AiPD: Autoinhibited Protein Database

P17252

Gene name	PRKCA (PKCA, PRKACA)
Protein name	Protein kinase C alpha type
Names	PKC-A, PKC-alpha
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5578
EC number	2.7.11.13: Protein-serine/threonine kinases
Protein Class	SERINE/THREONINE-PROTEIN KINASE (PTHR24356)

Descriptions

PRKCA encodes for Protein kinase C (PKC) alpha type belonging to the PCKs family and is involved in various cellular processes, including cell growth, immune response, muscle contraction, and synaptic plasticity. A well-known autoinhibitory region of the PKC family is a pseudosubstrate sequence at residues 1-30 that directly interacts with and blocks the catalytic activity of the kinase domain. Subsequences of the pseudosubstrate region are the C1 domains (C1A and C1B that bind diacylglycerol (DAG)), and the C2 domain (which binds to anionic phospholipids in a Ca2+-dependent manner). The C1A (residues 31-100) domain coordinates a network of domain-domain intramolecular interactions, including direct C1A-C2 contacts. The pseudosubstrate and C1A domains function as a single functional unit and are required to maintain autoinhibition. Additionally, the absence of the C1A domain significantly increases basal activity.

Autoinhibitory domains (AIDs)

Target domain	328-668 (Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha)
Relief mechanism	Ligand binding
Assay	Mutagenesis experiment, Deletion assay, Structural analysis

AID

1-30 (Pseudosubstrate domain)

Target domain

328-668 (Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha)

Relief mechanism

Ligand binding (Binding of anionic phospholipids to the C2 domain)

Assay

Mutagenesis experiment, Deletion assay, Structural analysis

Target domain	328-668 (Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha)
Relief mechanism	Ligand binding
Assay	Mutagenesis experiment, Deletion assay

AID

31-100 (C1A domain)

Target domain

328-668 (Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha)

Relief mechanism

Ligand binding (Binding of anionic phospholipids to the C2 domain)

Assay

Mutagenesis experiment, Deletion assay

Accessory elements

480-503 (Activation loop from InterPro)

Target domain	328-668 (Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha)
Relief mechanism
Assay

References

Steinberg SF (2008) "Structural basis of protein kinase C isoform function", Physiological reviews, 88, 1341-78

Sommese RF et al. (2017) "The Role of Regulatory Domains in Maintaining Autoinhibition in the Multidomain Kinase PKCα", The Journal of biological chemistry, 292, 2873-2880

Pears CJ et al. (1990) "Mutagenesis of the pseudosubstrate site of protein kinase C leads to activation", European journal of biochemistry, 194, 89-94

Smith MK et al. (1990) "Specificities of autoinhibitory domain peptides for four protein kinases. Implications for intact cell studies of protein kinase function", The Journal of biological chemistry, 265, 1837-40

Slater SJ et al. (2002) "Regulation of PKC alpha activity by C1-C2 domain interactions", The Journal of biological chemistry, 277, 15277-85

Jones AC et al. (2020) "Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes", IUBMB life, 72, 2584-2590

Kirwan AF et al. (2003) "Inhibition of protein kinase C catalytic activity by additional regions within the human protein kinase Calpha-regulatory domain lying outside of the pseudosubstrate sequence", The Biochemical journal, 373, 571-81

Huang X et al. (2003) "Crystal structure of an inactive Akt2 kinase domain", Structure (London, England : 1993), 11, 21-30

Truebestein L et al. (2021) "Structure of autoinhibited Akt1 reveals mechanism of PIP(3)-mediated activation", Proceedings of the National Academy of Sciences of the United States of America, 118,

Lučić I et al. (2018) "Conformational sampling of membranes by Akt controls its activation and inactivation", Proceedings of the National Academy of Sciences of the United States of America, 115, E3940-E3949

Wagner J et al. (2009) "Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes", Journal of medicinal chemistry, 52, 6193-6

Autoinhibited structure

Activated structure

7 structures for P17252

Entry ID	Method	Resolution	Chain	Position	Source
2ELI	NMR	-	A	93-169	PDB
3IW4	X-ray	280 A	A/B/C	320-672	PDB
4DNL	X-ray	190 A	A	155-293	PDB
4RA4	X-ray	263 A	A	318-672	PDB
8U37	X-ray	248 A	A	320-672	PDB
8UAK	X-ray	282 A	A	320-672	PDB
AF-P17252-F1	Predicted				AlphaFoldDB

