190425377	277	C>S		No	TOPMed gnomAD
rs998751117	278	V>F		No	TOPMed
rs754006853	279	A>V		No	ExAC gnomAD
rs1222426721	281	P>S		No	gnomAD
TCGA novel	282	S>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1047186045	283	G>D		No	TOPMed gnomAD
rs760751325	283	G>S		No	ExAC TOPMed gnomAD
rs1047186045	283	G>V		No	TOPMed gnomAD
rs751565118	284	S>Y		No	ExAC gnomAD
rs764084713	285	Y>H		No	ExAC gnomAD
rs149680322	286	R>G		No	ESP ExAC TOPMed gnomAD
rs759111320	286	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs149680322	286	R>W		No	ESP ExAC TOPMed gnomAD
COSM4941066	287	M>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2116626971	287	M>T		No	Ensembl
rs1586583888	288	D>G		No	Ensembl
rs139580332	289	M>I		No	ESP ExAC TOPMed gnomAD
rs1420650893	289	M>K		No	gnomAD
rs931346217 COSM373322 COSM373323	289	M>V	lung [Cosmic]	No	cosmic curated TOPMed gnomAD
rs376356192	292	P>L		No	ESP ExAC gnomAD
rs201804057	292	P>S		No	1000Genomes ExAC TOPMed gnomAD
rs201804057	292	P>T		No	1000Genomes ExAC TOPMed gnomAD
rs1805352648	294	C>F		No	TOPMed gnomAD
rs372725643	294	C>R		No	ESP ExAC gnomAD
TCGA novel	294	C>V	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1805352648	294	C>Y		No	TOPMed gnomAD
rs1209926212	295	L>F		No	TOPMed gnomAD
rs749818737	296	T>M		No	ExAC gnomAD
rs2116626902	296	T>P		No	Ensembl
rs779130970	299	Q>*		No	ExAC gnomAD
rs1433233682	299	Q>L		No	gnomAD
rs1234156393	300	Q>*		No	gnomAD
rs1234156393	300	Q>K		No	gnomAD
rs1269104175	301	S>I		No	gnomAD
rs1179553928	301	S>R		No	gnomAD
rs1369463541	302	T>A		No	gnomAD
rs1305651240	303	A>T		No	gnomAD
COSM599769 rs1805351654 COSM599770	306	E>*	lung [Cosmic]	No	cosmic curated TOPMed
rs755294761	307	G>R		No	ExAC TOPMed gnomAD
rs1287321074	308	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs150974578	308	A>V		No	1000Genomes ESP TOPMed gnomAD
rs749476007	309	T>A		No	ExAC TOPMed gnomAD
rs1805351077	309	T>I		No	Ensembl
rs368306573	310	I>L		No	ESP ExAC TOPMed gnomAD
rs368306573	310	I>V		No	ESP ExAC TOPMed gnomAD
rs1199574359	313	C>*		No	TOPMed gnomAD
rs866186417	313	C>F		No	Ensembl
rs1805350772	313	C>R		No	TOPMed
rs55874355	314	E>D		No	1000Genomes ExAC TOPMed gnomAD
rs538968659 COSM421566 COSM421565	314	E>K	urinary_tract [Cosmic]	No	cosmic curated 1000Genomes ExAC gnomAD
rs752606620	315	S>N		No	ExAC gnomAD
rs769788964	315	S>R		No	ExAC TOPMed gnomAD
rs766012017	316	G>D		No	ExAC gnomAD
rs776167447	316	G>S		No	ExAC TOPMed gnomAD
rs1210636799	319	R>G		No	TOPMed gnomAD
rs1402059738	319	R>S		No	Ensembl
rs553135371	320	A>G		No	1000Genomes ExAC gnomAD
rs1346262028	320	A>T		No	gnomAD
rs553135371	320	A>V		No	1000Genomes ExAC gnomAD
rs1028814084	322	G>R		No	TOPMed gnomAD
rs1341375671	323	E>D		No	gnomAD
TCGA novel	323	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1805348964	325	P>S		No	TOPMed
rs1805348666	326	Q>H		No	TOPMed
rs1563118204	326	Q>P		No	Ensembl
rs920137837	327	V>A		No	TOPMed
rs748648594	327	V>M		No	ExAC gnomAD
rs1377102797	329	C>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1787360676	330	T>I		No	gnomAD
rs1358763630	331	G>D		No	gnomAD
COSM3635271	331	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs781511591	332	P>A		No	ExAC TOPMed gnomAD
rs1238073297	332	P>L		No	gnomAD
rs781511591	332	P>S		No	ExAC TOPMed gnomAD
rs781511591	332	P>T		No	ExAC TOPMed gnomAD
rs778751497	333	P>L		No	ExAC gnomAD
rs1008147879	333	P>S		No	TOPMed gnomAD
rs754919004	334	S>L		No	ExAC TOPMed gnomAD
rs779818196	335	A>P		No	ExAC TOPMed gnomAD
rs779818196	335	A>T		No	ExAC TOPMed gnomAD
rs755838535	335	A>V		No	ExAC TOPMed gnomAD
rs1440878134	336	P>H		No	TOPMed gnomAD
rs1440878134	336	P>L		No	TOPMed gnomAD
rs1181013168	336	P>S		No	gnomAD
rs767116546	337	R>*		No	ExAC TOPMed gnomAD
rs201581948 COSM48320	337	R>Q	lung [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs1805338938	338	N>K		No	TOPMed
rs1805338699	340	S>R		No	Ensembl
rs199837219	341	F>C		No	1000Genomes TOPMed
rs199837219	341	F>S		No	1000Genomes TOPMed
rs143872412	342	S>C		No	ESP ExAC TOPMed gnomAD
rs1805338501	342	S>T		No	TOPMed
rs1204837184	344	S>P		No	gnomAD
rs763514757	346	T>A		No	ExAC gnomAD
rs776076308	346	T>I		No	ExAC gnomAD
rs895369223	347	Q>E		No	TOPMed gnomAD
rs1240735868	347	Q>R		No	TOPMed gnomAD
rs1370189067	348	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1300542881	348	L>P		No	gnomAD
rs1056746694	349	S>Y		No	TOPMed gnomAD
rs56006153 VAR_042115	351	R>C		No	UniProt ESP ExAC TOPMed dbSNP gnomAD
COSM1205431 COSM1205432 rs111641464	351	R>H	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs111641464	351	R>L		No	1000Genomes ExAC TOPMed gnomAD
rs1398632917	352	W>C		No	gnomAD
rs771244062	354	P>T		No	ExAC gnomAD
rs747104136	355	P>T		No	ExAC gnomAD
rs777893167	356	A>E		No	ExAC gnomAD
COSM4929245	357	D>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1192382687	357	D>Y		No	gnomAD
COSM4929218	358	T>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs370810516	358	T>M		No	ESP ExAC TOPMed gnomAD
rs1192707729	359	G>A		No	gnomAD
rs1192707729	359	G>E		No	gnomAD
rs750188342	360	G>E		No	ExAC gnomAD
rs139831060	360	G>R		No	ESP ExAC TOPMed gnomAD
rs200253721	361	R>C		No	1000Genomes ESP ExAC TOPMed gnomAD
rs144736263 COSM1086798 COSM1086799	361	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs1367657243	362	Q>H		No	gnomAD
rs1220921084	362	Q>P		No	gnomAD
rs1220921084	362	Q>R		No	gnomAD
rs1269108743	364	V>I		No	TOPMed gnomAD
rs1478960763	365	R>G		No	TOPMed
rs1424510804	365	R>S		No	TOPMed
rs751098607	366	Y>F		No	ExAC gnomAD
rs965820153	366	Y>H		No	Ensembl
rs763667866	367	S>T		No	ExAC gnomAD
rs1805335025	370	C>Y		No	TOPMed
rs1420692583	371	S>A		No	gnomAD
rs1161570547	372	Q>P		No	TOPMed gnomAD
rs1161570547	372	Q>R		No	TOPMed gnomAD
rs1805334671	373	C>Y		No	TOPMed
rs765803133	374	Q>*		No	ExAC
rs1805334538	374	Q>L		No	TOPMed
COSM1086797	375	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs149370167	375	G>S		No	ESP ExAC TOPMed gnomAD
