AiPD: Autoinhibited Protein Database

P17706

Gene name	PTPN2 (PTPT)
Protein name	Tyrosine-protein phosphatase non-receptor type 2
Names	T-cell protein-tyrosine phosphatase, TCPTP
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5771
EC number	3.1.3.48: Phosphoric monoester hydrolases
Protein Class	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F (PTHR46047)

Descriptions

T cell protein tyrosine phosphatase(Tyrosine-protein phosphatase non-receptor type 2, TCPTP) is a regulator of diverse physiological processes such as cell growth, gene expression, differentiation, cytoskeletal dynamics, and cell motility. Alternative mRNA splicing results in variation in the sequence at the extreme C terminus of TCPTP and generates a 45-kDa form (TC45) that is targeted to the nucleus and a 48-kDa variant (TC48) associated with membranes of the endoplasmic reticulum. Analysis of the time course of limited trypsinolysis revealed that proteolytic activation occurred following cleavage of a protease-sensitive region (residues 353–387) located at the C terminus of TC45.

Autoinhibitory domains (AIDs)

Target domain	1-288 (Catalytic domain)
Relief mechanism	Cleavage
Assay	Deletion assay

AID

353-387 (C-terminal noncatalytic segment of TC45)

Target domain

1-288 (Catalytic domain)

Relief mechanism

Cleavage (Proteolytic cleavage of a protease-sensitive region)

Assay

Deletion assay

Accessory elements

No accessory elements

References

Hao L et al. (1997) "The noncatalytic C-terminal segment of the T cell protein tyrosine phosphatase regulates activity via an intramolecular mechanism", The Journal of biological chemistry, 272, 29322-9

Autoinhibited structure

Activated structure

6 structures for P17706

Entry ID	Method	Resolution	Chain	Position	Source
1L8K	X-ray	256 A	A	1-314	PDB
6ZZ4	X-ray	243 A	A/B	1-314	PDB
7F5N	X-ray	193 A	A/B/C	1-314	PDB
7F5O	X-ray	170 A	A/B/C	1-302	PDB
7UAD	X-ray	204 A	A	1-314	PDB
AF-P17706-F1	Predicted				AlphaFoldDB

