AiPD: Autoinhibited Protein Database

P21127

Gene name	CDK11B (CDC2L1, CDK11, PITSLREA, PK58)
Protein name	Cyclin-dependent kinase 11B
Names	Cell division cycle 2-like protein kinase 1, CLK-1, Cell division protein kinase 11B, Galactosyltransferase-associated protein kinase p58/GTA, PITSLRE serine/threonine-protein kinase CDC2L1, p58 CLK-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:984
EC number	2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

27-151 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

27-151 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

579-602 (Activation loop from InterPro)

Target domain	438-723 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for P21127

Entry ID	Method	Resolution	Chain	Position	Source
7UKZ	X-ray	260 A	A/B/C/D/E/F	428-736	PDB
AF-P21127-F1	Predicted				AlphaFoldDB

520 variants for P21127

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	2	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	5	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1306776210 CA337897894	6	D>E		No	ClinGen gnomAD
rs111987770 CA16790104	16	I>V		No	ClinGen Ensembl
TCGA novel	22	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1429250619 CA337897548	23	R>K		No	ClinGen TOPMed
rs1456532562 CA337897526	25	E>K		No	ClinGen gnomAD
CA529487 rs761815656	27	E>K		No	ClinGen ExAC TOPMed gnomAD
CA337897476 rs761815656	27	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA337897464 rs1182195538	27	E>V		No	ClinGen gnomAD
CA337897434 rs1249490619	29	K>R		No	ClinGen gnomAD
CA529484 rs763206919	32	I>R		No	ClinGen ExAC gnomAD
rs763206919 CA529483	32	I>T		No	ClinGen ExAC gnomAD
TCGA novel	33	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1207552906 CA337897355	33	K>R		No	ClinGen gnomAD
rs1355162260 CA337897336	34	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs775810981 CA529482	34	R>H		No	ClinGen ExAC gnomAD
CA337897267 rs1229375743	37	N>H		No	ClinGen gnomAD
TCGA novel	37	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	37	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1207358214 CA337896751	38	S>F		No	ClinGen gnomAD
CA529433 rs144413330	38	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1207358214 CA337896753	38	S>Y		No	ClinGen gnomAD
rs1553165542 RCV000626811 CA337896738	40	D>G		No	ClinGen ClinVar Ensembl dbSNP
rs756005151 CA337896734	41	R>G		No	ClinGen ExAC TOPMed gnomAD
rs756005151 CA529432	41	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1274189920 CA337896722	43	S>P		No	ClinGen gnomAD
CA337896689 rs1282147202	45	R>Q		No	ClinGen gnomAD
rs1381635294 CA337896694	45	R>W		No	ClinGen TOPMed gnomAD
CA337896687 rs1461840614	46	D>N		No	ClinGen TOPMed gnomAD
CA337896628 rs1359507487	50	E>*		No	ClinGen TOPMed
CA529429 rs781122852	51	G>R		No	ClinGen ExAC gnomAD
CA16789331 rs866980379	53	L>V		No	ClinGen Ensembl
rs1294942464 CA337896576	55	D>H		No	ClinGen TOPMed
rs758430961 CA529428	56	H>Q		No	ClinGen ExAC gnomAD
VAR_041958 CA529427 rs752740049	57	R>C		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
TCGA novel	62	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA529426 rs765350101	62	I>V		No	ClinGen ExAC gnomAD
CA337896466 rs1350866229	63	R>K		No	ClinGen TOPMed
CA337896458 rs1325594545	64	N>H		No	ClinGen TOPMed
rs755140664 CA529425	64	N>K		No	ClinGen ExAC TOPMed gnomAD
CA337896444 rs1411218541	65	S>P		No	ClinGen gnomAD
rs1475114736 CA337896416	67	Y>C		No	ClinGen gnomAD
CA529423 rs369063477	70	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA337896378 rs1482109985	70	E>D		No	ClinGen gnomAD
rs1222407831 CA337896351	72	S>C		No	ClinGen gnomAD
CA529420 rs768172239	73	M>V		No	ClinGen ExAC gnomAD
CA337896314 rs1227497560	75	D>H		No	ClinGen gnomAD
CA337895298 rs1463952954	79	E>D		No	ClinGen TOPMed
rs1200345107 CA337895076	93	R>Q		No	ClinGen TOPMed
VAR_057775 rs1059831	93	R>W		No	UniProt dbSNP
rs1059830 VAR_062199 CA530655	109	R>C		No	ClinGen UniProt 1000Genomes ExAC dbSNP gnomAD
rs1490138549 CA890510055	109	R>H		No	ClinGen TOPMed
rs1289281189 CA890510054	112	R>H		No	ClinGen TOPMed
rs1339974096 CA337894958	116	A>T		No	ClinGen TOPMed
rs1250630063 CA337894952	116	A>V		No	ClinGen TOPMed
CA337894930 rs1332282385	118	G>R		No	ClinGen TOPMed
rs1283555117 CA337894918	118	G>V		No	ClinGen TOPMed
rs1301675317 CA337894909	119	G>R		No	ClinGen TOPMed
rs1252661600 CA890508372	122	A>T		No	ClinGen TOPMed
rs1204480273 CA890508357	128	E>D		No	ClinGen TOPMed
CA890508350 rs1298828898	133	R>H		No	ClinGen TOPMed