350 variants for P17252

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1169715895 CA400679737	2	A>G		No	ClinGen TOPMed
rs571827499 CA293124407	4	V>I		No	ClinGen Ensembl
CA400679764 rs879211098	6	P>L		No	ClinGen gnomAD
rs879211098 CA293124419	6	P>R		No	ClinGen gnomAD
rs761243704 CA8720584	7	G>D		No	ClinGen ExAC gnomAD
rs1241363040 CA400679765	7	G>S		No	ClinGen gnomAD
CA8720585 rs201024698	8	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA8720586 rs754430626	9	D>Y		No	ClinGen ExAC gnomAD
CA400679800 rs1567761628	12	A>G		No	ClinGen Ensembl
CA400679807 rs1220774095	13	S>F		No	ClinGen gnomAD
CA293124435 rs956503012	14	Q>E		No	ClinGen TOPMed gnomAD
CA293124438 rs12944151	14	Q>H		No	ClinGen Ensembl
CA400679810 rs1334216181	14	Q>P		No	ClinGen gnomAD
CA8720589 rs370194402	15	D>E		No	ClinGen ESP ExAC gnomAD
rs370194402 CA400679820	15	D>E		No	ClinGen ESP ExAC gnomAD
rs758584716 CA8720590	16	V>L		No	ClinGen ExAC gnomAD
rs747039638 CA8720592	17	A>V		No	ClinGen ExAC gnomAD
rs542395606 CA8720594	18	N>K		No	ClinGen ExAC gnomAD
rs755078848 CA8720593	18	N>S		No	ClinGen ExAC TOPMed gnomAD
CA400679840 rs1346778661	19	R>H		No	ClinGen gnomAD
rs1264883870 CA400679854	21	A>V		No	ClinGen gnomAD
rs1261479202 CA400679866	23	K>R		No	ClinGen gnomAD
rs527574267 CA293124452	32	H>N		No	ClinGen Ensembl
CA8720596 rs749195097	32	H>Q		No	ClinGen ExAC gnomAD
CA400679930 rs749195097	32	H>Q		No	ClinGen ExAC gnomAD
CA293124459 rs987622627	33	E>Q		No	ClinGen TOPMed
rs1193055442 CA400679993	41	A>S		No	ClinGen gnomAD
CA8720599 rs200801878	45	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1567761731 CA400680045	48	T>I		No	ClinGen Ensembl
CA400680041 rs1321995232	48	T>P		No	ClinGen gnomAD
rs760225427 CA8720601	50	C>S		No	ClinGen ExAC gnomAD
CA400680071 rs1332665914	52	H>N		No	ClinGen gnomAD
rs768288690 CA8720602	52	H>R		No	ClinGen ExAC gnomAD
rs1229194759 CA400680101	56	F>Y		No	ClinGen gnomAD
CA400680112 rs1330669334	57	I>M		No	ClinGen TOPMed
rs1231145168 CA400680107	57	I>V		No	ClinGen TOPMed
rs1208642777 CA400680140 COSM1239941	60	F>L	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed
CA293125379 rs376921936	68	Q>H		No	ClinGen ESP TOPMed
rs1567858622 CA400801675	80	E>A		No	ClinGen Ensembl
CA400801687 rs1168036317	81	F>L		No	ClinGen gnomAD
rs1461673002 CA400801720	86	C>*		No	ClinGen gnomAD
rs915754719 COSM4139760 CA293516493	89	A>V	ovary [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1450533796 CA400801743	90	D>G		No	ClinGen gnomAD
COSM983139 rs758445868 CA8720653	94	D>N	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8720654 rs766268531	95	T>S		No	ClinGen ExAC gnomAD
CA8720678 rs762002113	100	S>N		No	ClinGen ExAC gnomAD
CA8720679 rs766356302	101	K>R		No	ClinGen ExAC TOPMed gnomAD
CA400685067 rs1165951448	103	K>N		No	ClinGen gnomAD
rs1445801890 CA400685062	103	K>R		No	ClinGen gnomAD
rs1355069162 CA400685083	105	K>E		No	ClinGen TOPMed
CA293153097 rs201729185	106	I>V		No	ClinGen Ensembl
rs267605006 CA293153101	107	H>Y		No	ClinGen Ensembl
rs752262521 CA8720683	113	T>A		No	ClinGen ExAC gnomAD
CA293153161 rs879027569	117	H>R		No	ClinGen TOPMed gnomAD
CA293153167 rs201664310	122	L>H		No	ClinGen 1000Genomes
CA293153169 rs1038606242	123	Y>C		No	ClinGen Ensembl
CA400685309 rs1205570869	127	H>R		No	ClinGen gnomAD
rs753287547 CA8720686	127	H>Y		No	ClinGen ExAC gnomAD
rs1236116445 CA400685351	132	C>W		No	ClinGen TOPMed gnomAD
rs1324531129 CA400685389	136	D>N		No	ClinGen gnomAD
rs879077468 CA293155987	137	M>T		No	ClinGen Ensembl
CA8720716 rs773494079	137	M>V		No	ClinGen ExAC gnomAD
CA8720717 rs759379662	138	N>D		No	ClinGen ExAC gnomAD
rs1567951979 CA400685412	139	V>A		No	ClinGen Ensembl
CA8720718 rs771987815	139	V>I		No	ClinGen ExAC TOPMed gnomAD
CA8720720 rs760478437	141	K>N		No	ClinGen ExAC
CA8720719 rs775294696	141	K>R		No	ClinGen ExAC gnomAD
rs776243082 CA8720722	144	V>I		No	ClinGen ExAC gnomAD
rs376472217 CA8720724	145	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA8720723 rs761489847	145	I>N		No	ClinGen ExAC
rs1459780030 CA400685450	145	I>V		No	ClinGen TOPMed
rs750003387 CA8720725	146	N>S		No	ClinGen ExAC gnomAD
CA400685461 rs1196245554	147	V>I		No	ClinGen TOPMed