269 variants for P17706

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA8898923 rs771614274	2	P>H		No	ClinGen ExAC TOPMed gnomAD
CA8898924 rs771614274	2	P>L		No	ClinGen ExAC TOPMed gnomAD
CA402035792 rs771614274	2	P>R		No	ClinGen ExAC TOPMed gnomAD
rs867096066 CA296791307	2	P>S		No	ClinGen TOPMed
CA402035787 rs1276711486	3	T>I		No	ClinGen TOPMed gnomAD
rs1276711486 CA402035788	3	T>S		No	ClinGen TOPMed gnomAD
rs1385843772 CA402035791	3	T>S		No	ClinGen TOPMed
CA296791299 rs945467973	4	T>A		No	ClinGen TOPMed
rs747486746 CA402035782	4	T>I		No	ClinGen ExAC gnomAD
CA8898922 rs747486746	4	T>N		No	ClinGen ExAC gnomAD
CA402035783 rs747486746	4	T>S		No	ClinGen ExAC gnomAD
CA8898921 rs778310630	6	E>K		No	ClinGen ExAC TOPMed gnomAD
CA8898920 rs758737273	6	E>V		No	ClinGen ExAC gnomAD
rs150641661 CA402035757	8	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1337353757 CA402035762	8	E>K		No	ClinGen TOPMed gnomAD
CA402035763 rs1337353757	8	E>Q		No	ClinGen TOPMed gnomAD
rs1451616383 CA402035758	8	E>V		No	ClinGen gnomAD
rs1598913685 CA402035750	9	F>C		No	ClinGen Ensembl
rs1598913694 CA402035753	9	F>V		No	ClinGen Ensembl
CA402035740 rs1568185242	10	E>D		No	ClinGen Ensembl
rs1395399977 CA402035734	11	E>D		No	ClinGen TOPMed gnomAD
rs200164592 CA402035739	11	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200164592 CA8898918	11	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA296791270 rs867997369	12	L>F		No	ClinGen Ensembl
CA402035729 rs1445972788	12	L>S		No	ClinGen gnomAD
CA8898916 rs369944958	14	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA402035716 rs1184779249	14	T>N		No	ClinGen gnomAD
rs1184779249 CA402035715	14	T>S		No	ClinGen gnomAD
CA402035706 rs1466257016	15	Q>H		No	ClinGen TOPMed
rs1236087183 CA402035705	16	R>C		No	ClinGen gnomAD
CA402035700 rs1206823913	16	R>H		No	ClinGen TOPMed gnomAD
CA402035702 rs1206823913	16	R>L		No	ClinGen TOPMed gnomAD
CA402035698 rs1438599484	17	R>G		No	ClinGen gnomAD
CA402035696 rs1272652429	17	R>H		No	ClinGen TOPMed gnomAD
CA402035682 rs1203075385	19	Q>*		No	ClinGen gnomAD
rs562857102 CA8898915	20	P>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs562857102 CA402035673	20	P>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1361746465 CA402035674	20	P>S		No	ClinGen TOPMed gnomAD
rs756085499 CA8898914	21	L>V		No	ClinGen ExAC gnomAD
CA402035666 rs1281057841	22	Y>H		No	ClinGen gnomAD
rs1457235029 CA402035654	23	L>F		No	ClinGen TOPMed
rs748912308 CA8898897	24	E>A		No	ClinGen ExAC gnomAD
CA402035632 rs1285609315	25	I>V		No	ClinGen TOPMed
rs779572195 CA8898896	26	R>L		No	ClinGen ExAC gnomAD
CA296769472 rs950185463	27	N>S		No	ClinGen TOPMed
CA402035602 rs1266017550	29	S>F		No	ClinGen gnomAD
CA8898895 rs755572904	30	H>N		No	ClinGen ExAC TOPMed gnomAD
rs917217934 CA296769459	30	H>R		No	ClinGen gnomAD
CA296769452 rs950936929	31	D>G		No	ClinGen Ensembl
CA296769442 rs1027932038	32	Y>C		No	ClinGen TOPMed gnomAD
CA402035576 rs1375809882	33	P>L		No	ClinGen gnomAD
rs750374603 CA8898894	35	R>S		No	ClinGen ExAC TOPMed gnomAD
CA8898893 rs537221478	36	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1291106111 CA402035550	38	K>Q		No	ClinGen gnomAD