CA890508348 rs1230160650	134	R>Q		No	ClinGen TOPMed
rs1350981089 CA997716521	136	R>W		No	ClinGen TOPMed
rs1407417723 CA890508343	138	R>*		No	ClinGen TOPMed
CA890508340 rs1303063468	138	R>P		No	ClinGen TOPMed
rs1303063468 CA890508341	138	R>Q		No	ClinGen TOPMed
rs1465175604 CA890508339	143	K>E		No	ClinGen TOPMed
CA890508336 rs1377437836	145	R>C		No	ClinGen TOPMed
rs1473878201 CA890508334	145	R>H		No	ClinGen TOPMed
CA890508333 rs1473878201	145	R>L		No	ClinGen TOPMed
CA890508331 rs1181616728	146	R>Q		No	ClinGen TOPMed
rs1570173314 CA997716516	146	R>W		No	ClinGen Ensembl
CA890508330 rs1436136818	151	Q>H		No	ClinGen TOPMed
CA890508323 rs1483013369	156	M>I		No	ClinGen TOPMed
CA890508322 rs1210317328	157	A>P		No	ClinGen TOPMed
CA890508321 rs1210317328	157	A>S		No	ClinGen TOPMed
CA337888739 rs1174653196	166	D>Y		No	ClinGen gnomAD
CA337888728 rs1339724000	167	R>H		No	ClinGen TOPMed gnomAD
CA337888727 rs1339724000	167	R>P		No	ClinGen TOPMed gnomAD
CA529101 rs773495263	168	L>M		No	ClinGen ExAC TOPMed gnomAD
CA337888716 rs1377552420	169	E>A		No	ClinGen gnomAD
rs767819308 CA529100	171	L>S		No	ClinGen ExAC gnomAD
rs1293507267 CA337888693	172	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA529097 rs774737300	174	K>E		No	ClinGen ExAC TOPMed gnomAD
rs769130614 CA529095	177	R>W		No	ClinGen ExAC gnomAD
rs749864489 CA529093	178	E>G		No	ClinGen ExAC gnomAD
rs1270568313 CA337888649	179	R>C		No	ClinGen gnomAD
rs774860795 CA529092	179	R>H		No	ClinGen ExAC gnomAD
rs1276985518 CA337888630	181	M>I		No	ClinGen gnomAD
rs1570117644 CA337888634	181	M>T		No	ClinGen Ensembl
rs1446527171 CA337888629	182	R>G		No	ClinGen gnomAD
CA337888619 rs1331864720	183	E>D		No	ClinGen TOPMed gnomAD
rs745455961 CA529089	183	E>K		No	ClinGen ExAC gnomAD
CA337888613 rs746773384	184	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs781016922 CA529088	184	Q>K		No	ClinGen ExAC gnomAD
CA529087 rs757081958	184	Q>P		No	ClinGen ExAC
rs1338035736 CA337888607	185	Q>R		No	ClinGen gnomAD
rs777765880 CA337888603	186	K>E		No	ClinGen ExAC TOPMed
rs777765880 CA529085	186	K>Q		No	ClinGen ExAC TOPMed
rs758400906 CA529084	188	Q>H		No	ClinGen ExAC gnomAD
rs752682015 CA337888581	189	R>G		No	ClinGen ExAC gnomAD
CA337888579 rs1245402769	189	R>P		No	ClinGen TOPMed
CA337888580 rs1245402769	189	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA529083 rs752682015	189	R>W		No	ClinGen ExAC gnomAD
CA16784153 rs1038411084	191	Q>*		No	ClinGen TOPMed gnomAD
rs1442085216 CA337888548	193	E>D		No	ClinGen gnomAD
CA337888544 rs1273399302	194	R>C		No	ClinGen gnomAD
rs1557687409 CA337888543	194	R>P		No	ClinGen Ensembl
rs766308868 CA529077	195	E>K		No	ClinGen ExAC gnomAD
rs756238735 CA529076	196	R>Q		No	ClinGen ExAC
CA337888532 rs941349586	196	R>W		No	ClinGen TOPMed gnomAD
CA337888529 rs1321091565	197	R>W		No	ClinGen TOPMed
CA529073 rs762070251	199	E>Q		No	ClinGen ExAC gnomAD
CA337888483 rs1281936866	201	R>Q		No	ClinGen gnomAD
rs1557687207 VAR_041959 CA337888489	201	R>W		No	ClinGen UniProt Ensembl dbSNP
CA529071 rs751909295	202	R>S		No	ClinGen ExAC gnomAD
CA337888460 rs1557687041	203	K>E		No	ClinGen Ensembl
CA529069 rs764511274	203	K>R		No	ClinGen ExAC gnomAD
rs763302908 CA529068	204	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1462441459 CA337888416	205	R>L		No	ClinGen gnomAD
rs1462441459 CA337888420	205	R>Q		No	ClinGen gnomAD
CA337888423 rs1170511382	205	R>W		No	ClinGen gnomAD
rs1472575491 CA337888374	208	R>C		No	ClinGen TOPMed gnomAD
CA337888378 rs1472575491	208	R>G		No	ClinGen TOPMed gnomAD
rs1233715782 CA337888370	208	R>H		No	ClinGen gnomAD
CA337888356 rs1180261446	210	E>K		No	ClinGen gnomAD
rs1456327163 CA337888331	211	V>M		No	ClinGen gnomAD
rs1254451635 CA337888146	214	H>R		No	ClinGen TOPMed
CA337886452 rs1194056744	215	H>R		No	ClinGen gnomAD
rs1489402875 CA337886439	216	R>*		No	ClinGen TOPMed gnomAD
CA16783411 rs1017192386	216	R>L		No	ClinGen TOPMed gnomAD
rs1017192386 CA337886432	216	R>Q		No	ClinGen TOPMed gnomAD
rs1361634214 CA337886297	220	E>G		No	ClinGen TOPMed
CA337886269 rs1284884868	221	D>E		No	ClinGen TOPMed
rs1243906393 CA337886166	223	S>N		No	ClinGen TOPMed
rs1447013785 CA337886142	223	S>R		No	ClinGen gnomAD
CA337886111 rs1287563199	224	D>N		No	ClinGen TOPMed gnomAD
CA337886072 rs1319964780	225	K>N		No	ClinGen TOPMed
CA337885839 rs1308950435	233	R>C		No	ClinGen TOPMed gnomAD
rs1235539064 CA337885835	233	R>H		No	ClinGen TOPMed gnomAD
CA337885769 rs1292362553	235	P>L		No	ClinGen TOPMed gnomAD
rs1367228995 CA337885711	237	R>Q		No	ClinGen TOPMed
