AiPD: Autoinhibited Protein Database

P19419

Gene name	ELK1
Protein name	ETS domain-containing protein Elk-1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2002
EC number
Protein Class	ETS (PTHR11849)

Descriptions

ELK1 belongs to a subfamily of ETS domain transcription factors. Its characteristic property is the ability to form a ternary nucleoprotein complex with the serum response factor (SRF) over the serum response element (SRE) of the c-fos promoter. The R motif is a repressor domain that dampens the activity of the C-terminal activation domain through recruitment of histone deacetylase complexes.

Autoinhibitory domains (AIDs)

Target domain	351-399 (C-terminal activation domain)
Relief mechanism	PTM
Assay	Deletion assay, Mutagenesis experiment, Structural analysis

AID

148-168 (R motif)

Target domain

351-399 (C-terminal activation domain)

Relief mechanism

PTM (Phosphorylation of C-terminal domain by MAP kinase)

Assay

Deletion assay, Mutagenesis experiment, Structural analysis

Accessory elements

No accessory elements

References

Buchwalter G et al. (2004) "Ets ternary complex transcription factors", Gene, 324, 1-14

Mo Y et al. (2000) "Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA", Nature structural biology, 7, 292-7

Autoinhibited structure

Activated structure

3 structures for P19419

Entry ID	Method	Resolution	Chain	Position	Source
1DUX	X-ray	210 A	C/F	1-94	PDB
5VVT	X-ray	280 A	B/D	378-385	PDB
AF-P19419-F1	Predicted				AlphaFoldDB

