P18053

SS
Gene name
Prosalpha3 (PROS-29, Pros29, CG9327)
Protein name
Proteasome subunit alpha type-4
Names
PROS-Dm29 , Proteasome 29 kDa subunit
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG9327
EC number
Protein Class

Descriptions

PRE9, proteasome subunit α type-3, is a subunit of the proteasome. The core particle (CP) is a cylindrical particle composed of four stacked rings of subunits, with each ring containing seven distinct subunits. The outer rings are composed of seven α subunits, the inner rings of seven β subunits, which contain the active sites. The N-terminal segments of the α3 subunit seals the central channel, which prevents substrate entry by imposing topological closure on the CP. Inhibition by the α3 subunit tail is relieved upon binding of the regulatory particle to the CP to form the proteasome holoenzyme.

Autoinhibitory domains (AIDs)

1-9 (N-terminal tail of the α3 subunit) SS

Target domain

29-219 (Central channel of proteasome)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P18053

Entry ID Method Resolution Chain Position Source
AF-P18053-F1 Predicted AlphaFoldDB

No variants for P18053

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P18053

No associated diseases with P18053

6 regional properties for P18053

Type Name Position InterPro Accession
domain Zinc finger C2H2-type 63 - 90 IPR013087-1
domain Zinc finger C2H2-type 91 - 118 IPR013087-2
domain Zinc finger C2H2-type 119 - 146 IPR013087-3
domain Zinc finger C2H2-type 147 - 174 IPR013087-4
domain Zinc finger C2H2-type 177 - 204 IPR013087-5
domain Zinc finger C2H2-type 213 - 245 IPR013087-6

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex.
proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P23638 PRE9 Proteasome subunit alpha type-3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
Q3ZCK9 PSMA4 Proteasome subunit alpha type-4 Bos taurus (Bovine) SS
Q9VA12 Prosalpha3T Proteasome subunit alpha type-4-like Drosophila melanogaster (Fruit fly) SS
P25789 PSMA4 Proteasome subunit alpha type-4 Homo sapiens (Human) SS
Q9R1P0 Psma4 Proteasome subunit alpha type-4 Mus musculus (Mouse) SS
P21670 Psma4 Proteasome subunit alpha type-4 Rattus norvegicus (Rat) SS
P0DKK3 PAC1A Proteasome subunit alpha type-4-1 Oryza sativa subsp. japonica (Rice) SS
Q5VRG3 Os06g0167600 Proteasome subunit alpha type-4-2 Oryza sativa subsp. japonica (Rice) SS
Q9N599 pas-3 Proteasome subunit alpha type-4 Caenorhabditis elegans SS
F4JJE5 PAC2 Putative proteasome subunit alpha type-4-B Arabidopsis thaliana (Mouse-ear cress) SS
O81148 PAC1 Proteasome subunit alpha type-4-A Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MARRYDSRTT IFSPEGRLYQ VEYAMEAISH AGTCLGILAE DGILLAAECR STNKLLDSAI
70 80 90 100 110 120
PSEKIYRLND NMVCSVAGIT SDANVLTSEL RLIAQRYQFS YGEVIPCEQL VSHLCDIKQA
130 140 150 160 170 180
YTQYGGKRPF GVSLLYMGWD NKYGYQLYQS DPSGNYGGWK ATCIGNNFGA AISMLKQELA
190 200 210 220 230 240
DKENVKLTLA DAKDLAIKVL SMTLDTTKLT PEKVEMATLQ RVDNKTVYSV LEKPDVEKLI
250 260
EKYTKVQAEA EAAKKEKQAK QPTK