P18031

PR
Gene name
PTPN1 (PTP1B)
Protein name
Tyrosine-protein phosphatase non-receptor type 1
Names
Protein-tyrosine phosphatase 1B, PTP-1B
Species
Homo sapiens (Human)
KEGG Pathway
hsa:5770
EC number
3.1.3.48: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

429 structures for P18031

Entry ID Method Resolution Chain Position Source
1A5Y X-ray 250 A A 1-330 PDB
1AAX X-ray 190 A A 1-321 PDB
1BZC X-ray 235 A A 1-321 PDB
1BZH X-ray 210 A A 1-298 PDB
1BZJ X-ray 225 A A 2-298 PDB
1C83 X-ray 180 A A 1-298 PDB
1C84 X-ray 235 A A 1-298 PDB
1C85 X-ray 272 A A 1-298 PDB
1C86 X-ray 230 A A 1-298 PDB
1C87 X-ray 210 A A 1-298 PDB
1C88 X-ray 180 A A 1-298 PDB
1ECV X-ray 195 A A 1-298 PDB
1EEN X-ray 190 A A 1-321 PDB
1EEO X-ray 180 A A 1-321 PDB
1G1F X-ray 200 A A 1-298 PDB
1G1G X-ray 220 A A 1-298 PDB
1G1H X-ray 240 A A 1-298 PDB
1G7F X-ray 180 A A 1-298 PDB
1G7G X-ray 220 A A 1-298 PDB
1GFY X-ray 213 A A 1-298 PDB
1I57 X-ray 210 A A 1-298 PDB
1JF7 X-ray 220 A A/B 1-298 PDB
1KAK X-ray 250 A A 1-298 PDB
1KAV X-ray 235 A A 1-298 PDB
1L8G X-ray 250 A A 1-321 PDB
1LQF X-ray 250 A A/B/C/D 1-283 PDB
1NL9 X-ray 240 A A 1-321 PDB
1NNY X-ray 240 A A 1-321 PDB
1NO6 X-ray 240 A A 1-321 PDB
1NWE X-ray 310 A A 1-298 PDB
1NWL X-ray 240 A A 1-298 PDB
1NZ7 X-ray 240 A A 1-321 PDB
1OEM X-ray 180 A X 1-321 PDB
1OEO X-ray 215 A X 1-321 PDB
1OES X-ray 220 A A 1-321 PDB
1OET X-ray 230 A A 1-321 PDB
1OEU X-ray 250 A A 1-321 PDB
1OEV X-ray 220 A A 1-321 PDB
1ONY X-ray 215 A A 1-321 PDB
1ONZ X-ray 240 A A 1-321 PDB
1PA1 X-ray 160 A A 1-298 PDB
1PH0 X-ray 220 A A 1-321 PDB
1PTT X-ray 290 A A 1-321 PDB
1PTU X-ray 260 A A 1-321 PDB
1PTV X-ray 230 A A 1-321 PDB
1PTY X-ray 185 A A 1-321 PDB
1PXH X-ray 215 A A 1-321 PDB
1PYN X-ray 220 A A 1-321 PDB
1Q1M X-ray 260 A A 1-321 PDB
1Q6J X-ray 220 A A 1-298 PDB
1Q6M X-ray 220 A A 1-298 PDB
1Q6N X-ray 210 A A/B 1-298 PDB
1Q6P X-ray 230 A A/B 1-298 PDB
1Q6S X-ray 220 A A/B 1-298 PDB
1Q6T X-ray 230 A A/B 1-298 PDB
1QXK X-ray 230 A A 1-321 PDB
1SUG X-ray 195 A A 1-321 PDB
1T48 X-ray 220 A A 1-298 PDB
1T49 X-ray 190 A A 1-298 PDB
1T4J X-ray 270 A A 1-298 PDB
1WAX X-ray 220 A A 1-321 PDB
1XBO X-ray 250 A A 1-321 PDB
2AZR X-ray 200 A A 1-299 PDB
2B07 X-ray 210 A A 1-299 PDB
2B4S X-ray 230 A A/C 1-298 PDB
2BGD X-ray 240 A A 1-321 PDB
2BGE X-ray 180 A A 1-321 PDB
2CM2 X-ray 150 A A 2-298 PDB
2CM3 X-ray 210 A A/B 1-298 PDB
2CM7 X-ray 210 A A 1-321 PDB
2CM8 X-ray 210 A A 1-321 PDB
2CMA X-ray 230 A A 1-321 PDB
2CMB X-ray 170 A A 1-298 PDB
2CMC X-ray 220 A A 1-298 PDB
2CNE X-ray 180 A A 1-298 PDB
2CNF X-ray 220 A A 1-321 PDB
2CNG X-ray 190 A A 1-321 PDB
2CNH X-ray 180 A A 1-321 PDB
2CNI X-ray 200 A A 1-321 PDB
2F6F X-ray 200 A A 1-298 PDB
2F6T X-ray 170 A A 1-298 PDB
2F6V X-ray 170 A A 1-298 PDB
2F6W X-ray 220 A A 1-298 PDB
2F6Y X-ray 215 A A 1-298 PDB
2F6Z X-ray 170 A A 1-298 PDB
2F70 X-ray 212 A A 1-298 PDB
2F71 X-ray 155 A A 1-298 PDB
2FJM X-ray 210 A A/B 1-298 PDB
2FJN X-ray 220 A A/B 1-298 PDB
2H4G X-ray 250 A A 1-299 PDB
2H4K X-ray 230 A A 1-299 PDB
2HB1 X-ray 200 A A 1-299 PDB
2HNP X-ray 285 A A 1-321 PDB
2HNQ X-ray 285 A A 1-321 PDB
2NT7 X-ray 210 A A 1-299 PDB
2NTA X-ray 210 A A 1-299 PDB
2QBP X-ray 250 A A 1-299 PDB
2QBQ X-ray 210 A A 1-299 PDB
2QBR X-ray 230 A A 1-299 PDB
2QBS X-ray 210 A A 1-299 PDB
2VEU X-ray 240 A A 1-321 PDB
2VEV X-ray 180 A A 1-321 PDB
2VEW X-ray 200 A A 1-321 PDB
2VEX X-ray 220 A A 1-321 PDB
2VEY X-ray 220 A A 1-321 PDB
2ZMM X-ray 210 A A 1-299 PDB
2ZN7 X-ray 210 A A 1-299 PDB
3A5J X-ray 170 A A 2-321 PDB
3A5K X-ray 185 A A 2-298 PDB
3CWE X-ray 160 A A 1-283 PDB
3D9C X-ray 230 A A 1-321 PDB
3EAX X-ray 190 A A 1-321 PDB
3EB1 X-ray 240 A A 1-321 PDB
3EU0 X-ray 270 A A 1-282 PDB
3I7Z X-ray 230 A A 1-321 PDB
3I80 X-ray 225 A A 1-321 PDB
3QKP X-ray 205 A A 1-321 PDB
3QKQ X-ray 220 A A 1-321 PDB
3SME X-ray 170 A A 1-298 PDB
3ZMP X-ray 262 A A/B 1-321 PDB
3ZMQ X-ray 330 A A 1-321 PDB
3ZV2 X-ray 280 A A 1-320 PDB
4BJO X-ray 206 A A/B 2-321 PDB
4I8N X-ray 250 A A 1-320 PDB
4QAH X-ray 240 A A 1-299 PDB
4QAP X-ray 190 A A 1-299 PDB
4QBE X-ray 229 A A 1-298 PDB
4QBW X-ray 191 A A 1-299 PDB
4Y14 X-ray 190 A A/B 2-301 PDB