COSM1086795	376	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1474516797	376	T>I		No	gnomAD
rs1805334092	378	Q>*		No	TOPMed
rs964228335	379	D>N		No	TOPMed gnomAD
rs773238741	380	G>E		No	ExAC TOPMed gnomAD
rs760945286	380	G>R		No	ExAC TOPMed gnomAD
rs773238741	380	G>V		No	ExAC TOPMed gnomAD
rs1274962847	381	G>E		No	TOPMed gnomAD
rs1805333227	381	G>R		No	Ensembl
rs57652656	382	P>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs57652656	382	P>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1212296171	385	P>S		No	gnomAD
rs1805332302	386	C>W		No	Ensembl
rs1034352541	387	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs150254405	387	G>R		No	ESP TOPMed gnomAD
rs756937821	389	G>D		No	ExAC TOPMed gnomAD
rs145891509	390	V>L		No	ESP ExAC TOPMed gnomAD
rs145891509 COSM745166 COSM745165	390	V>M	lung [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs752219228	391	H>R		No	ExAC gnomAD
rs1416363336	391	H>Y		No	TOPMed gnomAD
rs765890431	393	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
COSM1448845 COSM1448846 rs140236236	394	P>L	liver large_intestine [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs760889211	396	A>T		No	ExAC TOPMed gnomAD
rs151135649	396	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs143087087	397	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs375682369	397	R>W		No	ESP ExAC TOPMed gnomAD
rs769791439	399	L>F		No	ExAC gnomAD
rs1483496235	400	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
COSM4431866	400	T>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1041401654	401	T>I		No	TOPMed
rs776377613	402	P>R		No	ExAC gnomAD
rs745812223	402	P>S		No	ExAC TOPMed gnomAD
rs745812223	402	P>T		No	ExAC TOPMed gnomAD
rs1805329865	403	A>V		No	TOPMed
rs1258191923	404	V>L		No	gnomAD
rs1805329541	405	H>P		No	Ensembl
rs373557157	405	H>Q		No	ESP ExAC TOPMed gnomAD
rs1332253649	405	H>Y		No	TOPMed gnomAD
rs1473289970	406	V>A		No	TOPMed gnomAD
rs1389778296	407	N>D		No	gnomAD
rs1230393947	407	N>S		No	TOPMed gnomAD
COSM3635264	408	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1412334805	412	Y>H		No	TOPMed
rs867325911	413	A>V		No	Ensembl
rs2116624872	414	N>D		No	Ensembl
rs1805328809	416	T>N		No	TOPMed
rs199888663	418	N>K		No	1000Genomes ExAC TOPMed gnomAD
rs1805328525	419	V>A		No	Ensembl
rs1388321070	419	V>M		No	gnomAD
TCGA novel	420	E>K	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs778558358	420	E>K		No	ExAC gnomAD
rs766865327	421	A>D		No	ExAC TOPMed gnomAD
rs754469465	421	A>T		No	ExAC gnomAD
rs766865327	421	A>V		No	ExAC TOPMed gnomAD
rs942524237	422	Q>*		No	TOPMed gnomAD
rs942524237	422	Q>E		No	TOPMed gnomAD
rs756532762	425	V>M		No	ExAC TOPMed gnomAD
rs1805328001	426	S>*		No	gnomAD
rs767837551	427	G>V		No	ExAC gnomAD
rs1212536971	428	L>Q		No	TOPMed gnomAD
rs762019218	429	G>R		No	ExAC TOPMed gnomAD
rs762019218	429	G>S		No	ExAC TOPMed gnomAD
rs1266841388	431	S>C		No	gnomAD
COSM421568	431	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1203283583	431	S>P		No	TOPMed
rs1322662465	432	G>V		No	TOPMed gnomAD
rs149068255	433	H>R		No	ESP ExAC TOPMed gnomAD
rs368513616	434	A>V		No	ExAC TOPMed gnomAD
rs1440252878	436	T>A		No	gnomAD
rs763362632	436	T>I		No	ExAC TOPMed gnomAD
rs763362632	436	T>N		No	ExAC TOPMed gnomAD
rs1440252878	436	T>P		No	gnomAD
rs1563117532	437	S>L		No	Ensembl
rs760562408	438	V>I		No	ExAC TOPMed gnomAD
rs772865226	442	M>V		No	ExAC gnomAD
rs1805326512	443	G>E		No	gnomAD
rs771914513	445	A>E		No	ExAC gnomAD
rs1156638928	445	A>T		No	TOPMed gnomAD
rs747805007	446	E>K		No	ExAC gnomAD
rs773138765	450	G>D		No	ExAC gnomAD
rs1805320693	450	G>S		No	Ensembl
rs1805320167	451	L>P		No	Ensembl
rs774180152	452	S>C		No	ExAC gnomAD
rs774180152	452	S>F		No	ExAC gnomAD
rs768392833	456	V>L		No	ExAC gnomAD
rs748879034	457	K>M		No	ExAC gnomAD
rs1805319547	457	K>N		No	TOPMed
rs779424882	458	K>T		No	ExAC gnomAD
rs202178565	460	P>L		No	ExAC TOPMed gnomAD
rs1805319219	460	P>S		No	TOPMed gnomAD
rs1295746198	461	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs757242801	462	Q>*		No	TOPMed
rs1805318678	462	Q>L		No	TOPMed
rs1805318625	464	E>G		No	Ensembl
rs539891278	466	T>N		No	1000Genomes ExAC gnomAD
COSM1086793	467	W>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs751886971	467	W>L		No	ExAC TOPMed gnomAD
rs757647389	467	W>R		No	ExAC TOPMed gnomAD
rs577729690	468	A>V		No	TOPMed gnomAD
rs758540262	469	G>E		No	ExAC TOPMed gnomAD
rs1003754616	469	G>R		No	TOPMed
rs143535859	471	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs145268229	471	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM1743259 rs201944531 COSM1743258	473	R>*	Variant assessed as Somatic; HIGH impact. biliary_tract [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs201944531	473	R>G		No	ExAC TOPMed gnomAD
rs147852131	473	R>L		No	ESP ExAC TOPMed gnomAD
rs147852131	473	R>Q		No	ESP ExAC TOPMed gnomAD
rs1331468050	474	S>R		No	TOPMed gnomAD
COSM1086791	475	P>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs187179716	475	P>S		No	1000Genomes ExAC TOPMed gnomAD
rs1187305212	476	G>W		No	gnomAD
rs373049955	477	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs775148876	480	T>I		No	ExAC gnomAD
rs1805316774	480	T>P		No	TOPMed gnomAD
rs769207409	481	Y>C		No	ExAC TOPMed gnomAD
rs73154214	484	H>Q		No	1000Genomes ExAC TOPMed gnomAD
rs1805316262	485	V>E		No	TOPMed
rs144470322	485	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM1448844 COSM1448843 rs144470322	485	V>M	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	487	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs749437637	489	D>H		No	ExAC TOPMed gnomAD
rs749437637	489	D>N		No	ExAC TOPMed gnomAD
rs749437637	489	D>Y		No	ExAC TOPMed gnomAD
rs11768549 VAR_028266	492	R>Q		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
