AiPD: Autoinhibited Protein Database

P19086

Gene name	GNAZ
Protein name	Guanine nucleotide-binding protein G
Names	z subunit alpha , G, x alpha chain , Gz-alpha
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2781
EC number
Protein Class

Descriptions

Gαi1 is a G-protein alpha subunit that plays a crucial role in signal transduction pathway initiated by G-protein-coupled receptor (GPCR) activation. G proteins function as transducers downstream of GPCRs in numerous signaling cascades. The alpha subunit contains the guanine nucleotide binding site and alternates between an active (GTP-bound state) and an inactive (GDP-bound state). Activated GPCR induces conformational change in Gαi1, which allows for GDP-to-GTP exchange by binding to the GPCR-binding site within a Ras-like domain, leading to dissociation of the Gαi1 subunit and initiation of downstream signaling.

Autoinhibitory domains (AIDs)

62-178 (α-H domain) SS

Target domain	185-349 (Ras-like domain)
Relief mechanism	Ligand binding, Partner binding
Assay

AID

62-178 (α-H domain)

Target domain

185-349 (Ras-like domain)

Relief mechanism

Ligand binding (GTP binding), Partner binding(Binding of activated GPCR)

Assay

Accessory elements

No accessory elements

References

Goricanec D et al. (2016) "Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding", Proceedings of the National Academy of Sciences of the United States of America, 113, E3629-38

Coleman DE et al. (1999) "Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex", The Journal of biological chemistry, 274, 16669-72

Lutz S et al. (2007) "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs", Science (New York, N.Y.), 318, 1923-7

Autoinhibited structure

Activated structure

2 structures for P19086

Entry ID	Method	Resolution	Chain	Position	Source
8DZS	EM	265 A	B	30-355	PDB
AF-P19086-F1	Predicted				AlphaFoldDB