CA402035535 rs1432117963	39	F>L		No	ClinGen TOPMed gnomAD
CA402035536 rs1432117963	39	F>L		No	ClinGen TOPMed gnomAD
rs1172950151 CA402035529	40	P>L		No	ClinGen gnomAD
rs1318954462 CA402035522	41	E>D		No	ClinGen gnomAD
rs763765476 CA8898891	44	N>D		No	ClinGen ExAC gnomAD
rs763765476 CA8898890	44	N>Y		No	ClinGen ExAC gnomAD
CA776261315 rs1191212687	48	Y>*		No	ClinGen TOPMed
rs759832705 CA8898889	48	Y>F		No	ClinGen ExAC gnomAD
CA296757886 rs913379921	55	D>G		No	ClinGen Ensembl
CA296757885 rs996337306	63	N>S		No	ClinGen TOPMed gnomAD
rs1455114748 CA402035103	72	S>N		No	ClinGen gnomAD
CA402035090 rs1201944113	74	V>L		No	ClinGen TOPMed
rs902050146 CA296757882	76	I>T		No	ClinGen TOPMed
CA8898848 rs752113628	77	E>Q		No	ClinGen ExAC gnomAD
rs953123344 CA296757878	79	A>G		No	ClinGen TOPMed
rs74163638 CA8898845	82	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA402035035 rs74163638	82	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA296757874 rs943757284	83	Y>H		No	ClinGen TOPMed
rs1267220108 CA402035008	86	T>P		No	ClinGen gnomAD
CA402034951 rs1568124158	92	N>K		No	ClinGen Ensembl
rs774373051 CA8898818	94	C>S		No	ClinGen ExAC gnomAD
rs768576389 CA8898817	97	F>L		No	ClinGen ExAC gnomAD
CA296755265 rs889010899	99	L>F		No	ClinGen TOPMed gnomAD
rs1432576957 CA402034891	101	V>I		No	ClinGen gnomAD
CA402034860 rs1408071596	105	K>Q		No	ClinGen gnomAD
CA402034850 rs1336909079	106	T>S		No	ClinGen gnomAD
rs1413571843 CA402034835	108	A>S		No	ClinGen TOPMed gnomAD
CA402034813 rs1475479415	111	M>I		No	ClinGen gnomAD
rs779886860 CA8898815	111	M>R		No	ClinGen ExAC
rs1169141526 CA402034818	111	M>V		No	ClinGen gnomAD
CA8898814 rs771096169 COSM1387818	114	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA8898813 COSM986672 rs145657672	114	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA8898812 rs777852241	115	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1188747865 CA402034780	117	E>*		No	ClinGen gnomAD
rs758414586 CA296755255	120	S>*		No	ClinGen ExAC gnomAD
CA8898811 rs758414586	120	S>L		No	ClinGen ExAC gnomAD
CA402034736 rs1290556737	121	V>A		No	ClinGen gnomAD
CA402034723 rs1400499894	123	C>Y		No	ClinGen TOPMed gnomAD
CA402034700 rs1354030120	126	Y>C		No	ClinGen gnomAD
rs1280858319 CA402034671	130	D>G		No	ClinGen gnomAD
CA296753533 rs756443279	132	Q>H		No	ClinGen ExAC gnomAD
CA8898781 rs750105074	135	L>M		No	ClinGen ExAC TOPMed gnomAD
rs142645165 CA8898780	136	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA402034606 rs1400124644	139	T>A		No	ClinGen gnomAD
rs1352097620 CA402034591	141	F>C		No	ClinGen gnomAD
CA402034584 rs1213254112	142	S>T		No	ClinGen TOPMed
CA8898779 rs761548219	145	L>F		No	ClinGen ExAC TOPMed gnomAD
rs148072900 CA8898777	146	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA296753505 rs929363513	150	V>A		No	ClinGen TOPMed
rs568984333 CA296753502	151	K>N		No	ClinGen 1000Genomes
CA402034524 rs1160459981	151	K>R		No	ClinGen gnomAD
CA402034519 rs1473036088	152	S>A		No	ClinGen gnomAD
rs1411593047 CA402034516	152	S>L		No	ClinGen TOPMed gnomAD
rs1189334871 CA402034514	153	Y>H		No	ClinGen TOPMed
CA8898772 rs776397445	158	L>V		No	ClinGen ExAC gnomAD
CA8898771 rs772328138	160	Q>P		No	ClinGen ExAC gnomAD