COSM167118 COSM3411726 rs756203512	492	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine central_nervous_system [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1805309396	494	Q>*		No	TOPMed gnomAD
rs375144213	494	Q>H		No	ExAC TOPMed gnomAD
TCGA novel	494	Q>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs752512314	495	M>T		No	ExAC TOPMed gnomAD
rs1303820676	495	M>V		No	TOPMed gnomAD
rs764851795	496	V>A		No	ExAC gnomAD
rs2116623305	496	V>I		No	Ensembl
rs759180125	497	L>I		No	ExAC gnomAD
rs759180125	497	L>V		No	ExAC gnomAD
rs1706447180	499	P>L		No	Ensembl
rs765891077	500	R>G		No	ExAC TOPMed gnomAD
rs765891077	500	R>W		No	ExAC TOPMed gnomAD
rs1331331625	501	V>F		No	gnomAD
rs1399765615	507	Q>*		No	TOPMed gnomAD
rs1228564780	509	D>N		No	Ensembl
rs773742864	513	I>V		No	ExAC TOPMed gnomAD
COSM320146 rs567483385 COSM320145	514	V>I	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs567483385	514	V>L		No	1000Genomes ExAC TOPMed gnomAD
rs774766257	515	R>*		No	ExAC gnomAD
rs964910085	515	R>S		No	TOPMed gnomAD
rs1805307392	516	V>F		No	TOPMed
rs200836382 COSM1644198 COSM1644199	517	R>Q	Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1193288958	518	M>T		No	gnomAD
rs372088764	518	M>V		No	ESP ExAC TOPMed gnomAD
rs2116623121	520	T>S		No	Ensembl
rs371246344	524	P>H		No	gnomAD
rs371246344	524	P>L		No	gnomAD
rs1805306785	524	P>S		No	Ensembl
rs150816053	526	P>R		No	ESP ExAC TOPMed gnomAD
rs1805306617	526	P>S		No	TOPMed
rs867003393	527	F>I		No	Ensembl
COSM452535	527	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3635258	528	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs777617799	528	S>Y		No	ExAC gnomAD
COSM3635256	529	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1275810756	530	D>N		No	gnomAD
rs1449976693	531	H>N		No	Ensembl
rs1220447296	531	H>R		No	gnomAD
rs1181962967	532	E>G		No	gnomAD
rs778778160	534	R>Q		No	ExAC TOPMed gnomAD
rs142265364	534	R>W		No	ESP ExAC TOPMed gnomAD
rs765978732	536	S>I		No	ExAC TOPMed gnomAD
rs765978732	536	S>N		No	ExAC TOPMed gnomAD
COSM3635254	537	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1332849160	538	P>A		No	gnomAD
rs760220358	538	P>L		No	ExAC TOPMed gnomAD
rs760220358	538	P>R		No	ExAC TOPMed gnomAD
rs1332849160	538	P>S		No	gnomAD
TCGA novel	539	V>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs1805296522	539	V>A		No	TOPMed gnomAD
rs771069813	540	S>P		No	ExAC gnomAD
rs774390706	542	G>A		No	ExAC TOPMed gnomAD
rs747022455	542	G>S		No	ExAC TOPMed gnomAD
rs774390706	542	G>V		No	ExAC TOPMed gnomAD
rs1277534592	545	G>A		No	TOPMed gnomAD
rs1805295704	545	G>R		No	TOPMed
TCGA novel	547	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs936860521	547	E>D		No	TOPMed
rs1805295461	547	E>K		No	TOPMed gnomAD
rs1298929475	548	I>T		No	gnomAD
rs1381290223	549	V>A		No	TOPMed gnomAD
rs1805295088	550	A>P		No	Ensembl
rs779820434	550	A>V		No	ExAC gnomAD
rs1357284899	551	V>D		No	TOPMed gnomAD
rs535509887	551	V>I		No	1000Genomes ExAC TOPMed gnomAD
rs1425152855	552	I>V		No	TOPMed gnomAD
rs780668174	553	F>S		No	ExAC TOPMed gnomAD
rs780668174	553	F>Y		No	ExAC TOPMed gnomAD
rs1207373721	555	L>R		No	TOPMed gnomAD
rs111778416	558	G>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1805294004	558	G>C		No	TOPMed
rs111778416	558	G>D		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM1661674 COSM1661675 rs1805294004	558	G>S	kidney [Cosmic]	No	cosmic curated TOPMed
rs111778416	558	G>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1250670366	560	A>G		No	TOPMed gnomAD
rs1437436171	560	A>T		No	TOPMed
rs1805293117	564	G>R		No	Ensembl
TCGA novel	566	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM86807 COSM3366837 rs555414886	567	V>I	kidney ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs555414886	567	V>L		No	1000Genomes ExAC TOPMed gnomAD
rs1360684162	568	F>S		No	gnomAD
rs776947009	569	R>P		No	ExAC TOPMed gnomAD
rs776947009 COSM3878959	569	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs200212760	569	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs765726381	570	S>F		No	TOPMed gnomAD
rs1365759219	571	R>G		No	gnomAD
rs1002258055	573	A>T		No	TOPMed gnomAD
rs560427865	573	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs1366219382	574	Q>*		No	TOPMed gnomAD
rs1366219382	574	Q>E		No	TOPMed gnomAD
rs1263031167	574	Q>H		No	TOPMed gnomAD
VAR_042116 rs35719334	575	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	UniProt NCI-TCGA TOPMed dbSNP gnomAD
rs780288031	575	R>W		No	ExAC TOPMed gnomAD
rs1301595315	576	Q>H		No	TOPMed gnomAD
rs1454467110	577	R>*		No	TOPMed gnomAD
rs750667620	577	R>G		No	ExAC gnomAD
rs1805283440	578	Q>*		No	Ensembl
rs1013254568	578	Q>R		No	TOPMed
rs1317538155	579	Q>*		No	gnomAD
rs1317538155	579	Q>E		No	gnomAD
rs1052212564	579	Q>H		No	TOPMed
rs1563116532	581	Q>*		No	Ensembl
rs574748801	582	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs555587376	582	R>H		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	582	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1229337821	583	D>H		No	gnomAD
rs983868627	584	R>C		No	TOPMed gnomAD
rs765284054	584	R>H		No	1000Genomes ExAC TOPMed gnomAD
VAR_042117 COSM5152790 rs34178823	585	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic UniProt 1000Genomes NCI-TCGA TOPMed dbSNP gnomAD
rs1336834470	585	A>V		No	gnomAD
TCGA novel	586	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1172447950	587	D>E		No	gnomAD
rs866192433	587	D>H		No	TOPMed gnomAD
rs866192433	587	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs866192433	587	D>Y		No	TOPMed gnomAD
rs1463832415	588	V>M		No	gnomAD
rs1374033123	589	D>G		No	gnomAD
rs1033504857	589	D>N		No	TOPMed
rs776941825	590	R>*		No	TOPMed gnomAD
rs776941825	590	R>G		No	TOPMed gnomAD
rs1052285437	590	R>Q		No	TOPMed gnomAD
rs1352423458	591	E>D		No	TOPMed
TCGA novel	592	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs781449260	592	D>H		No	ExAC TOPMed gnomAD
rs781449260	592	D>Y		No	ExAC TOPMed gnomAD
