P20447
Gene name |
DBP3 (YGL078C) |
Protein name |
ATP-dependent RNA helicase DBP3 |
Names |
DEAD box protein 3, Helicase CA3 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGL078C |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P20447
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P20447-F1 | Predicted | AlphaFoldDB |
6 variants for P20447
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-361844 | 7 | A>T | No | SGRP | |
| s07-361768 | 32 | K>R | No | SGRP | |
| s07-361707 | 52 | E>D | No | SGRP | |
| s07-361550 | 105 | S>P | No | SGRP | |
| s07-361544 | 107 | D>N | No | SGRP | |
| s07-360707 | 386 | V>I | No | SGRP |
No associated diseases with P20447
3 regional properties for P20447
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | 14-3-3 protein, conserved site | 48 - 58 | IPR023409-1 |
| conserved_site | 14-3-3 protein, conserved site | 220 - 239 | IPR023409-2 |
| domain | 14-3-3 domain | 8 - 251 | IPR023410 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| preribosome, large subunit precursor | A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent activity, acting on RNA | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12099 | FAL1 | ATP-dependent RNA helicase FAL1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q07478 | SUB2 | ATP-dependent RNA helicase SUB2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P23394 | PRP28 | Pre-mRNA-splicing ATP-dependent RNA helicase PRP28 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTKEEIADKK | RKVVDEEVIE | KKKSKKHKKD | KKDKKEKKDK | KHKKHKKEKK | GEKEVEVPEK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ESEKKPEPTS | AVASEFYVQS | EALTSLPQSD | IDEYFKENEI | AVEDSLDLAL | RPLLSFDYLS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDSSIQAEIS | KFPKPTPIQA | VAWPYLLSGK | DVVGVAETGS | GKTFAFGVPA | ISHLMNDQKK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RGIQVLVISP | TRELASQIYD | NLIVLTDKVG | MQCCCVYGGV | PKDEQRIQLK | KSQVVVATPG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLLDLLQEGS | VDLSQVNYLV | LDEADRMLEK | GFEEDIKNII | RETDASKRQT | LMFTATWPKE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VRELASTFMN | NPIKVSIGNT | DQLTANKRIT | QIVEVVDPRG | KERKLLELLK | KYHSGPKKNE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KVLIFALYKK | EAARVERNLK | YNGYNVAAIH | GDLSQQQRTQ | ALNEFKSGKS | NLLLATDVAA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RGLDIPNVKT | VINLTFPLTV | EDYVHRIGRT | GRAGQTGTAH | TLFTEQEKHL | AGGLVNVLNG |
| 490 | 500 | 510 | 520 | ||
| ANQPVPEDLI | KFGTHTKKKE | HSAYGSFFKD | VDLTKKPKKI | TFD |