AiPD: Autoinhibited Protein Database

P17676

Gene name	CEBPB
Protein name	CCAAT/enhancer-binding protein beta
Names	C/EBP beta, Liver activator protein, LAP, Liver-enriched inhibitory protein, LIP, Nuclear factor NF-IL6, Transcription factor 5, TCF-5
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1051
EC number
Protein Class	CCAAT/ENHANCER BINDING PROTEIN (PTHR23334)

Descriptions

CEBPB is a transcription factor that regulates oncogenic H-RasV12-induced senescence and growth arrest. Three distinct N-terminal sequences that are predicted to form secondary structures inhibit CEBPB DNA binding. These include the autoinhibitory domain, which is located within CR5, and two LX motifs (LX1 and LX2). CEBPB is autoinhibited by these multiple elements, which also play a role in mediating interactions with coactivators. The autoinhibitory region physically interacts with the basic region within the DNA-binding domain to achieve autoinhibition.Truncation of the autoinhibitory domain, LX1, and/or LX2 recovered CEBPB DNA binding activity

Autoinhibitory domains (AIDs)

Target domain	269-334 (DNA-binding domain (bZIP region))
Relief mechanism	Partner binding, PTM
Assay	Deletion assay, Mutagenesis experiment

AID

88-165 (N-terminal autoinhibitory region)

Target domain

269-334 (DNA-binding domain (bZIP region))

Relief mechanism

Partner binding (Ras binding), PTM(Phosphorylation of Ser-273

Assay

Deletion assay, Mutagenesis experiment

Accessory elements

No accessory elements

References

Lee S et al. (2010) "CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP)", The Journal of biological chemistry, 285, 21399-410

Autoinhibited structure

Activated structure

16 structures for P17676

Entry ID	Method	Resolution	Chain	Position	Source
1GTW	X-ray	185 A	A/B	259-336	PDB
1GU4	X-ray	180 A	A/B	259-336	PDB
1GU5	X-ray	210 A	A/B	259-336	PDB
1H88	X-ray	280 A	A/B	259-336	PDB
1H89	X-ray	245 A	A/B	273-336	PDB
1H8A	X-ray	223 A	A/B	259-336	PDB
1HJB	X-ray	300 A	A/B/D/E	259-345	PDB
1IO4	X-ray	300 A	A/B	259-336	PDB
2E42	X-ray	180 A	A/B	259-336	PDB
2E43	X-ray	210 A	A/B	259-336	PDB
6MG1	X-ray	175 A	A/B	269-344	PDB
6MG2	X-ray	193 A	A/B	269-344	PDB
6MG3	X-ray	205 A	A/B	269-344	PDB
7L4V	X-ray	175 A	A/B	269-344	PDB
7UPZ	X-ray	249 A	A/B	257-336	PDB
AF-P17676-F1	Predicted				AlphaFoldDB