rs1345803144 CA337885741	237	R>W		No	ClinGen TOPMed gnomAD
CA337885697 rs1300140364	238	P>R		No	ClinGen TOPMed gnomAD
CA337885668 rs1303407692	239	P>L		No	ClinGen TOPMed gnomAD
CA337885642 rs1209325457	240	R>Q		No	ClinGen TOPMed
rs1418049739 CA337885657	240	R>W		No	ClinGen TOPMed gnomAD
CA337885624 rs1354421198	241	E>Q		No	ClinGen TOPMed
CA337885594 rs1174004818	242	R>Q		No	ClinGen TOPMed gnomAD
rs1434744269 CA337885557	244	E>K		No	ClinGen TOPMed gnomAD
CA337885501 rs1322730373	245	L>F		No	ClinGen gnomAD
rs1422809295 CA337885444	248	G>S		No	ClinGen TOPMed gnomAD
rs1475715948 CA337885415	249	R>Q		No	ClinGen TOPMed gnomAD
CA337885417 rs1190497380	249	R>W		No	ClinGen TOPMed gnomAD
CA16783404 rs984320513	253	E>D		No	ClinGen TOPMed
CA337885315 rs1170112862	254	A>T		No	ClinGen TOPMed
rs1264662623 CA337885268	256	P>L		No	ClinGen TOPMed gnomAD
CA337885251 rs1213878582	257	A>V		No	ClinGen TOPMed gnomAD
CA337885210 rs1430186658	259	A>G		No	ClinGen TOPMed gnomAD
CA337885209 rs1430186658	259	A>V		No	ClinGen TOPMed gnomAD
CA337885102 rs1317244941	263	A>G		No	ClinGen TOPMed
rs1477205786 CA337885112	263	A>T		No	ClinGen TOPMed gnomAD
CA337885085 rs1255856740	264	Q>H		No	ClinGen TOPMed
TCGA novel	264	Q>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	268	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1280134060 CA337884932	270	M>V		No	ClinGen TOPMed gnomAD
rs1192689926 CA337884865	274	D>G		No	ClinGen TOPMed
rs759121244 CA529065	275	L>V		No	ClinGen ExAC gnomAD
CA337884813 rs1244504220	278	D>N		No	ClinGen TOPMed
rs1557679291 CA337884779	280	Q>*		No	ClinGen Ensembl
CA337884700 rs1357168041	284	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA337884664 rs1429020925	286	E>K		No	ClinGen TOPMed gnomAD
rs1425752604 CA337884560	291	S>A		No	ClinGen gnomAD
rs770690340 CA529063	291	S>L		No	ClinGen ExAC TOPMed gnomAD
CA337884524 rs1169970382	293	E>G		No	ClinGen TOPMed
rs1183180806 CA337884529	293	E>K		No	ClinGen TOPMed gnomAD
rs1463857018 CA337884512	294	S>A		No	ClinGen TOPMed
CA337884508 rs1482083687	294	S>F		No	ClinGen gnomAD
rs572321697 CA16783318	295	S>L		No	ClinGen 1000Genomes TOPMed gnomAD
CA529062 rs746722072	296	S>L		No	ClinGen ExAC gnomAD
CA337884406 rs1417877699	297	A>V		No	ClinGen TOPMed
rs1039813692 CA16783299	300	G>R		No	ClinGen TOPMed
CA337884219 rs1247150802	304	E>D		No	ClinGen gnomAD
CA337884217 rs1320129526	305	E>K		No	ClinGen gnomAD
rs1354450751 CA337884108	308	E>G		No	ClinGen TOPMed
rs1431640583 CA337884069	310	E>G		No	ClinGen gnomAD
rs1313433763 CA337883932	315	E>V		No	ClinGen TOPMed
CA337883831 rs1156320622	320	S>G		No	ClinGen TOPMed
rs1455980297 CA337883738	324	E>Q		No	ClinGen TOPMed gnomAD
rs1570085118 CA337883571	330	E>K		No	ClinGen Ensembl
rs1268736511 CA337883329	336	E>D		No	ClinGen TOPMed gnomAD
CA337883341 rs1457697050	336	E>G		No	ClinGen gnomAD
rs1570084592 CA337883328	337	T>P		No	ClinGen Ensembl
rs1487509362 CA337883315	338	G>R		No	ClinGen TOPMed gnomAD
CA337883300 rs1487509362	338	G>S		No	ClinGen TOPMed gnomAD
CA337883095 rs984392575	343	E>A		No	ClinGen TOPMed
CA16783260 rs984392575	343	E>V		No	ClinGen TOPMed
rs1264953898 CA337883070	344	A>S		No	ClinGen gnomAD
CA337883042 rs1457859985	346	E>K		No	ClinGen TOPMed
CA337883028 rs1457859985	346	E>Q		No	ClinGen TOPMed
rs951578924 CA16783258	348	S>A		No	ClinGen TOPMed
CA337882931 rs1356159584	350	E>K		No	ClinGen gnomAD
CA337882610 rs1478879731	351	E>V		No	ClinGen gnomAD
rs1261125314 CA337882583	352	V>I		No	ClinGen gnomAD
rs1279664552 CA337882556	353	S>G		No	ClinGen TOPMed
rs747942866 CA337882356	360	D>H		No	ClinGen ExAC TOPMed gnomAD
CA529041 rs747942866	360	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA337882314 rs1198569829	361	E>V		No	ClinGen gnomAD
CA337882284 rs1344206965	363	R>*		No	ClinGen TOPMed gnomAD
rs778622403 CA529040	363	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1461219235 CA337882174	369	L>F		No	ClinGen TOPMed
rs1277046603 CA337882127	370	L>F		No	ClinGen gnomAD
CA337881931 rs1361466218	372	V>G		No	ClinGen gnomAD
CA529001 rs769701760	373	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA337881910 rs1436737357	374	E>K		No	ClinGen TOPMed
rs540718028 CA529000	375	S>*		No	ClinGen 1000Genomes ExAC gnomAD
CA528999 rs773272740	376	R>Q		No	ClinGen ExAC gnomAD
CA337881873 rs1191642385	376	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs748349947 CA528997	378	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1287801341 CA337881835	379	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA528995 rs377732366	379	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA528994 rs749647213	380	D>G		No	ClinGen ExAC gnomAD