264 variants for P19086

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs773947794	4	R>Q		No	ExAC TOPMed gnomAD
COSM3552500 rs189374840	4	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	5	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM3309365 rs2069104142	9	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
COSM4102956	10	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs772805782	11	E>A		No	ExAC TOPMed gnomAD
rs866852399	13	A>D		No	Ensembl
rs760505008	14	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs753636007	15	R>Q		No	ExAC TOPMed gnomAD
COSM726191 rs766030793	15	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs898310493	17	R>Q		No	TOPMed
rs1188639934	17	R>W		No	gnomAD
rs879182489	20	D>A		No	Ensembl
rs995461477	20	D>N		No	Ensembl
TCGA novel	20	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1028260962	21	R>C		No	gnomAD
rs200927041	21	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs1462919254	24	R>C		No	TOPMed gnomAD
rs781475556	24	R>H		No	ExAC TOPMed gnomAD
rs1329272614	29	R>Q		No	gnomAD
rs1432707029	31	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs756359282	32	R>C		No	ExAC TOPMed gnomAD
rs1339551949	32	R>H		No	TOPMed gnomAD
COSM3842272 rs974996242	33	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs2069106385	35	K>M		No	gnomAD
COSM4102957	35	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	37	L>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1190591240	41	T>A		No	TOPMed
rs267606186	43	N>S		No	Ensembl
COSM1032555	45	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1565995 rs2069107342	50	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs2069107578	53	M>I		No	gnomAD
rs1218480736	53	M>V		No	gnomAD
rs2069107690	57	H>P		No	Ensembl
rs1243088869	58	S>G		No	gnomAD
COSM1415126	58	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM726190	59	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1569172679	59	G>S		No	TOPMed
COSM1032556	60	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs771539649	60	G>S		No	ExAC TOPMed gnomAD
rs1162115413	62	N>K		No	gnomAD
rs2146315927	64	E>G		No	Ensembl
rs17853741	65	A>S		No	gnomAD
rs17853741	65	A>T		No	gnomAD
rs2069108356	70	K>T		No	TOPMed
rs1318832362	72	L>I		No	gnomAD
rs2069109116	74	I>M		No	Ensembl
rs1359718743	74	I>V		No	gnomAD
rs988956804	75	Y>H		No	TOPMed gnomAD
rs1276612366	76	N>D		No	gnomAD
rs147402483	78	I>L		No	ESP ExAC TOPMed gnomAD
rs147402483	78	I>V		No	ESP ExAC TOPMed gnomAD
rs1354293183	79	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
COSM142289 rs1331938640	80	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
rs761943894	82	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs761943894	82	T>N		No	ExAC gnomAD
rs1601792664	82	T>P		No	Ensembl
rs1485802752	83	R>C		No	TOPMed gnomAD
rs1485802752	83	R>G		No	TOPMed gnomAD
rs556083506	86	R>P		No	1000Genomes
rs556083506	86	R>Q		No	1000Genomes
COSM4102959 rs1366225244	86	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1379606183	89	A>T		No	gnomAD
rs780469417	90	A>S		No	ExAC TOPMed gnomAD
rs780469417	90	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2146316286	93	I>S		No	Ensembl
rs574541604	94	D>N		No	1000Genomes ExAC TOPMed gnomAD
rs938228823	95	F>L		No	TOPMed gnomAD
rs1333699803	96	H>Y		No	TOPMed gnomAD
rs748545161	97	N>D		No	ExAC TOPMed gnomAD
rs1601792822	97	N>T		No	Ensembl
rs2146316392	99	D>A		No	Ensembl
rs1310716515	99	D>E		No	gnomAD
rs1458257062	99	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs777109231	100	R>C		No	ExAC TOPMed gnomAD
rs746553162	100	R>H		No	ExAC TOPMed gnomAD
rs746553162 COSM726189	100	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1346089765	101	A>T		No	gnomAD
rs2069112311	102	Y>C		No	TOPMed
rs1253604242 COSM1032557	103	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs143839657	104	A>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs143839657	104	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs199547495	104	A>V		No	1000Genomes TOPMed gnomAD
rs2069113107	107	L>I		No	Ensembl