283 variants for P17676

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA408946977 rs1174067697	2	Q>*		No	ClinGen gnomAD
rs1408002318 CA408947043	3	R>H		No	ClinGen gnomAD
CA9906214 rs751204816	7	W>C		No	ClinGen ExAC TOPMed gnomAD
rs1258959413 CA408947154	8	D>N		No	ClinGen TOPMed
CA9906215 rs759182476	10	A>G		No	ClinGen ExAC gnomAD
CA408947252 rs1568673101	12	L>P		No	ClinGen Ensembl
rs1326067176 CA408947386	17	P>L		No	ClinGen gnomAD
rs1041584212 CA315203351	18	P>L		No	ClinGen TOPMed
rs1260313083 CA408947391	18	P>S		No	ClinGen TOPMed gnomAD
CA408947411 rs1206905908	19	P>L		No	ClinGen gnomAD
rs1000008468 CA315203383	20	A>S		No	ClinGen TOPMed gnomAD
CA9906225 rs377368819	20	A>V		No	ClinGen ESP ExAC gnomAD
CA315203405 rs1034526659	23	S>F		No	ClinGen TOPMed
rs746123580 CA9906226	24	M>T		No	ClinGen ExAC gnomAD
CA408947547 rs1157927460	25	E>D		No	ClinGen gnomAD
rs1361637653 CA408947563	26	V>A		No	ClinGen gnomAD
CA408947556 rs1422775925	26	V>L		No	ClinGen gnomAD
CA9906227 rs772304270	27	A>T		No	ClinGen ExAC gnomAD
CA9906228 rs781028963	30	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs1411297267 CA408947648	30	Y>H		No	ClinGen TOPMed
CA408947691 rs1404927663	31	Y>C		No	ClinGen gnomAD
CA408947679 rs747920655	31	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs747920655 CA9906229	31	Y>N		No	ClinGen ExAC TOPMed gnomAD
CA408947708 rs1301797980	32	E>Q		No	ClinGen gnomAD
rs1179373108 CA408947762	33	A>V		No	ClinGen TOPMed
rs769517052 CA9906230	34	D>E		No	ClinGen ExAC gnomAD
rs1224443397 CA408947841	37	A>P		No	ClinGen TOPMed gnomAD
CA408947843 rs1224443397	37	A>S		No	ClinGen TOPMed gnomAD
rs1224443397 CA408947840	37	A>T		No	ClinGen TOPMed gnomAD
rs371495742 CA9906231	38	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1241425543 CA408947879	39	A>P		No	ClinGen gnomAD
CA408947888 rs1422705747	39	A>V		No	ClinGen TOPMed gnomAD
rs770372476 CA9906233	41	G>C		No	ClinGen ExAC TOPMed gnomAD
CA408947935 rs770372476	41	G>R		No	ClinGen ExAC TOPMed gnomAD
CA9906234 rs773893525	42	G>C		No	ClinGen ExAC gnomAD
CA9906235 rs200084272	42	G>D		No	ClinGen ExAC TOPMed gnomAD
CA408947954 rs773893525	42	G>S		No	ClinGen ExAC gnomAD
CA315203433 rs200084272	42	G>V		No	ClinGen ExAC TOPMed gnomAD
CA9906236 rs767276248	43	K>R		No	ClinGen ExAC
CA315203475 rs867722941	44	A>E		No	ClinGen Ensembl
CA408948045 rs1295266659	45	A>T		No	ClinGen TOPMed
rs1490452851 CA408948072	45	A>V		No	ClinGen gnomAD
CA408948122 rs1176472291	47	A>P		No	ClinGen gnomAD
CA408948158 rs1248138498	48	A>P		No	ClinGen gnomAD
CA315203501 rs753171398	49	P>A		No	ClinGen ExAC TOPMed gnomAD
rs761135515 CA408948190	49	P>H		No	ClinGen ExAC TOPMed gnomAD