rs752033472 CA8720728	149	S>R		No	ClinGen ExAC gnomAD
rs752033472 CA400685479	149	S>R		No	ClinGen ExAC gnomAD
CA8720730 rs781720378	152	G>R		No	ClinGen ExAC gnomAD
CA400685525 rs1567952072	156	T>A		No	ClinGen Ensembl
CA400685543 rs1382662679	158	K>R		No	ClinGen TOPMed gnomAD
rs1567952088 CA400685549	159	R>T		No	ClinGen Ensembl
rs1303564138 COSM76052 CA400685561	161	R>Q	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
CA293156044 rs372542565	162	I>V		No	ClinGen ESP TOPMed
rs1407008672 CA400685574	163	Y>F		No	ClinGen gnomAD
rs778155542 CA8720733	165	K>N		No	ClinGen ExAC TOPMed gnomAD
CA8720734 rs749323079	166	A>T		No	ClinGen ExAC gnomAD
CA400685594 rs1263068379	166	A>V		No	ClinGen gnomAD
rs1349191801 CA400685624	171	E>Q		No	ClinGen gnomAD
CA400685632 rs1216473892	172	K>E		No	ClinGen TOPMed gnomAD
rs376898012 CA8720735	174	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs376898012 CA400685649	174	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1710660 rs1567952142 CA400685647	174	H>Y	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
COSM163728 rs1462693086 CA400684183	178	R>*	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
rs151214307 CA293134860	178	R>Q		No	ClinGen ESP TOPMed gnomAD
CA400684211 rs1446131290	182	N>S		No	ClinGen gnomAD
rs776863583 CA8720756	182	N>Y		No	ClinGen ExAC gnomAD
rs778898336 CA8720757	183	L>R		No	ClinGen ExAC gnomAD
CA400684237 COSM1710661 rs1308387490	186	M>I	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
CA8720758 rs200732611	186	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1037966573 CA293134886	201	I>T		No	ClinGen TOPMed
rs776558609 CA293134894	203	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1368594029 CA400684348	203	D>H		No	ClinGen gnomAD
rs776558609 CA8720760	203	D>V		No	ClinGen ExAC TOPMed gnomAD
CA400684366 rs1343859163	205	K>N		No	ClinGen TOPMed
rs1200620032 CA400684363	205	K>R		No	ClinGen TOPMed
CA400684404 rs1459950139	210	Q>R		No	ClinGen gnomAD
CA400684424 rs1411621502	213	K>T		No	ClinGen gnomAD
CA400684438 rs1181146279	215	I>N		No	ClinGen gnomAD
rs769603612 CA8720762	216	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8720763 rs532000022	216	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs140400644 CA8720764	217	S>C		No	ClinGen ESP ExAC
rs759130548 CA8720767	221	P>L		No	ClinGen ExAC TOPMed gnomAD
CA8720769 rs753286297	222	Q>H		No	ClinGen ExAC gnomAD
rs1428713498 CA400684503	225	E>A		No	ClinGen TOPMed
CA400684500 rs1297560368	225	E>Q		No	ClinGen TOPMed
rs761072166 CA293134929	228	T>I		No	ClinGen ExAC gnomAD
rs761072166 CA8720770	228	T>K		No	ClinGen ExAC gnomAD
rs1337976930 CA400684572	233	P>R		No	ClinGen gnomAD
CA400684570 rs1360216746	233	P>S		No	ClinGen gnomAD
rs1404643413 CA400684601	237	D>G		No	ClinGen TOPMed
CA293135382 rs878902960	238	R>*		No	ClinGen gnomAD
CA400684606 rs776118914	238	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8720787 rs776118914	238	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8720788 rs761303069	239	R>*		No	ClinGen ExAC gnomAD
rs199575835 CA8720790	242	V>I		No	ClinGen ExAC TOPMed gnomAD
rs199575835 CA8720789	242	V>L		No	ClinGen ExAC TOPMed gnomAD
CA400684630 rs1318686404	243	E>G		No	ClinGen gnomAD
CA293135404 rs879174883	247	W>R		No	ClinGen Ensembl
CA8720792 rs1191887100	249	R>Q		No	ClinGen TOPMed
rs749197302 CA293135405	252	R>G		No	ClinGen Ensembl
CA8720795 rs750671800	254	D>V		No	ClinGen ExAC gnomAD
rs1257897049 CA400684718	255	F>L		No	ClinGen TOPMed
rs758455185 CA8720796	256	M>V		No	ClinGen ExAC gnomAD
CA8720799 rs756067154	266	L>V		No	ClinGen ExAC gnomAD
CA400684795 rs1231170984	267	M>I		No	ClinGen TOPMed
rs1408759009 CA400684791	267	M>L		No	ClinGen TOPMed gnomAD
rs748972010 CA8720801	269	M>I		No	ClinGen ExAC TOPMed
rs770791840 CA8720802	270	P>L		No	ClinGen ExAC TOPMed gnomAD
rs770791840 CA400684817	270	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA400684825 rs1425686580	272	S>C		No	ClinGen gnomAD
CA293135439 rs771675464	272	S>R		No	ClinGen ExAC TOPMed gnomAD
rs372242332 CA8720804	272	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs745511133 CA8720822	275	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs140607549 CA8720824	278	L>F		No	ClinGen ESP ExAC gnomAD