rs143546199 CA296753490	161	L>I		No	ClinGen ESP TOPMed gnomAD
rs1286069969 CA402034443	163	N>K		No	ClinGen gnomAD
rs1417557137 CA402034437	164	I>T		No	ClinGen gnomAD
rs1447598742 CA402034430	165	N>S		No	ClinGen TOPMed
CA296750857 rs1026936564	166	S>N		No	ClinGen Ensembl
rs1254988153 CA402032832	168	E>K		No	ClinGen gnomAD
RCV000955616 CA8898744 rs78174797	171	T>K		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1251890800 CA402032794	173	S>F		No	ClinGen gnomAD
CA296750853 rs1019476175	175	F>L		No	ClinGen Ensembl
rs1203900630 CA402032759	177	Y>C		No	ClinGen gnomAD
CA296750851 rs527692021	178	T>A		No	ClinGen TOPMed gnomAD
rs1249657620 CA402032735	179	T>A		No	ClinGen TOPMed
CA8898741 rs757973522	179	T>S		No	ClinGen ExAC gnomAD
CA402032708 rs752299864	181	P>S		No	ClinGen ExAC TOPMed gnomAD
rs752299864 CA8898740	181	P>T		No	ClinGen ExAC TOPMed gnomAD
rs766175622 CA402032532	206	N>K		No	ClinGen ExAC TOPMed gnomAD
CA8898736 rs753727316	206	N>S		No	ClinGen ExAC gnomAD
rs1295244418 CA402032526	207	P>L		No	ClinGen gnomAD
rs1368613939 CA402032529	207	P>S		No	ClinGen TOPMed gnomAD
CA402032432 rs1324373480	209	H>R		No	ClinGen TOPMed
CA402032420 rs1162194232	211	P>S		No	ClinGen gnomAD
rs764438771 CA8898732	212	A>V		No	ClinGen ExAC TOPMed gnomAD
rs893136826 CA296750787	213	V>M		No	ClinGen Ensembl
rs1324789871 CA402032404	214	I>F		No	ClinGen TOPMed
rs1180798384 CA402032393	215	H>Q		No	ClinGen gnomAD
CA402032348 rs1248980805	222	R>C		No	ClinGen TOPMed gnomAD
rs769957418 CA8898729	223	S>C		No	ClinGen ExAC gnomAD
rs772643237 CA8898728	227	S>C		No	ClinGen ExAC gnomAD
rs750274051 COSM1263355 CA296750761	229	V>A	oesophagus [Cosmic]	No	ClinGen cosmic curated Ensembl
rs777208240 CA8898727	229	V>I		No	ClinGen ExAC gnomAD
CA402032279 rs1331450260	233	L>I		No	ClinGen gnomAD
RCV000883504 CA8898726 rs77573141	234	V>I		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1348743305 CA402032263	235	L>F		No	ClinGen gnomAD
CA402032247 rs1188397881	236	M>V		No	ClinGen gnomAD
rs778472790 CA8898700	238	K>E		No	ClinGen ExAC TOPMed gnomAD
COSM228678 CA8898699 rs768294026	239	G>R	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA402032223 COSM228678 rs768294026	239	G>R	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA8898697 rs779521258	240	D>Y		No	ClinGen ExAC
rs929466536 CA296749353	243	N>K		No	ClinGen Ensembl
rs750290141 CA8898695	244	I>T		No	ClinGen ExAC gnomAD
rs142941831 CA8898696	244	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA402032177 rs1296589139	245	K>I		No	ClinGen gnomAD
rs61731982 CA8898694	247	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA296749346 rs918133281	249	L>M		No	ClinGen Ensembl
CA296749343 rs756931750	250	N>K		No	ClinGen ExAC gnomAD
CA8898693 rs756931750	250	N>K		No	ClinGen ExAC gnomAD
CA296749335 rs1001108405	251	M>I		No	ClinGen Ensembl
CA8898692 rs751393298	251	M>L		No	ClinGen ExAC gnomAD
rs1394909927 CA402032121	254	Y>H		No	ClinGen gnomAD
CA8898689 rs754009863	256	M>L		No	ClinGen ExAC TOPMed gnomAD
rs754009863 CA8898690	256	M>V		No	ClinGen ExAC TOPMed gnomAD
CA8898688 rs766526989	257	G>C		No	ClinGen ExAC gnomAD
CA8898687 rs761265276	262	P>S		No	ClinGen ExAC gnomAD