rs761135515 CA9906239	49	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9906238 rs753171398	49	P>S		No	ClinGen ExAC TOPMed gnomAD
CA408948185 rs753171398	49	P>T		No	ClinGen ExAC TOPMed gnomAD
CA408948217 rs1384108590	50	P>R		No	ClinGen gnomAD
rs1162239063 CA408948228	51	A>T		No	ClinGen gnomAD
CA408948271 rs1156781585	52	A>V		No	ClinGen TOPMed
CA408948273 rs1437803509	53	R>G		No	ClinGen gnomAD
rs1298012826 CA408948283	53	R>I		No	ClinGen gnomAD
CA315203519 rs1033481854	53	R>S		No	ClinGen Ensembl
rs975638329 CA315203529	54	P>L		No	ClinGen TOPMed gnomAD
rs975638329 CA315203525	54	P>R		No	ClinGen TOPMed gnomAD
rs962886579 CA315203521	54	P>S		No	ClinGen TOPMed gnomAD
CA408948327 rs934133431	55	G>E		No	ClinGen TOPMed
rs1307918746 CA408948306	55	G>R		No	ClinGen TOPMed gnomAD
rs934133431 CA315203539	55	G>V		No	ClinGen TOPMed
rs533532702 CA315203559	56	P>L		No	ClinGen 1000Genomes
rs896368541 CA315203562	57	R>P		No	ClinGen Ensembl
CA408948401 rs1382138459	58	P>H		No	ClinGen gnomAD
CA408948413 rs987282182	59	P>A		No	ClinGen TOPMed gnomAD
CA315203572 rs913912949	59	P>L		No	ClinGen TOPMed gnomAD
rs913912949 CA315203570	59	P>R		No	ClinGen TOPMed gnomAD
rs987282182 CA315203567	59	P>T		No	ClinGen TOPMed gnomAD
rs1436941998 CA408948508	62	E>G		No	ClinGen TOPMed
CA408948482 rs1249448053	62	E>K		No	ClinGen gnomAD
CA408948531 rs1177452475	64	G>D		No	ClinGen gnomAD
CA408948552 rs1456605960	65	S>R		No	ClinGen TOPMed
CA408948628 rs1601257450	67	G>D		No	ClinGen Ensembl
CA9906243 rs778896468	68	D>N		No	ClinGen ExAC TOPMed gnomAD
CA315203593 rs1055656289	69	H>N		No	ClinGen TOPMed
CA408948781 rs1255238207	73	I>L		No	ClinGen TOPMed
CA315203595 rs551520247	77	P>L		No	ClinGen 1000Genomes TOPMed gnomAD
rs1170311066 CA408949027	79	L>P		No	ClinGen TOPMed gnomAD
rs1170311066 CA408949032	79	L>R		No	ClinGen TOPMed gnomAD
rs1224552608 CA408948996	79	L>V		No	ClinGen TOPMed gnomAD
rs1278207940 CA408949042	80	E>Q		No	ClinGen TOPMed
CA9906244 rs750509396	81	P>T		No	ClinGen ExAC gnomAD
rs1379952079 CA408949216	86	Q>H		No	ClinGen TOPMed gnomAD
CA408949191 rs1317315198	86	Q>K		No	ClinGen gnomAD
CA408949221 rs1434354584	87	A>T		No	ClinGen TOPMed
rs1362562294 CA408949239	88	P>S		No	ClinGen TOPMed
rs1014037357 CA315203602	95	D>A		No	ClinGen TOPMed gnomAD
CA408949390 rs1436160535	96	T>N		No	ClinGen TOPMed
rs1176370107 CA408949375	96	T>P		No	ClinGen TOPMed
CA315203618 rs1024026253	97	F>L		No	ClinGen TOPMed gnomAD
rs1205138242 CA408949418	98	E>Q		No	ClinGen gnomAD
CA408949551 rs1171898938	105	A>G		No	ClinGen TOPMed gnomAD
rs886775109 CA315203637	105	A>T		No	ClinGen TOPMed gnomAD
CA408949553 rs1171898938	105	A>V		No	ClinGen TOPMed gnomAD