4ZRT X-ray 174 A A 1-298 PDB
5K9V X-ray 190 A A 1-301 PDB
5K9W X-ray 201 A A 1-301 PDB
5KA0 X-ray 199 A A 1-284 PDB
5KA1 X-ray 184 A A 1-284 PDB
5KA2 X-ray 207 A A 1-301 PDB
5KA3 X-ray 214 A A 1-301 PDB
5KA4 X-ray 219 A A 1-301 PDB
5KA7 X-ray 206 A A 1-301 PDB
5KA8 X-ray 197 A A 1-301 PDB
5KA9 X-ray 207 A A 1-301 PDB
5KAA X-ray 197 A A 1-284 PDB
5KAB X-ray 197 A A 1-284 PDB
5KAC X-ray 190 A A 1-301 PDB
5KAD X-ray 190 A A/B 1-301 PDB
5QDE X-ray 176 A A 1-321 PDB
5QDF X-ray 171 A A 1-321 PDB
5QDG X-ray 179 A A 1-321 PDB
5QDH X-ray 168 A A 1-321 PDB
5QDI X-ray 162 A A 1-321 PDB
5QDJ X-ray 176 A A 1-321 PDB
5QDK X-ray 155 A A 1-321 PDB
5QDL X-ray 183 A A 1-321 PDB
5QDM X-ray 265 A A 1-321 PDB
5QDN X-ray 182 A A 1-321 PDB
5QDO X-ray 179 A A 1-321 PDB
5QDP X-ray 174 A A 1-321 PDB
5QDQ X-ray 157 A A 1-321 PDB
5QDR X-ray 178 A A 1-321 PDB
5QDS X-ray 175 A A 1-321 PDB
5QDT X-ray 182 A A 1-321 PDB
5QDU X-ray 167 A A 1-321 PDB
5QDV X-ray 177 A A 1-321 PDB
5QDW X-ray 221 A A 1-321 PDB
5QDX X-ray 206 A A 1-321 PDB
5QDY X-ray 183 A A 1-321 PDB
5QDZ X-ray 214 A A 1-321 PDB
5QE0 X-ray 198 A A 1-321 PDB
5QE1 X-ray 169 A A 1-321 PDB
5QE2 X-ray 179 A A 1-321 PDB
5QE3 X-ray 174 A A 1-321 PDB
5QE4 X-ray 185 A A 1-321 PDB
5QE5 X-ray 177 A A 1-321 PDB
5QE6 X-ray 177 A A 1-321 PDB
5QE7 X-ray 171 A A 1-321 PDB
5QE8 X-ray 181 A A 1-321 PDB
5QE9 X-ray 169 A A 1-321 PDB
5QEA X-ray 174 A A 1-321 PDB
5QEB X-ray 173 A A 1-321 PDB
5QEC X-ray 167 A A 1-321 PDB
5QED X-ray 175 A A 1-321 PDB
5QEE X-ray 193 A A 1-321 PDB
5QEF X-ray 160 A A 1-321 PDB
5QEG X-ray 197 A A 1-321 PDB
5QEH X-ray 194 A A 1-321 PDB
5QEI X-ray 174 A A 1-321 PDB
5QEJ X-ray 192 A A 1-321 PDB
5QEK X-ray 190 A A 1-321 PDB
5QEL X-ray 165 A A 1-321 PDB
5QEM X-ray 175 A A 1-321 PDB
5QEN X-ray 177 A A 1-321 PDB
5QEO X-ray 172 A A 1-321 PDB
5QEP X-ray 177 A A 1-321 PDB
5QEQ X-ray 197 A A 1-321 PDB
5QER X-ray 173 A A 1-321 PDB
5QES X-ray 175 A A 1-321 PDB
5QET X-ray 172 A A 1-321 PDB
5QEU X-ray 174 A A 1-321 PDB
5QEV X-ray 172 A A 1-321 PDB
5QEW X-ray 183 A A 1-321 PDB
5QEX X-ray 167 A A 1-321 PDB
5QEY X-ray 177 A A 1-321 PDB
5QEZ X-ray 165 A A 1-321 PDB
5QF0 X-ray 171 A A 1-321 PDB
5QF1 X-ray 184 A A 1-321 PDB
5QF2 X-ray 177 A A 1-321 PDB
5QF3 X-ray 156 A A 1-321 PDB
5QF4 X-ray 183 A A 1-321 PDB
5QF5 X-ray 173 A A 1-321 PDB
5QF6 X-ray 176 A A 1-321 PDB
5QF7 X-ray 175 A A 1-321 PDB
5QF8 X-ray 199 A A 1-321 PDB
5QF9 X-ray 194 A A 1-321 PDB
5QFA X-ray 174 A A 1-321 PDB
5QFB X-ray 185 A A 1-321 PDB
5QFC X-ray 184 A A 1-321 PDB
5QFD X-ray 169 A A 1-321 PDB
5QFE X-ray 156 A A 1-321 PDB
5QFF X-ray 170 A A 1-321 PDB
5QFG X-ray 165 A A 1-321 PDB
5QFH X-ray 159 A A 1-321 PDB
5QFI X-ray 168 A A 1-321 PDB
5QFJ X-ray 195 A A 1-321 PDB
5QFK X-ray 159 A A 1-321 PDB
5QFL X-ray 182 A A 1-321 PDB
5QFM X-ray 183 A A 1-321 PDB
5QFN X-ray 168 A A 1-321 PDB
5QFO X-ray 185 A A 1-321 PDB
5QFP X-ray 177 A A 1-321 PDB
5QFQ X-ray 162 A A 1-321 PDB
5QFR X-ray 162 A A 1-321 PDB
5QFS X-ray 185 A A 1-321 PDB
5QFT X-ray 196 A A 1-321 PDB
5QFU X-ray 161 A A 1-321 PDB
5QFV X-ray 164 A A 1-321 PDB
5QFW X-ray 166 A A 1-321 PDB
5QFX X-ray 182 A A 1-321 PDB
5QFY X-ray 177 A A 1-321 PDB
5QFZ X-ray 172 A A 1-321 PDB
5QG0 X-ray 175 A A 1-321 PDB
5QG1 X-ray 221 A A 1-321 PDB
5QG2 X-ray 212 A A 1-321 PDB
5QG3 X-ray 165 A A 1-321 PDB
5QG4 X-ray 179 A A 1-321 PDB
5QG5 X-ray 207 A A 1-321 PDB
5QG6 X-ray 173 A A 1-321 PDB
5QG7 X-ray 181 A A 1-321 PDB
5QG8 X-ray 163 A A 1-321 PDB
5QG9 X-ray 167 A A 1-321 PDB
5QGA X-ray 165 A A 1-321 PDB
5QGB X-ray 155 A A 1-321 PDB
5QGC X-ray 159 A A 1-321 PDB
5QGD X-ray 166 A A 1-321 PDB
5QGE X-ray 170 A A 1-321 PDB
5QGF X-ray 151 A A 1-321 PDB
5T19 X-ray 210 A A 1-321 PDB
6B8E X-ray 182 A A 1-321 PDB
6B8T X-ray 185 A A 1-321 PDB
6B8X X-ray 174 A A 1-321 PDB
6B8Z X-ray 180 A A 1-321 PDB
6B90 X-ray 195 A A 1-321 PDB
6B95 X-ray 195 A A 1-321 PDB
6BAI X-ray 195 A A 1-321 PDB
6CWU X-ray 208 A A 1-321 PDB
6CWV X-ray 198 A A 1-321 PDB
6NTP X-ray 189 A A 1-298 PDB
6OL4 X-ray 215 A A 2-297 PDB
6OLQ X-ray 210 A A 2-298 PDB
6OLV X-ray 210 A A 2-297 PDB
6OMY X-ray 210 A A 2-298 PDB
6PFW X-ray 234 A A 2-298 PDB
6PG0 X-ray 210 A A 2-298 PDB