rs1474643355 CA402032061	263	D>G		No	ClinGen gnomAD
CA8898684 rs199581316	270	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs762152963 CA8898683	272	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1207461588 CA402031974	276	A>T		No	ClinGen gnomAD
CA402031952 rs1273897023	278	C>Y		No	ClinGen gnomAD
CA296749303 rs201489635	279	I>V		No	ClinGen TOPMed gnomAD
CA402031930 rs1324827128	281	G>E		No	ClinGen TOPMed
CA8898681 rs768347316	281	G>R		No	ClinGen ExAC gnomAD
rs748912257 CA8898680	284	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1568101581 CA402031875	284	S>R		No	ClinGen Ensembl
CA296749300 rs937963823	286	Q>K		No	ClinGen Ensembl
rs967979446 CA296741439	287	K>R		No	ClinGen TOPMed
CA8898664 rs531038472	288	R>L		No	ClinGen 1000Genomes ExAC gnomAD
CA8898665 rs531038472 COSM1387814	288	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs1568085594 CA402031206	289	W>R		No	ClinGen Ensembl
rs767968416 CA8898663	290	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1324580908 CA402031170	294	K>E		No	ClinGen gnomAD
rs1023064878 CA296741425	294	K>R		No	ClinGen Ensembl
rs1327473482 CA402031147	297	L>V		No	ClinGen TOPMed
rs200711300 CA8898661	298	S>A		No	ClinGen ExAC TOPMed gnomAD
rs764406914 CA8898660	298	S>C		No	ClinGen ExAC gnomAD
rs200711300 CA402031140	298	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1214528299 CA402031130	300	A>P		No	ClinGen TOPMed
rs762619357 CA8898659	301	F>S		No	ClinGen ExAC gnomAD
rs1272668578 CA402031090	306	N>D		No	ClinGen TOPMed
rs202049574 CA296741405	310	T>A		No	ClinGen gnomAD
rs202049574 CA402031057	310	T>P		No	ClinGen gnomAD
CA8898657 rs769480553	311	E>K		No	ClinGen ExAC TOPMed gnomAD
CA402031033 rs1478967579	313	Y>C		No	ClinGen gnomAD
CA8898656 rs745424901	314	N>S		No	ClinGen ExAC gnomAD
rs1269551755 CA402031014	316	N>Y		No	ClinGen gnomAD
rs1007687769 CA296741380	317	R>I		No	ClinGen gnomAD
rs1281520282 CA402030999	318	I>K		No	ClinGen TOPMed gnomAD
rs1190838392 CA402030997	318	I>M		No	ClinGen TOPMed
rs1281520282 CA402031000	318	I>T		No	ClinGen TOPMed gnomAD
CA8898653 rs746902207	318	I>V		No	ClinGen ExAC gnomAD
rs530108359 CA8898651	321	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs530108359 CA8898652	321	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA8898649 rs749523806	327	G>S		No	ClinGen ExAC gnomAD
rs1598742182 CA402030930	329	R>*		No	ClinGen Ensembl
rs370657302 CA8898647	329	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8898646 rs750518471	330	C>S		No	ClinGen ExAC TOPMed gnomAD
rs781301782 CA8898645	331	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1458373462 CA402030908	333	L>V		No	ClinGen TOPMed
rs148776205 CA8898642	338	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs763240651 CA8898641	338	Q>H		No	ClinGen ExAC gnomAD
CA402030851 rs1189050273	341	M>T		No	ClinGen TOPMed gnomAD
CA296741338 rs934635618	341	M>V		No	ClinGen TOPMed
rs764843165 CA8898639	343	E>K		No	ClinGen ExAC gnomAD
rs1568084999 CA402030819	345	S>T		No	ClinGen Ensembl
CA401966442 rs1172559636	348	A>V		No	ClinGen TOPMed
CA401966440 rs1393218349	349	L>V		No	ClinGen gnomAD