rs1405777201 CA408949560	106	P>A		No	ClinGen TOPMed gnomAD
rs747170675 CA9906248	106	P>H		No	ClinGen ExAC TOPMed gnomAD
rs1405777201 CA408949556	106	P>T		No	ClinGen TOPMed gnomAD
CA9906249 rs755939066	108	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1359843144 CA408949612	109	A>S		No	ClinGen gnomAD
CA408949666 rs1430043245	111	S>F		No	ClinGen gnomAD
CA9906250 rs777498639	112	G>R		No	ClinGen ExAC TOPMed gnomAD
rs777498639 CA315203645	112	G>R		No	ClinGen ExAC TOPMed gnomAD
CA408949695 rs1312933241	113	Q>H		No	ClinGen TOPMed
rs1377861808 CA408949690	113	Q>P		No	ClinGen TOPMed
CA315203649 rs868698135	114	H>N		No	ClinGen Ensembl
CA408949744 rs1364075169	115	H>R		No	ClinGen gnomAD
CA408949761 rs1262441606	116	D>G		No	ClinGen gnomAD
CA9906255 rs773801449	124	D>E		No	ClinGen ExAC TOPMed gnomAD
CA408949976 rs1244778086	125	D>G		No	ClinGen TOPMed gnomAD
rs745370394 CA9906256	125	D>N		No	ClinGen ExAC gnomAD
rs1486654464 CA408950001	126	Y>C		No	ClinGen TOPMed
rs1487164082 CA408949992	126	Y>N		No	ClinGen gnomAD
rs775313594 CA9906258	127	G>R		No	ClinGen ExAC gnomAD
CA408950030 rs1204640186	127	G>V		No	ClinGen TOPMed
rs760354287 CA9906259	128	G>D		No	ClinGen ExAC gnomAD
rs760354287 CA408950051	128	G>V		No	ClinGen ExAC gnomAD
rs777022308 CA9906261	130	N>S		No	ClinGen ExAC TOPMed
rs1302415362 CA408950159	134	P>Q		No	ClinGen gnomAD
CA408950161 rs1302415362	134	P>R		No	ClinGen gnomAD
CA315203715 rs865996366	134	P>T		No	ClinGen Ensembl
rs1348029400 CA408950166	135	A>T		No	ClinGen TOPMed
rs1275211281 CA408950230	137	Y>H		No	ClinGen gnomAD
rs1221691260 CA408950265	138	G>A		No	ClinGen gnomAD
rs1349574578 CA408950252	138	G>C		No	ClinGen gnomAD
CA408950247 rs1349574578	138	G>S		No	ClinGen gnomAD
CA9906264 rs750834194	139	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs750834194 CA408950269	139	Y>N		No	ClinGen ExAC TOPMed gnomAD
CA408950293 rs1353755963	140	V>L		No	ClinGen TOPMed gnomAD
CA408950297 rs1353755963	140	V>M		No	ClinGen TOPMed gnomAD
CA408950316 rs1218018800	141	S>C		No	ClinGen gnomAD
CA408950320 rs1268733163	141	S>N		No	ClinGen gnomAD
CA408950346 rs1568673694	142	L>P		No	ClinGen Ensembl
CA408950347 rs1028525078	143	G>R		No	ClinGen TOPMed gnomAD
rs1028525078 CA315203722	143	G>W		No	ClinGen TOPMed gnomAD
rs1157017002 CA408950367	144	R>C		No	ClinGen TOPMed gnomAD
CA9906267 rs751807082	144	R>H		No	ClinGen ExAC gnomAD
rs1157017002 CA408950363	144	R>S		No	ClinGen TOPMed gnomAD
CA315203742 rs868040290	145	L>P		No	ClinGen Ensembl
rs868040290 CA408950383	145	L>Q		No	ClinGen Ensembl
CA408950379 rs1420321062	145	L>V		No	ClinGen gnomAD
CA408950398 rs1162857185	146	G>E		No	ClinGen gnomAD
