AiPD: Autoinhibited Protein Database

P17544

Gene name	ATF7 (ATFA)
Protein name	Cyclic AMP-dependent transcription factor ATF-7
Names	cAMP-dependent transcription factor ATF-7, Activating transcription factor 7, Transcription factor ATF-A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11016
EC number
Protein Class

Descriptions

(Annotation based on sequence homology with P15336)
ATF-2 is a cellular basic region-leucine zipper (bZIP) transcription factor that can mediate diverse transcriptional responses, including activation by the adenovirus Ela protein. ATF-2 contains an activation domain, required for transcriptional activity, but in the absence of an appropriate inducer, full-length ATF-2 is transcriptionally inactive. The ATF-2 bZIP (residues 350-415) suppresses the ATF-2 and the related Ela activation domains but not acidic- and glutamine-rich activation domains. The ATF-2 bZIP and activation domain are engaged in an inhibitory intramolecular interaction and the inducers of ATF-2 disrupt this interaction to activate transcription.

Autoinhibitory domains (AIDs)

5-477 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

5-477 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P17544

Entry ID	Method	Resolution	Chain	Position	Source
AF-P17544-F1	Predicted				AlphaFoldDB

280 variants for P17544

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs750602287 CA6602812	2	G>A		No	ClinGen ExAC TOPMed gnomAD
rs372629058 CA6602810	4	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA385227927 rs1565589241	8	V>L		No	ClinGen Ensembl
CA237203886 rs917606606	10	N>S		No	ClinGen TOPMed
CA385227862 rs1374407068	12	P>A		No	ClinGen TOPMed gnomAD
CA385227857 rs201947521	12	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6602808 rs201947521	12	P>R		No	ClinGen ExAC TOPMed gnomAD
CA385227810 rs1565589173	15	G>A		No	ClinGen Ensembl
rs759982875 CA6602786	21	E>K		No	ClinGen ExAC TOPMed gnomAD
rs777012356 CA6602785	29	H>Q		No	ClinGen ExAC TOPMed
CA385086198 rs1426936540	29	H>Y		No	ClinGen gnomAD
rs367614281 CA6602782	39	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA385085949 rs1204593056	40	A>G		No	ClinGen gnomAD
rs1463954473 CA385085937 COSM941040	41	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA385085922 rs1210281470	42	T>N		No	ClinGen TOPMed
rs748832822 CA6602780	44	S>L		No	ClinGen ExAC TOPMed gnomAD
CA385083356 rs1345294041	51	T>M		No	ClinGen gnomAD
rs1384143079 CA385083345	52	P>R		No	ClinGen TOPMed gnomAD
rs766713782 CA6602763	53	T>S		No	ClinGen ExAC gnomAD
rs375152787 CA6602762	55	T>S		No	ClinGen ESP ExAC gnomAD
CA385083249 rs1338586322	59	K>N	Variant assessed as Somatic; 4.874e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6602761 rs773957754	60	N>S		No	ClinGen ExAC TOPMed gnomAD
rs550085986 CA6602759	68	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775028139 CA6602758	69	E>D		No	ClinGen ExAC gnomAD
CA6602755 rs775488861	76	H>R		No	ClinGen ExAC TOPMed gnomAD
rs770845683 CA6602754	78	F>L		No	ClinGen ExAC gnomAD
rs894453225 CA237359810	81	A>V		No	ClinGen Ensembl
rs1250238840 CA385082953	82	A>S		No	ClinGen gnomAD
rs1250238840 CA385082956	82	A>T		No	ClinGen gnomAD
CA385082947 rs1202645721	82	A>V		No	ClinGen gnomAD
CA385082906 rs1463592018	84	E>D		No	ClinGen TOPMed gnomAD
rs746841064 CA6602753	86	E>K		No	ClinGen ExAC gnomAD
CA237359809 rs370615566	87	K>E		No	ClinGen ESP
rs771041872 CA6602734	90	A>V		No	ClinGen ExAC gnomAD
CA385080794 rs1352563187	91	A>S		No	ClinGen TOPMed gnomAD
rs746973760 CA6602733	93	P>L		No	ClinGen ExAC gnomAD