rs558014719 CA8898601	350	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs779158537 CA8898599	352	R>C		No	ClinGen ExAC gnomAD
rs1485325592 CA401966397	353	I>M		No	ClinGen gnomAD
rs376625912 CA296736382	353	I>T		No	ClinGen ESP TOPMed gnomAD
CA401966391 rs754147924	354	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8898597 rs754147924	354	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1469212865 CA401966380	356	D>N		No	ClinGen TOPMed gnomAD
rs766193092 CA8898596	357	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1568075133 CA401966360	358	K>E		No	ClinGen Ensembl
rs755807202 CA8898595	360	T>A		No	ClinGen ExAC gnomAD
CA8898594 rs373011018	360	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs767098194 CA8898593	361	T>A		No	ClinGen ExAC TOPMed gnomAD
rs754659029 CA296736371	361	T>I		No	ClinGen Ensembl
CA401966322 rs1598727976	362	A>T		No	ClinGen Ensembl
CA401966308 rs1345870640	363	Q>H		No	ClinGen TOPMed
CA8898592 rs761682597	364	K>N		No	ClinGen ExAC TOPMed gnomAD
rs144276145 CA8898591	365	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs775240072 CA8898588	370	Q>K		No	ClinGen ExAC gnomAD
rs536642089 CA8898586	371	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs536642089 CA8898587	371	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1451022700 CA401966188	375	N>S		No	ClinGen gnomAD
CA8898584 rs753694114	377	R>L		No	ClinGen ExAC gnomAD
CA296736352 rs753694114	377	R>Q		No	ClinGen ExAC gnomAD
rs1568074907 CA401966157	378	K>R		No	ClinGen Ensembl
CA296736349 rs1011286538	379	R>T		No	ClinGen Ensembl
rs566280122 CA8898583	384	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA8898581 rs368834137	385	W>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8898580 rs780534824	387	P>L		No	ClinGen ExAC gnomAD
CA8898579 rs780534824	387	P>R		No	ClinGen ExAC gnomAD
rs755863299 CA8898578	388	I>V		No	ClinGen ExAC TOPMed gnomAD
rs891105715 CA296736338	389	L>F		No	ClinGen TOPMed gnomAD
CA8898576 rs767151704	390	T>A		No	ClinGen ExAC gnomAD
rs1450842484 CA401965977	392	M>V		No	ClinGen TOPMed
rs751031063 CA8898574	393	G>E		No	ClinGen ExAC gnomAD
rs762765433 CA8898572	395	M>I		No	ClinGen ExAC gnomAD
CA401965925 rs1168717190	395	M>V		No	ClinGen TOPMed
CA296736323 rs937020466	396	S>L		No	ClinGen gnomAD
rs767583744 CA296736320	397	V>I		No	ClinGen Ensembl
CA8898570 rs764960685	400	V>F		No	ClinGen ExAC gnomAD
rs1045651503 CA296736308	401	G>A		No	ClinGen Ensembl
rs74163636 CA296736311	401	G>C		No	ClinGen gnomAD
CA8898568 COSM986662 rs773354544	402	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA8898567 rs374559958	403	F>I		No	ClinGen ESP ExAC gnomAD
CA401965756 rs1454835324	404	V>F		No	ClinGen gnomAD
rs748317104 CA8898566	406	W>R		No	ClinGen ExAC gnomAD
CA401965676 rs1373821237	408	L>Q		No	ClinGen gnomAD
rs1192755703 CA401965667	409	F>V		No	ClinGen TOPMed gnomAD
rs769245865 CA8898564	410	F>S		No	ClinGen ExAC gnomAD
rs1258342176 CA401965599	412	Q>*		No	ClinGen gnomAD
rs1285450753 CA401965597	412	Q>P		No	ClinGen Ensembl
CA401965570 rs1568074548	413	N>S		No	ClinGen Ensembl
rs1342999390 CA401965540	414	A>G		No	ClinGen gnomAD
rs780589820 CA8898563	415	L>I		No	ClinGen ExAC gnomAD
CA401965504 rs1278131043	416	L>Y		No	ClinGen gnomAD

