AiPD: Autoinhibited Protein Database

P20339

Gene name	RAB5A (RAB5)
Protein name	Ras-related protein Rab-5A
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5868
EC number	3.6.5.2: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

163-215 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

163-215 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

15 structures for P20339

Entry ID	Method	Resolution	Chain	Position	Source
1N6H	X-ray	151 A	A	15-184	PDB
1N6I	X-ray	160 A	A	15-184	PDB
1N6K	X-ray	155 A	A	15-184	PDB
1N6L	X-ray	160 A	A	15-184	PDB
1N6N	X-ray	160 A	A	15-184	PDB
1N6O	X-ray	180 A	A	15-184	PDB
1N6P	X-ray	154 A	A	15-184	PDB
1N6R	X-ray	155 A	A	15-184	PDB
1R2Q	X-ray	105 A	A	15-184	PDB
1TU3	X-ray	231 A	A/B/C/D/E	15-184	PDB
1TU4	X-ray	220 A	A/B/C/D	15-184	PDB
3MJH	X-ray	203 A	A/C	16-183	PDB
4Q9U	X-ray	462 A	B/F	15-184	PDB
7BL1	EM	980 A	DDD	16-183	PDB
AF-P20339-F1	Predicted				AlphaFoldDB

143 variants for P20339

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA351870721 rs1575065947	2	A>G		No	ClinGen Ensembl
CA2283947 rs774566349	3	S>N		No	ClinGen ExAC gnomAD
rs200047397 CA351870756	4	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2283948 rs200047397	4	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA351870768 rs1165832157	5	G>D		No	ClinGen gnomAD
COSM2948363 rs144198452 CA2283950	6	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA2283952 rs765282057	7	T>A		No	ClinGen ExAC TOPMed gnomAD
rs765282057 CA351870796	7	T>P		No	ClinGen ExAC TOPMed gnomAD
CA351870814 rs1279277845	8	R>G		No	ClinGen TOPMed
rs1450539066 CA351870854	10	N>D		No	ClinGen gnomAD
rs1336388627 CA351870861	10	N>S		No	ClinGen TOPMed gnomAD
CA70736027 rs139006514	11	G>E		No	ClinGen 1000Genomes TOPMed gnomAD
CA351870871 rs1247949373 CA351870876	11	G>R		No	ClinGen TOPMed gnomAD
CA351870944 rs1160737451	14	T>M		No	ClinGen TOPMed
CA2283955 rs149206559	14	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs781668564 CA2283958	15	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1007656246 CA70736031	15	G>R		No	ClinGen TOPMed
rs1202465417 CA351871025	17	K>R		No	ClinGen gnomAD
CA2283960 rs147139196	19	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA351871064 rs147139196	19	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1175071032 CA351871072	19	C>Y		No	ClinGen gnomAD
CA2283961 rs778287571	20	Q>E		No	ClinGen ExAC gnomAD
CA351871129 rs1418797273	22	K>R		No	ClinGen gnomAD
TCGA novel	23	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	25	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2283967 rs772319638	37	V>A		No	ClinGen ExAC gnomAD
rs772319638 CA2283966	37	V>G		No	ClinGen ExAC gnomAD
CA351871486 rs1317673177	39	R>C		No	ClinGen TOPMed
CA351871491 rs1559484871	39	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA351871533 rs1296605076	41	V>L		No	ClinGen TOPMed gnomAD
rs775197969 CA2283969	45	F>L		No	ClinGen ExAC gnomAD
rs773130913 CA2283970	46	H>N		No	ClinGen ExAC gnomAD
CA2283971 rs762827236	50	E>D		No	ClinGen ExAC gnomAD
rs1222784580 CA351871855	51	S>N		No	ClinGen gnomAD
CA2283972 rs765895417	55	A>T		No	ClinGen ExAC gnomAD
rs372972286 CA2284006	62	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs372972286 CA2284005	62	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs749099814 CA2284007	63	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA2284008 rs770773757	65	D>A		No	ClinGen ExAC gnomAD
CA351857481 rs770773757	65	D>G		No	ClinGen ExAC gnomAD
rs1468347379 CA351857514	67	T>A		No	ClinGen gnomAD
rs745834147 CA351857576	70	K>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	74	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	75	D>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA351857693 rs1458399542	76	T>I		No	ClinGen gnomAD
rs1185033870 CA351857727	79	Q>E		No	ClinGen TOPMed
CA351857725 rs1185033870	79	Q>K		No	ClinGen TOPMed
CA351857732 rs1575076122	79	Q>P		No	ClinGen Ensembl
rs1049089 CA70738526	81	R>G		No	ClinGen ExAC TOPMed gnomAD
CA70738530 rs969117779 COSM3365145	81	R>Q	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1452938110 CA351857801	83	H>R		No	ClinGen gnomAD
CA70738532 rs371989994	87	P>L		No	ClinGen ESP TOPMed
rs760341655 CA2284013	88	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1440455566 CA351857855	91	R>K		No	ClinGen gnomAD
rs1259412635 CA351857860	92	G>R		No	ClinGen TOPMed
rs1198661606 CA351857870	93	A>G		No	ClinGen TOPMed
CA70738540 rs896085692	94	Q>R		No	ClinGen TOPMed gnomAD
CA351857879 rs549562506	95	A>P		No	ClinGen Ensembl
rs549562506 CA70738542	95	A>T		No	ClinGen Ensembl
CA351857881 rs1229696502	95	A>V		No	ClinGen TOPMed
rs762022235 CA2284016	97	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1010513577 CA70738546	99	V>L		No	ClinGen TOPMed
rs1034793274 CA70738548	101	D>N		No	ClinGen Ensembl