rs1324018352 CA408950435	147	A>G		No	ClinGen gnomAD
CA408950414 rs777472730	147	A>P		No	ClinGen ExAC TOPMed gnomAD
CA9906269 rs777472730	147	A>T		No	ClinGen ExAC TOPMed gnomAD
CA408950430 rs1324018352	147	A>V		No	ClinGen gnomAD
CA408950440 rs1280881046	148	A>D		No	ClinGen gnomAD
rs778923544 CA9906272	148	A>T		No	ClinGen ExAC gnomAD
CA408950444 rs1280881046	148	A>V		No	ClinGen gnomAD
rs1244522460 CA408950463	149	K>R		No	ClinGen gnomAD
CA9906274 rs771728816	151	A>S		No	ClinGen ExAC gnomAD
CA408950505 rs771728816	151	A>T		No	ClinGen ExAC gnomAD
rs775117213 CA9906275	151	A>V		No	ClinGen ExAC gnomAD
rs1234746665 CA408950540	153	H>N		No	ClinGen gnomAD
rs1183129152 CA408950573	154	P>R		No	ClinGen gnomAD
CA408950557 rs1440542889	154	P>T		No	ClinGen gnomAD
CA315203787 rs986907543	155	G>D		No	ClinGen TOPMed gnomAD
rs552807936 CA408950591	155	G>R		No	ClinGen 1000Genomes TOPMed gnomAD
rs552807936 CA315203781	155	G>S		No	ClinGen 1000Genomes TOPMed gnomAD
rs1163728431 CA408950632	156	C>Y		No	ClinGen gnomAD
CA408950673 rs1215435519	157	F>L		No	ClinGen TOPMed
rs1407948246 CA408950686	158	A>S		No	ClinGen gnomAD
rs1330481183 CA408950722	159	P>L		No	ClinGen gnomAD
rs1322081722 CA408950711	159	P>T		No	ClinGen gnomAD
rs1021034803 CA315203806	161	H>L		No	ClinGen TOPMed gnomAD
rs1021034803 CA315203791	161	H>P		No	ClinGen TOPMed gnomAD
rs746697753 CA9906276	162	P>A		No	ClinGen ExAC gnomAD
CA9906277 rs768417455	164	P>L		No	ClinGen ExAC TOPMed gnomAD
CA315203875 rs935971375	165	P>A		No	ClinGen TOPMed
rs1056106431 CA315203910	169	P>L		No	ClinGen TOPMed gnomAD
CA408950979 rs1601257957	170	P>A		No	ClinGen Ensembl
rs1179981504 CA408951011	171	A>S		No	ClinGen Ensembl
rs1365763947 CA408951058	172	E>K		No	ClinGen TOPMed
rs1363436869 CA408951068	172	E>V		No	ClinGen Ensembl
rs1568673871 CA408951199	177	P>T		No	ClinGen Ensembl
CA408951228 rs1194501927	178	G>D		No	ClinGen gnomAD
rs949881400 CA315203934	181	P>S		No	ClinGen TOPMed
CA408951342 rs1241391459	182	A>E		No	ClinGen gnomAD
rs1425585166 CA408951393	183	D>V		No	ClinGen gnomAD
rs1188181806 CA408951505	187	K>E		No	ClinGen gnomAD
rs1601258021 CA408951642	190	A>T		No	ClinGen Ensembl
rs1352138512 CA408951704	191	G>R		No	ClinGen TOPMed
rs1232023086 CA408951740	192	A>E		No	ClinGen TOPMed
CA408951724 rs1253901803	192	A>T		No	ClinGen TOPMed
CA315203964 rs886887483	193	P>Q		No	ClinGen TOPMed gnomAD
rs886887483 CA315203990	193	P>R		No	ClinGen TOPMed gnomAD
CA315203957 rs977528485	193	P>S		No	ClinGen TOPMed gnomAD
rs977528485 CA408951744	193	P>T		No	ClinGen TOPMed gnomAD
CA9906285 rs763405415	194	G>D		No	ClinGen ExAC TOPMed gnomAD