No associated diseases with P17706

6 regional properties for P17706

Type	Name	Position	InterPro Accession
domain	DRF autoregulatory	1027 - 1041	IPR010465
domain	Formin, FH3 domain	246 - 444	IPR010472
domain	Formin, GTPase-binding domain	59 - 241	IPR010473
domain	Diaphanous autoregulatory (DAD) domain	1022 - 1054	IPR014767
domain	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain	59 - 431	IPR014768
domain	Formin, FH2 domain	601 - 1044	IPR015425

Functions

		Description
EC Number	3.1.3.48	Phosphoric monoester hydrolases
Subcellular Localization	[Isoform 1]: Endoplasmic reticulum Endoplasmic reticulum-Golgi intermediate compartment	Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region
PANTHER Family	PTHR46047	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F
PANTHER Subfamily	PTHR46047:SF1	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 2
PANTHER Protein Class	protein phosphatase protein modifying enzyme
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum-Golgi intermediate compartment	A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name	Definition
integrin binding	Binding to an integrin.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein tyrosine phosphatase activity	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
receptor tyrosine kinase binding	Binding to a receptor that possesses protein tyrosine kinase activity.
STAT family protein binding	Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.
syntaxin binding	Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.

32 GO annotations of biological process

Name	Definition
B cell differentiation	The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
erythrocyte differentiation	The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
glucose homeostasis	Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
insulin receptor signaling pathway	The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of chemotaxis	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
negative regulation of epidermal growth factor receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
negative regulation of ERK1 and ERK2 cascade	Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
negative regulation of inflammatory response	Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
negative regulation of insulin receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
negative regulation of interferon-gamma-mediated signaling pathway	Any process that decreases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway.
negative regulation of interleukin-2-mediated signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2-mediated signaling pathway.
negative regulation of interleukin-4-mediated signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-4-mediated signaling pathway.
negative regulation of interleukin-6-mediated signaling pathway	Any process that decreases the rate, frequency or extent of an interleukin-6-mediated signaling pathway.
negative regulation of lipid storage	Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
negative regulation of macrophage colony-stimulating factor signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway.
negative regulation of macrophage differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation.
negative regulation of platelet-derived growth factor receptor-beta signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.
negative regulation of positive thymic T cell selection	Any process that stops, prevents or reduces the frequency, rate or extent of positive thymic T cell selection.
negative regulation of protein tyrosine kinase activity	Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity.
negative regulation of T cell receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of tumor necrosis factor-mediated signaling pathway	Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
negative regulation of type I interferon-mediated signaling pathway	Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway.
negative regulation of tyrosine phosphorylation of STAT protein	Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
peptidyl-tyrosine dephosphorylation	The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Any process that activates or increases the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.
positive regulation of gluconeogenesis	Any process that activates or increases the frequency, rate or extent of gluconeogenesis.
positive regulation of PERK-mediated unfolded protein response	Any process that activates or increases the frequency, rate or extent of the PERK-mediated unfolded protein response.
regulation of hepatocyte growth factor receptor signaling pathway	Any process that modulates the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway.
regulation of interferon-gamma-mediated signaling pathway	Any process that modulates the rate, frequency or extent of an interferon-gamma-mediated signaling pathway.
T cell differentiation	The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P18031	PTPN1	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (Human)	PR
P35821	Ptpn1	Tyrosine-protein phosphatase non-receptor type 1	Mus musculus (Mouse)	PR
Q06180	Ptpn2	Tyrosine-protein phosphatase non-receptor type 2	Mus musculus (Mouse)	SS
P20417	Ptpn1	Tyrosine-protein phosphatase non-receptor type 1	Rattus norvegicus (Rat)	PR
A1L1L3	Ptpn20	Tyrosine-protein phosphatase non-receptor type 20	Rattus norvegicus (Rat)	PR
P35233	Ptpn2	Tyrosine-protein phosphatase non-receptor type 2	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MPTTIEREFE	ELDTQRRWQP	LYLEIRNESH	DYPHRVAKFP	ENRNRNRYRD	VSPYDHSRVK
70	80	90	100	110	120
LQNAENDYIN	ASLVDIEEAQ	RSYILTQGPL	PNTCCHFWLM	VWQQKTKAVV	MLNRIVEKES
130	140	150	160	170	180
VKCAQYWPTD	DQEMLFKETG	FSVKLLSEDV	KSYYTVHLLQ	LENINSGETR	TISHFHYTTW
190	200	210	220	230	240
PDFGVPESPA	SFLNFLFKVR	ESGSLNPDHG	PAVIHCSAGI	GRSGTFSLVD	TCLVLMEKGD
250	260	270	280	290	300
DINIKQVLLN	MRKYRMGLIQ	TPDQLRFSYM	AIIEGAKCIK	GDSSIQKRWK	ELSKEDLSPA
310	320	330	340	350	360
FDHSPNKIMT	EKYNGNRIGL	EEEKLTGDRC	TGLSSKMQDT	MEENSESALR	KRIREDRKAT
370	380	390	400	410
TAQKVQQMKQ	RLNENERKRK	RWLYWQPILT	KMGFMSVILV	GAFVGWTLFF	QQNAL