rs1325571451 CA385080716 COSM1188511	96	M>V	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs377338085 CA6602731	97	S>F		No	ClinGen ESP ExAC gnomAD
CA6602730 rs748388475	99	P>L		No	ClinGen ExAC gnomAD
rs779068166 CA6602729	101	T>A		No	ClinGen ExAC gnomAD
CA6602728 rs768746722	103	D>G		No	ClinGen ExAC gnomAD
rs749373628 CA6602727	104	I>M		No	ClinGen ExAC gnomAD
CA237358381 rs536043254	104	I>T		No	ClinGen 1000Genomes gnomAD
CA6602726 rs780132757	105	K>R		No	ClinGen ExAC gnomAD
rs149888264 CA385080519	111	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs547054037 CA6602723	111	P>R		No	ClinGen 1000Genomes ExAC gnomAD
rs149888264 CA6602724	111	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1329674334 CA385080512	112	V>L		No	ClinGen gnomAD
CA385080475 rs1592815088	115	D>A		No	ClinGen Ensembl
rs570482405 CA6602721	116	S>L		No	ClinGen 1000Genomes ExAC gnomAD
CA385080456 rs1592815066	117	S>P		No	ClinGen Ensembl
CA237358372 rs759070419	119	P>S		No	ClinGen TOPMed
rs752391905 CA6602720	120	D>N		No	ClinGen ExAC gnomAD
CA385080378 rs1264093826	123	A>G		No	ClinGen gnomAD
CA237358371 rs1001038358	124	S>C		No	ClinGen Ensembl
CA385080328 rs1459274128	127	C>R		No	ClinGen gnomAD
rs753357293 CA6602718	129	P>A		No	ClinGen ExAC gnomAD
rs753357293 CA6602717	129	P>S		No	ClinGen ExAC gnomAD
rs760630122 CA385080290	130	P>Q		No	ClinGen ExAC gnomAD
rs760630122 CA6602715	130	P>R		No	ClinGen ExAC gnomAD
rs765992393 CA6602716	130	P>S		No	ClinGen ExAC TOPMed gnomAD
CA237358367 rs756543569	133	E>G		No	ClinGen TOPMed gnomAD
rs773338922 CA6602714	133	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1360548051 CA385079514	136	V>F		No	ClinGen TOPMed gnomAD
CA385079493 rs1565929320	137	T>N		No	ClinGen Ensembl
rs1592808249 CA385079498	137	T>P		No	ClinGen Ensembl
CA385079454 rs1387823346	140	P>A		No	ClinGen gnomAD
rs1565929293 CA385079436	141	V>D		No	ClinGen Ensembl
CA385079416 rs1388109792	143	I>F		No	ClinGen gnomAD
rs1165304667 CA385079388	145	T>A		No	ClinGen TOPMed gnomAD
rs1425063517 CA385079383	145	T>N		No	ClinGen TOPMed gnomAD
rs1165304667 CA385079390	145	T>P		No	ClinGen TOPMed gnomAD
CA6602695 rs767401896	146	P>S		No	ClinGen ExAC gnomAD
rs773980962 CA6602693	149	T>A		No	ClinGen ExAC gnomAD
rs773980962 CA385079332	149	T>P		No	ClinGen ExAC gnomAD
CA385079313 rs1484151341	150	I>V		No	ClinGen gnomAD
rs1237825732 CA385079297	151	V>I		No	ClinGen gnomAD
rs1211928764 CA385079281 COSM3398854	152	R>C	central_nervous_system [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs768505148 COSM3772664 CA6602692	152	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1272616708 CA385079245	154	G>V		No	ClinGen TOPMed gnomAD
CA385079241 rs1592808002	155	S>P		No	ClinGen Ensembl
rs763108851 CA6602691	158	L>P		No	ClinGen ExAC gnomAD
rs558589104 CA6602689	159	H>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6602688 rs558589104	159	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1381854521 CA385079173	160	L>F		No	ClinGen gnomAD
rs747554656 CA6602685	161	G>A		No	ClinGen ExAC TOPMed gnomAD
CA6602686 rs747554656	161	G>D		No	ClinGen ExAC TOPMed gnomAD
rs747554656 CA385079168	161	G>V		No	ClinGen ExAC TOPMed gnomAD
rs367730193 CA6602684	162	Y>C		No	ClinGen ESP ExAC gnomAD
CA385079131 rs1309330356	167	P>A		No	ClinGen gnomAD
CA385079122 rs1429754568	168	T>N		No	ClinGen gnomAD
CA385079125 rs1592807877	168	T>P		No	ClinGen Ensembl
CA6602681 rs779890063	172	P>L		No	ClinGen ExAC gnomAD
CA237357631 rs1048148817	172	P>S		No	ClinGen Ensembl
rs755660019 CA6602680	173	T>A		No	ClinGen ExAC TOPMed gnomAD
rs767082558 CA6602678	177	T>A		No	ClinGen ExAC gnomAD
rs1249823603 CA385079048	178	Q>*		No	ClinGen TOPMed gnomAD
