P21670

SS
Gene name
Psma4
Protein name
Proteasome subunit alpha type-4
Names
Macropain subunit C9 , Multicatalytic endopeptidase complex subunit C9 , Proteasome component C9 , Proteasome subunit L
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:29671
EC number
Protein Class

Descriptions

PRE9, proteasome subunit α type-3, is a subunit of the proteasome. The core particle (CP) is a cylindrical particle composed of four stacked rings of subunits, with each ring containing seven distinct subunits. The outer rings are composed of seven α subunits, the inner rings of seven β subunits, which contain the active sites. The N-terminal segments of the α3 subunit seals the central channel, which prevents substrate entry by imposing topological closure on the CP. Inhibition by the α3 subunit tail is relieved upon binding of the regulatory particle to the CP to form the proteasome holoenzyme.

Autoinhibitory domains (AIDs)

1-9 (N-terminal tail of the α3 subunit) SS

Target domain

29-216 (Central channel of proteasome)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P21670

Entry ID Method Resolution Chain Position Source
6EPC EM 1230 A C 1-261 PDB
6EPD EM 1540 A C 1-261 PDB
6EPE EM 1280 A C 1-261 PDB
6EPF EM 1180 A C 1-261 PDB
6TU3 EM 270 A C/Q 1-261 PDB
AF-P21670-F1 Predicted AlphaFoldDB

No variants for P21670

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P21670

No associated diseases with P21670

3 regional properties for P21670

Type Name Position InterPro Accession
domain Protein kinase domain 60 - 341 IPR000719
active_site Serine/threonine-protein kinase, active site 197 - 209 IPR008271
binding_site Protein kinase, ATP binding site 66 - 87 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (By similarity)
  • Colocalizes with TRIM5 in the cytoplasmic bodies (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex.
proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P23638 PRE9 Proteasome subunit alpha type-3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
Q3ZCK9 PSMA4 Proteasome subunit alpha type-4 Bos taurus (Bovine) SS
P18053 Prosalpha3 Proteasome subunit alpha type-4 Drosophila melanogaster (Fruit fly) SS
Q9VA12 Prosalpha3T Proteasome subunit alpha type-4-like Drosophila melanogaster (Fruit fly) SS
P25789 PSMA4 Proteasome subunit alpha type-4 Homo sapiens (Human) SS
Q9R1P0 Psma4 Proteasome subunit alpha type-4 Mus musculus (Mouse) SS
P0DKK3 PAC1A Proteasome subunit alpha type-4-1 Oryza sativa subsp. japonica (Rice) SS
Q5VRG3 Os06g0167600 Proteasome subunit alpha type-4-2 Oryza sativa subsp. japonica (Rice) SS
Q9N599 pas-3 Proteasome subunit alpha type-4 Caenorhabditis elegans SS
F4JJE5 PAC2 Putative proteasome subunit alpha type-4-B Arabidopsis thaliana (Mouse-ear cress) SS
O81148 PAC1 Proteasome subunit alpha type-4-A Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MSRRYDSRTT IFSPEGRLYQ VEYAMEAIGH AGTCLGILAN DGVLLAAERR NIHKLLDEVF
70 80 90 100 110 120
FSEKIYKLNE DMACSVAGIT SDANVLTNEL RLIAQRYLLQ YQEPIPCEQL VTALCDIKQA
130 140 150 160 170 180
YTQFGGKRPF GVSLLYIGWD KHYGFQLYQS DPSGNYGGWK ATCIGNNSAA AVSMLKQDYK
190 200 210 220 230 240
EGEMTLKSAL ALAVKVLNKT MDVSKLSAEK VEIATLTREN GKTVIRVLKQ KEVEQLIKKH
250 260
EEEEAKAERE KKEKEQREKD K