TCGA novel	382	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA528992 rs200227742	382	G>R		No	ClinGen ExAC TOPMed gnomAD
CA337881781 rs1273133831	383	E>G		No	ClinGen gnomAD
rs750899653 CA528991	383	E>K		No	ClinGen ExAC gnomAD
rs756741517 CA528989	385	E>*		No	ClinGen ExAC
rs976711816 CA16782299	386	E>A		No	ClinGen TOPMed gnomAD
CA337881693 rs1344336261	388	E>D		No	ClinGen TOPMed gnomAD
rs1418110685 CA337881697	388	E>G		No	ClinGen gnomAD
CA337881686 rs371344302	389	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs371344302 CA528987	389	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1416067608 CA337881657	391	V>G		No	ClinGen gnomAD
rs1198063869 CA337881645	392	G>D		No	ClinGen gnomAD
TCGA novel	394	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA16782267 rs376460943	395	T>M		No	ClinGen ESP TOPMed gnomAD
rs759406847 CA528983	396	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1367855230 CA337881542	398	S>R		No	ClinGen gnomAD
CA337881537 rs1292215621	398	S>T		No	ClinGen gnomAD
rs761764777 CA528980	400	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1223441158 CA337881499	401	L>V		No	ClinGen gnomAD
rs1398340470 CA337881458	402	T>I		No	ClinGen gnomAD
CA528978 rs768985113	402	T>S		No	ClinGen ExAC gnomAD
rs780499738 CA528976	405	D>N		No	ClinGen ExAC TOPMed gnomAD
rs201923408 CA528975	406	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1473303388 CA337881367	406	Y>D		No	ClinGen gnomAD
rs1357220714 CA337881339	407	V>A		No	ClinGen gnomAD
rs375622928 CA528973	409	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA528972 rs757824725	410	S>Y		No	ClinGen ExAC gnomAD
rs751014233 CA337881286	411	P>H		No	ClinGen ExAC gnomAD
rs751014233 CA528971	411	P>L		No	ClinGen ExAC gnomAD
rs1409812261 CA337881248	412	A>V		No	ClinGen TOPMed
CA528968 rs752355633	413	L>V		No	ClinGen ExAC gnomAD
VAR_041960 CA337881209 rs1241694892	414	S>L		No	ClinGen UniProt TOPMed dbSNP gnomAD
CA528966 rs759277726	415	P>L		No	ClinGen ExAC TOPMed gnomAD
CA337881156 rs1441181585	416	I>M		No	ClinGen TOPMed
CA528965 rs200966225	416	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766202713 CA528964	417	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA528963 rs760722578	418	L>F		No	ClinGen ExAC gnomAD
rs1269189922 CA337881115	419	K>E		No	ClinGen gnomAD
rs1447391391 CA337881037	423	P>L		No	ClinGen gnomAD
CA337881007 rs1570061156	425	Y>S		No	ClinGen Ensembl
TCGA novel	426	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369699548 CA16782121	426	L>V		No	ClinGen ESP
rs1402438913 CA337880979	427	P>L		No	ClinGen TOPMed gnomAD
TCGA novel	428	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA337880535 rs1157234581	433	R>L		No	ClinGen gnomAD
CA337880542 rs1157234581	433	R>Q		No	ClinGen gnomAD
CA528939 rs765357030	433	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA528937 rs776858200	435	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1268283770 CA337880430	438	F>L		No	ClinGen gnomAD
CA528935 rs747420978	441	L>P		No	ClinGen ExAC gnomAD
CA528933 rs772604810	445	E>K		No	ClinGen ExAC gnomAD
rs747632761 CA528932	448	T>A		No	ClinGen ExAC gnomAD
CA337880239 rs1322153382	448	T>I		No	ClinGen gnomAD
CA337880235 rs1570034859	449	Y>C		No	ClinGen Ensembl
VAR_045577	452	V>A		No	UniProt
rs1316669460 CA337880186	453	Y>H		No	ClinGen gnomAD
rs1432408391 CA337880163	454	R>I		No	ClinGen TOPMed gnomAD
CA528929 rs748973415	457	D>H		No	ClinGen ExAC TOPMed gnomAD
rs748973415 CA337880133	457	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA528928 rs779656126	458	K>E		No	ClinGen ExAC gnomAD
rs1435691040 CA337880085	460	T>R		No	ClinGen TOPMed
rs1466638149 CA337931837	461	D>G		No	ClinGen TOPMed
CA337880074 rs1476500609	461	D>N		No	ClinGen TOPMed gnomAD
CA337931832 rs1358437732	462	E>K		No	ClinGen TOPMed
rs745607448 CA528906	463	I>T		No	ClinGen ExAC TOPMed gnomAD
VAR_041961	463	I>V		No	UniProt
rs1367752921 CA337931810	464	V>M		No	ClinGen gnomAD
CA337931772 rs1423693273	468	R>Q		No	ClinGen TOPMed gnomAD
rs1170462648 CA337931736	472	E>Q		No	ClinGen TOPMed gnomAD
rs1557662466	473	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778841263 CA528901	479	P>L		No	ClinGen ExAC
CA337931637 rs1482647669	481	T>M		No	ClinGen TOPMed
rs977110041 CA16848682	482	S>*		No	ClinGen Ensembl