6PGT X-ray 220 A A 2-299 PDB
6PHA X-ray 230 A A 2-298 PDB
6PHS X-ray 213 A A 2-298 PDB
6PM8 X-ray 206 A A 2-298 PDB
6W30 X-ray 210 A A 1-321 PDB
6XE8 X-ray 195 A A 1-321 PDB
6XEA X-ray 155 A A 1-321 PDB
6XED X-ray 179 A A 1-321 PDB
6XEE X-ray 250 A A 1-321 PDB
6XEF X-ray 205 A A 1-321 PDB
6XEG X-ray 255 A A 1-321 PDB
7FQM X-ray 194 A A 1-321 PDB
7FQN X-ray 204 A A 1-321 PDB
7FQO X-ray 193 A A 1-321 PDB
7FQP X-ray 188 A A 1-321 PDB
7FQQ X-ray 188 A A 1-321 PDB
7FQR X-ray 190 A A 1-321 PDB
7FQS X-ray 212 A A 1-321 PDB
7FQT X-ray 254 A A 1-321 PDB
7FQU X-ray 186 A A 1-321 PDB
7FQV X-ray 204 A A 1-321 PDB
7FQW X-ray 217 A A 1-321 PDB
7FQX X-ray 246 A A 1-321 PDB
7FQY X-ray 213 A A 1-321 PDB
7FQZ X-ray 209 A A 1-321 PDB
7FRE X-ray 185 A A 1-321 PDB
7FRF X-ray 215 A A 1-321 PDB
7FRG X-ray 184 A A 1-321 PDB
7FRH X-ray 184 A A 1-321 PDB
7FRI X-ray 186 A A 1-321 PDB
7FRJ X-ray 180 A A 1-321 PDB
7FRK X-ray 180 A A 1-321 PDB
7FRL X-ray 179 A A 1-321 PDB
7FRM X-ray 191 A A 1-321 PDB
7FRN X-ray 185 A A 1-321 PDB
7FRO X-ray 193 A A 1-321 PDB
7FRP X-ray 177 A A 1-321 PDB
7FRQ X-ray 201 A A 1-321 PDB
7FRR X-ray 183 A A 1-321 PDB
7FRS X-ray 183 A A 1-321 PDB
7FRT X-ray 186 A A 1-321 PDB
7FRU X-ray 198 A A 1-321 PDB
7GS7 X-ray 166 A A 1-321 PDB
7GS8 X-ray 167 A A 1-321 PDB
7GS9 X-ray 196 A A 1-321 PDB
7GSA X-ray 172 A A 1-321 PDB
7GSB X-ray 172 A A 1-321 PDB
7GSC X-ray 169 A A 1-321 PDB
7GSD X-ray 180 A A 1-321 PDB
7GSE X-ray 189 A A 1-321 PDB
7GSF X-ray 178 A A 1-321 PDB
7GSG X-ray 190 A A 1-321 PDB
7GSH X-ray 188 A A 1-321 PDB
7GSI X-ray 171 A A 1-321 PDB
7GSJ X-ray 177 A A 1-321 PDB
7GSK X-ray 184 A A 1-321 PDB
7GSL X-ray 177 A A 1-321 PDB
7GSM X-ray 203 A A 1-321 PDB
7GSN X-ray 187 A A 1-321 PDB
7GSO X-ray 172 A A 1-321 PDB
7GSQ X-ray 173 A A 1-321 PDB
7GSR X-ray 169 A A 1-321 PDB
7GST X-ray 164 A A 1-321 PDB
7GSU X-ray 165 A A 1-321 PDB
7GSV X-ray 192 A A 1-321 PDB
7GSW X-ray 179 A A 1-321 PDB
7GSX X-ray 167 A A 1-321 PDB
7GSY X-ray 197 A A 1-321 PDB
7GSZ X-ray 191 A A 1-321 PDB
7GT0 X-ray 176 A A 1-321 PDB
7GT1 X-ray 191 A A 1-321 PDB
7GT2 X-ray 190 A A 1-321 PDB
7GT3 X-ray 159 A A 1-321 PDB
7GT4 X-ray 175 A A 1-321 PDB
7GT5 X-ray 161 A A 1-321 PDB
7GT6 X-ray 166 A A 1-321 PDB
7GT7 X-ray 184 A A 1-321 PDB
7GT8 X-ray 191 A A 1-321 PDB
7GT9 X-ray 190 A A 1-321 PDB
7GTA X-ray 206 A A 1-321 PDB
7GTB X-ray 186 A A 1-321 PDB
7GTC X-ray 192 A A 1-321 PDB
7GTD X-ray 191 A A 1-321 PDB
7GTE X-ray 190 A A 1-321 PDB
7GTF X-ray 197 A A 1-321 PDB
7GTG X-ray 169 A A 1-321 PDB
7GTH X-ray 166 A A 1-321 PDB
7GTI X-ray 166 A A 1-321 PDB
7GTJ X-ray 183 A A 1-321 PDB
7GTK X-ray 176 A A 1-321 PDB
7GTL X-ray 183 A A 1-321 PDB
7GTM X-ray 172 A A 1-321 PDB
7GTN X-ray 166 A A 1-321 PDB
7GTO X-ray 165 A A 1-321 PDB
7GTP X-ray 247 A A 1-321 PDB
7GTQ X-ray 209 A A 1-321 PDB
7GTR X-ray 178 A A 1-321 PDB
7GTS X-ray 180 A A 1-321 PDB
7GTT X-ray 193 A A 1-321 PDB
7GTU X-ray 208 A A 1-321 PDB
7GTV X-ray 172 A A 1-321 PDB
7GTW X-ray 151 A A 1-321 PDB
7GTX X-ray 151 A A 1-321 PDB
7GTY X-ray 154 A A 1-321 PDB
7GTZ X-ray 160 A A 1-321 PDB
7GU0 X-ray 166 A A 1-321 PDB
7GU1 X-ray 159 A A 1-321 PDB
7GU2 X-ray 180 A A 1-321 PDB
7GU3 X-ray 174 A A 1-321 PDB
7GU4 X-ray 159 A A 1-321 PDB
7GU5 X-ray 152 A A 1-321 PDB
7GU6 X-ray 156 A A 1-321 PDB
7GU7 X-ray 170 A A 1-321 PDB
7GU8 X-ray 159 A A 1-321 PDB
7GU9 X-ray 153 A A 1-321 PDB
7GUA X-ray 163 A A 1-321 PDB
7GUB X-ray 194 A A 1-321 PDB
7GUC X-ray 178 A A 1-321 PDB
7KEN X-ray 180 A A 2-323 PDB
7KEY X-ray 177 A A 2-283 PDB
7KLX X-ray 184 A A 2-283 PDB
7L0C X-ray 180 A A 1-321 PDB
7L0H X-ray 210 A A 1-321 PDB
7LFO X-ray 194 A A 1-321 PDB
7MKZ X-ray 140 A A 1-301 PDB
7MM1 X-ray 185 A A 1-321 PDB
7MN7 X-ray 195 A A 1-301 PDB
7MN9 X-ray 124 A A 1-284 PDB
7MNA X-ray 147 A A 1-284 PDB
7MNB X-ray 220 A A 1-301 PDB
7MNC X-ray 185 A A 1-301 PDB
7MND X-ray 229 A A 1-301 PDB
7MNE X-ray 160 A A 1-301 PDB
7MNF X-ray 170 A A 1-301 PDB
7MOU X-ray 148 A A 1-284 PDB
7MOV X-ray 165 A A/B 1-301 PDB
7MOW X-ray 180 A A 1-301 PDB
7RIN X-ray 185 A A 1-321 PDB
7S4F X-ray 165 A A 1-298 PDB
8DU7 X-ray 240 A A 1-284 PDB
8EXI X-ray 160 A A 1-297 PDB
8EXJ X-ray 230 A A 1-299 PDB