CA400684901 rs1309379769	281	E>K		No	ClinGen gnomAD
CA400684917 rs1196807485	283	G>S		No	ClinGen gnomAD
rs748732162 CA8720828	288	V>I		No	ClinGen ExAC gnomAD
CA8720829 rs770142713	289	P>S		No	ClinGen ExAC gnomAD
rs773628505 CA8720830	290	I>V		No	ClinGen ExAC gnomAD
CA400684977 rs1168175864	291	P>L		No	ClinGen TOPMed gnomAD
CA293135771 rs121917733	294	D>G		No	ClinGen Ensembl
CA8720835 rs774664493	299	M>V		No	ClinGen ExAC gnomAD
rs1598875342 CA400685159	301	L>F		No	ClinGen Ensembl
rs759487890 CA8720836	302	R>K		No	ClinGen ExAC gnomAD
CA400685228 rs1598875352	305	F>S		No	ClinGen Ensembl
rs1355720093 CA400685238	306	E>K		No	ClinGen TOPMed
rs772038327 CA8720855	310	L>V		No	ClinGen ExAC gnomAD
rs760849115 CA8720857	312	P>R		No	ClinGen ExAC gnomAD
CA400685718 rs1220072648	312	P>S		No	ClinGen TOPMed
rs1288619916 CA400685750	317	V>I		No	ClinGen gnomAD
CA8720858 rs765196382	319	S>N		No	ClinGen ExAC gnomAD
CA8720860 rs762784660	321	S>P		No	ClinGen ExAC gnomAD
rs1196162859 CA400685790	323	D>H		No	ClinGen gnomAD
CA8720863 rs754719581	324	R>G		No	ClinGen ExAC gnomAD
rs1160172620 CA400685797	324	R>K		No	ClinGen gnomAD
rs1269273559 CA400685806	325	K>R		No	ClinGen TOPMed
CA400685811 rs1378321864	326	Q>E		No	ClinGen gnomAD
rs1418829771 CA400685819	327	P>A		No	ClinGen TOPMed gnomAD
CA8720864 rs780725433	327	P>L		No	ClinGen ExAC gnomAD
CA8720865 rs752189270	328	S>A		No	ClinGen ExAC gnomAD
CA8720866 rs149601883	329	N>D		No	ClinGen ESP ExAC gnomAD
CA400685836 rs1330535595	330	N>D		No	ClinGen gnomAD
CA400685845 rs1383892769	331	L>V		No	ClinGen Ensembl
CA400685849 rs1303683158	332	D>N		No	ClinGen TOPMed
rs749845868 CA8720868	333	R>*		No	ClinGen ExAC TOPMed gnomAD
CA8720869 rs376086959	333	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8720870 rs376086959	333	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1383145434 CA400685863	334	V>A		No	ClinGen gnomAD
rs1274003131 CA400685875	336	L>F		No	ClinGen TOPMed
rs148368351 CA8720872	337	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1489277782 CA400685904	340	N>S		No	ClinGen gnomAD
rs773258598 CA8720876	343	M>T		No	ClinGen ExAC gnomAD
CA8720877 rs373125854	344	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8720904 rs147347370	357	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8720905 rs765731873	360	G>S		No	ClinGen ExAC gnomAD
CA8720906 rs139505198	365	Y>F		No	ClinGen ESP ExAC TOPMed
rs1158533362 CA400686132	371	K>N		No	ClinGen gnomAD
CA400686155 rs1321517380	375	V>M		No	ClinGen Ensembl
CA400686167 rs879041600	376	I>M		No	ClinGen TOPMed
rs1220047208 CA400686165	376	I>T		No	ClinGen gnomAD
rs1417568507 CA400686176	378	D>N		No	ClinGen TOPMed
rs748202197 CA8720914	381	V>M		No	ClinGen ExAC TOPMed gnomAD
rs769786910 CA8720916	385	M>K		No	ClinGen ExAC gnomAD
rs769786910 CA8720915	385	M>T		No	ClinGen ExAC gnomAD
rs745835054 CA8720917	388	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA400686256 rs1199673071	389	R>*		No	ClinGen TOPMed gnomAD
COSM983153 CA8720918 rs561747335	389	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA400686262 rs1260537657	390	V>A		No	ClinGen TOPMed
rs775320348 CA8720919	390	V>I		No	ClinGen ExAC TOPMed gnomAD
CA293167562 rs878948261	392	A>V		No	ClinGen TOPMed
rs1568003918 CA400686285	394	L>P		No	ClinGen Ensembl
CA8720920 rs760475739	395	D>E		No	ClinGen ExAC gnomAD
rs912687125 CA293167581	395	D>G		No	ClinGen Ensembl
rs1421635110 CA400686301	397	P>T		No	ClinGen gnomAD
rs145121663 CA8720921	398	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs145121663 CA8720922	398	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA400686309 rs1477516481	398	P>S		No	ClinGen gnomAD
rs764698470 CA8720924	401	T>M		No	ClinGen ExAC gnomAD
CA400686350 rs995374816	404	H>Q		No	ClinGen TOPMed gnomAD
rs995374816 CA293167620	404	H>Q		No	ClinGen TOPMed gnomAD
CA400686357 rs1339360556	406	C>S		No	ClinGen gnomAD
rs1598908430 CA400686406	411	D>Y		No	ClinGen Ensembl
rs1025381258 CA293169732	412	R>Q		No	ClinGen gnomAD
CA400686436 rs768035157	415	F>L		No	ClinGen ExAC TOPMed gnomAD
CA8720948 rs541841621	416	V>I		No	ClinGen ExAC TOPMed gnomAD