TCGA novel	482	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762295562 CA528894	485	E>D		No	ClinGen ExAC gnomAD
CA337931595 rs886688865	487	N>S		No	ClinGen TOPMed gnomAD
rs886688865 CA16848647	487	N>T		No	ClinGen TOPMed gnomAD
rs1225944289 CA337931582	488	T>I		No	ClinGen TOPMed gnomAD
rs774972708 CA528893	489	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1347476518 CA337931561	491	K>Q		No	ClinGen gnomAD
rs1301467630 CA337931556	491	K>T		No	ClinGen gnomAD
rs762484910 CA528891	495	P>R		No	ClinGen ExAC gnomAD
CA528887 rs781127365	498	V>I		No	ClinGen ExAC gnomAD
CA528884 rs777730613	500	V>I		No	ClinGen ExAC
CA337931455 rs1266168455	501	R>G		No	ClinGen gnomAD
rs760252594 CA528849	502	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1389425879 CA337931396	503	I>L		No	ClinGen gnomAD
CA528848 rs773057444	503	I>T		No	ClinGen ExAC gnomAD
VAR_045578	506	G>S		No	UniProt
CA337931348 rs1473778680	508	N>T		No	ClinGen gnomAD
CA528842 rs781262255	509	M>I		No	ClinGen ExAC
rs745898300 CA528843	509	M>T		No	ClinGen ExAC gnomAD
rs768611687 CA528844	509	M>V		No	ClinGen ExAC gnomAD
CA528841 rs757431996	510	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1380316890 CA337931310	511	K>R		No	ClinGen gnomAD
CA337931299 rs1557660593	512	I>M		No	ClinGen Ensembl
CA528840 rs747259510	514	I>V		No	ClinGen ExAC gnomAD
rs753220778 CA528837	515	V>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs753220778 CA528838	515	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA337931262 rs1186999203	516	M>T		No	ClinGen gnomAD
CA528836 rs370329622	518	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs370329622 CA337931237	518	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1383791147 CA337931192	522	D>N		No	ClinGen gnomAD
CA528832 rs760363996	525	S>N		No	ClinGen ExAC gnomAD
CA528830 rs767313483	528	E>K		No	ClinGen ExAC gnomAD
rs1300593168 CA337931112	529	T>I		No	ClinGen TOPMed
CA16848012 rs202208701	531	K>Q		No	ClinGen Ensembl
CA528826 rs776685455	532	Q>H		No	ClinGen ExAC gnomAD
rs564859169 CA16847963	536	P>R		No	ClinGen Ensembl
CA337930998 rs1187750677	537	G>E		No	ClinGen gnomAD
CA337930982 rs1570009624	539	V>G		No	ClinGen Ensembl
rs753866422 CA528769	540	K>N		No	ClinGen ExAC gnomAD
rs1460447094 CA337930969	541	T>I		No	ClinGen gnomAD
rs555805101 CA528767	542	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA528765 rs764354479	543	M>I		No	ClinGen ExAC gnomAD
TCGA novel	544	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1271422192 CA337930947	545	Q>*		No	ClinGen TOPMed
rs1451121916 CA337930934	547	L>P		No	ClinGen gnomAD
rs1339904146 CA337930929	548	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1339904146 CA337930930	548	R>G		No	ClinGen TOPMed gnomAD
rs770250152 CA528762	548	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1394679088 CA337930923	549	G>A		No	ClinGen gnomAD
rs1391651825 CA337930899	552	H>Q		No	ClinGen TOPMed
rs1172247765 CA337930894	553	L>P		No	ClinGen TOPMed
CA528759 CA337930887 rs746469679	554	H>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	555	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1425004481 CA337930886	555	D>N		No	ClinGen TOPMed
CA528756 rs758045840	556	N>S		No	ClinGen ExAC gnomAD
TCGA novel	558	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1183434157 CA337930814	561	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs778552932 CA528754	561	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA337930794 rs1222782510	563	L>F		No	ClinGen gnomAD
rs780093115 CA528751	565	T>M		No	ClinGen ExAC TOPMed gnomAD
rs764335905 CA528748	567	N>S		No	ClinGen ExAC gnomAD
rs763073129 CA528747	571	S>N		No	ClinGen ExAC gnomAD
CA528745 rs202189602	573	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs771365504 CA528742	574	G>D		No	ClinGen ExAC gnomAD
CA528743 rs777000516	574	G>S		No	ClinGen ExAC gnomAD
TCGA novel rs1570007532 CA337930654	577	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
rs750812716 CA528705	578	V>G		No	ClinGen ExAC TOPMed gnomAD
CA337930568 rs375742587	581	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1420640807 CA337930576	581	F>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs773909896 CA528702	582	G>V		No	ClinGen ExAC gnomAD
CA337930547 rs1462668002	584	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs769600864 CA528698	585	R>G		No	ClinGen ExAC gnomAD
rs1277215727 CA337930539	585	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA337930541 rs769600864	585	R>W		No	ClinGen ExAC gnomAD
CA528697 rs745605505	586	E>K		No	ClinGen ExAC gnomAD