rs763405415 CA315203997	194	G>V		No	ClinGen ExAC TOPMed gnomAD
VAR_016300 CA315203998 rs4253440	195	G>S		No	ClinGen UniProt 1000Genomes TOPMed dbSNP gnomAD
CA408951807 rs1396037022	195	G>V		No	ClinGen gnomAD
CA408952006 rs1387171267	202	G>S		No	ClinGen TOPMed
CA408952084 rs1171071138	204	P>R		No	ClinGen TOPMed
rs936053017 CA315204004	205	Y>H		No	ClinGen Ensembl
CA408952130 rs1434311111	206	A>E		No	ClinGen TOPMed
rs1450841958 CA408952113	206	A>S		No	ClinGen gnomAD
CA408952174 rs1395513520	208	R>C		No	ClinGen TOPMed
CA9906286 rs766497042	210	Y>H		No	ClinGen ExAC gnomAD
CA315204030 rs955586069	211	L>F		No	ClinGen TOPMed
rs1280535006 CA408952406	216	V>L		No	ClinGen gnomAD
rs894690458 CA315204034	217	P>S		No	ClinGen Ensembl
CA408952449 rs1437427883	218	S>G		No	ClinGen gnomAD
rs1177525422 CA408952461	218	S>T		No	ClinGen gnomAD
rs1223154252 CA408952482	219	G>S		No	ClinGen gnomAD
CA408952524 rs1261434142	220	S>N		No	ClinGen gnomAD
CA408952536 rs1021065134	221	S>C		No	ClinGen TOPMed gnomAD
CA315204045 rs1021065134	221	S>G		No	ClinGen TOPMed gnomAD
rs1195720392 CA408952732	226	T>M		No	ClinGen gnomAD
rs1479961355 CA408952794	229	S>L		No	ClinGen gnomAD
rs1173816740 CA408952802	230	S>A		No	ClinGen gnomAD
rs1379073346 CA408952804	230	S>F		No	ClinGen gnomAD
rs1270154591 CA408952842	232	P>Q		No	ClinGen TOPMed
CA408952849 rs1157530393	233	P>S		No	ClinGen gnomAD
rs757080333 CA408952975	237	S>N		No	ClinGen ExAC gnomAD
CA9906291 rs757080333	237	S>T		No	ClinGen ExAC gnomAD
CA315204076 rs993194118	238	P>A		No	ClinGen TOPMed gnomAD
rs993194118 CA408952998	238	P>S		No	ClinGen TOPMed gnomAD
rs1281768059 CA408953047	240	D>V		No	ClinGen gnomAD
CA315204100 rs979483213	241	A>V		No	ClinGen TOPMed gnomAD
CA408953141 rs1234214452	243	A>T		No	ClinGen gnomAD
rs1260263794 CA408953159	243	A>V		No	ClinGen gnomAD
CA408953230 rs1263727087	246	T>I		No	ClinGen TOPMed gnomAD
rs1490163883 CA408953247	247	A>S		No	ClinGen gnomAD
CA408953252 rs1197080663	247	A>V		No	ClinGen TOPMed gnomAD
CA408953319 rs1269170784	250	A>T		No	ClinGen gnomAD
CA408953332 rs1433450143	250	A>V		No	ClinGen TOPMed gnomAD
rs1361582241 CA408953357	251	G>A		No	ClinGen gnomAD
CA408953381 rs758377322	252	A>G		No	ClinGen ExAC TOPMed gnomAD
CA408953368 rs1160981231	252	A>P		No	ClinGen gnomAD
rs758377322 CA9906295	252	A>V		No	ClinGen ExAC TOPMed gnomAD
rs576451769 CA408953401	253	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9906296 rs576451769	253	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1568674231 CA408953511	258	Q>*		No	ClinGen Ensembl
rs1370147348 CA408953551	259	V>F		No	ClinGen gnomAD
rs1370147348 CA408953548	259	V>I		No	ClinGen gnomAD
rs1370147348 CA408953549	259	V>L		No	ClinGen gnomAD