rs1249823603 CA385079050	178	Q>E		No	ClinGen TOPMed gnomAD
CA237357629 rs539048082	178	Q>H		No	ClinGen gnomAD
rs757078736 CA6602677	184	R>T		No	ClinGen ExAC gnomAD
rs751531265 CA6602676	186	M>I		No	ClinGen ExAC gnomAD
CA385078728 rs1304588401	192	S>T		No	ClinGen gnomAD
rs772532612 CA6602665	192	S>Y		No	ClinGen ExAC gnomAD
CA237356877 rs867384786	198	H>R		No	ClinGen TOPMed
rs1274279486 CA385078556	200	A>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA385078398 rs1296075393	205	M>T		No	ClinGen gnomAD
CA237356864 rs978219733	216	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA237356858 rs777022786	219	I>M		No	ClinGen gnomAD
rs372435342 COSM941038 CA6602660	220	S>L	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
rs945074150 CA237356848	220	S>P		No	ClinGen TOPMed
rs544146784 CA6602639	222	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1367224951 CA385076658	225	V>M		No	ClinGen gnomAD
rs1395182061 CA385076612	226	S>T		No	ClinGen gnomAD
CA385076600 rs1360368616	227	M>L		No	ClinGen TOPMed
CA6602637 rs769158979	228	V>A		No	ClinGen ExAC TOPMed gnomAD
CA6602638 rs371280390	228	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA237356484 rs1009302687	231	I>M		No	ClinGen Ensembl
CA6602636 rs745497695	231	I>S		No	ClinGen ExAC gnomAD
rs1448235783 CA385076465	232	P>H		No	ClinGen gnomAD
CA385076440 rs1250372470	233	G>V		No	ClinGen gnomAD
rs1254501724 CA385076373	235	P>L		No	ClinGen gnomAD
CA6602635 rs377621370	235	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6602634 rs770319516	236	G>V		No	ClinGen ExAC gnomAD
rs777288564 CA6602632	237	P>L		No	ClinGen ExAC gnomAD
CA6602633 rs746579725	237	P>S		No	ClinGen ExAC gnomAD
CA6602630 rs375304633	241	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA6602629 rs778664832	242	S>R		No	ClinGen ExAC gnomAD
rs1000723515 CA237356471	243	G>D		No	ClinGen TOPMed
CA6602628 rs754866750	245	I>L		No	ClinGen ExAC gnomAD
CA385076113 rs1592802362	248	S>P		No	ClinGen Ensembl
CA385076047 rs1592802339	250	H>P		No	ClinGen Ensembl
CA6602626 rs200070412	250	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA6602625 rs760825979	251	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1238956800 CA385076028	251	P>T		No	ClinGen TOPMed
CA385075988 rs1427834284	252	I>T		No	ClinGen gnomAD
CA385075967 rs1421720665	253	P>L		No	ClinGen gnomAD
CA6602624 rs750472425	256	A>T		No	ClinGen ExAC gnomAD
rs903706927 CA237356467	258	M>T		No	ClinGen TOPMed gnomAD
rs373048999 CA6602611	259	R>K		No	ClinGen ESP ExAC
CA385075712 rs1470947163	262	A>V		No	ClinGen gnomAD
rs1319296570 CA385075676	265	T>I		No	ClinGen TOPMed
rs753617105 CA6602610	265	T>S		No	ClinGen ExAC gnomAD
rs1319296570 CA385075678	265	T>S		No	ClinGen TOPMed
CA237356187 rs370004741	266	H>Q		No	ClinGen ESP TOPMed gnomAD
CA385075669 rs1464454373	266	H>R		No	ClinGen TOPMed
rs779740185 CA6602609	266	H>Y		No	ClinGen ExAC gnomAD
rs1402625370 CA385075654	267	Q>H		No	ClinGen TOPMed
CA6602608 rs377461299	268	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA385075633 rs1291863744	269	S>Y		No	ClinGen gnomAD
rs750683783 CA6602607	270	S>L		No	ClinGen ExAC gnomAD
CA385075602 rs1265971342	271	I>V		No	ClinGen gnomAD
rs544572146 CA385075566	272	N>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs544572146 CA6602606	272	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs760681922 CA237356171	274	G>V		No	ClinGen Ensembl
CA6602605 rs762053427	275	C>Y		No	ClinGen ExAC gnomAD
rs539011357 CA237356142	276	G>R		No	ClinGen Ensembl
CA6602603 rs764750823	277	M>I		No	ClinGen ExAC gnomAD
rs752086200 CA385075438	277	M>L		No	ClinGen ExAC TOPMed gnomAD
CA6602604 rs752086200	277	M>V		No	ClinGen ExAC TOPMed gnomAD