rs1570004109 CA337930519	587	Y>D		No	ClinGen Ensembl
CA337930509 rs1225987760	588	G>R		No	ClinGen gnomAD
rs1364199097 CA337930491	589	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA16846834 rs948513727	590	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1294459593 CA337930487	590	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs779031774 CA528693	595	T>A		No	ClinGen ExAC TOPMed gnomAD
CA528692 rs755056478	595	T>I		No	ClinGen ExAC gnomAD
rs537877586 CA528689	597	V>I		No	ClinGen ExAC TOPMed gnomAD
rs200190129 CA528685 VAR_041962	601	L>Q		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
CA337930364 rs1481080808	603	Y>C		No	ClinGen gnomAD
rs1203299811 CA337930356	604	R>C		No	ClinGen gnomAD
CA528684 rs542159780	604	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA337930353 rs542159780	604	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759262305 CA528681	605	A>S		No	ClinGen ExAC TOPMed gnomAD
CA528680 rs759262305	605	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1308982194 CA337930344	605	A>V		No	ClinGen TOPMed gnomAD
rs1557656551 CA337930334	606	P>L		No	ClinGen Ensembl
rs776479657 CA528679	606	P>S		No	ClinGen ExAC gnomAD
CA337930332 rs1374890801	607	E>*		No	ClinGen gnomAD
CA528676 rs772985283	611	G>S		No	ClinGen ExAC gnomAD
rs576381801 CA528675	612	A>T		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	612	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	613	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA528632 rs776784906	615	Y>*		No	ClinGen ExAC gnomAD
CA528631 rs574549646	617	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA528630 rs747318216	617	T>M		No	ClinGen ExAC TOPMed gnomAD
CA337930192 rs574549646	617	T>P		No	ClinGen 1000Genomes ExAC gnomAD
CA337930185 rs773696333	618	A>S		No	ClinGen ExAC TOPMed gnomAD
rs773696333 CA528629	618	A>T		No	ClinGen ExAC TOPMed gnomAD
rs772610257 CA528628	619	V>L		No	ClinGen ExAC gnomAD
rs772610257 CA337930176	619	V>M		No	ClinGen ExAC gnomAD
rs1557655576 CA337930166	620	D>N		No	ClinGen Ensembl
rs1295978790 CA337930152	621	M>L		No	ClinGen TOPMed gnomAD
CA528626 rs779515788	621	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1295978790 CA337930154	621	M>V		No	ClinGen TOPMed gnomAD
CA337930133 rs1557655509	622	W>C		No	ClinGen Ensembl
CA337930118 rs1383571103	624	V>A		No	ClinGen gnomAD
CA337930122 rs1302968235	624	V>L		No	ClinGen TOPMed
rs375402811 CA528623	627	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1473407271 CA337930072	629	G>R		No	ClinGen gnomAD
rs750126951 CA337930053	631	L>M		No	ClinGen ExAC TOPMed gnomAD
rs1445209438 CA337930004	636	P>A		No	ClinGen TOPMed gnomAD
CA337930002 rs1445209438	636	P>S		No	ClinGen TOPMed gnomAD
CA528618 rs373048979	638	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA16846270 rs934264822	639	P>L		No	ClinGen TOPMed
rs867526990 CA16846284	639	P>S		No	ClinGen Ensembl
CA528615 CA528614 rs766534863	640	G>R		No	ClinGen ExAC gnomAD
rs1470035005 CA337929969	641	K>E		No	ClinGen TOPMed
rs1231675499 CA337929965	641	K>M		No	ClinGen TOPMed
CA528612 VAR_041963 rs1059815	641	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen UniProt ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
TCGA novel	642	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368684206 CA528609	643	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA528610 rs748468119	643	E>K		No	ClinGen ExAC gnomAD
rs749864472 CA528607	645	D>N		No	ClinGen ExAC gnomAD
CA337929925 rs375076568	646	Q>*		No	ClinGen ESP TOPMed gnomAD
CA16846201 rs375076568	646	Q>E		No	ClinGen ESP TOPMed gnomAD
rs1230454139 CA337929921	646	Q>H		No	ClinGen TOPMed gnomAD
CA337929919 rs1329733028	647	I>L		No	ClinGen TOPMed gnomAD
rs779410025 CA528606	647	I>M		No	ClinGen ExAC gnomAD
CA337929918 rs1329733028	647	I>V		No	ClinGen TOPMed gnomAD
CA337929904 rs1306698051	649	K>E		No	ClinGen gnomAD
rs17424311 CA337929899	649	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA337929901 rs1368437160	649	K>R		No	ClinGen TOPMed gnomAD
rs1374588001 CA337929897	650	V>L		No	ClinGen TOPMed
rs150949339 CA337929857 CA528568	653	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1189900905 CA337929849	655	G>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA337929845 rs1249125779	656	T>P		No	ClinGen gnomAD
rs746631092 CA528564	658	S>G		No	ClinGen ExAC
rs777440368 CA528562	659	E>K		No	ClinGen ExAC gnomAD
TCGA novel	659	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1211054274 CA337929818	660	K>E		No	ClinGen gnomAD