rs369040226	593	K>N		No	ESP ExAC TOPMed gnomAD
rs1221511235	594	L>M		No	TOPMed gnomAD
rs764091010	596	L>M		No	ExAC gnomAD
rs1805255051	597	K>N		No	TOPMed
rs758452852	598	P>A		No	ExAC gnomAD
rs753747935	599	Y>*		No	ExAC gnomAD
rs1805254747	600	V>M		No	gnomAD
rs1805254640	601	D>N		No	Ensembl
rs1805254383	603	Q>H		No	TOPMed
rs1419645656	604	A>E		No	gnomAD
rs1378490342	605	Y>H		No	gnomAD
rs754397131	606	E>K		No	ExAC TOPMed gnomAD
rs146399527	607	D>A		No	ESP TOPMed gnomAD
rs1197085174	611	G>*		No	gnomAD
rs376643332	612	A>D		No	ESP TOPMed gnomAD
rs376643332	612	A>G		No	ESP TOPMed gnomAD
rs767349665	612	A>T		No	ExAC gnomAD
rs10952549	613	L>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1678992035	613	L>R		No	TOPMed
TCGA novel	614	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs768075049	616	T>S		No	ExAC gnomAD
rs138935836	617	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs200018558	617	R>W		No	1000Genomes ExAC TOPMed gnomAD
rs1392328745	618	E>Q		No	TOPMed
rs1805251041	619	L>I		No	TOPMed gnomAD
rs1805251041	619	L>V		No	TOPMed gnomAD
rs1805250826	620	D>G		No	Ensembl
rs1284336251	620	D>H		No	gnomAD
rs1399859924	621	P>L		No	TOPMed gnomAD
rs1399859924	621	P>R		No	TOPMed gnomAD
rs200499248	622	A>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200499248	622	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1316479823	624	L>R		No	TOPMed
rs1190218089	625	M>T		No	TOPMed gnomAD
rs1805249902	626	V>A		No	gnomAD
rs747214273	627	D>G		No	ExAC gnomAD
rs1429662347	628	T>A		No	gnomAD
rs1805249359	628	T>I		No	TOPMed
rs1805249359	628	T>S		No	TOPMed
rs1196145922	629	V>I		No	TOPMed gnomAD
rs1476759571	630	I>T		No	gnomAD
rs1805248910	630	I>V		No	TOPMed
rs1805219347	633	G>E		No	TOPMed gnomAD
rs369094884	633	G>R		No	ESP ExAC TOPMed gnomAD
TCGA novel	634	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs899153539	634	E>D		No	TOPMed
rs1170878071	637	E>*		No	TOPMed gnomAD
rs1404616704	637	E>G		No	gnomAD
rs1383290063	638	V>L		No	TOPMed gnomAD
rs544066979	639	Y>C		No	gnomAD
COSM205472 rs112723648	640	R>*	Variant assessed as Somatic; HIGH impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs112723648	640	R>G		No	ESP ExAC TOPMed gnomAD
rs761006248	640	R>Q		No	ExAC TOPMed gnomAD
rs529885927	641	G>R		No	1000Genomes ExAC gnomAD
rs1586579610	642	T>P		No	Ensembl
COSM1645551 COSM1645552 rs1805218153	644	R>K	large_intestine [Cosmic]	No	cosmic curated gnomAD
rs772261312	645	L>I		No	ExAC TOPMed gnomAD
rs1586579598	645	L>P		No	Ensembl
rs748417082	646	P>L		No	ExAC gnomAD
rs1805217669	647	S>I		No	Ensembl
rs768890787	648	Q>*		No	ExAC gnomAD
rs1290195084	649	D>N		No	gnomAD
rs1248856138	650	C>R		No	gnomAD
rs373965465	650	C>S		No	ESP TOPMed gnomAD
rs373965465	650	C>Y		No	ESP TOPMed gnomAD
rs749349744	651	K>T		No	ExAC gnomAD
rs2116616798	652	T>A		No	Ensembl
rs374663592	655	I>M		No	Ensembl
rs879098618	655	I>V		No	TOPMed
rs1805216810 COSM4898074	658	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed gnomAD
rs781335770	659	K>E		No	ExAC gnomAD
rs1375790178	662	S>Y		No	TOPMed gnomAD
rs757213006	663	P>L		No	ExAC TOPMed gnomAD
rs751386524	664	G>C		No	ExAC TOPMed gnomAD
rs751386524	664	G>R		No	ExAC TOPMed gnomAD
rs1375071460	665	G>S		No	TOPMed
rs777636741	666	Q>H		No	ExAC gnomAD
rs993369891	666	Q>R		No	TOPMed
rs1805216048	667	W>*		No	Ensembl
rs1805216103	667	W>R		No	TOPMed
rs1805215988	670	F>L		No	Ensembl
rs1805215813	671	L>F		No	TOPMed gnomAD
COSM1086785	671	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs758075798	672	R>*		No	ExAC gnomAD
rs752373855	672	R>Q		No	ExAC TOPMed gnomAD
rs1398707074	673	E>G		No	TOPMed gnomAD
rs759092209	674	A>S		No	ExAC TOPMed gnomAD
rs759092209	674	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs753335365	677	M>L		No	ExAC TOPMed gnomAD
rs766864547	678	G>R		No	ExAC gnomAD
TCGA novel	679	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2116616616	681	S>C		No	1000Genomes
COSM3878957	682	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs140700329	683	P>L		No	ESP ExAC TOPMed gnomAD
rs200904525	683	P>T		No	ESP ExAC TOPMed gnomAD
rs774757061	684	H>R		No	ExAC gnomAD
rs1213712645	685	I>V		No	gnomAD
rs371479433	687	H>L		No	ExAC gnomAD
rs371479433	687	H>P		No	ExAC gnomAD
rs371479433	687	H>R		No	ExAC gnomAD
rs1805214243	687	H>Y		No	gnomAD
rs1343356019	688	L>V		No	gnomAD
RCV000895356 rs145160235	691	V>I		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs758249861	692	V>I		No	ExAC TOPMed gnomAD
COSM1086781 COSM1086780 rs747914291	695	R>*	Variant assessed as Somatic; HIGH impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
COSM3635252	695	R>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1805209495	697	P>A		No	Ensembl
rs34372369 VAR_042118	697	P>L		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs752053540	699	M>T		No	ExAC TOPMed gnomAD
rs1364115555	701	I>F		No	gnomAD
rs1336934305	703	E>D		No	gnomAD
rs764574963	703	E>G		No	ExAC gnomAD
VAR_042119	703	E>K	a breast pleomorphic lobular carcinoma sample; somatic mutation [UniProt]	No	UniProt
rs763368841	705	M>T		No	ExAC TOPMed gnomAD
rs1445606633	705	M>V		No	gnomAD
rs375566010	706	E>D		No	ESP ExAC TOPMed gnomAD
rs1805208756	706	E>V		No	TOPMed
TCGA novel	707	N>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM4947049	710	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	711	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	713	F>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1294092057	715	R>W		No	TOPMed gnomAD
rs147817243	716	E>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1222747501	717	R>G		No	Ensembl
rs144535927	717	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs144535927	717	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1222747501	717	R>W		No	Ensembl
rs758879954	718	E>D		No	ExAC gnomAD
rs1362250559	718	E>K		No	gnomAD
rs2116615669	719	D>N		No	Ensembl
rs548151465	720	Q>*		No	1000Genomes ExAC
rs149121680	724	G>E		No	ESP ExAC gnomAD