rs756351469 CA8720949	420	V>I		No	ClinGen ExAC gnomAD
rs1331371121 COSM3764621 CA400686480	422	G>S	central_nervous_system [Cosmic]	No	ClinGen cosmic curated TOPMed
CA8720953 rs531167467	426	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs565487208 CA8720952	426	M>T		No	ClinGen 1000Genomes ExAC
CA8720954 rs375513201	430	Q>*		No	ClinGen ESP ExAC gnomAD
CA293169805 rs375513201	430	Q>K		No	ClinGen ESP ExAC gnomAD
rs1598908491 CA400686556	433	G>R		No	ClinGen Ensembl
CA400686578 rs1157234209	436	K>E		No	ClinGen gnomAD
rs1396470503 CA400686591	437	E>D		No	ClinGen TOPMed
CA293169815 rs990115740	437	E>G		No	ClinGen Ensembl
rs780913123 CA8720956	440	A>V		No	ClinGen ExAC gnomAD
CA8720975 rs747860021	443	Y>*		No	ClinGen ExAC gnomAD
CA8720976 COSM212252 rs755962439	444	A>V	endometrium breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs772638644 CA8720982	452	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1175972657 CA400686699	452	F>L		No	ClinGen TOPMed gnomAD
CA400686714 rs1278940098	454	L>V		No	ClinGen gnomAD
CA8720984 rs760897668	457	R>I		No	ClinGen ExAC gnomAD
rs916837548 CA293172148	458	G>A		No	ClinGen TOPMed gnomAD
COSM1180088 CA8720998 rs745329705	469	V>I	pancreas prostate [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA400686837 rs1568007965	470	M>K		No	ClinGen Ensembl
rs771633891 CA8720999	470	M>L		No	ClinGen ExAC gnomAD
rs1568007965 CA400686838	470	M>T		No	ClinGen Ensembl
CA8721000 rs771633891	470	M>V		No	ClinGen ExAC gnomAD
rs768894580 CA8721002	474	E>K		No	ClinGen ExAC gnomAD
rs765405625 CA8721005	485	C>G		No	ClinGen ExAC
rs1377657903 CA400686980	489	M>I		No	ClinGen gnomAD
rs34406842 VAR_042303 CA8721007	489	M>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs766524625 CA8721008	490	M>T		No	ClinGen ExAC gnomAD
CA8721009 rs752577272	491	D>G		No	ClinGen ExAC TOPMed gnomAD
rs760726899 CA8721010	493	V>I		No	ClinGen ExAC gnomAD
rs763954407 CA400687012	494	T>M		No	ClinGen ExAC TOPMed gnomAD
rs763954407 CA8721011	494	T>R		No	ClinGen ExAC TOPMed gnomAD
rs867898293 CA293172787	498	F>I		No	ClinGen Ensembl
rs750145950 CA8721015	506	A>P		No	ClinGen ExAC TOPMed gnomAD
CA400687089 rs750145950	506	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8721016 rs757811919	508	E>V		No	ClinGen ExAC gnomAD
rs750091036 CA8721034	511	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8721036 rs758127330	512	Y>F		No	ClinGen ExAC
CA8721037 rs779586057	514	P>L		No	ClinGen ExAC TOPMed gnomAD
rs929429787 CA293155223	516	G>E		No	ClinGen TOPMed gnomAD
rs1400087303 CA400687168	516	G>R		No	ClinGen TOPMed
CA400687182 rs1181432857	518	S>P		No	ClinGen gnomAD
CA8721040 rs781649712	524	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs748695583 CA8721041	525	G>S		No	ClinGen ExAC gnomAD
COSM561868 CA8721043 rs563946455	526	V>I	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA400687253 rs1398642855	528	L>F		No	ClinGen gnomAD
rs1568025885 CA400687274	531	M>T		No	ClinGen Ensembl
CA293166651 rs926571782	542	D>N		No	ClinGen Ensembl
rs1568034041 CA400687847	542	D>V		No	ClinGen Ensembl
rs989781281 CA293166667	544	D>N		No	ClinGen gnomAD
rs1482134884 CA400687865	545	E>K		No	ClinGen TOPMed gnomAD
CA293166684 rs34133255	548	Q>H		No	ClinGen Ensembl
CA293166702 rs145582519	550	I>V		No	ClinGen ESP TOPMed gnomAD
rs200189588 CA293166713	554	N>H		No	ClinGen Ensembl
CA293166731 rs945360674	554	N>S		No	ClinGen TOPMed gnomAD
CA293166735 rs1041174047	555	V>I		No	ClinGen TOPMed gnomAD
CA400687946 rs1340824301	556	S>F		No	ClinGen TOPMed
rs758561582 CA400687954	557	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs932834899 CA293166755	558	P>Q		No	ClinGen Ensembl
CA400687969 rs1308056551	560	S>P		No	ClinGen gnomAD
CA8721067 rs775765715	562	S>T		No	ClinGen ExAC
rs1205271820 CA400687991	563	K>M		No	ClinGen TOPMed gnomAD
rs1205271820 CA400687990	563	K>R		No	ClinGen TOPMed gnomAD
CA400688009 rs1174674611	566	V>L		No	ClinGen TOPMed
CA8721068 rs6504459 VAR_050558	568	V>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA8721071 rs762789455	570	K>Q		No	ClinGen ExAC
CA8721118 rs763386871	573	M>I		No	ClinGen ExAC gnomAD
CA8721117 rs750987304	573	M>L		No	ClinGen ExAC gnomAD