rs1382257865 CA337929812	660	K>N		No	ClinGen gnomAD
rs1314221225 CA337929805	661	I>M		No	ClinGen TOPMed gnomAD
rs1193802370 CA337929807	661	I>T		No	ClinGen TOPMed
CA528561 rs771639524	663	P>R		No	ClinGen ExAC gnomAD
CA16845837 rs370926382	663	P>S		No	ClinGen ESP TOPMed
rs1239138600 CA337929789	664	G>D		No	ClinGen TOPMed
rs377152408 CA528559	664	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA337929770 rs1306894881	667	E>K		No	ClinGen TOPMed
CA528556 rs781390964	669	P>L		No	ClinGen ExAC gnomAD
rs1059811 VAR_041964 CA528554	670	A>V		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
TCGA novel	671	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764317861 CA528553	671	V>G		No	ClinGen ExAC
CA528549 rs544476560	673	K>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1363358102 CA337929664	674	M>I		No	ClinGen TOPMed
CA337929671 rs1454387502	674	M>T		No	ClinGen TOPMed
rs1182586795 CA337929575	678	E>K		No	ClinGen TOPMed gnomAD
rs772605268 CA528545	679	H>L		No	ClinGen ExAC TOPMed gnomAD
rs772605268 CA337929542	679	H>P		No	ClinGen ExAC TOPMed gnomAD
rs772605268 CA528544	679	H>R		No	ClinGen ExAC TOPMed gnomAD
CA337929529 rs771754680	680	P>H		No	ClinGen ExAC gnomAD
rs771754680 CA528543	680	P>R		No	ClinGen ExAC gnomAD
CA337929515 rs1276563976	681	Y>C		No	ClinGen gnomAD
CA337929488 rs1349322374	683	N>D		No	ClinGen TOPMed
rs1312805373 CA337929467	684	L>F		No	ClinGen gnomAD
CA337929469 rs1312805373	684	L>V		No	ClinGen gnomAD
rs1376368167 CA337929448	685	R>H		No	ClinGen TOPMed gnomAD
rs1376368167 CA337929446	685	R>P		No	ClinGen TOPMed gnomAD
rs749127161 CA528539	686	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1557652895 CA337929419	687	R>C		No	ClinGen Ensembl
CA528538 rs369695164	687	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1390024579 CA337929394	689	G>E		No	ClinGen TOPMed gnomAD
CA337929401 rs1428375413	689	G>R		No	ClinGen gnomAD
rs1425585204 CA337929387	690	A>T		No	ClinGen gnomAD
CA528535 rs558444447	692	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs558444447 CA337929363	692	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA337929337 rs1482609380	694	D>N		No	ClinGen gnomAD
CA337928697 rs1223716962	696	G>S		No	ClinGen gnomAD
CA528531 rs765551155	698	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA528529 rs754220811	699	L>V		No	ClinGen ExAC TOPMed gnomAD
CA337928633 rs1317097195	700	M>L		No	ClinGen TOPMed gnomAD
CA528527 rs761155518	700	M>T		No	ClinGen ExAC gnomAD
CA337928630 rs1317097195	700	M>V		No	ClinGen TOPMed gnomAD
CA337928601 rs1193412235	701	N>K		No	ClinGen TOPMed
rs1245715314 CA337928508	704	L>M		No	ClinGen TOPMed gnomAD
CA337928506 rs1245715314	704	L>V		No	ClinGen TOPMed gnomAD
rs1223130557 CA337928491	706	Y>H		No	ClinGen TOPMed
CA337928437 rs1370933393	710	R>K		No	ClinGen TOPMed gnomAD
CA337928385 rs1432548296	714	A>P		No	ClinGen TOPMed
rs1569983299 CA337928302	720	H>N		No	ClinGen Ensembl
rs1235798629 CA337928248	724	R>C		No	ClinGen gnomAD
rs1310825098 CA337928243	724	R>L		No	ClinGen gnomAD
CA337928240 rs1167488059	725	E>K		No	ClinGen TOPMed
CA337928216 rs1475726841	726	T>I		No	ClinGen TOPMed
CA337928228 rs1569982956	726	T>P		No	ClinGen Ensembl
rs1569982722 CA337928198	728	L>P		No	ClinGen Ensembl
CA337928199 rs1436512563	728	L>V		No	ClinGen gnomAD
CA16845484 rs888686909	729	P>L		No	ClinGen TOPMed gnomAD
CA337928181 rs888686909	729	P>R		No	ClinGen TOPMed gnomAD
rs1318687184 CA337928176	730	I>V		No	ClinGen TOPMed gnomAD
CA337928157 rs1208187954	731	D>H		No	ClinGen TOPMed
CA337928136 rs1403094020	732	P>H		No	ClinGen gnomAD
CA337928129 rs1569982357	733	S>P		No	ClinGen Ensembl
rs1463454727 CA337928113	734	M>V		No	ClinGen TOPMed
rs1569982248 CA337928092	735	F>S		No	ClinGen Ensembl
rs1274995966 CA337928076	737	T>M		No	ClinGen TOPMed
rs1569982069 CA337928065	738	W>*		No	ClinGen Ensembl
rs1394287812 CA337928011	742	S>G		No	ClinGen gnomAD
rs1169112508 CA337927936	746	R>C		No	ClinGen TOPMed gnomAD
rs1215906723 CA337927930	746	R>H		No	ClinGen TOPMed
rs1362233771 CA337927889	748	K>N		No	ClinGen TOPMed
rs1287743213 CA337927873	749	R>Q		No	ClinGen TOPMed
rs1387775314 CA337927782	755	P>S		No	ClinGen gnomAD
CA337927631 rs1328479117	763	S>G		No	ClinGen TOPMed
CA337927628 rs1553156055	763	S>N		No	ClinGen Ensembl
rs1569980453 CA337927570	766	G>D		No	ClinGen Ensembl
CA337927458 rs1303580057	773	T>M		No	ClinGen TOPMed
rs1292105702 CA337927324	787	A>T		No	ClinGen TOPMed
CA337927298 rs1168198221	790	G>S		No	ClinGen TOPMed