186 variants for P19419

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs929560262 CA329079781	2	D>E		No	ClinGen TOPMed
rs749137065 CA10399244	3	P>S		No	ClinGen ExAC gnomAD
rs867615728 CA329079753	14	L>R		No	ClinGen Ensembl
CA412843211 rs1428854653	16	R>K		No	ClinGen gnomAD
CA10399240 rs781144254	29	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs752089855 CA10399238	35	K>E		No	ClinGen ExAC gnomAD
CA329079705 rs952223352	42	V>G		No	ClinGen Ensembl
CA412842946 rs1247971240	49	R>H		No	ClinGen gnomAD
rs1322016948 CA412842849	62	R>W		No	ClinGen gnomAD
rs1418561205 CA412842831	65	R>W		No	ClinGen Ensembl
CA10399214 rs747137558	74	R>H		No	ClinGen ExAC gnomAD
CA412842650 rs1323184353	88	Y>C		No	ClinGen TOPMed
rs752325820 CA412842625	92	A>S		No	ClinGen ExAC TOPMed gnomAD
CA10399208 rs752325820	92	A>T		No	ClinGen ExAC TOPMed gnomAD
CA412842617 rs1319243021	93	G>A		No	ClinGen gnomAD
rs1461519983 CA412842603	95	S>C		No	ClinGen gnomAD
rs767319405 CA10399207	97	E>K		No	ClinGen ExAC gnomAD
CA10399206 rs759095742	98	D>E		No	ClinGen ExAC gnomAD
CA10399205 rs368756202	100	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA10399204 rs766352376	107	V>I		No	ClinGen ExAC gnomAD
CA10399203 rs762811151	108	T>S		No	ClinGen ExAC gnomAD
CA412842503 rs1247970715	111	M>T		No	ClinGen gnomAD
CA412842505 rs1486387588	111	M>V		No	ClinGen TOPMed
CA412842496 rs773009947	112	P>S		No	ClinGen ExAC TOPMed gnomAD
rs773009947 CA10399202	112	P>T		No	ClinGen ExAC TOPMed gnomAD
CA412842455 rs1271496609	118	A>V		No	ClinGen gnomAD
CA10399201 rs769505956	121	A>T		No	ClinGen ExAC gnomAD
CA412842433 rs776692129	122	A>S		No	ClinGen ExAC TOPMed gnomAD
CA10399199 rs776692129	122	A>T		No	ClinGen ExAC TOPMed gnomAD
rs201738800 CA10399198	125	D>H		No	ClinGen ExAC TOPMed gnomAD
CA329078465 rs201738800	125	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs372037647 CA10399196	133	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA412842358 rs1455773025	134	P>H		No	ClinGen TOPMed
CA412842357 rs1455773025	134	P>L		No	ClinGen TOPMed
CA412842343 rs1321143986	136	G>V		No	ClinGen gnomAD
CA10399194 rs746386556	137	A>T		No	ClinGen ExAC TOPMed gnomAD
CA412842338 rs1396796884	137	A>V		No	ClinGen TOPMed gnomAD
rs1169952022 CA412842334	138	G>E		No	ClinGen gnomAD
CA10399192 RCV000961794 rs1997639 VAR_017108	144	G>S		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs767265910 CA10399190	147	R>C		No	ClinGen ExAC gnomAD
CA412842278 rs1251256386	147	R>H		No	ClinGen gnomAD
rs1438557541 CA412842271	148	S>N		No	ClinGen gnomAD
CA10399187 rs766008788	155	R>H		No	ClinGen ExAC TOPMed gnomAD
rs765265714 CA10399184	161	T>P		No	ClinGen ExAC gnomAD
rs761496675 CA10399183	163	T>P		No	ClinGen ExAC gnomAD
rs1335915496 CA412842006	167	L>P		No	ClinGen gnomAD
CA10399180 rs147404955	169	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA412841942 rs1437078658	171	P>L		No	ClinGen gnomAD
rs142782368 CA10399178 RCV000887319	172	P>A		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1172009340 CA412841932	172	P>L		No	ClinGen gnomAD
rs779268688 CA412841923	173	P>H		No	ClinGen ExAC TOPMed gnomAD
rs779268688 CA10399176	173	P>L		No	ClinGen ExAC TOPMed gnomAD
CA10399177 rs746000987	173	P>S		No	ClinGen ExAC TOPMed gnomAD
rs779929555 CA10399175	176	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1251434810 CA412841877	178	A>T		No	ClinGen TOPMed
CA10399174 rs749612460	180	V>M		No	ClinGen ExAC TOPMed gnomAD
CA10399173 rs375434138	181	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1349893650 CA412841829	182	P>L		No	ClinGen gnomAD
CA10399172 rs368570204	182	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1173620494 CA412841827	183	S>G		No	ClinGen TOPMed
rs1059579 CA10399171 VAR_017109	183	S>N		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA412841822 rs1059579	183	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1435171839 CA412841806	185	A>T		No	ClinGen TOPMed
rs779892081 CA412841372	188	G>E		No	ClinGen ExAC TOPMed gnomAD
CA10399170 rs779892081	188	G>V		No	ClinGen ExAC TOPMed gnomAD
rs757822037 CA10399169	191	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1349525756 CA412841352	192	P>T		No	ClinGen TOPMed gnomAD
rs1417022392 CA412841343	193	P>R		No	ClinGen TOPMed gnomAD
COSM3844805 COSM3844804 CA10399165 rs753575056	194	S>L	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA10399163 rs760849742	198	S>N		No	ClinGen ExAC
rs772387253 CA10399161	199	T>I		No	ClinGen ExAC gnomAD
rs1486570352 CA412841291	201	P>S		No	ClinGen gnomAD
rs746505555 CA10399160	203	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs774557863 CA10399159	204	L>S		No	ClinGen ExAC gnomAD
CA10399158 rs771276099	206	A>T		No	ClinGen ExAC
rs371184593 CA10399156	209	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs749835250 CA10399157	209	E>K		No	ClinGen ExAC TOPMed gnomAD
rs866250043 CA329078189	210	A>S		No	ClinGen gnomAD
CA10399155 rs777360067	212	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1165925496 CA412841217	212	E>G		No	ClinGen TOPMed gnomAD
rs1235524850 CA412841221	212	E>K		No	ClinGen gnomAD
CA10399152 rs746742977	214	G>S		No	ClinGen ExAC TOPMed gnomAD
rs141670214 CA412841181	218	Q>P		No	ClinGen ESP TOPMed gnomAD
CA329078142 rs141670214	218	Q>R		No	ClinGen ESP TOPMed gnomAD
rs1434452310 CA412841137	223	P>L		No	ClinGen gnomAD
rs774244991 CA10399140	224	P>S		No	ClinGen ExAC gnomAD
CA412841131 rs1349536506	225	E>K		No	ClinGen gnomAD
CA10399136 rs770479468	231	S>L		No	ClinGen ExAC gnomAD
rs1377606649 CA412841073	233	E>G		No	ClinGen TOPMed
rs200141730 CA10399135	238	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10399132 rs376822462	242	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA10399133 rs371259584	242	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA10399131 rs778250617	243	A>S		No	ClinGen ExAC gnomAD