rs759467773	106	E>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1324344650 CA351857966	106	E>G		No	ClinGen TOPMed
CA2284039 rs752124120	106	E>Q		No	ClinGen ExAC gnomAD
rs1559491993 CA351857972	107	S>T		No	ClinGen Ensembl
CA2284041 rs373073333	109	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1184774975 CA351858009	111	A>T		No	ClinGen gnomAD
rs1344123730 CA351858023	112	K>E		No	ClinGen gnomAD
TCGA novel	113	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA351858125 rs1488785493	119	Q>E		No	ClinGen gnomAD
rs756454883 CA2284043	119	Q>R		No	ClinGen ExAC gnomAD
CA2284046 rs181298476	123	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs779797281 CA2284047	124	P>A		No	ClinGen ExAC gnomAD
rs1451771428 CA351858199	124	P>L		No	ClinGen TOPMed gnomAD
rs1451771428 CA351858201	124	P>R		No	ClinGen TOPMed gnomAD
rs1383291378 CA351858204	125	N>D		No	ClinGen TOPMed
rs140005569 CA2284048	125	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA70738655 rs375086132	125	N>S		No	ClinGen ESP gnomAD
CA2284049 rs754401679	126	I>T		No	ClinGen ExAC gnomAD
rs1458883312 CA351858219	126	I>V		No	ClinGen gnomAD
rs1575076324 CA351858253	128	I>M		No	ClinGen Ensembl
rs1382973577 CA351858263	129	A>G		No	ClinGen gnomAD
rs1321527286 CA351858289	131	S>L		No	ClinGen TOPMed gnomAD
CA351858309 rs1450671486	133	N>S		No	ClinGen gnomAD
CA70738663 rs550288787	135	A>G		No	ClinGen gnomAD
CA2284054 rs749601586	136	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs760110691 CA2284057	138	A>S		No	ClinGen ExAC gnomAD
rs760110691 CA2284058	138	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2284059 rs775680725	142	A>G		No	ClinGen ExAC gnomAD
rs1459723987 CA351858423	142	A>T		No	ClinGen gnomAD
CA2284082 rs764274481	148	A>P		No	ClinGen ExAC gnomAD
rs200242114 CA2284083	148	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201422065 CA2284084	149	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs766063435 CA2284085	151	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1341285683 CA351859243	151	Y>H		No	ClinGen TOPMed
CA351859272 rs1274095230	152	A>G		No	ClinGen gnomAD
CA351859268 rs1254575777	152	A>S		No	ClinGen gnomAD
rs1190653315 CA351859282	153	D>A		No	ClinGen TOPMed gnomAD
CA351859284 rs1190653315	153	D>G		No	ClinGen TOPMed gnomAD
rs751408634 CA2284086	153	D>H		No	ClinGen ExAC gnomAD
CA351859334 rs1435148044	155	N>S		No	ClinGen gnomAD
CA351859403 rs1369719292	160	M>K		No	ClinGen gnomAD
CA70739377 rs147085379 CA2284087	160	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA351859400 rs147085379	160	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs772699440 CA2284088	161	E>K		No	ClinGen ExAC gnomAD
CA2284091 rs777286944	164	A>T		No	ClinGen ExAC TOPMed gnomAD
rs753467909 CA2284092	167	S>*		No	ClinGen ExAC gnomAD
rs998497699 CA70739387	167	S>T		No	ClinGen Ensembl
rs575707256 CA2284093	168	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA351859532 rs1413976208	169	N>K		No	ClinGen TOPMed
CA351859556 rs1559492752	171	N>I		No	ClinGen Ensembl
CA351859607 rs1212448971	175	M>V		No	ClinGen gnomAD
TCGA novel	176	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2284094 rs779142398	177	I>V		No	ClinGen ExAC gnomAD
TCGA novel	180	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA351860488 rs1190693269	180	K>R		No	ClinGen TOPMed gnomAD
rs1472341323 CA351860502	182	P>R		No	ClinGen TOPMed gnomAD
CA2284114 rs758749672	184	N>S		No	ClinGen ExAC gnomAD
rs780583803 CA2284115	185	E>K		No	ClinGen ExAC gnomAD
CA2284116 rs747492893	186	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1157810705 CA351860552	189	P>L		No	ClinGen gnomAD
rs781415431 CA2284118	191	A>V		No	ClinGen ExAC TOPMed gnomAD
rs748204519 CA2284119	193	S>F		No	ClinGen ExAC gnomAD
CA2284120 rs769770592	194	A>T		No	ClinGen ExAC TOPMed gnomAD
rs55823411 CA70741468	195	R>G		No	ClinGen Ensembl
rs1285345308 CA351860584	195	R>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1382009772 CA351860604	198	G>E		No	ClinGen gnomAD
CA351860607 rs1227048864	199	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA351860608 rs1227048864	199	V>L		No	ClinGen gnomAD
rs150383454 CA70741471	203	E>D		No	ClinGen ESP
CA2284123 rs771833104	203	E>K		No	ClinGen ExAC TOPMed gnomAD
rs775305902 CA2284124	205	T>I		No	ClinGen ExAC gnomAD
CA2284126 rs764079310	207	P>S		No	ClinGen ExAC TOPMed gnomAD
CA351860680 rs761318666	210	N>I		No	ClinGen ExAC TOPMed gnomAD
CA2284128 rs761318666	210	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	211	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA70741493 rs764684048	211	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA351860686 rs1249748048	211	Q>P		No	ClinGen TOPMed
CA351860707 rs1265203602	214	S>G		No	ClinGen TOPMed
TCGA novel	215	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758032572 CA2284131	216	N>Q		No	ClinGen ExAC gnomAD