8EXK X-ray 210 A A 3-299 PDB
8EXM X-ray 235 A A 1-299 PDB
8EXN X-ray 215 A A 1-299 PDB
8EYA X-ray 210 A A/B 1-301 PDB
8EYB X-ray 235 A A/B 2-297 PDB
8EYC X-ray 299 A A 1-299 PDB
8F88 X-ray 310 A A/B/C 1-321 PDB
8G65 X-ray 145 A A/B 1-298 PDB
8G67 X-ray 153 A A/B 1-298 PDB
8G68 X-ray 182 A A/B 1-298 PDB
8G69 X-ray 153 A A/B 1-298 PDB
8G6A X-ray 162 A A/B 1-298 PDB
8SKL X-ray 155 A A 1-321 PDB
8U1E X-ray 143 A A/B 1-321 PDB
8XOY X-ray 155 A A 1-321 PDB
AF-P18031-F1 Predicted AlphaFoldDB

237 variants for P18031

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1407157199
CA408968464
 2 E>V No ClinGen
TOPMed
rs755655338
CA315210982
 5 K>N No ClinGen
Ensembl
CA315210983
rs148137197
 6 E>V No ClinGen
ESP
TOPMed
gnomAD
rs1489441940
CA408968635
 7 F>L No ClinGen
gnomAD
CA408968695
rs1258528842
 9 Q>R No ClinGen
TOPMed
CA408968731
rs1246414151
 10 I>N No ClinGen
gnomAD
CA408968745
rs1487620720
 11 D>Y No ClinGen
gnomAD
CA315210984
rs925151133
 12 K>R No ClinGen
Ensembl
CA9906383
rs748228918
 13 S>Y No ClinGen
ExAC
gnomAD
rs1401777841
CA408968885
 15 S>N No ClinGen
Ensembl
CA9906385
rs777863121
 15 S>R No ClinGen
ExAC
gnomAD
CA408968957
rs1381957080
 18 A>V No ClinGen
gnomAD
CA9906386
rs150635098
 19 I>V No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA408962618
rs1443524226
 24 R>* Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
rs545064112
CA9906397
 25 H>R No ClinGen
1000Genomes
ExAC
gnomAD
rs751952672
CA9906398
 26 E>D No ClinGen
ExAC
gnomAD
CA315194068
rs201758338
 28 S>N No ClinGen
1000Genomes
TOPMed
rs201758338
CA408962645
 28 S>T No ClinGen
1000Genomes
TOPMed
rs755602646
CA9906399
 29 D>V No ClinGen
ExAC
gnomAD
rs759320660
CA315194085
 43 R>* No ClinGen
Ensembl
TCGA novel 43 R>Q Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 44 N>K Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA315194090
rs767518093
 46 Y>* No ClinGen
Ensembl
CA9906401
rs753192131
 47 R>K No ClinGen
ExAC
gnomAD
CA9906403
rs777861433
 49 V>I No ClinGen
ExAC
gnomAD
CA408962796
rs1473624032
 50 S>C No ClinGen
gnomAD
rs1267779326
CA408962797
 50 S>N No ClinGen
TOPMed
TCGA novel 51 P>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs753938375
CA9906424
 54 H>P No ClinGen
ExAC
gnomAD
CA315196010
rs753938375
 54 H>R No ClinGen
ExAC
gnomAD
rs779200250
CA9906426
 57 I>T No ClinGen
ExAC
gnomAD
CA315196035
rs746039629
 63 D>V No ClinGen
Ensembl
TCGA novel 69 A>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 69 A>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 70 S>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA9906428
rs754785542
 76 E>D No ClinGen
ExAC
TOPMed
gnomAD
rs992322197
CA315196047
 76 E>K No ClinGen
TOPMed
rs780939045
CA9906429
 78 Q>R No ClinGen
ExAC
TOPMed
gnomAD
CA408963029
rs1273120831
 80 S>R No ClinGen
TOPMed
gnomAD
CA408963062
rs1285079073
 85 Q>R No ClinGen
gnomAD
TCGA novel 88 L>M Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1217160644
CA408963103
 89 P>L No ClinGen
TOPMed
gnomAD
rs189361363
CA9906450
 92 C>R No ClinGen
1000Genomes
ExAC
gnomAD
rs770497491
CA9906452
 93 G>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
CA9906453
rs770497491
 93 G>S No ClinGen
ExAC
gnomAD
rs1330974189
CA408963175
 99 V>A No ClinGen
TOPMed
CA408963215
rs1177454007
 104 S>I No ClinGen
gnomAD
rs775223257
CA9906456
 108 V>I No ClinGen
ExAC
gnomAD
CA408963265
rs1364690180
 112 R>G No ClinGen
gnomAD
CA9906457
rs375554144
 114 M>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs768861855
CA9906458
 115 E>Q No ClinGen
ExAC
gnomAD
CA9906459
rs777216811
 116 K>R No ClinGen
ExAC
gnomAD
CA408963312
rs1173031559
 118 S>L No ClinGen
TOPMed
CA9906473
rs779882276
 122 A>T No ClinGen
ExAC
gnomAD
CA408963393
rs1430775714
 128 K>E No ClinGen
TOPMed
CA408963436
rs1414699318
 133 M>T No ClinGen
gnomAD
TCGA novel 134 I>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA408963486
rs1601413769
 140 L>M No ClinGen
Ensembl
CA408963494
rs1209225422
 141 K>E No ClinGen
gnomAD
CA9906478
rs762446257
 149 I>S No ClinGen
ExAC
TOPMed
gnomAD
rs762446257
CA9906477
 149 I>T No ClinGen
ExAC
TOPMed
gnomAD
CA408963551
rs1475678011
 149 I>V No ClinGen
