P21137

PR
Gene name
kin-1 (ZK909.2)
Protein name
cAMP-dependent protein kinase catalytic subunit
Names
PKA C
Species
Caenorhabditis elegans
KEGG Pathway
EC number
2.7.11.11: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

221-241 (Activation loop from InterPro)

Target domain

81-335 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P21137

Entry ID Method Resolution Chain Position Source
AF-P21137-F1 Predicted AlphaFoldDB

No variants for P21137

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P21137

No associated diseases with P21137

3 regional properties for P21137

Type Name Position InterPro Accession
domain Protein kinase domain 81 - 335 IPR000719
active_site Serine/threonine-protein kinase, active site 200 - 212 IPR008271
binding_site Protein kinase, ATP binding site 87 - 110 IPR017441

Functions

Description
EC Number 2.7.11.11 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
AMP-activated protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cAMP-dependent protein kinase activity cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

3 GO annotations of biological process

Name Definition
positive regulation of oocyte maturation Any process that activates or increases the frequency, rate or extent of oocyte maturation.
protein kinase A signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
protein phosphorylation The process of introducing a phosphate group on to a protein.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P00517 PRKACA cAMP-dependent protein kinase catalytic subunit alpha Bos taurus (Bovine) PR
Q8MJ44 PRKACA cAMP-dependent protein kinase catalytic subunit alpha Canis lupus familiaris (Dog) (Canis familiaris) PR
Q03043 for cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B Drosophila melanogaster (Fruit fly) SS
P16911 Pka-C2 cAMP-dependent protein kinase catalytic subunit 2 Drosophila melanogaster (Fruit fly) PR
P17612 PRKACA cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens (Human) PR
Q922R0 Prkx cAMP-dependent protein kinase catalytic subunit PRKX Mus musculus (Mouse) PR
P05132 Prkaca cAMP-dependent protein kinase catalytic subunit alpha Mus musculus (Mouse) PR
P36887 PRKACA cAMP-dependent protein kinase catalytic subunit alpha Sus scrofa (Pig) PR
O62846 PRKACG cAMP-dependent protein kinase catalytic subunit gamma Macaca mulatta (Rhesus macaque) PR
Q7JP68 F47F2.1 cAMP-dependent protein kinase, catalytic subunit-like Caenorhabditis elegans PR
O76360 egl-4 cGMP-dependent protein kinase egl-4 Caenorhabditis elegans PR
10 20 30 40 50 60
MPTRLDIVGN LQFSSSTDNG DEDQEADVTA CFVLPSPSSF SKLSILDDPV EDFKEFLDKA
70 80 90 100 110 120
REDFKQRWEN PAQNTACLDD FDRIKTLGTG SFGRVMLVKH KQSGNYYAMK ILDKQKVVKL
130 140 150 160 170 180
KQVEHTLNEK RILQAIDFPF LVNMTFSFKD NSNLYMVLEF ISGGEMFSHL RRIGRFSEPH
190 200 210 220 230 240
SRFYAAQIVL AFEYLHSLDL IYRDLKPENL LIDSTGYLKI TDFGFAKRVK GRTWTLCGTP
250 260 270 280 290 300
EYLAPEIILS KGYNKAVDWW ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVKFPSHFS
310 320 330 340 350 360
NELKDLLKNL LQVDLTKRYG NLKNGVADIK NHKWFGSTDW IAIYQKKITP PSFSKGESNG
370 380 390 400
RLFEALYPRV DGPADTRHFV EEVQEPTEFV IAATPQLEEL FVEF