No associated diseases with P20339

1 regional properties for P20339

Type	Name	Position	InterPro Accession
domain	Small GTP-binding protein domain	21 - 176	IPR005225

Functions

		Description
EC Number	3.6.5.2	Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization	Cell membrane ; Lipid-anchor ; Cytoplasmic side Early endosome membrane ; Lipid-anchor Melanosome Cytoplasmic vesicle Cell projection, ruffle Membrane Cytoplasm, cytosol Cytoplasmic vesicle, phagosome membrane Endosome membrane	Enriched in stage I melanosomes (PubMed:17081065) Alternates between membrane-bound and cytosolic forms (Probable)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

29 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
anchored component of synaptic vesicle membrane	The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
axon terminus	Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
clathrin-coated endocytic vesicle membrane	The lipid bilayer surrounding a clathrin-coated endocytic vesicle.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic side of early endosome membrane	The side (leaflet) of the early endosome membrane that faces the cytoplasm.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
early endosome	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
early endosome membrane	The lipid bilayer surrounding an early endosome.
early phagosome	A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
endocytic vesicle	A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
endosome membrane	The lipid bilayer surrounding an endosome.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
melanosome	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane raft	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
phagocytic vesicle	A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
phagocytic vesicle membrane	The lipid bilayer surrounding a phagocytic vesicle.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic early endosome	An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling.
ruffle	Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
somatodendritic compartment	The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.
synaptic vesicle	A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
terminal bouton	Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.

4 GO annotations of molecular function

Name	Definition
G protein activity	A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
GDP binding	Binding to GDP, guanosine 5'-diphosphate.
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

15 GO annotations of biological process

Name	Definition
amyloid-beta clearance by transcytosis	The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier.
early endosome to late endosome transport	The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.
endocytosis	A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
modulation by host of viral process	A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected.
phagocytosis	A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
positive regulation of exocytosis	Any process that activates or increases the frequency, rate or extent of exocytosis.
receptor internalization involved in canonical Wnt signaling pathway	A receptor internalization process that contributes to canonical Wnt signaling pathway.
regulation of autophagosome assembly	Any process that modulates the frequency, rate or extent of autophagosome assembly.
regulation of endocytosis	Any process that modulates the frequency, rate or extent of endocytosis.
regulation of endosome size	Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis.
regulation of filopodium assembly	Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
regulation of long-term neuronal synaptic plasticity	A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
regulation of synaptic vesicle exocytosis	Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
synaptic vesicle recycling	The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P38146	YPT10	GTP-binding protein YPT10	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9NRW1	RAB6B	Ras-related protein Rab-6B	Homo sapiens (Human)	PR
Q5JT25	RAB41	Ras-related protein Rab-41	Homo sapiens (Human)	PR
P20340	RAB6A	Ras-related protein Rab-6A	Homo sapiens (Human)	PR
Q9NP72	RAB18	Ras-related protein Rab-18	Homo sapiens (Human)	PR
A4D1S5	RAB19	Ras-related protein Rab-19	Homo sapiens (Human)	PR
Q9ULC3	RAB23	Ras-related protein Rab-23	Homo sapiens (Human)	PR

10	20	30	40	50	60
MASRGATRPN	GPNTGNKICQ	FKLVLLGESA	VGKSSLVLRF	VKGQFHEFQE	STIGAAFLTQ
70	80	90	100	110	120
TVCLDDTTVK	FEIWDTAGQE	RYHSLAPMYY	RGAQAAIVVY	DITNEESFAR	AKNWVKELQR
130	140	150	160	170	180
QASPNIVIAL	SGNKADLANK	RAVDFQEAQS	YADDNSLLFM	ETSAKTSMNV	NEIFMAIAKK
190	200	210
LPKNEPQNPG	ANSARGRGVD	LTEPTQPTRN	QCCSN