rs760710752	725	Q>H		No	ExAC TOPMed gnomAD
rs1204021687	725	Q>R		No	gnomAD
rs774312704	727	V>E		No	ExAC gnomAD
rs768560146	729	M>I		No	ExAC gnomAD
rs1177683199	729	M>R		No	TOPMed
rs1283061958	731	Q>K		No	TOPMed gnomAD
rs775145198	733	I>M		No	ExAC TOPMed gnomAD
rs1805203620	733	I>T		No	TOPMed
rs1805203677	733	I>V		No	Ensembl
rs1367983073	734	A>T		No	gnomAD
rs553708553	737	M>I		No	ExAC TOPMed gnomAD
rs915206166	739	Y>*		No	TOPMed gnomAD
rs1805203133	739	Y>F		No	TOPMed
rs1563115168	739	Y>H		No	Ensembl
rs964365496	741	S>N		No	TOPMed gnomAD
COSM3878955	741	S>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1805202930	742	N>S		No	TOPMed
rs1160462380	743	H>Y		No	TOPMed gnomAD
rs1454514009	744	N>D		No	gnomAD
rs1428259311	744	N>S		No	TOPMed gnomAD
rs1805202609	747	H>Y		No	Ensembl
rs145070507	748	R>G		No	ESP ExAC TOPMed gnomAD
COSM1086779 rs376954641 COSM1086778	748	R>Q	endometrium [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs145070507	748	R>W		No	ESP ExAC TOPMed gnomAD
rs778478420	749	D>H		No	ExAC gnomAD
rs758966764	749	D>V		No	ExAC gnomAD
rs1205296887	751	A>T		No	gnomAD
rs1307412502	757	V>E		No	TOPMed gnomAD
rs1347822108	757	V>M		No	gnomAD
rs2116615370	758	N>T		No	Ensembl
rs1805201406	759	Q>*		No	Ensembl
rs1805201342	760	N>K		No	gnomAD
COSM381177 rs1805201208 COSM381176	761	L>Q	lung [Cosmic]	No	cosmic curated Ensembl
rs1805201071	763	C>R		No	TOPMed
rs1758168775	763	C>W		No	gnomAD
rs756235783	763	C>Y		No	ExAC gnomAD
rs750490381	764	K>E		No	ExAC TOPMed gnomAD
rs73726637	764	K>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs73726637	764	K>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1470816324	765	V>L		No	gnomAD
rs1425649832	766	S>T		No	gnomAD
rs775447726	767	D>G		No	ExAC gnomAD
rs1167212623	767	D>N		No	gnomAD
rs764971738	768	F>S		No	ExAC gnomAD
rs146094673	771	T>S		No	ESP ExAC TOPMed gnomAD
rs1197422509	772	R>C		No	TOPMed
rs1197422509	772	R>G		No	TOPMed
rs550789024	772	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs1012896062	773	L>H		No	TOPMed gnomAD
rs144262121	775	D>G		No	ESP ExAC TOPMed gnomAD
rs771554580	777	F>C		No	ExAC gnomAD
rs771554580	777	F>S		No	ExAC gnomAD
rs757458618	778	D>E		No	Ensembl
rs748628634	778	D>Y		No	ExAC TOPMed gnomAD
rs749718342	779	G>D		No	TOPMed gnomAD
rs373447921	779	G>S		No	ESP ExAC TOPMed gnomAD
rs749718342	779	G>V		No	TOPMed gnomAD
rs755342811	781	Y>*		No	ExAC TOPMed gnomAD
rs1382179005	781	Y>H		No	TOPMed gnomAD
rs1382179005	781	Y>N		No	TOPMed gnomAD
COSM3258237 rs1454804041	782	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs549847780	785	G>*		No	ExAC TOPMed gnomAD
rs1490332858	786	G>A		No	TOPMed gnomAD
rs754947166	787	K>R		No	ExAC gnomAD
rs1805180693	789	P>L		No	TOPMed gnomAD
rs753768975	790	I>T		No	ExAC TOPMed gnomAD
rs766301333	791	R>C		No	ExAC TOPMed gnomAD
rs139711610	791	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs139711610	791	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM3832166	791	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2116614034	792	W>C		No	Ensembl
rs1805179812	793	T>P		No	gnomAD
rs1805179502	794	A>G		No	Ensembl
rs1805179605	794	A>S		No	Ensembl
rs1805179290	795	P>S		No	TOPMed
COSM1488316	796	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1805179198	797	A>V		No	gnomAD
rs767987164	798	I>V		No	ExAC gnomAD
rs1805178890	800	H>R		No	gnomAD
rs775933608	801	R>G		No	ExAC TOPMed gnomAD
rs770181636	801	R>Q		No	ExAC TOPMed gnomAD
rs775933608	801	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1156441347	803	F>C		No	gnomAD
rs991771396	804	T>A		No	TOPMed
rs1805177911	805	T>I		No	TOPMed
rs781323096	806	A>V		No	ExAC
rs771180177	807	S>C		No	ExAC
COSM3878951	807	S>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
VAR_042120 rs56244405	807	S>R		No	UniProt TOPMed dbSNP gnomAD
COSM745169 COSM745170 rs747132712	808	D>N	lung Variant assessed as Somatic; MODERATE impact. skin [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1805177081	809	V>M		No	Ensembl
rs1193453669	810	W>*		No	TOPMed gnomAD
rs372075941	810	W>*		No	ESP ExAC gnomAD
rs1488827817	813	G>R		No	gnomAD
rs1805176623	814	I>F		No	Ensembl
rs758500982	816	M>I		No	ExAC gnomAD
rs753859464	817	W>*		No	ExAC gnomAD
TCGA novel	818	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	818	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1586578240	819	V>G		No	Ensembl
rs780109666	819	V>M		No	ExAC gnomAD
rs1209190903	820	L>P		No	TOPMed gnomAD
rs1805175758	821	S>G		No	TOPMed
rs750219974	823	G>R		No	ExAC TOPMed gnomAD
rs1186505049	824	D>E		No	TOPMed gnomAD
rs761535126	826	P>L		No	ExAC gnomAD
rs767146354	826	P>S		No	ExAC TOPMed gnomAD
rs767146354	826	P>T		No	ExAC TOPMed gnomAD
rs190709674	828	G>V		No	1000Genomes
rs1426261434	828	G>W		No	TOPMed gnomAD
rs763688617	830	M>I		No	ExAC TOPMed gnomAD
rs1164168455	830	M>R		No	TOPMed gnomAD
rs1164168455	830	M>T		No	TOPMed gnomAD
rs1175311514	831	S>N		No	gnomAD
rs1388224522	832	N>S		No	TOPMed gnomAD
rs1563114662	833	Q>*		No	TOPMed gnomAD
rs1805173824	834	E>K		No	TOPMed
rs1805163746	836	M>T		No	gnomAD
rs1008251277	838	S>G		No	gnomAD
rs1008251277	838	S>R		No	gnomAD
rs1362271571	839	I>T		No	TOPMed gnomAD
COSM3832164	840	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1390900021	840	E>K		No	gnomAD
rs951430650	841	D>N		No	Ensembl
rs764660537	842	G>A		No	ExAC TOPMed gnomAD
rs764660537	842	G>E		No	ExAC TOPMed gnomAD
COSM1205430 rs766796352 COSM1205429	844	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
COSM1086777 rs753822753 COSM1086776	844	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1213536991	846	P>L		No	gnomAD
rs555934791	847	P>R		No	1000Genomes ExAC gnomAD
COSM4902767	847	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs772410524	849	V>M		No	ExAC TOPMed gnomAD
rs1805162328	852	P>A		No	TOPMed
rs748306167	853	A>T		No	ExAC gnomAD
rs768802916	854	P>L		No	ExAC TOPMed gnomAD