gnomAD
rs1314516315
CA408963634
 161 E>G No ClinGen
gnomAD
rs1392325234
CA408963654
 164 T>A No ClinGen
Ensembl
rs1272267070
CA408963656
 164 T>I No ClinGen
TOPMed
CA9906505
rs149080433
 165 T>I No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA408964167
rs1349231783
 166 Q>K No ClinGen
TOPMed
gnomAD
rs529107431
CA315204335
 166 Q>P No ClinGen
Ensembl
rs762225731
CA408964175
 167 E>A No ClinGen
gnomAD
CA408964177
rs1568797402
 167 E>D No ClinGen
Ensembl
rs762225731
CA315204342
 167 E>G No ClinGen
gnomAD
rs761728507
CA9906506
 168 T>I No ClinGen
ExAC
gnomAD
rs765072009
CA9906507
 169 R>Q No ClinGen
ExAC
gnomAD
CA9906508
rs750431969
 171 I>M No ClinGen
ExAC
TOPMed
gnomAD
rs1195564673
CA408964259
 179 W>* No ClinGen
gnomAD
CA9906511
rs372483862
 180 P>S No ClinGen
ESP
ExAC
gnomAD
TCGA novel 184 V>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA9906512
rs754452008
 186 E>K No ClinGen
ExAC
gnomAD
TCGA novel 187 S>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1568797471
CA408964324
 189 A>G No ClinGen
Ensembl
TCGA novel 195 L>P Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs756494977
CA9906515
 196 F>S No ClinGen
ExAC
gnomAD
CA9906516
rs370578341
 199 R>* No ClinGen
ESP
ExAC
gnomAD
CA315204417
rs1000153249
 202 G>R No ClinGen
TOPMed
rs1191599473
CA408964419
 204 L>F No ClinGen
TOPMed
rs1372426323
CA408964426
 205 S>G No ClinGen
gnomAD
rs771341376
CA9906518
 206 P>L No ClinGen
ExAC
gnomAD
CA408964450
rs1453864113
 208 H>R No ClinGen
TOPMed
rs1224554949
CA408964454
 209 G>R No ClinGen
gnomAD
CA315204445
rs1006731785
 211 V>I Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
TCGA novel 220 G>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 221 R>K Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA9906524
rs760953373
 222 S>A No ClinGen
ExAC
gnomAD
CA408964542
rs1234412248
 222 S>C No ClinGen
gnomAD
rs1601415665
CA408964550
 224 T>P No ClinGen
Ensembl
rs1181068233
CA408964567
 226 C>Y No ClinGen
gnomAD
CA408964593
rs1601415670
 230 T>P No ClinGen
Ensembl
CA9906526
rs199565200
 230 T>S No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA408964615
rs763041976
 233 L>F No ClinGen
ExAC
TOPMed
gnomAD
CA9906556
rs572308077
 236 D>G No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1207659580
CA408964642
 236 D>N No ClinGen
TOPMed
rs1311537624
CA408964650
 237 K>E No ClinGen
gnomAD
CA9906559
rs747098306
 240 D>N No ClinGen
ExAC
gnomAD
TCGA novel 241 P>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs768787011
CA9906560
 242 S>F No ClinGen
ExAC
gnomAD
rs1242137245
CA408964699
 244 V>A No ClinGen
TOPMed
gnomAD
CA9906563
rs371730106
 244 V>I Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs774164787
CA9906564
 247 K>R No ClinGen
ExAC
gnomAD
CA408964746
rs1437045880
 251 L>S No ClinGen
gnomAD
CA9906565
rs759459286
 254 R>S No ClinGen
ExAC
gnomAD
TCGA novel 256 F>missing Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA408964792
rs1384590527
 257 R>Q Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
rs1452015420
CA408964789
 257 R>W Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
TCGA novel 261 I>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA408964840
rs763558512
 265 D>H No ClinGen
ExAC
TOPMed
gnomAD
rs763558512
CA9906569
 265 D>N Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
CA408964862
rs1437231621
 268 R>C No ClinGen
gnomAD
rs889277600
CA315204993
 275 I>L No ClinGen
TOPMed
gnomAD
CA408964915
rs1467589776
 276 E>G No ClinGen
gnomAD
rs1250785943
CA408964913
 276 E>K No ClinGen
TOPMed
rs1176307007
CA408964929
 278 A>V No ClinGen
TOPMed
CA9906574
rs146919360
 279 K>R No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA9906576
rs752071908
CA408964953
 282 M>L No ClinGen
ExAC
gnomAD
rs967086398
CA315205023
 284 D>Y No ClinGen
TOPMed
rs1363544131
CA408964979
 285 S>F No ClinGen
gnomAD
TCGA novel 286 S>F Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs748360940
CA9906581
CA9906580
 287 V>L No ClinGen
ExAC
TOPMed
gnomAD
rs748360940
CA9906579
 287 V>M No ClinGen
ExAC
TOPMed
gnomAD
rs1297475988
CA408965009
 289 D>N No ClinGen
TOPMed
gnomAD
rs752809061
CA9906598