CA6602602 rs763392814	278	V>L		No	ClinGen ExAC gnomAD
rs1388430101 CA385075343	280	G>S		No	ClinGen gnomAD
CA6602598 rs760319013	282	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1408175219 CA385075187	286	V>M		No	ClinGen gnomAD
rs775588703 CA6602594	289	R>C		No	ClinGen ExAC TOPMed gnomAD
rs775588703 CA6602595	289	R>G		No	ClinGen ExAC TOPMed gnomAD
rs199777559 CA6602592	289	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199777559 CA6602593	289	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6602591 rs779837589	290	P>L		No	ClinGen ExAC gnomAD
CA6602589 rs139241958	294	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1318973503 CA385074909	295	I>V		No	ClinGen TOPMed gnomAD
CA6602587 rs200961997	296	L>I		No	ClinGen 1000Genomes ExAC gnomAD
CA6602585 rs764112606	299	H>P		No	ClinGen ExAC gnomAD
rs1592800253 CA385074684	302	A>P		No	ClinGen Ensembl
CA6602583 rs753159900	303	P>L		No	ClinGen ExAC gnomAD
rs77776977 CA6602582	304	S>P		No	ClinGen ExAC gnomAD
rs1333168665 CA385074608	305	P>R		No	ClinGen gnomAD
rs772827879 CA6602580	306	A>P		No	ClinGen ExAC gnomAD
CA385074555 rs1448800795	307	Q>R		No	ClinGen TOPMed gnomAD
rs753215408 CA6602562	313	A>S		No	ClinGen ExAC gnomAD
CA237350155 rs953991849	314	Q>E		No	ClinGen TOPMed
CA385071998 rs1231786260	314	Q>R		No	ClinGen gnomAD
CA385071948 rs112122884	316	T>N		No	ClinGen TOPMed gnomAD
CA237350153 rs112122884	316	T>S		No	ClinGen TOPMed gnomAD
rs765711886 CA385071910	318	S>C		No	ClinGen ExAC gnomAD
CA6602561 rs765711886	318	S>G		No	ClinGen ExAC gnomAD
rs755497609 CA6602560	318	S>I		No	ClinGen ExAC gnomAD
CA385071885 rs754161452	319	T>I		No	ClinGen ExAC TOPMed gnomAD
rs754161452 CA385071891	319	T>N		No	ClinGen ExAC TOPMed gnomAD
rs754161452 CA6602559	319	T>S		No	ClinGen ExAC TOPMed gnomAD
CA237350130 rs753884312	322	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6602555 rs763653671	323	R>P		No	ClinGen ExAC gnomAD
rs763653671 CA6602556	323	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA237350124 rs371745709	323	R>W		No	ClinGen ESP gnomAD
CA237350118 rs201908592	324	R>Q		No	ClinGen TOPMed gnomAD
CA6602554 rs762412634	324	R>W		No	ClinGen ExAC gnomAD
CA6602551 rs759577252	325	R>H		No	ClinGen ExAC gnomAD
rs759577252 CA6602552	325	R>L		No	ClinGen ExAC gnomAD
CA385071751 rs1565919438	326	T>A		No	ClinGen Ensembl
rs1592781269 CA385071700	327	V>I		No	ClinGen Ensembl
rs770864141 CA6602549	328	D>V		No	ClinGen ExAC gnomAD
rs776502480 CA6602550	328	D>Y		No	ClinGen ExAC gnomAD
CA385071619 rs1337461013	329	E>K		No	ClinGen gnomAD
CA6602548 rs747223058	330	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA385071357 COSM3792771 rs1333584812	334	R>Q	Variant assessed as Somatic; 4.792e-05 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA385071331 rs1306023146	335	R>Q		No	ClinGen TOPMed
CA385071269 rs1391408696	337	R>C		No	ClinGen gnomAD
rs760791156 CA237350086	337	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA385071153 rs1309875882	342	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA385071156 rs1309875882	342	N>T		No	ClinGen TOPMed
CA385071141 rs1442969845	343	R>Q		No	ClinGen gnomAD
CA385071146 rs772167688	343	R>W		No	ClinGen ExAC gnomAD
CA385070907 rs1362206328	353	R>Q		No	ClinGen gnomAD
CA385070846 rs1324096564	355	L>V		No	ClinGen TOPMed
CA919091197 rs1565919291	356	W>*		No	ClinGen Ensembl
rs1592781048 CA385070766	358	S>A		No	ClinGen Ensembl
CA6602543 rs375648683	359	S>T		No	ClinGen ESP ExAC gnomAD
rs1419820889 CA385070689	362	K>Q		No	ClinGen gnomAD
CA385070629 rs1192363054	365	E>K		No	ClinGen gnomAD
CA6602542 rs754353322	366	E>V		No	ClinGen ExAC gnomAD