rs1172258202	110	L>R		No	gnomAD
rs1400331956	111	T>M		No	TOPMed gnomAD
rs1332143513	112	G>A		No	gnomAD
rs1332143513	112	G>D		No	gnomAD
COSM3912462 rs1376170210	113	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1315151887	114	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs755263774	116	S>N		No	ExAC gnomAD
rs1008145135	119	E>K		No	gnomAD
rs758676841	122	P>R		No	Ensembl
rs1231691438	122	P>S		No	TOPMed
rs1019323839	123	E>K		No	gnomAD
rs1199757798	126	G>C		No	TOPMed gnomAD
rs1199757798	126	G>S		No	TOPMed gnomAD
rs2069115288	128	M>L		No	TOPMed
rs2069115419	129	R>Q		No	TOPMed
rs745469780	130	R>Q		No	ExAC gnomAD
rs1432454071	130	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs796810282	131	L>I		No	gnomAD
rs1467385561	133	A>T		No	gnomAD
COSM4102960	133	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs17852409	135	P>Q		No	TOPMed
rs1399705899	136	G>W		No	gnomAD
COSM4102961	137	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs775094245	139	A>S		No	ExAC gnomAD
rs775094245	139	A>T		No	ExAC gnomAD
rs951767417 COSM1307997	143	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1299646054	144	S>F		No	gnomAD
rs1601793263	145	S>G		No	TOPMed
rs1601793263	145	S>R		No	TOPMed
rs1328521572	145	S>R		No	TOPMed gnomAD
TCGA novel	146	E>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2069116391	146	E>K		No	Ensembl
rs1601793283	147	Y>D		No	Ensembl
rs1218883952	148	H>P		No	gnomAD
rs1010010129	149	L>V		No	TOPMed gnomAD
rs148874764	151	D>N		No	Ensembl
rs1237639616	153	A>T		No	TOPMed
rs200414454	153	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs1488125051	155	Y>H		No	gnomAD
rs1207921295	158	N>D		No	gnomAD
rs766508619	158	N>K		No	ExAC TOPMed gnomAD
rs1412507158	159	D>E		No	TOPMed gnomAD
rs377139627	159	D>N		No	ESP ExAC TOPMed gnomAD
rs377139627	159	D>Y		No	ESP ExAC TOPMed gnomAD
TCGA novel	162	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2069117466	162	R>H		No	TOPMed
rs918141111	163	I>V		No	TOPMed gnomAD
COSM4102962 rs765527032	164	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1601793391	165	A>T		No	TOPMed gnomAD
COSM3693965	165	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1158510415	166	A>T		No	TOPMed gnomAD
rs2069117947	166	A>V		No	TOPMed
rs1475853215	167	D>G		No	TOPMed gnomAD
rs1569173107	167	D>N		No	TOPMed
rs1895286336	168	Y>C		No	TOPMed
rs2069118392	171	T>S		No	TOPMed
rs2069118493	172	V>I		No	TOPMed gnomAD
rs1457866450	173	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1485440291	175	I>M		No	TOPMed gnomAD
rs2069119077 COSM4102963	175	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs2069118957	175	I>V		No	TOPMed
rs2069119286	177	R>C		No	Ensembl
rs369848697	177	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs369848697	177	R>L		No	ESP ExAC TOPMed gnomAD
COSM3552505	178	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1297276620	180	D>E		No	gnomAD
rs866909344	181	M>V		No	Ensembl
rs1234684162	183	T>M		No	gnomAD
rs1242546685	185	I>V		No	gnomAD
rs1262387602	188	N>K		No	TOPMed gnomAD
rs1227709638	189	K>R		No	TOPMed gnomAD
rs1215609247	191	T>I		No	gnomAD
rs755736229	196	T>I		No	ExAC gnomAD
rs2069121219	198	K>N		No	Ensembl
rs2069121283	200	V>G		No	TOPMed
COSM1208403	201	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1294568586	201	D>N		No	TOPMed
rs749025428	202	V>M		No	ExAC gnomAD
rs1423293042	203	G>A		No	TOPMed gnomAD
rs1423293042	203	G>E		No	TOPMed gnomAD
COSM1415127 rs752075537	205	Q>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
TCGA novel	205	Q>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM3309388	205	Q>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2069122359	207	S>L		No	gnomAD
rs2069122601	209	R>C		No	TOPMed
COSM4102964	209	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1158434104	215	C>Y		No	gnomAD
rs1303018992	217	E>K		No	gnomAD
rs1303018992	217	E>Q		No	gnomAD
rs775837880	219	V>I		No	ExAC TOPMed gnomAD
COSM1032558	221	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1032559	221	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4102965	223	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	224	F>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1309128778	224	F>Y		No	gnomAD