rs139316476 CA9906298	260	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1387599771 CA408953571	260	K>R		No	ClinGen gnomAD
rs1334074288 CA408953593	261	S>G		No	ClinGen gnomAD
CA9906299 rs780897586	261	S>N		No	ClinGen ExAC gnomAD
rs747712410 CA9906300	263	A>T		No	ClinGen ExAC gnomAD
rs770219852 CA9906301	264	K>E		No	ClinGen ExAC gnomAD
rs763493442 CA9906303	267	V>A		No	ClinGen ExAC TOPMed gnomAD
CA9906302 rs773431251	267	V>M		No	ClinGen ExAC TOPMed gnomAD
CA408953754 rs1568674270	269	K>Q		No	ClinGen Ensembl
rs774473666 CA9906305	271	S>T		No	ClinGen ExAC gnomAD
rs949986667 CA315204176	272	D>N		No	ClinGen TOPMed gnomAD
rs1352010258 CA408953825	273	E>D		No	ClinGen TOPMed gnomAD
rs1352010258 CA408953827	273	E>D		No	ClinGen TOPMed gnomAD
rs1163247707 CA408953822	273	E>G		No	ClinGen gnomAD
rs1444609103 CA408953816	273	E>Q		No	ClinGen gnomAD
rs1297957411 CA408953858	275	K>M		No	ClinGen gnomAD
rs1449245373 CA408953883	277	R>Q		No	ClinGen gnomAD
rs1398446653 CA408953882	277	R>W		No	ClinGen gnomAD
rs1249391818 CA408954103	289	R>H		No	ClinGen gnomAD
CA408954125 rs1198850318	290	D>G		No	ClinGen gnomAD
rs1459556014 CA408955116	292	A>T		No	ClinGen gnomAD
rs750238105 COSM1412416 CA408955153	293	K>N	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA408955169 rs1416508856	294	M>I		No	ClinGen gnomAD
rs868421494 CA315204205	295	R>C		No	ClinGen Ensembl
rs1179622728 CA408955245	298	E>A		No	ClinGen TOPMed
rs1184743924 CA408955351	302	K>N		No	ClinGen gnomAD
CA408955344 rs1405457475	302	K>R		No	ClinGen gnomAD
rs1213898726 CA408955436	306	L>F		No	ClinGen gnomAD
rs1218889971 CA408955535	311	E>K		No	ClinGen TOPMed gnomAD
CA9906319 rs778180638	318	E>Q		No	ClinGen ExAC gnomAD
rs749640653 CA9906320	319	Q>*		No	ClinGen ExAC gnomAD
CA408955748 rs771228331	320	L>M		No	ClinGen ExAC gnomAD
rs1478974180 CA408955838	325	S>G		No	ClinGen gnomAD
CA315204281 rs867148328	328	R>W		No	ClinGen Ensembl
rs1178388370 CA408955905	330	L>F		No	ClinGen gnomAD
CA9906326 rs761024259	332	K>R		No	ClinGen ExAC gnomAD
rs1342163109 CA408955984	336	E>D		No	ClinGen gnomAD
rs1342163109 CA408955986	336	E>D		No	ClinGen gnomAD
rs1601258595 CA408955977	336	E>Q		No	ClinGen Ensembl
CA408955990 rs1400314604	337	P>A		No	ClinGen gnomAD
rs1400314604 CA408955988	337	P>T		No	ClinGen gnomAD
CA9906329 rs762842653	339	L>F		No	ClinGen ExAC gnomAD
rs766233869 CA9906330	340	A>P		No	ClinGen ExAC TOPMed gnomAD
CA408956024 rs766233869	340	A>T		No	ClinGen ExAC TOPMed gnomAD
rs751561149 CA9906331	341	S>A		No	ClinGen ExAC gnomAD
CA408956037 rs751561149	341	S>T		No	ClinGen ExAC gnomAD
CA408956041 rs1315756377	341	S>Y		No	ClinGen gnomAD