CA385070485 rs1348115201	370	Q>H		No	ClinGen TOPMed gnomAD
rs370788955 CA6602541	372	I>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA385070380 rs1239310564	374	L>V		No	ClinGen gnomAD
CA385070131 rs1487695345	376	N>Y		No	ClinGen TOPMed
CA6602525 rs748406956	382	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6602524 rs778796399	383	N>S		No	ClinGen ExAC TOPMed gnomAD
rs768778931 CA6602523	384	E>K		No	ClinGen ExAC gnomAD
rs976363361 CA237349477	396	K>E		No	ClinGen Ensembl
CA385069577 rs1409157464	397	D>V		No	ClinGen TOPMed
CA6602522 rs749787942	400	V>L		No	ClinGen ExAC gnomAD
CA385069492 rs1592778512	401	T>S		No	ClinGen Ensembl
CA385069365 rs1456197222	408	Q>P		No	ClinGen TOPMed
CA6602518 rs145586636	409	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6602519 rs145586636	409	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1376138037 CA385069322	410	Y>S		No	ClinGen gnomAD
CA6602502 rs770163984	420	P>S		No	ClinGen ExAC gnomAD
rs746395605 CA6602501	421	T>A		No	ClinGen ExAC gnomAD
rs781357887 CA6602500	421	T>M		No	ClinGen ExAC TOPMed gnomAD
rs757702111 CA6602499	423	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA6602498 rs747755290	424	P>A		No	ClinGen ExAC gnomAD
CA385066777 rs1439506410	425	A>S		No	ClinGen gnomAD
rs1273701636 CA385066697	429	Q>R		No	ClinGen gnomAD
rs778750390 CA6602497	430	H>R		No	ClinGen ExAC gnomAD
rs774608144 CA385066568	434	T>I		No	ClinGen gnomAD
CA237346672 rs774608144	434	T>K		No	ClinGen gnomAD
rs1592764173 CA385066578	434	T>P		No	ClinGen Ensembl
rs1344386728 CA385066559	435	A>T		No	ClinGen TOPMed
CA385066520 rs1291459229	437	S>C		No	ClinGen Ensembl
CA385066518 rs1274788521	437	S>N		No	ClinGen gnomAD
rs1235394870 CA385066482	438	N>S		No	ClinGen TOPMed gnomAD
CA385066419 rs1392607871	441	S>R		No	ClinGen TOPMed
CA6602496 rs200035659	442	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1512461 CA385066376 rs1326602415	443	R>C	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs560379424 CA6602495	443	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA6602493 rs376315527	445	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1306994461 CA385066313	445	A>T		No	ClinGen TOPMed
rs1230673269 CA385066285	446	A>V		No	ClinGen TOPMed
CA385066222 rs1565913324	451	T>N		No	ClinGen Ensembl
CA385066231 rs1592763990	451	T>P		No	ClinGen Ensembl
CA6602492 rs750432602	452	S>L		No	ClinGen ExAC gnomAD
CA237346647 rs759923052	452	S>P		No	ClinGen Ensembl
rs1592763905 CA385066139	455	T>P		No	ClinGen Ensembl
CA385066086 rs1212699908	456	Q>H		No	ClinGen TOPMed
CA237346641 rs868781389	458	A>V		No	ClinGen TOPMed
rs1461647467 CA385065990	459	S>N		No	ClinGen TOPMed gnomAD
CA6602489 rs561172676	464	L>P		No	ClinGen ExAC gnomAD
CA385065804 rs1407229750	465	S>I		No	ClinGen TOPMed
CA385065763 rs1192983306	466	M>I		No	ClinGen gnomAD
rs922425121 CA237346589	467	P>L		No	ClinGen gnomAD
CA237346603 rs866863073	467	P>S		No	ClinGen Ensembl
CA6602486 rs369327954	469	Q>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1461064502 CA385065661	470	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs574027901 CA237346564	471	H>R		No	ClinGen Ensembl
CA6602482 rs771171680	472	V>I		No	ClinGen ExAC gnomAD
rs1280164795 CA385065575	473	I>T		No	ClinGen gnomAD
CA6602481 rs747327111	473	I>V		No	ClinGen ExAC gnomAD
CA385065564 rs1592763681	474	M>V		No	ClinGen Ensembl
rs369186071 CA6602479	481	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369186071 CA6602480	481	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1328362953 CA385065384	482	G>D		No	ClinGen gnomAD
CA385065368 rs1442174240	483	R>K		No	ClinGen gnomAD