CA412841014 rs778250617	243	A>T		No	ClinGen ExAC gnomAD
rs1205657053 CA412840997	245	P>L		No	ClinGen gnomAD
CA412840925 rs1569338633	256	E>Q		No	ClinGen Ensembl
rs1603090117 RCV000999411	260	A>missing		No	ClinVar dbSNP
CA412840892 rs1429361584	260	A>V		No	ClinGen TOPMed
CA10399127 rs756113016	262	E>Q		No	ClinGen ExAC gnomAD
rs1228370729 CA412840860	265	F>C		No	ClinGen gnomAD
CA412840808 rs1569338618	273	E>A		No	ClinGen Ensembl
CA412840811 rs1385167733	273	E>K		No	ClinGen gnomAD
rs1392089075 CA412840799	274	P>R		No	ClinGen TOPMed
CA10399124 rs755114172	277	P>L		No	ClinGen ExAC TOPMed gnomAD
rs751772833 CA10399123	279	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1303896473 CA412840762	280	E>A		No	ClinGen TOPMed
CA412840754 rs766556938	281	G>D		No	ClinGen ExAC TOPMed gnomAD
CA10399122 rs766556938	281	G>V		No	ClinGen ExAC TOPMed gnomAD
rs376525319 CA412840752	282	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA10399121 rs376525319	282	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA10399120 rs773489927	283	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1569338598 CA412840732	285	R>L		No	ClinGen Ensembl
rs1339450750 CA412840728	286	L>P		No	ClinGen TOPMed
CA412840717 rs373267605	288	A>G		No	ClinGen ESP TOPMed gnomAD
rs765768273 CA10399119	288	A>T		No	ClinGen ExAC gnomAD
CA329077708 rs373267605	288	A>V		No	ClinGen ESP TOPMed gnomAD
CA412840699 rs1307791776	291	M>I		No	ClinGen Ensembl
CA10399116 rs769100410	291	M>T		No	ClinGen ExAC TOPMed gnomAD
CA10399115 rs747375894	292	D>V		No	ClinGen ExAC gnomAD
rs1231153523 CA412840683	294	A>T		No	ClinGen TOPMed gnomAD
CA412840670 rs1311735097	296	Q>E		No	ClinGen gnomAD
CA412840666 rs1307949414	296	Q>R		No	ClinGen gnomAD
CA412840659 rs774035251	297	A>G		No	ClinGen ExAC TOPMed gnomAD
rs774035251 CA10399114	297	A>V		No	ClinGen ExAC TOPMed gnomAD
rs777459618 CA329077644	299	G>A		No	ClinGen 1000Genomes
rs1305900488 CA412840651	299	G>S		No	ClinGen TOPMed gnomAD
CA412840617 rs1168578918	304	S>N		No	ClinGen TOPMed
CA10399113 rs770629454	304	S>R		No	ClinGen ExAC gnomAD
CA412840602 rs1391158248	306	E>A		No	ClinGen gnomAD
rs1375988578 CA412840606	306	E>Q		No	ClinGen gnomAD
CA412840575 rs1569338557	310	P>L		No	ClinGen Ensembl
CA10399112 rs748793978	311	Q>H		No	ClinGen ExAC gnomAD
rs1462531059 CA412840550	314	R>W		No	ClinGen TOPMed
rs1159237568 CA412840531	317	R>W		No	ClinGen gnomAD
rs199829517 CA10399110	322	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs763316945 CA10399109	324	S>C		No	ClinGen ExAC TOPMed gnomAD
CA10399107 rs754780539	325	P>L		No	ClinGen ExAC gnomAD
CA412840459 rs1482948626	329	G>S		No	ClinGen gnomAD
rs1327259369 CA412840443	331	P>L		No	ClinGen gnomAD
rs766616373 CA10399105	331	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1243372607 CA412840437	332	G>V		No	ClinGen TOPMed
rs1227543183 CA412840429	334	E>Q		No	ClinGen gnomAD
rs758694016 CA10399104	335	R>G		No	ClinGen ExAC gnomAD
COSM1205190 COSM1205191 CA412840422 rs758694016	335	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA412840414 rs1263180389	336	T>S		No	ClinGen TOPMed
rs1394178773 CA412840405	338	G>R		No	ClinGen gnomAD
CA412840387 rs1288887383	341	S>G		No	ClinGen TOPMed gnomAD
CA10399103 rs747885568	342	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA412840374 rs1464708658	343	S>P		No	ClinGen TOPMed
CA10399102 rs765426882	343	S>Y		No	ClinGen ExAC
CA10399100 rs777167555	344	G>A		No	ClinGen ExAC TOPMed gnomAD
rs952906295 CA412840369	344	G>C		No	ClinGen TOPMed gnomAD
rs952906295 CA329077576	344	G>S		No	ClinGen TOPMed gnomAD
rs1185904662 CA412840360	346	Q>K		No	ClinGen gnomAD
rs778401778 CA10399098	346	Q>P		No	ClinGen 1000Genomes ExAC
rs1027014686 CA329077558	347	A>P		No	ClinGen TOPMed
rs775785466 CA10399097	347	A>V		No	ClinGen ExAC gnomAD
CA10399095 rs762609294	348	P>L		No	ClinGen ExAC TOPMed gnomAD
CA10399096 rs770504652	348	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1267720408 CA412840343	349	G>W		No	ClinGen gnomAD
rs772662025 CA10399094	350	P>L		No	ClinGen ExAC gnomAD
CA412840337 rs1214598916	350	P>S		No	ClinGen gnomAD
CA412840334 rs1242365905	351	A>T		No	ClinGen gnomAD
rs1339738858 CA412840329	351	A>V		No	ClinGen gnomAD
rs1451309958 CA412840289	358	P>L		No	ClinGen TOPMed
CA10399089 rs746747467	359	T>A		No	ClinGen ExAC gnomAD
CA412840270 rs1461600649	361	T>I		No	ClinGen gnomAD
CA10399073 rs776005990	364	P>L		No	ClinGen ExAC gnomAD
CA412840148 rs1603089263	379	W>G		No	ClinGen Ensembl
CA10399071 rs202001852	386	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA10399068 rs745709371	388	R>C		No	ClinGen ExAC gnomAD
CA329077224 rs763209954	388	R>L		No	ClinGen 1000Genomes gnomAD
CA412840019 rs1310179982	396	Q>R		No	ClinGen gnomAD
CA412839969 rs1281894739	402	S>G		No	ClinGen TOPMed
rs770813034 COSM3406397 CA412839967 COSM3406396	402	S>N	central_nervous_system [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA10399054 rs770813034	402	S>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775548786 CA10399052	403	A>T		No	ClinGen ExAC gnomAD
rs1236583483 CA412839918	409	S>C		No	ClinGen TOPMed
CA412839916 rs1473919771	410	I>V		No	ClinGen TOPMed
rs201735887 CA10399047	412	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1406928207 CA412839874	416	S>L		No	ClinGen gnomAD
CA412839862 rs1473705330	418	P>L		No	ClinGen gnomAD
CA10399045 rs777870023	419	V>M		No	ClinGen ExAC gnomAD
rs1269600558 CA412839836	423	P>T		No	ClinGen gnomAD
CA10399044 rs756124582	425	P>T		No	ClinGen ExAC TOPMed gnomAD
CA412839819 rs1290974281	426	Q>K		No	ClinGen gnomAD