rs774581597	854	P>S		No	ExAC gnomAD
rs2116612768	856	Y>H		No	Ensembl
rs1433805900	859	M>R		No	gnomAD
rs1433805900	859	M>T		No	gnomAD
rs1270475638	860	K>N		No	TOPMed
rs780958221	861	N>K		No	ExAC
COSM5164397	864	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1805161267	865	Y>*		No	Ensembl
rs1586577733	866	D>A		No	Ensembl
rs199929557	867	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs766464624	867	R>H		No	ExAC TOPMed gnomAD
rs766464624	867	R>P		No	ExAC TOPMed gnomAD
rs1371180068	868	A>D		No	gnomAD
rs1371180068	868	A>G		No	gnomAD
rs758050233	869	R>C		No	ExAC TOPMed gnomAD
rs1055875730	869	R>H		No	Ensembl
rs146374704	870	R>L		No	ESP ExAC TOPMed gnomAD
rs146374704	870	R>P		No	ESP ExAC TOPMed gnomAD
rs146374704	870	R>Q		No	ESP ExAC TOPMed gnomAD
rs374097841	870	R>W		No	ESP TOPMed gnomAD
rs56124846	872	H>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1418235400	873	F>L		No	gnomAD
rs1248159907	874	Q>R		No	gnomAD
rs1207144543	875	K>E		No	gnomAD
rs1483335998	876	L>F		No	gnomAD
rs1483335998	876	L>I		No	gnomAD
rs754403787	878	A>E		No	ExAC TOPMed gnomAD
rs1805159716	878	A>T		No	TOPMed gnomAD
rs754411170	882	Q>*		No	ExAC gnomAD
rs891269774	884	L>F		No	TOPMed gnomAD
rs891269774	884	L>I		No	TOPMed gnomAD
rs537988053	888	H>D		No	ExAC gnomAD
rs537988053	888	H>Y		No	ExAC gnomAD
rs761160914	889	S>F		No	ExAC TOPMed gnomAD
rs372390038	889	S>P		No	gnomAD
rs370603321	890	L>P		No	ESP ExAC TOPMed gnomAD
rs762143229	891	R>Q		No	ExAC TOPMed gnomAD
rs767930814	891	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs148388192	892	T>I		No	ESP ExAC TOPMed gnomAD
rs138978752	893	I>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1164006815	893	I>V		No	gnomAD
rs1362341860	894	A>S		No	gnomAD
rs1362341860	894	A>T		No	gnomAD
rs776685006	895	N>H		No	ExAC gnomAD
rs770766668	896	F>L		No	ExAC TOPMed gnomAD
rs1472820846	896	F>V		No	gnomAD
rs1586577581	896	F>Y		No	Ensembl
rs746892705	897	D>Y		No	ExAC gnomAD
rs777558068	898	P>H		No	ExAC gnomAD
rs1248591499	898	P>S		No	TOPMed gnomAD
rs1764865478	899	R>G		No	TOPMed
rs778597320	899	R>S		No	ExAC gnomAD
rs1405011301	900	M>I		No	gnomAD
rs6967117	900	M>L		No	1000Genomes ESP ExAC TOPMed gnomAD
VAR_028267 rs6967117	900	M>V		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1586575815	901	T>P		No	Ensembl
TCGA novel	902	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs748905712	903	R>C		No	ExAC TOPMed gnomAD
rs200265062	903	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs748905712	903	R>S		No	ExAC TOPMed gnomAD
rs1167311375	906	S>R		No	gnomAD
rs1425745397	906	S>T		No	gnomAD
rs1805094085	907	L>P		No	Ensembl
rs1474111055	908	S>G		No	gnomAD
rs1391513028	908	S>N		No	gnomAD
TCGA novel	909	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1188722292	912	G>R		No	gnomAD
rs755605986	913	I>V		No	ExAC TOPMed gnomAD
COSM1086774 COSM1086775 rs751001344	914	P>L	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs751001344	914	P>R		No	ExAC TOPMed gnomAD
rs1805093585	914	P>S		No	Ensembl
rs541812228	916	R>*		No	1000Genomes ExAC TOPMed gnomAD
rs541812228	916	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs919532275 COSM205471	916	R>Q	large_intestine [Cosmic]	No	cosmic curated gnomAD
TCGA novel	918	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs530042951	918	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA gnomAD
rs759578750	920	E>D		No	ExAC gnomAD
rs146963652	920	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA
rs773180572	921	W>C		No	ExAC gnomAD
rs1554446949	923	E>A		No	TOPMed gnomAD
rs1554446949	923	E>G		No	TOPMed gnomAD
rs141196081	923	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs141196081	923	E>Q		No	1000Genomes ExAC TOPMed gnomAD
rs748919069	924	S>A		No	ExAC
rs2116607287	925	I>M		No	Ensembl
rs1371801556	925	I>T		No	gnomAD
rs1427742183	925	I>V		No	gnomAD
rs138715519	926	R>C		No	ESP ExAC TOPMed gnomAD
COSM74525 COSM4946952 rs138715519	926	R>G	ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC TOPMed gnomAD
rs201517649	926	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs201517649	926	R>P		No	1000Genomes ExAC TOPMed gnomAD
rs138715519	926	R>S		No	ESP ExAC TOPMed gnomAD
rs745352332	927	M>V		No	ExAC TOPMed gnomAD
rs1805090487	928	K>E		No	TOPMed
rs1586575626	928	K>N		No	Ensembl
COSM1205435 rs781780617 COSM1205436	929	R>C	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs201365734	929	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	930	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs747457918	931	I>L		No	ExAC TOPMed gnomAD
rs1805089338	934	F>S		No	TOPMed gnomAD
rs1277477714	934	F>V		No	gnomAD
COSM1086773	934	F>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs752900413	935	H>Q		No	ExAC TOPMed gnomAD
rs765474060	936	S>*		No	ExAC TOPMed gnomAD
rs1287929809	936	S>A		No	gnomAD
COSM5651737 rs765474060	936	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1287929809	936	S>P		No	gnomAD
rs1407825756	938	G>E		No	TOPMed gnomAD
rs1805088030	938	G>R		No	TOPMed
rs1472955372	942	M>K		No	TOPMed gnomAD
rs1472955372	942	M>R		No	TOPMed gnomAD
rs753912953	942	M>V		No	ExAC gnomAD
rs1805087262	943	E>D		No	gnomAD
rs1162277611	943	E>Q		No	TOPMed gnomAD
rs1308613660 COSM1205433 COSM1205434	944	C>R	large_intestine [Cosmic]	No	cosmic curated gnomAD
rs1423404234	944	C>Y		No	gnomAD
rs146015036	945	V>L		No	ESP ExAC TOPMed gnomAD
rs1166389916	947	E>D		No	gnomAD
rs1805086597	947	E>Q		No	TOPMed
rs774299123	948	L>P		No	ExAC gnomAD
rs775057203	950	A>D		No	ExAC gnomAD
rs762781363	950	A>P		No	ExAC TOPMed gnomAD
rs762781363	950	A>S		No	ExAC TOPMed gnomAD
COSM3258215 COSM216046 rs762781363	950	A>T	Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1805085858	951	E>G		No	gnomAD
rs1805085919	951	E>K		No	TOPMed
rs1805085919	951	E>Q		No	TOPMed
rs760208570	952	D>G		No	ExAC gnomAD
rs760208570	952	D>V		No	ExAC gnomAD
rs773648089	953	L>Q		No	ExAC
rs748538824	954	T>M		No	ExAC TOPMed gnomAD