No associated diseases with P17676

1 regional properties for P17676

Type	Name	Position	InterPro Accession
domain	Basic-leucine zipper domain	269 - 334	IPR004827

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm	Translocates to the nucleus when phosphorylated at Ser-288 In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity)
PANTHER Family	PTHR23334	CCAAT/ENHANCER BINDING PROTEIN
PANTHER Subfamily	PTHR23334:SF21	CCAAT_ENHANCER-BINDING PROTEIN BETA
PANTHER Protein Class	DNA-binding transcription factor basic leucine zipper transcription factor
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
C/EBP complex	A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T
CHOP-C/EBP complex	A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors.
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
condensed chromosome, centromeric region	The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear matrix	The dense fibrillar network lying on the inner side of the nuclear membrane.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase II transcription regulator complex	A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.

18 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription repressor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
glucocorticoid receptor binding	Binding to a nuclear glucocorticoid receptor.
histone acetyltransferase binding	Binding to an histone acetyltransferase.
histone deacetylase binding	Binding to histone deacetylase.
kinase binding	Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II core promoter sequence-specific DNA binding	Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
ubiquitin-like protein ligase binding	Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase.

41 GO annotations of biological process

Name	Definition
acute-phase response	An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.
brown fat cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
cellular response to amino acid stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
cellular response to interleukin-1	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
cellular response to lipopolysaccharide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to organic cyclic compound	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
defense response to bacterium	Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
embryonic placenta development	The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
granuloma formation	The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic.
hepatocyte proliferation	The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.
immune response	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
liver regeneration	The regrowth of lost or destroyed liver.
mammary gland epithelial cell differentiation	The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland.
mammary gland epithelial cell proliferation	The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
memory	The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
negative regulation of neuron apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
negative regulation of T cell proliferation	Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuron.
ovarian follicle development	The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
positive regulation of biomineral tissue development	Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.
positive regulation of cold-induced thermogenesis	Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
positive regulation of fat cell differentiation	Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
positive regulation of inflammatory response	Any process that activates or increases the frequency, rate or extent of the inflammatory response.
positive regulation of interleukin-4 production	Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
positive regulation of osteoblast differentiation	Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
positive regulation of sodium-dependent phosphate transport	Any process that activates or increases the frequency, rate or extent of sodium-dependent phosphate transport.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress.
positive regulation of transcription, DNA-templated	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
regulation of cell differentiation	Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
regulation of dendritic cell differentiation	Any process that modulates the frequency, rate or extent of dendritic cell differentiation.
regulation of interleukin-6 production	Any process that modulates the frequency, rate, or extent of interleukin-6 production.
regulation of odontoblast differentiation	Any process that modulates the frequency, rate or extent of odontoblast differentiation.
regulation of osteoclast differentiation	Any process that modulates the frequency, rate or extent of osteoclast differentiation.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
regulation of transcription, DNA-templated	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
response to endoplasmic reticulum stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
T-helper 1 cell activation	The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O02755	CEBPB	CCAAT/enhancer-binding protein beta	Bos taurus (Bovine)	SS
Q90Z72	NFIL3	Nuclear factor interleukin-3-regulated protein	Gallus gallus (Chicken)	PR
Q16649	NFIL3	Nuclear factor interleukin-3-regulated protein	Homo sapiens (Human)	PR
O08750	Nfil3	Nuclear factor interleukin-3-regulated protein	Mus musculus (Mouse)	PR
P28033	Cebpb	CCAAT/enhancer-binding protein beta	Mus musculus (Mouse)	SS
Q6IMZ0	Nfil3	Nuclear factor interleukin-3-regulated protein	Rattus norvegicus (Rat)	PR
P21272	Cebpb	CCAAT/enhancer-binding protein beta	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MQRLVAWDPA	CLPLPPPPPA	FKSMEVANFY	YEADCLAAAY	GGKAAPAAPP	AARPGPRPPA
70	80	90	100	110	120
GELGSIGDHE	RAIDFSPYLE	PLGAPQAPAP	ATATDTFEAA	PPAPAPAPAS	SGQHHDFLSD
130	140	150	160	170	180
LFSDDYGGKN	CKKPAEYGYV	SLGRLGAAKG	ALHPGCFAPL	HPPPPPPPPP	AELKAEPGFE
190	200	210	220	230	240
PADCKRKEEA	GAPGGGAGMA	AGFPYALRAY	LGYQAVPSGS	SGSLSTSSSS	SPPGTPSPAD
250	260	270	280	290	300
AKAPPTACYA	GAAPAPSQVK	SKAKKTVDKH	SDEYKIRRER	NNIAVRKSRD	KAKMRNLETQ
310	320	330	340
HKVLELTAEN	ERLQKKVEQL	SRELSTLRNL	FKQLPEPLLA	SSGHC