No associated diseases with P21127

3 regional properties for P21127

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	438 - 723	IPR000719
active_site	Serine/threonine-protein kinase, active site	558 - 570	IPR008271
domain	Cyclin-dependent kinase 11/PITSLRE, catalytic domain	432 - 723	IPR045267

Functions

		Description
EC Number	2.7.11.22	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
RNA binding	Binding to an RNA molecule or a portion thereof.

10 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of apoptotic process	Any process that modulates the occurrence or rate of cell death by apoptotic process.
regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.
regulation of cell growth	Any process that modulates the frequency, rate, extent or direction of cell growth.
regulation of centrosome cycle	Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of mitotic cell cycle	Any process that modulates the rate or extent of progress through the mitotic cell cycle.
regulation of mRNA processing	Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.

18 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2TBL8	CDK10	Cyclin-dependent kinase 10	Bos taurus (Bovine)	PR
Q15131	CDK10	Cyclin-dependent kinase 10	Homo sapiens (Human)	PR
Q9UQ88	CDK11A	Cyclin-dependent kinase 11A	Homo sapiens (Human)	PR
Q00526	CDK3	Cyclin-dependent kinase 3	Homo sapiens (Human)	PR
Q96Q40	CDK15	Cyclin-dependent kinase 15	Homo sapiens (Human)	PR
O94921	CDK14	Cyclin-dependent kinase 14	Homo sapiens (Human)	PR
Q00537	CDK17	Cyclin-dependent kinase 17	Homo sapiens (Human)	PR
P49336	CDK8	Cyclin-dependent kinase 8	Homo sapiens (Human)	PR
Q9BWU1	CDK19	Cyclin-dependent kinase 19	Homo sapiens (Human)	PR
P50750	CDK9	Cyclin-dependent kinase 9	Homo sapiens (Human)	PR
Q5MAI5	CDKL4	Cyclin-dependent kinase-like 4	Homo sapiens (Human)	PR
Q00532	CDKL1	Cyclin-dependent kinase-like 1	Homo sapiens (Human)	PR
Q92772	CDKL2	Cyclin-dependent kinase-like 2	Homo sapiens (Human)	PR
Q8IZL9	CDK20	Cyclin-dependent kinase 20	Homo sapiens (Human)	PR
Q3UMM4	Cdk10	Cyclin-dependent kinase 10	Mus musculus (Mouse)	PR
Q4KM47	Cdk10	Cyclin-dependent kinase 10	Rattus norvegicus (Rat)	PR
Q09437	cdk-11.1	Cyclin-dependent kinase 11.1	Caenorhabditis elegans	PR
Q9FGW5	CDKG1	Cyclin-dependent kinase G1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MGDEKDSWKV	KTLDEILQEK	KRRKEQEEKA	EIKRLKNSDD	RDSKRDSLEE	GELRDHRMEI
70	80	90	100	110	120
TIRNSPYRRE	DSMEDRGEED	DSLAIKPPQQ	MSRKEKAHHR	KDEKRKEKRR	HRSHSAEGGK
130	140	150	160	170	180
HARVKEKERE	HERRKRHREE	QDKARREWER	QKRREMAREH	SRRERDRLEQ	LERKRERERK
190	200	210	220	230	240
MREQQKEQRE	QKERERRAEE	RRKEREARRE	VSAHHRTMRE	DYSDKVKASH	WSRSPPRPPR
250	260	270	280	290	300
ERFELGDGRK	PGEARPAPAQ	KPAQLKEEKM	EERDLLSDLQ	DISDSERKTS	SAESSSAESG
310	320	330	340	350	360
SGSEEEEEEE	EEEEEEGSTS	EESEEEEEEE	EEEEEETGSN	SEEASEQSAE	EVSEEEMSED
370	380	390	400	410	420
EERENENHLL	VVPESRFDRD	SGESEEAEEE	VGEGTPQSSA	LTEGDYVPDS	PALSPIELKQ
430	440	450	460	470	480
ELPKYLPALQ	GCRSVEEFQC	LNRIEEGTYG	VVYRAKDKKT	DEIVALKRLK	MEKEKEGFPI
490	500	510	520	530	540
TSLREINTIL	KAQHPNIVTV	REIVVGSNMD	KIYIVMNYVE	HDLKSLMETM	KQPFLPGEVK
550	560	570	580	590	600
TLMIQLLRGV	KHLHDNWILH	RDLKTSNLLL	SHAGILKVGD	FGLAREYGSP	LKAYTPVVVT
610	620	630	640	650	660
LWYRAPELLL	GAKEYSTAVD	MWSVGCIFGE	LLTQKPLFPG	KSEIDQINKV	FKDLGTPSEK
670	680	690	700	710	720
IWPGYSELPA	VKKMTFSEHP	YNNLRKRFGA	LLSDQGFDLM	NKFLTYFPGR	RISAEDGLKH
730	740	750	760	770	780
EYFRETPLPI	DPSMFPTWPA	KSEQQRVKRG	TSPRPPEGGL	GYSQLGDDDL	KETGFHLTTT
790
NQGASAAGPG	FSLKF