No associated diseases with P19419

3 regional properties for P19419

Type	Name	Position	InterPro Accession
domain	Pleckstrin homology domain	535 - 663	IPR001849
domain	ELMO domain	292 - 479	IPR006816
domain	ELMO, armadillo-like helical domain	116 - 268	IPR024574

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family	PTHR11849	ETS
PANTHER Subfamily	PTHR11849:SF178	ETS DOMAIN-CONTAINING PROTEIN ELK-1
PANTHER Protein Class	DNA-binding transcription factor helix-turn-helix transcription factor winged helix/forkhead transcription factor
PANTHER Pathway Category	Interleukin signaling pathway ELK Gonadotropin-releasing hormone receptor pathway ELK1 p38 MAPK pathway ELK PDGF signaling pathway ELK Ras Pathway Elk-1 Oxidative stress response Elk-1 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade ELK CCKR signaling map ELK1 Angiotensin II-stimulated signaling through G proteins and beta-arrestin ELK1 Toll receptor signaling pathway Elk1 Parkinson disease Elk-1

7 GO annotations of cellular component

Name	Definition
axon terminus	Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

9 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
nuclear receptor coactivator activity	A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II-specific DNA-binding transcription factor binding	Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

12 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cellular response to gamma radiation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
cellular response to testosterone stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
gene expression	The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes.
liver development	The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
lung development	The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
positive regulation of neuron death	Any process that activates or increases the frequency, rate or extent of neuron death.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of transcription, DNA-templated	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to fibroblast growth factor	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus.
response to light stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.