CA8721119 rs766918637	574	T>I		No	ClinGen ExAC gnomAD
rs1598945323 CA400688082	575	K>N		No	ClinGen Ensembl
rs1598945336 CA400688087	576	H>P		No	ClinGen Ensembl
rs751820837 CA8721120	576	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA400688086 rs1272799772	576	H>Y		No	ClinGen gnomAD
CA8721122 rs755097684	578	A>G		No	ClinGen ExAC gnomAD
CA8721121 rs755097684	578	A>V		No	ClinGen ExAC gnomAD
CA8721123 rs752683507	579	K>N		No	ClinGen ExAC gnomAD
CA400688107 rs752683507	579	K>N		No	ClinGen ExAC gnomAD
CA400688109 rs1467859917	580	R>W		No	ClinGen TOPMed
CA400688132 rs1193798167	584	G>R		No	ClinGen TOPMed gnomAD
CA8721126 rs144172717	586	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144172717 CA8721125	586	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8721128 rs779879529	587	G>R		No	ClinGen ExAC gnomAD
CA293168319 rs779879529	587	G>W		No	ClinGen ExAC gnomAD
CA400688158 rs1598945398	588	E>G		No	ClinGen Ensembl
rs1283176712 CA400688171	590	D>N		No	ClinGen TOPMed
CA8721131 rs776376975	591	V>M		No	ClinGen ExAC TOPMed gnomAD
CA400688190 rs1304789263	593	E>Q		No	ClinGen TOPMed
rs867890925 CA293168349	594	H>N		No	ClinGen gnomAD
rs867890925 CA400688198	594	H>Y		No	ClinGen gnomAD
CA400688216 rs769392914	596	F>L		No	ClinGen ExAC TOPMed gnomAD
CA400688224 rs1328249752	597	F>L		No	ClinGen gnomAD
rs773823088 CA8721134	598	R>W		No	ClinGen ExAC TOPMed gnomAD
rs763614166 CA8721135	599	R>W		No	ClinGen ExAC gnomAD
CA293168384 rs923604011	601	D>N		No	ClinGen TOPMed
CA8721136 rs767006638	602	W>*		No	ClinGen ExAC gnomAD
rs1236969177 CA400688258	603	E>K		No	ClinGen gnomAD
CA400688269 rs1157251571	604	K>T		No	ClinGen TOPMed
rs759979805 CA8721138	607	N>H		No	ClinGen ExAC gnomAD
CA293168388 rs765617766	608	R>G		No	ClinGen gnomAD
CA8721139 COSM1263057 rs767590051	609	E>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA400688313 rs1568035475	610	I>M		No	ClinGen Ensembl
CA400688328 rs1192456628	613	P>T		No	ClinGen gnomAD
CA400688364 rs1191547383	618	V>M		No	ClinGen gnomAD
CA293182340 rs369523075	619	C>Y		No	ClinGen ESP TOPMed
CA293182351 rs879207427	621	K>R		No	ClinGen Ensembl
rs1289928115 CA400688406	622	G>*		No	ClinGen TOPMed
rs868351119 CA293182352	622	G>E		No	ClinGen Ensembl
rs1598021084 CA400688450	628	K>T		No	ClinGen Ensembl
rs755762168 CA8721171	629	F>S		No	ClinGen ExAC TOPMed gnomAD
rs561355502 COSM1324893 CA8721173	632	R>*	ovary [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA8721174 COSM1563701 rs140466753	632	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed
CA400688483 rs1197371682	633	G>E		No	ClinGen gnomAD
RCV000957647 CA8721179 rs141376042	636	V>I		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA8721182 rs761859483	645	I>V		No	ClinGen ExAC gnomAD
CA400688572 rs1377169489	647	N>S		No	ClinGen gnomAD
rs759461144 CA8721185	648	I>M		No	ClinGen ExAC gnomAD
CA8721184 rs751445956	648	I>T		No	ClinGen ExAC TOPMed gnomAD
CA8721183 rs765338275	648	I>V		No	ClinGen ExAC TOPMed gnomAD
rs767363000 CA8721186	649	D>E		No	ClinGen ExAC gnomAD
rs1412397562 CA400688594	650	Q>H		No	ClinGen gnomAD
rs752497956 CA8721187	651	S>F		No	ClinGen ExAC gnomAD
rs369070488 CA293182408 COSM983166	657	S>L	endometrium [Cosmic]	No	ClinGen cosmic curated ESP TOPMed gnomAD
rs753589948 CA8721190	659	V>A		No	ClinGen ExAC gnomAD
CA400688660 rs1258505958	660	N>S		No	ClinGen gnomAD
rs778547161 CA8721192	661	P>T		No	ClinGen ExAC gnomAD
rs745380001 CA8721193	662	Q>R		No	ClinGen ExAC gnomAD
rs1173120345 CA400688703	666	P>L		No	ClinGen gnomAD
CA8721195 rs373125445	667	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA400688705 rs373125445	667	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA8721197 rs747321782	668	L>F		No	ClinGen ExAC gnomAD
CA400688713 rs1173461311	668	L>S		No	ClinGen gnomAD
CA8721198 rs150241910	669	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1311799900 CA400688724	670	S>G		No	ClinGen gnomAD
rs538946868 CA8721199	670	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA400688732 rs1171007232	671	A>S		No	ClinGen TOPMed
rs773277158 CA8721201	672	V>A		No	ClinGen ExAC TOPMed gnomAD
CA400688742 rs1233714386	673	V>R		No	ClinGen gnomAD