 290 Q>H No ClinGen
ExAC
TOPMed
gnomAD
CA408965026
rs1435238590
 291 W>G No ClinGen
TOPMed
rs1328987907
CA408965070
 297 E>K No ClinGen
TOPMed
CA408965081
rs1601416296
 298 D>A No ClinGen
Ensembl
CA9906600
rs778065017
 299 L>M No ClinGen
ExAC
gnomAD
rs1410854108
CA408965088
 299 L>P No ClinGen
TOPMed
CA408965098
rs1231034866
 301 P>T No ClinGen
TOPMed
gnomAD
CA315205434
rs749433251
 302 P>L No ClinGen
ExAC
TOPMed
gnomAD
rs749433251
CA408965107
 302 P>Q No ClinGen
ExAC
TOPMed
gnomAD
CA9906601
rs749433251
 302 P>R No ClinGen
ExAC
TOPMed
gnomAD
rs116696243
CA9906603
 304 E>K No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA408965125
rs1251310006
 305 H>R No ClinGen
gnomAD
CA408965123
rs1226045495
 305 H>Y No ClinGen
gnomAD
rs1601416324
CA408965133
 306 I>T No ClinGen
Ensembl
rs1479925061
CA408965141
 307 P>L No ClinGen
gnomAD
CA408965144
rs1182862210
 308 P>S No ClinGen
TOPMed
CA408965153
rs1239562012
 309 P>L No ClinGen
gnomAD
rs747013111
CA9906605
 310 P>R No ClinGen
ExAC
gnomAD
rs963999479
CA315205478
 311 R>Q No ClinGen
gnomAD
CA9906606
rs369115465
 311 R>W No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1420127286
CA408965172
 313 P>L No ClinGen
gnomAD
rs776371372
CA9906607
 313 P>S No ClinGen
ExAC
gnomAD
CA408965174
rs1424527605
 314 K>E No ClinGen
gnomAD
rs747697304
CA9906608
 314 K>R No ClinGen
ExAC
gnomAD
CA9906609
rs769146045
 315 R>Q No ClinGen
ExAC
gnomAD
rs372989529
CA9906610
 316 I>F No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA408965211
rs1568798391
 320 H>Y No ClinGen
Ensembl
CA408965219
rs1325608761
 321 N>Y No ClinGen
TOPMed
rs1374557375
CA408965235
 323 K>R No ClinGen
gnomAD
TCGA novel 324 C>F Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs762671904
CA9906611
 324 C>R No ClinGen
ExAC
gnomAD
CA9906612
rs766891909
 324 C>Y No ClinGen
ExAC
gnomAD
rs774853431
CA9906613
 330 N>D No ClinGen
ExAC
gnomAD
TCGA novel 331 H>Y Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA9906614
rs760178512
 332 Q>R No ClinGen
ExAC
TOPMed
gnomAD
rs910605795
CA315205529
 339 Q>H No ClinGen
TOPMed
gnomAD
rs1329732327
CA408965360
 340 E>G No ClinGen
TOPMed
rs1275800499
CA408965358
 340 E>K No ClinGen
TOPMed
gnomAD
CA9906617
rs377517343
 341 D>N No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1209157184
CA408965384
 343 D>V No ClinGen
TOPMed
gnomAD
rs976787239
CA315205530
 346 I>M No ClinGen
TOPMed
gnomAD
CA9906618
rs756253013
 349 E>G No ClinGen
ExAC
TOPMed
gnomAD
rs1186030764
CA408965431
 350 K>E No ClinGen
gnomAD
CA9906619
rs764034146
 350 K>N No ClinGen
ExAC
gnomAD
CA9906620
rs371063445
 352 S>N No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA9906622
rs757463233
 353 P>A No ClinGen
ExAC
gnomAD
rs757463233
CA9906621
 353 P>S No ClinGen
ExAC
gnomAD
rs751365357
CA9906623
 355 N>H No ClinGen
ExAC
gnomAD
rs1432702842
CA408965465
 355 N>S No ClinGen
TOPMed
gnomAD
rs781220884
CA9906626
 357 A>T No ClinGen
ExAC
gnomAD
CA408965484
rs1363364671
 358 P>L No ClinGen
gnomAD
CA315205566
rs866027737
 359 Y>C No ClinGen
Ensembl
rs777117770
CA9906629
 360 G>S No ClinGen
ExAC
TOPMed
gnomAD
rs1370899418
CA408965499
 361 I>F No ClinGen
TOPMed
gnomAD
CA9906632
rs370509709
 361 I>M No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA9906630
rs749017764
 361 I>T No ClinGen
ExAC
gnomAD
rs759986577
CA9906633
COSM1533509
 362 E>K lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] No ClinGen
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs759986577
CA408965502
 362 E>Q No ClinGen
ExAC
TOPMed
gnomAD
rs778743864
CA9906650
 365 S>N No ClinGen
ExAC
gnomAD
CA315206480
rs893742215
 368 T>A No ClinGen
TOPMed
gnomAD
rs138343840
CA9906652
 375 V>M Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs777051895
CA9906656
 376 G>A No ClinGen
ExAC
gnomAD
CA9906655
rs769052153
 376 G>R No ClinGen
ExAC
gnomAD
rs144346092
CA9906659
 378 S>G No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1175258966 378 S>K Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
CA9906658
rs144346092
 378 S>R No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
COSM1027936
rs763052949
CA9906661
 380 R>* Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