40 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A1A4L6	ETS2	Protein C-ets-2	Bos taurus (Bovine)	SS
Q2KIC2	ETV1	ETS translocation variant 1	Bos taurus (Bovine)	SS
P15062	ETS1	Transforming protein p68/c-ets-1	Gallus gallus (Chicken)	SS
P10157	ETS2	Protein C-ets-2	Gallus gallus (Chicken)	SS
Q90837	ERG	Transcriptional regulator Erg	Gallus gallus (Chicken)	SS
A2T762	ETV3	ETS translocation variant 3	Pan troglodytes (Chimpanzee)	PR
Q04688	Ets97D	DNA-binding protein Ets97D	Drosophila melanogaster (Fruit fly)	PR
Q9Y603	ETV7	Transcription factor ETV7	Homo sapiens (Human)	SS
P41212	ETV6	Transcription factor ETV6	Homo sapiens (Human)	SS
P78545	ELF3	ETS-related transcription factor Elf-3	Homo sapiens (Human)	SS
Q9UKW6	ELF5	ETS-related transcription factor Elf-5	Homo sapiens (Human)	EV
P32519	ELF1	ETS-related transcription factor Elf-1	Homo sapiens (Human)	PR
Q99607	ELF4	ETS-related transcription factor Elf-4	Homo sapiens (Human)	PR
Q06546	GABPA	GA-binding protein alpha chain	Homo sapiens (Human)	SS
O95238	SPDEF	SAM pointed domain-containing Ets transcription factor	Homo sapiens (Human)	PR
P50548	ERF	ETS domain-containing transcription factor ERF	Homo sapiens (Human)	PR
P41162	ETV3	ETS translocation variant 3	Homo sapiens (Human)	PR
P11308	ERG	Transcriptional regulator ERG	Homo sapiens (Human)	EV
P43268	ETV4	ETS translocation variant 4	Homo sapiens (Human)	EV
P41161	ETV5	ETS translocation variant 5	Homo sapiens (Human)	SS
P50549	ETV1	ETS translocation variant 1	Homo sapiens (Human)	EV
P41970	ELK3	ETS domain-containing protein Elk-3	Homo sapiens (Human)	SS
P28324	ELK4	ETS domain-containing protein Elk-4	Homo sapiens (Human)	EV
P15036	ETS2	Protein C-ets-2	Homo sapiens (Human)	EV
P14921	ETS1	Protein C-ets-1	Homo sapiens (Human)	EV
Q00422	Gabpa	GA-binding protein alpha chain	Mus musculus (Mouse)	EV
P28322	Etv4	ETS translocation variant 4	Mus musculus (Mouse)	SS
P15037	Ets2	Protein C-ets-2	Mus musculus (Mouse)	SS
P27577	Ets1	Protein C-ets-1	Mus musculus (Mouse)	EV
P70459	Erf	ETS domain-containing transcription factor ERF	Mus musculus (Mouse)	PR
Q9CXC9	Etv5	ETS translocation variant 5	Mus musculus (Mouse)	SS
P41164	Etv1	ETS translocation variant 1	Mus musculus (Mouse)	SS
P81270	Erg	Transcriptional regulator ERG	Mus musculus (Mouse)	SS
P41158	Elk4	ETS domain-containing protein Elk-4	Mus musculus (Mouse)	PR
P41971	Elk3	ETS domain-containing protein Elk-3	Mus musculus (Mouse)	EV
P41969	Elk1	ETS domain-containing protein Elk-1	Mus musculus (Mouse)	PR
P41156	Ets1	Protein C-ets-1	Rattus norvegicus (Rat)	SS
A4GTP4	Elk1	ETS domain-containing protein Elk-1	Rattus norvegicus (Rat)	PR
Q9PUQ1	etv4	ETS translocation variant 4	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
A3FEM2	fev	Protein FEV	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MDPSVTLWQF	LLQLLREQGN	GHIISWTSRD	GGEFKLVDAE	EVARLWGLRK	NKTNMNYDKL
70	80	90	100	110	120
SRALRYYYDK	NIIRKVSGQK	FVYKFVSYPE	VAGCSTEDCP	PQPEVSVTST	MPNVAPAAIH
130	140	150	160	170	180
AAPGDTVSGK	PGTPKGAGMA	GPGGLARSSR	NEYMRSGLYS	TFTIQSLQPQ	PPPHPRPAVV
190	200	210	220	230	240
LPSAAPAGAA	APPSGSRSTS	PSPLEACLEA	EEAGLPLQVI	LTPPEAPNLK	SEELNVEPGL
250	260	270	280	290	300
GRALPPEVKV	EGPKEELEVA	GERGFVPETT	KAEPEVPPQE	GVPARLPAVV	MDTAGQAGGH
310	320	330	340	350	360
AASSPEISQP	QKGRKPRDLE	LPLSPSLLGG	PGPERTPGSG	SGSGLQAPGP	ALTPSLLPTH
370	380	390	400	410	420
TLTPVLLTPS	SLPPSIHFWS	TLSPIAPRSP	AKLSFQFPSS	GSAQVHIPSI	SVDGLSTPVV

LSPGPQKP