No associated diseases with P17252

13 regional properties for P17252

Type	Name	Position	InterPro Accession
domain	C2 domain	158 - 277	IPR000008
domain	Protein kinase domain	339 - 597	IPR000719
domain	AGC-kinase, C-terminal	598 - 668	IPR000961
domain	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	36 - 87	IPR002219-1
domain	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	101 - 153	IPR002219-2
active_site	Serine/threonine-protein kinase, active site	459 - 471	IPR008271
binding_site	Protein kinase, ATP binding site	345 - 368	IPR017441
domain	Protein kinase, C-terminal	624 - 658	IPR017892
domain	Diacylglycerol/phorbol-ester binding	34 - 48	IPR020454-1
domain	Diacylglycerol/phorbol-ester binding	50 - 59	IPR020454-2
domain	Diacylglycerol/phorbol-ester binding	63 - 74	IPR020454-3
domain	Diacylglycerol/phorbol-ester binding	140 - 152	IPR020454-4
domain	Classical Protein Kinase C alpha, catalytic domain	328 - 668	IPR034663

Functions

		Description
EC Number	2.7.11.13	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Cell membrane ; Peripheral membrane protein Mitochondrion membrane ; Peripheral membrane protein Nucleus
PANTHER Family	PTHR24356	SERINE/THREONINE-PROTEIN KINASE
PANTHER Subfamily	PTHR24356:SF193	PROTEIN KINASE C ALPHA TYPE
PANTHER Protein Class	non-receptor serine/threonine protein kinase protein modifying enzyme
PANTHER Pathway Category	EGF receptor signaling pathway PKC CCKR signaling map PKCalpha Thyrotropin-releasing hormone receptor signaling pathway PKC Apoptosis signaling pathway PKCs Angiotensin II-stimulated signaling through G proteins and beta-arrestin PKC Gonadotropin-releasing hormone receptor pathway PKCs Alzheimer disease-amyloid secretase pathway PKC Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway PKC Alpha adrenergic receptor signaling pathway PKC Gonadotropin-releasing hormone receptor pathway PKCs(3) PDGF signaling pathway PKC Endothelin signaling pathway PKC Angiogenesis PKC 5HT2 type receptor mediated signaling pathway PKC FGF signaling pathway PKC VEGF signaling pathway PKC Histamine H1 receptor mediated signaling pathway PKC Muscarinic acetylcholine receptor 1 and 3 signaling pathway PKC Wnt signaling pathway Protein Kinase C Oxytocin receptor mediated signaling pathway PKC

10 GO annotations of cellular component

Name	Definition
alphav-beta3 integrin-PKCalpha complex	A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
mitochondrial membrane	Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

11 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium-dependent protein kinase C activity	Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
histone kinase activity (H3-T6 specific)	Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3.
integrin binding	Binding to an integrin.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein kinase C activity	Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
zinc ion binding	Binding to a zinc ion (Zn).