No associated diseases with P17544

2 regional properties for P17544

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	120 - 380	IPR000719
active_site	Serine/threonine-protein kinase, active site	239 - 251	IPR008271

Functions

		Description
EC Number
Subcellular Localization	Nucleus Nucleus, nucleoplasm Chromosome, telomere	Mainly nucleoplasmic Restricted distribution to the perinuculear region The sumoylated form locates to the nuclear periphery
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
chromosome, telomeric region	The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase II transcription regulator complex	A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.

11 GO annotations of molecular function

Name	Definition
cAMP response element binding	Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription repressor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
metal ion binding	Binding to a metal ion.
mitogen-activated protein kinase binding	Binding to a mitogen-activated protein kinase.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
transcription coactivator binding	Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.

4 GO annotations of biological process

Name	Definition
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

8 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O93602	ATF2	Cyclic AMP-dependent transcription factor ATF-2	Gallus gallus (Chicken)	SS
P15408	FOSL2	Fos-related antigen 2	Homo sapiens (Human)	PR
Q02930	CREB5	Cyclic AMP-responsive element-binding protein 5	Homo sapiens (Human)	SS
P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	Homo sapiens (Human)	EV
P47930	Fosl2	Fos-related antigen 2	Mus musculus (Mouse)	PR
P16951	Atf2	Cyclic AMP-dependent transcription factor ATF-2	Mus musculus (Mouse)	SS
Q8R0S1	Atf7	Cyclic AMP-dependent transcription factor ATF-7	Mus musculus (Mouse)	PR
Q00969	Atf2	Cyclic AMP-dependent transcription factor ATF-2	Rattus norvegicus (Rat)	SS

10	20	30	40	50	60
MGDDRPFVCN	APGCGQRFTN	EDHLAVHKHK	HEMTLKFGPA	RTDSVIIADQ	TPTPTRFLKN
70	80	90	100	110	120
CEEVGLFNEL	ASSFEHEFKK	AADEDEKKAA	AGPLDMSLPS	TPDIKIKEEE	PVEVDSSPPD
130	140	150	160	170	180
SPASSPCSPP	LKEKEVTPKP	VLISTPTPTI	VRPGSLPLHL	GYDPLHPTLP	SPTSVITQAP
190	200	210	220	230	240
PSNRQMGSPT	GSLPLVMHLA	NGQTMPVLPG	PPVQMPSVIS	LARPVSMVPN	IPGIPGPPVN
250	260	270	280	290	300
SSGSISPSGH	PIPSEAKMRL	KATLTHQVSS	INGGCGMVVG	TASTMVTARP	EQSQILIQHP
310	320	330	340	350	360
DAPSPAQPQV	SPAQPTPSTG	GRRRRTVDED	PDERRQRFLE	RNRAAASRCR	QKRKLWVSSL
370	380	390	400	410	420
EKKAEELTSQ	NIQLSNEVTL	LRNEVAQLKQ	LLLAHKDCPV	TALQKKTQGY	LESPKESSEP
430	440	450	460	470	480
TGSPAPVIQH	SSATAPSNGL	SVRSAAEAVA	TSVLTQMASQ	RTELSMPIQS	HVIMTPQSQS

AGR