gnomAD
CA9906660
rs763052949
 380 R>G No ClinGen
ExAC
gnomAD
rs752423818
CA9906662
 380 R>Q No ClinGen
ExAC
gnomAD
CA9906664
VAR_022013
rs16995304
 381 G>S No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
TCGA novel 381 G>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA9906666
rs146344551
 382 A>D No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1601417203
CA408965945
 383 Q>R No ClinGen
Ensembl
CA315206537
rs778546018
 386 S>F Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
rs778546018
CA9906667
 386 S>Y No ClinGen
ExAC
TOPMed
gnomAD
VAR_022014
rs16995309
CA9906668
 387 P>L associated with low glucose tolerance [UniProt] No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs1230084781
CA408966055
 389 K>R No ClinGen
TOPMed
gnomAD
COSM1027938
CA315206564
rs984329389
 392 P>L Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
NCI-TCGA
TOPMed
gnomAD
rs1412781369
CA408966137
 395 P>S No ClinGen
TOPMed
gnomAD
CA9906672
rs769020982
 396 E>K No ClinGen
ExAC
TOPMed
gnomAD
rs139630293
CA9906674
 398 D>E No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs769899825
CA9906675
 399 E>K No ClinGen
ExAC
gnomAD
CA408966240
rs1568799492
 400 D>H No ClinGen
Ensembl
CA408966261
rs1568799498
 401 H>R No ClinGen
Ensembl
CA408966257
rs1409849933
 401 H>Y Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA408966293
rs1400455774
 404 S>N No ClinGen
gnomAD
TCGA novel 410 L>W Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1279842769
CA408966399
 412 N>D No ClinGen
TOPMed
gnomAD
CA408966421
rs1294562007
 413 M>I No ClinGen
TOPMed
CA9906678
rs766525958
 413 M>V No ClinGen
ExAC
gnomAD
CA408966429
rs1457853372
 414 C>Y No ClinGen
TOPMed
CA9906680
rs760420089
 415 V>M Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs371791783
CA9906681
 416 A>T No ClinGen
ESP
ExAC
gnomAD
rs922314694
COSM1412424
CA315206615
 417 T>M large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] No ClinGen
cosmic curated
NCI-TCGA
TOPMed
CA9906682
rs145883911
 420 T>M No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1342682532
CA408966494
 421 A>T No ClinGen
gnomAD
rs549340238
CA9906685
 422 G>S No ClinGen
1000Genomes
ExAC
gnomAD
rs367996563
CA408966503
 423 A>P No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs367996563
CA315206642
 423 A>S No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs367996563
COSM1027940
CA9906687
 423 A>T Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1271273002
CA408966510
 424 Y>C No ClinGen
TOPMed
CA408966516
rs1219900969
 425 L>V No ClinGen
TOPMed
rs946652501
CA315206660
 428 R>G No ClinGen
TOPMed
CA408966539
rs1208059231
 428 R>T No ClinGen
gnomAD
TCGA novel 431 F>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1003217984
CA315207735
 432 N>I No ClinGen
TOPMed
CA9906718
rs779974899
 436 T>A No ClinGen
ExAC
gnomAD
rs773071006
CA9906720
 436 T>W No ClinGen
ExAC
gnomAD

No associated diseases with P18031

4 regional properties for P18031

Type Name Position InterPro Accession
domain Tyrosine-specific protein phosphatase, PTPase domain 3 - 279 IPR000242
domain Tyrosine-specific protein phosphatases domain 189 - 268 IPR000387
domain Protein-tyrosine phosphatase, catalytic 170 - 276 IPR003595
active_site Protein-tyrosine phosphatase, active site 213 - 223 IPR016130

Functions

Description
EC Number 3.1.3.48 Phosphoric monoester hydrolases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Interacts with EPHA3 at the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic side of endoplasmic reticulum membrane The side (leaflet) of the plasma membrane that faces the cytoplasm.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
mitochondrial crista Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
sorting endosome A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles.

11 GO annotations of molecular function

Name Definition
cadherin binding Binding to cadherin, a type I membrane protein involved in cell adhesion.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
ephrin receptor binding Binding to an ephrin receptor.
insulin receptor binding Binding to an insulin receptor.