rs2069123967	225	C>F		No	TOPMed
rs2069124183	226	V>M		No	TOPMed
rs768056901	230	G>C		No	ExAC TOPMed gnomAD
rs768056901	230	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs144435757	231	Y>*		No	1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	232	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs199896240	233	L>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1569173304	234	K>Q		No	gnomAD
rs2069125430	240	Q>H		No	gnomAD
rs777845926	243	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
COSM5742060 rs1365180134	249	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
COSM4687426 rs1221941233	249	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
COSM4102966	254	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2146403657	256	N>Y		No	Ensembl
rs1257765665	261	I>V		No	TOPMed gnomAD
rs374781793	265	L>F		No	ESP TOPMed gnomAD
rs1289265847	267	L>F		No	TOPMed
rs1222896224	270	N>K		No	gnomAD
rs1411935722	271	K>R		No	TOPMed gnomAD
rs2070079356	272	K>T		No	Ensembl
rs2070079449	273	D>Y		No	Ensembl
rs749371797	274	L>P		No	ExAC gnomAD
rs2070079698	277	E>D		No	Ensembl
COSM1751755	277	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1401045732	278	K>E		No	gnomAD
rs768904384	280	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs774616807	280	R>H		No	ExAC TOPMed gnomAD
rs772358501	281	R>C		No	ExAC gnomAD
rs773581427	281	R>H		No	ExAC TOPMed gnomAD
rs761195937	282	I>V		No	ExAC gnomAD
rs2070080304	283	P>A		No	TOPMed
rs759015647	286	I>V		No	ExAC gnomAD
rs2070080689	289	P>S		No	gnomAD
rs758126196	290	E>D		No	ExAC TOPMed gnomAD
rs148799264	290	E>K		No	ESP ExAC TOPMed gnomAD
rs148799264	290	E>Q		No	ESP ExAC TOPMed gnomAD
rs763921035	292	K>Q		No	ExAC gnomAD
rs372407179	292	K>R		No	ESP ExAC TOPMed gnomAD
TCGA novel	292	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1268518787	294	Q>H		No	gnomAD
rs940428715	296	T>A		No	Ensembl
rs1214420728	296	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
COSM4102967	297	Y>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs749377481	298	E>K		No	ExAC TOPMed gnomAD
rs995670740	299	E>K		No	Ensembl
rs2146404015	300	A>G		No	Ensembl
rs545366122	301	A>T		No	ExAC TOPMed gnomAD
rs773587124	302	V>I		No	ExAC TOPMed
rs773587124	302	V>L		No	ExAC TOPMed
rs2070082580	303	Y>N		No	gnomAD
rs368759895	306	R>Q		No	ESP ExAC TOPMed gnomAD
rs1267826319	306	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs200744011	307	Q>H		No	ExAC TOPMed gnomAD
rs1601842735	308	F>V		No	Ensembl
rs111937053	309	E>*		No	Ensembl
rs777062312	309	E>G		No	ExAC gnomAD
rs111937053	309	E>Q		No	Ensembl
COSM4102968	310	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2070083422	311	L>M		No	Ensembl
rs764771187	312	N>S		No	ExAC gnomAD
rs775149885 COSM5859007	313	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs762641601 COSM4102969	313	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1268875615	314	N>H		No	Ensembl
rs1399649296	316	E>A		No	gnomAD
rs1399649296	316	E>V		No	gnomAD
rs2070084557	318	K>N		No	Ensembl
rs1230402052	318	K>Q		No	TOPMed
rs2070084468	318	K>T		No	Ensembl
rs1601842799 COSM3552506	319	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs1342383509	320	I>F		No	gnomAD
rs1601842820	321	Y>S		No	Ensembl
rs757062183	322	S>C		No	ExAC gnomAD
rs1601842837	325	T>P		No	Ensembl
rs1287229592	327	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs569868909	329	D>N		No	1000Genomes ExAC TOPMed gnomAD
rs2070085996	331	S>G		No	TOPMed
rs2070086269	337	F>I		No	TOPMed
rs777904768	338	D>N		No	ExAC TOPMed gnomAD
rs1379507136 COSM6038529	339	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs2146404480	339	A>V		No	1000Genomes
rs776278844	343	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
TCGA novel	344	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	345	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1569188293	346	Q>L		No	Ensembl
rs2070087332	348	N>H		No	TOPMed