TCGA novel	955	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs142650387	957	G>E		No	1000Genomes ExAC TOPMed gnomAD
rs768961042	957	G>R		No	ExAC gnomAD
rs61732998	959	T>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs61732998	959	T>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1805080374	961	P>L		No	TOPMed
rs368297501	962	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1805079999	963	H>N		No	TOPMed
rs1805079688	965	K>R		No	TOPMed gnomAD
rs753594142 COSM74524 COSM4947010	966	R>C	ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs139482378	966	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1186849061	967	I>T		No	gnomAD
rs1805079387	967	I>V		No	TOPMed
TCGA novel	968	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs139639220	968	L>P		No	ESP ExAC TOPMed gnomAD
rs61732993	969	C>G		No	ESP ExAC TOPMed gnomAD
rs61732993	969	C>R		No	ESP ExAC TOPMed gnomAD
rs1199635094	971	I>T		No	gnomAD
rs771427284 COSM3635248	973	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA
rs1247231278	975	K>E		No	TOPMed
rs1482180615	975	K>T		No	TOPMed gnomAD
rs1805078324	976	D>N		No	TOPMed
rs1257638818	977	D>C		No	gnomAD
rs1805078241	977	D>R		No	Ensembl

No associated diseases with P21709

14 regional properties for P21709

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	624 - 884	IPR000719
domain	Ephrin receptor ligand binding domain	27 - 209	IPR001090
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	626 - 880	IPR001245
conserved_site	Tyrosine-protein kinase, receptor class V, conserved site	185 - 205	IPR001426-1
conserved_site	Tyrosine-protein kinase, receptor class V, conserved site	249 - 269	IPR001426-2
domain	Sterile alpha motif domain	910 - 976	IPR001660
domain	Fibronectin type III	332 - 445	IPR003961-1
domain	Fibronectin type III	447 - 538	IPR003961-2
active_site	Tyrosine-protein kinase, active site	745 - 757	IPR008266
domain	Tyrosine-protein kinase ephrin type A/B receptor-like	275 - 309	IPR011641
binding_site	Protein kinase, ATP binding site	630 - 656	IPR017441
domain	Tyrosine-protein kinase, catalytic domain	624 - 880	IPR020635
domain	Ephrin receptor, transmembrane domain	548 - 621	IPR027936
domain	Ephrin type-A receptor 1, ligand binding domain	27 - 203	IPR034251

Functions

		Description
EC Number	2.7.10.1	Protein-tyrosine kinases
Subcellular Localization	Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibronectin binding	Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
transmembrane receptor protein tyrosine kinase activity	Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction
transmembrane-ephrin receptor activity	Combining with a transmembrane ephrin to initiate a change in cell activity.

16 GO annotations of biological process

Name	Definition
activation of GTPase activity	Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
angiogenesis	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
axon guidance	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
cell surface receptor signaling pathway	The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
ephrin receptor signaling pathway	The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
negative regulation of cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of protein kinase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
peptidyl-tyrosine phosphorylation	The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
positive regulation of angiogenesis	Any process that activates or increases angiogenesis.
positive regulation of cell migration	Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cell-matrix adhesion	Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
positive regulation of stress fiber assembly	Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
regulation of GTPase activity	Any process that modulates the rate of GTP hydrolysis by a GTPase.
substrate adhesion-dependent cell spreading	The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

88 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P28693	EPHB2	Ephrin type-B receptor 2	Gallus gallus (Chicken)	PR
Q07496	EPHA4	Ephrin type-A receptor 4	Gallus gallus (Chicken)	SS
Q07494	EPHB1	Ephrin type-B receptor 1	Gallus gallus (Chicken)	SS
Q07497	EPHB5	Ephrin type-B receptor 5	Gallus gallus (Chicken)	PR
P29318	EPHA3	Ephrin type-A receptor 3	Gallus gallus (Chicken)	SS
O42422	EPHA7	Ephrin type-A receptor 7	Gallus gallus (Chicken)	SS
P54755	EPHA5	Ephrin type-A receptor 5	Gallus gallus (Chicken)	SS
Q07498	EPHB3	Ephrin type-B receptor 3	Gallus gallus (Chicken)	SS
P0C0K6	EPHB6	Ephrin type-B receptor 6	Pan troglodytes (Chimpanzee)	SS
P29322	EPHA8	Ephrin type-A receptor 8	Homo sapiens (Human)	SS
P54764	EPHA4	Ephrin type-A receptor 4	Homo sapiens (Human)	SS
P54753	EPHB3	Ephrin type-B receptor 3	Homo sapiens (Human)	SS
P29320	EPHA3	Ephrin type-A receptor 3	Homo sapiens (Human)	PR
Q15375	EPHA7	Ephrin type-A receptor 7	Homo sapiens (Human)	SS
Q5JZY3	EPHA10	Ephrin type-A receptor 10	Homo sapiens (Human)	SS
P29323	EPHB2	Ephrin type-B receptor 2	Homo sapiens (Human)	EV
Q9UF33	EPHA6	Ephrin type-A receptor 6	Homo sapiens (Human)	SS
P54762	EPHB1	Ephrin type-B receptor 1	Homo sapiens (Human)	SS
P54756	EPHA5	Ephrin type-A receptor 5	Homo sapiens (Human)	SS
O15197	EPHB6	Ephrin type-B receptor 6	Homo sapiens (Human)	SS
P07949	RET	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (Human)	EV
O15146	MUSK	Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (Human)	EV
Q01974	ROR2	Tyrosine-protein kinase transmembrane receptor ROR2	Homo sapiens (Human)	EV
Q01973	ROR1	Inactive tyrosine-protein kinase transmembrane receptor ROR1	Homo sapiens (Human)	PR
Q16832	DDR2	Discoidin domain-containing receptor 2	Homo sapiens (Human)	SS
Q08345	DDR1	Epithelial discoidin domain-containing receptor 1	Homo sapiens (Human)	EV
Q16620	NTRK2	BDNF/NT-3 growth factors receptor	Homo sapiens (Human)	EV