non-membrane spanning protein tyrosine phosphatase activity Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein phosphatase 2A binding Binding to protein phosphatase 2A.
protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
receptor tyrosine kinase binding Binding to a receptor that possesses protein tyrosine kinase activity.
RNA binding Binding to an RNA molecule or a portion thereof.
zinc ion binding Binding to a zinc ion (Zn).

26 GO annotations of biological process

Name Definition
actin cytoskeleton reorganization A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
cellular response to unfolded protein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
endoplasmic reticulum unfolded protein response The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
growth hormone receptor signaling pathway via JAK-STAT The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
insulin receptor signaling pathway The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
IRE1-mediated unfolded protein response The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.
negative regulation of ERK1 and ERK2 cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
negative regulation of insulin receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
negative regulation of MAP kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
negative regulation of PERK-mediated unfolded protein response Any process that stops, prevents or reduces the frequency, rate or extent of the PERK-mediated unfolded protein response.
negative regulation of signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
negative regulation of vascular endothelial growth factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
peptidyl-tyrosine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity.
platelet-derived growth factor receptor-beta signaling pathway The series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
positive regulation of IRE1-mediated unfolded protein response Any process that activates or increases the frequency, rate or extent of the IRE1-mediated unfolded protein response.
positive regulation of JUN kinase activity Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
positive regulation of protein tyrosine kinase activity Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
positive regulation of receptor catabolic process Any process that activates or increases the frequency, rate or extent of receptor catabolic process.
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.
regulation of endocytosis Any process that modulates the frequency, rate or extent of endocytosis.
regulation of hepatocyte growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway.
regulation of intracellular protein transport Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.
regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction.
regulation of type I interferon-mediated signaling pathway Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P17706 PTPN2 Tyrosine-protein phosphatase non-receptor type 2 Homo sapiens (Human) EV
Q06180 Ptpn2 Tyrosine-protein phosphatase non-receptor type 2 Mus musculus (Mouse) SS
P35821 Ptpn1 Tyrosine-protein phosphatase non-receptor type 1 Mus musculus (Mouse) PR
A1L1L3 Ptpn20 Tyrosine-protein phosphatase non-receptor type 20 Rattus norvegicus (Rat) PR
P35233 Ptpn2 Tyrosine-protein phosphatase non-receptor type 2 Rattus norvegicus (Rat) SS
P20417 Ptpn1 Tyrosine-protein phosphatase non-receptor type 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS PFDHSRIKLH
70 80 90 100 110 120
QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSLK
130 140 150 160 170 180
CAQYWPQKEE KEMIFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP
190 200 210 220 230 240
DFGVPESPAS FLNFLFKVRE SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD
250 260 270 280 290 300
PSSVDIKKVL LEMRKFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE
310 320 330 340 350 360
PPPEHIPPPP RPPKRILEPH NGKCREFFPN HQWVKEETQE DKDCPIKEEK GSPLNAAPYG
370 380 390 400 410 420
IESMSQDTEV RSRVVGGSLR GAQAASPAKG EPSLPEKDED HALSYWKPFL VNMCVATVLT
430
AGAYLCYRFL FNSNT