No associated diseases with P19086

No regional properties for P19086

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P19086

Functions

		Description
EC Number
Subcellular Localization	Membrane; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cell body	The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
heterotrimeric G-protein complex	Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

7 GO annotations of molecular function

Name	Definition
adenylate cyclase inhibitor activity	Binds to and decreases the activity adenylate cyclase.
G protein-coupled receptor binding	Binding to a G protein-coupled receptor.
G protein-coupled serotonin receptor binding	Binding to a metabotropic serotonin receptor.
G-protein beta/gamma-subunit complex binding	Binding to a complex of G-protein beta/gamma subunits.
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction
metal ion binding	Binding to a metal ion.

5 GO annotations of biological process

Name	Definition
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).
G protein-coupled receptor signaling pathway	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
G protein-coupled serotonin receptor signaling pathway	The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands.
negative regulation of insulin secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.

61 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P63097	GNAI1	Guanine nucleotide-binding protein G	Bos taurus (Bovine)	SS
P0C7Q4	GNAT3	Guanine nucleotide-binding protein G	Bos taurus (Bovine)	SS
P04696	GNAT2	Guanine nucleotide-binding protein G	Bos taurus (Bovine)	SS
P04695	GNAT1	Guanine nucleotide-binding protein G	Bos taurus (Bovine)	SS
P08239	GNAO1	Guanine nucleotide-binding protein G	Bos taurus (Bovine)	SS
P50147	GNAI2	Guanine nucleotide-binding protein G	Gallus gallus (Chicken)	SS
P50146	GNAI1	Guanine nucleotide-binding protein G	Gallus gallus (Chicken)	SS
P20353	Galphai	G protein alpha i subunit	Drosophila melanogaster (Fruit fly)	SS
P16378	Galphao	G protein alpha o subunit	Drosophila melanogaster (Fruit fly)	SS
P25157	cta	Guanine nucleotide-binding protein subunit alpha homolog	Drosophila melanogaster (Fruit fly)	SS
A8MTJ3	GNAT3	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P08754	GNAI3	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P11488	GNAT1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P19087	GNAT2	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P29992	GNA11	Guanine nucleotide-binding protein subunit alpha-11	Homo sapiens (Human)	SS
P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	Homo sapiens (Human)	SS
P50148	GNAQ	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
O95837	GNA14	Guanine nucleotide-binding protein subunit alpha-14	Homo sapiens (Human)	SS
Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	Homo sapiens (Human)	SS
Q03113	GNA12	Guanine nucleotide-binding protein subunit alpha-12	Homo sapiens (Human)	SS
P38405	GNAL	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P04899	GNAI2	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P63096	GNAI1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	EV
P09471	GNAO1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
Q9DC51	Gnai3	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
P27600	Gna12	Guanine nucleotide-binding protein subunit alpha-12	Mus musculus (Mouse)	SS
P20612	Gnat1	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
P27601	Gna13	Guanine nucleotide-binding protein subunit alpha-13	Mus musculus (Mouse)	SS
Q3V3I2	Gnat3	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
P50149	Gnat2	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
P08752	Gnai2	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
B2RSH2	Gnai1	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
P18872	Gnao1	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
O70443	Gnaz	Guanine nucleotide-binding protein G	Mus musculus (Mouse)	SS
P93564	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Solanum tuberosum (Potato)	SS
Q63210	Gna12	Guanine nucleotide-binding protein subunit alpha-12	Rattus norvegicus (Rat)	SS
P29348	Gnat3	Guanine nucleotide-binding protein G	Rattus norvegicus (Rat)	SS
P04897	Gnai2	Guanine nucleotide-binding protein G	Rattus norvegicus (Rat)	SS
P59215	Gnao1	Guanine nucleotide-binding protein G	Rattus norvegicus (Rat)	SS
P08753	Gnai3	Guanine nucleotide-binding protein G	Rattus norvegicus (Rat)	SS
Q6Q7Y5	Gna13	Guanine nucleotide-binding protein subunit alpha-13	Rattus norvegicus (Rat)	SS
P19627	Gnaz	Guanine nucleotide-binding protein G	Rattus norvegicus (Rat)	SS
Q0DJ33	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Oryza sativa subsp. japonica (Rice)	SS
P51875	goa-1	Guanine nucleotide-binding protein G	Caenorhabditis elegans	SS
Q18434	odr-3	Guanine nucleotide-binding protein alpha-17 subunit	Caenorhabditis elegans	SS
Q9BIG4	gpa-10	Guanine nucleotide-binding protein alpha-10 subunit	Caenorhabditis elegans	PR
P28052	gpa-3	Guanine nucleotide-binding protein alpha-3 subunit	Caenorhabditis elegans	SS
Q9XTB2	gpa-13	Guanine nucleotide-binding protein alpha-13 subunit	Caenorhabditis elegans	SS
Q9BIG5	gpa-4	Guanine nucleotide-binding protein alpha-4 subunit	Caenorhabditis elegans	SS
P28051	gpa-1	Guanine nucleotide-binding protein alpha-1 subunit	Caenorhabditis elegans	SS
Q9N2V6	gpa-16	Guanine nucleotide-binding protein alpha-16 subunit	Caenorhabditis elegans	SS
P91907	gpa-15	Guanine nucleotide-binding protein alpha-15 subunit	Caenorhabditis elegans	SS
Q20907	gpa-8	Guanine nucleotide-binding protein alpha-8 subunit	Caenorhabditis elegans	PR
Q21917	gpa-7	Guanine nucleotide-binding protein alpha-7 subunit	Caenorhabditis elegans	SS
Q93743	gpa-6	Guanine nucleotide-binding protein alpha-6 subunit	Caenorhabditis elegans	SS
O76584	gpa-11	Guanine nucleotide-binding protein alpha-11 subunit	Caenorhabditis elegans	SS
P49084	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Glycine max (Soybean) (Glycine hispida)	SS
P93163	GPA2	Guanine nucleotide-binding protein alpha-2 subunit	Glycine max (Soybean) (Glycine hispida)	SS
O80462	XLG1	Extra-large guanine nucleotide-binding protein 1	Arabidopsis thaliana (Mouse-ear cress)	PR
P18064	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Arabidopsis thaliana (Mouse-ear cress)	SS
P26981	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	SS

10	20	30	40	50	60
MGCRQSSEEK	EAARRSRRID	RHLRSESQRQ	RREIKLLLLG	TSNSGKSTIV	KQMKIIHSGG
70	80	90	100	110	120
FNLEACKEYK	PLIIYNAIDS	LTRIIRALAA	LRIDFHNPDR	AYDAVQLFAL	TGPAESKGEI
130	140	150	160	170	180
TPELLGVMRR	LWADPGAQAC	FSRSSEYHLE	DNAAYYLNDL	ERIAAADYIP	TVEDILRSRD
190	200	210	220	230	240
MTTGIVENKF	TFKELTFKMV	DVGGQRSERK	KWIHCFEGVT	AIIFCVELSG	YDLKLYEDNQ
250	260	270	280	290	300
TSRMAESLRL	FDSICNNNWF	INTSLILFLN	KKDLLAEKIR	RIPLTICFPE	YKGQNTYEEA
310	320	330	340	350
AVYIQRQFED	LNRNKETKEI	YSHFTCATDT	SNIQFVFDAV	TDVIIQNNLK	YIGLC