P04629	NTRK1	High affinity nerve growth factor receptor	Homo sapiens (Human)	EV
Q16288	NTRK3	NT-3 growth factor receptor	Homo sapiens (Human)	SS
P35916	FLT4	Vascular endothelial growth factor receptor 3	Homo sapiens (Human)	SS
P17948	FLT1	Vascular endothelial growth factor receptor 1	Homo sapiens (Human)	SS
P35968	KDR	Vascular endothelial growth factor receptor 2	Homo sapiens (Human)	EV
P29317	EPHA2	Ephrin type-A receptor 2	Homo sapiens (Human)	SS
P54760	EPHB4	Ephrin type-B receptor 4	Homo sapiens (Human)	SS
P29376	LTK	Leukocyte tyrosine kinase receptor	Homo sapiens (Human)	SS
Q9UM73	ALK	ALK tyrosine kinase receptor	Homo sapiens (Human)	EV
P08922	ROS1	Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (Human)	SS
P14616	INSRR	Insulin receptor-related protein	Homo sapiens (Human)	SS
P08069	IGF1R	Insulin-like growth factor 1 receptor	Homo sapiens (Human)	EV
P06213	INSR	Insulin receptor	Homo sapiens (Human)	EV
P11362	FGFR1	Fibroblast growth factor receptor 1	Homo sapiens (Human)	EV
P21802	FGFR2	Fibroblast growth factor receptor 2	Homo sapiens (Human)	EV
P22455	FGFR4	Fibroblast growth factor receptor 4	Homo sapiens (Human)	SS
P22607	FGFR3	Fibroblast growth factor receptor 3	Homo sapiens (Human)	EV
Q12866	MERTK	Tyrosine-protein kinase Mer	Homo sapiens (Human)	EV
Q04912	MST1R	Macrophage-stimulating protein receptor	Homo sapiens (Human)	EV
P30530	AXL	Tyrosine-protein kinase receptor UFO	Homo sapiens (Human)	PR
Q06418	TYRO3	Tyrosine-protein kinase receptor TYRO3	Homo sapiens (Human)	SS
P08581	MET	Hepatocyte growth factor receptor	Homo sapiens (Human)	EV
P04626	ERBB2	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (Human)	SS
Q15303	ERBB4	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (Human)	SS
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (Human)	SS
P00533	EGFR	Epidermal growth factor receptor	Homo sapiens (Human)	EV
P34925	RYK	Tyrosine-protein kinase RYK	Homo sapiens (Human)	PR
Q02763	TEK	Angiopoietin-1 receptor	Homo sapiens (Human)	SS
P35590	TIE1	Tyrosine-protein kinase receptor Tie-1	Homo sapiens (Human)	PR
P10721	KIT	Mast/stem cell growth factor receptor Kit	Homo sapiens (Human)	EV
P09619	PDGFRB	Platelet-derived growth factor receptor beta	Homo sapiens (Human)	EV
P07333	CSF1R	Macrophage colony-stimulating factor 1 receptor	Homo sapiens (Human)	SS
P16234	PDGFRA	Platelet-derived growth factor receptor alpha	Homo sapiens (Human)	EV
P36888	FLT3	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (Human)	EV
P54754	Ephb3	Ephrin type-B receptor 3	Mus musculus (Mouse)	SS
Q03145	Epha2	Ephrin type-A receptor 2	Mus musculus (Mouse)	PR
Q03137	Epha4	Ephrin type-A receptor 4	Mus musculus (Mouse)	SS
Q61772	Epha7	Ephrin type-A receptor 7	Mus musculus (Mouse)	SS
O09127	Epha8	Ephrin type-A receptor 8	Mus musculus (Mouse)	SS
Q8CBF3	Ephb1	Ephrin type-B receptor 1	Mus musculus (Mouse)	SS
Q8BYG9	Epha10	Ephrin type-A receptor 10	Mus musculus (Mouse)	SS
Q60629	Epha5	Ephrin type-A receptor 5	Mus musculus (Mouse)	SS
P29319	Epha3	Ephrin type-A receptor 3	Mus musculus (Mouse)	SS
Q62413	Epha6	Ephrin type-A receptor 6	Mus musculus (Mouse)	SS
P54763	Ephb2	Ephrin type-B receptor 2	Mus musculus (Mouse)	SS
P54761	Ephb4	Ephrin type-B receptor 4	Mus musculus (Mouse)	PR
O08644	Ephb6	Ephrin type-B receptor 6	Mus musculus (Mouse)	PR
Q60750	Epha1	Ephrin type-A receptor 1	Mus musculus (Mouse)	SS
P54757	Epha5	Ephrin type-A receptor 5	Rattus norvegicus (Rat)	SS
P54759	Epha7	Ephrin type-A receptor 7	Rattus norvegicus (Rat)	SS
P09759	Ephb1	Ephrin type-B receptor 1	Rattus norvegicus (Rat)	SS
P0C0K7	Ephb6	Ephrin type-B receptor 6	Rattus norvegicus (Rat)	SS
O08680	Epha3	Ephrin type-A receptor 3	Rattus norvegicus (Rat)	SS
O61460	vab-1	Ephrin receptor 1	Caenorhabditis elegans	SS
Q8RWZ5	SD25	G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q94AG2	SERK1	Somatic embryogenesis receptor kinase 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q3E991	PRK6	Pollen receptor-like kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FXF2	RKF1	Probable LRR receptor-like serine/threonine-protein kinase RFK1	Arabidopsis thaliana (Mouse-ear cress)	PR
O13147	ephb3	Ephrin type-B receptor 3	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
O73878	ephb4b	Ephrin type-B receptor 4b	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
O13146	epha3	Ephrin type-A receptor 3	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MERRWPLGLG	LVLLLCAPLP	PGARAKEVTL	MDTSKAQGEL	GWLLDPPKDG	WSEQQQILNG
70	80	90	100	110	120
TPLYMYQDCP	MQGRRDTDHW	LRSNWIYRGE	EASRVHVELQ	FTVRDCKSFP	GGAGPLGCKE
130	140	150	160	170	180
TFNLLYMESD	QDVGIQLRRP	LFQKVTTVAA	DQSFTIRDLV	SGSVKLNVER	CSLGRLTRRG
190	200	210	220	230	240
LYLAFHNPGA	CVALVSVRVF	YQRCPETLNG	LAQFPDTLPG	PAGLVEVAGT	CLPHARASPR
250	260	270	280	290	300
PSGAPRMHCS	PDGEWLVPVG	RCHCEPGYEE	GGSGEACVAC	PSGSYRMDMD	TPHCLTCPQQ
310	320	330	340	350	360
STAESEGATI	CTCESGHYRA	PGEGPQVACT	GPPSAPRNLS	FSASGTQLSL	RWEPPADTGG
370	380	390	400	410	420
RQDVRYSVRC	SQCQGTAQDG	GPCQPCGVGV	HFSPGARGLT	TPAVHVNGLE	PYANYTFNVE
430	440	450	460	470	480
AQNGVSGLGS	SGHASTSVSI	SMGHAESLSG	LSLRLVKKEP	RQLELTWAGS	RPRSPGANLT
490	500	510	520	530	540
YELHVLNQDE	ERYQMVLEPR	VLLTELQPDT	TYIVRVRMLT	PLGPGPFSPD	HEFRTSPPVS
550	560	570	580	590	600
RGLTGGEIVA	VIFGLLLGAA	LLLGILVFRS	RRAQRQRQQR	QRDRATDVDR	EDKLWLKPYV
610	620	630	640	650	660
DLQAYEDPAQ	GALDFTRELD	PAWLMVDTVI	GEGEFGEVYR	GTLRLPSQDC	KTVAIKTLKD
670	680	690	700	710	720
TSPGGQWWNF	LREATIMGQF	SHPHILHLEG	VVTKRKPIMI	ITEFMENGAL	DAFLREREDQ
730	740	750	760	770	780
LVPGQLVAML	QGIASGMNYL	SNHNYVHRDL	AARNILVNQN	LCCKVSDFGL	TRLLDDFDGT
790	800	810	820	830	840
YETQGGKIPI	RWTAPEAIAH	RIFTTASDVW	SFGIVMWEVL	SFGDKPYGEM	SNQEVMKSIE
850	860	870	880	890	900
DGYRLPPPVD	CPAPLYELMK	NCWAYDRARR	PHFQKLQAHL	EQLLANPHSL	RTIANFDPRM
910	920	930	940	950	960
TLRLPSLSGS	DGIPYRTVSE	WLESIRMKRY	ILHFHSAGLD	TMECVLELTA	EDLTQMGITL
970
PGHQKRILCS	IQGFKD