28 GO annotations of biological process

Name	Definition
angiogenesis	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
apoptotic signaling pathway	The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
desmosome assembly	A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
histone H3-T6 phosphorylation	OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
mitotic nuclear membrane disassembly	The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis.
negative regulation of glial cell apoptotic process	Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.
positive regulation of angiogenesis	Any process that activates or increases angiogenesis.
positive regulation of blood vessel endothelial cell migration	Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
positive regulation of bone resorption	Any process that activates or increases the frequency, rate or extent of bone resorption.
positive regulation of cardiac muscle hypertrophy	Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
positive regulation of cell adhesion	Any process that activates or increases the frequency, rate or extent of cell adhesion.
positive regulation of cell migration	Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of dense core granule biogenesis	Any process that activates or increases the frequency, rate or extent of dense core granule biogenesis.
positive regulation of endothelial cell migration	Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
positive regulation of endothelial cell proliferation	Any process that activates or increases the rate or extent of endothelial cell proliferation.
positive regulation of ERK1 and ERK2 cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of lipopolysaccharide-mediated signaling pathway	Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
positive regulation of macrophage differentiation	Any process that activates or increases the frequency, rate or extent of macrophage differentiation.
positive regulation of mitotic cell cycle	Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of mRNA stability	Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
regulation of platelet aggregation	Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
response to interleukin-1	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.

40 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P24583	PKC1	Protein kinase C-like 1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
P05128	PRKCG	Protein kinase C gamma type	Bos taurus (Bovine)	SS
P05126	PRKCB	Protein kinase C beta type	Bos taurus (Bovine)	SS
P04409	PRKCA	Protein kinase C alpha type	Bos taurus (Bovine)	EV SS
P13677	inaC	Protein kinase C, eye isozyme	Drosophila melanogaster (Fruit fly)	SS
P05130	Pkc53E	Protein kinase C, brain isozyme	Drosophila melanogaster (Fruit fly)	SS
O15530	PDPK1	3-phosphoinositide-dependent protein kinase 1	Homo sapiens (Human)	EV
Q05513	PRKCZ	Protein kinase C zeta type	Homo sapiens (Human)	SS
P41743	PRKCI	Protein kinase C iota type	Homo sapiens (Human)	EV
Q16512	PKN1	Serine/threonine-protein kinase N1	Homo sapiens (Human)	EV
Q6P5Z2	PKN3	Serine/threonine-protein kinase N3	Homo sapiens (Human)	SS
Q16513	PKN2	Serine/threonine-protein kinase N2	Homo sapiens (Human)	EV
P24723	PRKCH	Protein kinase C eta type	Homo sapiens (Human)	SS
Q02156	PRKCE	Protein kinase C epsilon type	Homo sapiens (Human)	SS
Q04759	PRKCQ	Protein kinase C theta type	Homo sapiens (Human)	PR
Q05655	PRKCD	Protein kinase C delta type	Homo sapiens (Human)	SS
P05129	PRKCG	Protein kinase C gamma type	Homo sapiens (Human)	SS
P05771	PRKCB	Protein kinase C beta type	Homo sapiens (Human)	SS
P31751	AKT2	RAC-beta serine/threonine-protein kinase	Homo sapiens (Human)	EV SS
P31749	AKT1	RAC-alpha serine/threonine-protein kinase	Homo sapiens (Human)	EV
Q9Y243	AKT3	RAC-gamma serine/threonine-protein kinase	Homo sapiens (Human)	SS
Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	Homo sapiens (Human)	SS
Q9HBY8	SGK2	Serine/threonine-protein kinase Sgk2	Homo sapiens (Human)	SS
O00141	SGK1	Serine/threonine-protein kinase Sgk1	Homo sapiens (Human)	PR
Q15208	STK38	Serine/threonine-protein kinase 38	Homo sapiens (Human)	EV
Q9Y2H1	STK38L	Serine/threonine-protein kinase 38-like	Homo sapiens (Human)	EV
Q6A1A2	PDPK2P	Putative 3-phosphoinositide-dependent protein kinase 2	Homo sapiens (Human)	PR
P63318	Prkcg	Protein kinase C gamma type	Mus musculus (Mouse)	SS
P68404	Prkcb	Protein kinase C beta type	Mus musculus (Mouse)	SS
P20444	Prkca	Protein kinase C alpha type	Mus musculus (Mouse)	SS
P16054	Prkce	Protein kinase C epsilon type	Mus musculus (Mouse)	PR
P23298	Prkch	Protein kinase C eta type	Mus musculus (Mouse)	PR
P68403	Prkcb	Protein kinase C beta type	Rattus norvegicus (Rat)	SS
P63319	Prkcg	Protein kinase C gamma type	Rattus norvegicus (Rat)	SS
Q64617	Prkch	Protein kinase C eta type	Rattus norvegicus (Rat)	PR
P05696	Prkca	Protein kinase C alpha type	Rattus norvegicus (Rat)	SS
P90980	pkc-2	Protein kinase C-like 2	Caenorhabditis elegans	SS
Q9SUA3	D6PKL1	Serine/threonine-protein kinase D6PKL1	Arabidopsis thaliana (Mouse-ear cress)	PR
A8KBH6	prkcb	Protein kinase C beta type	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	SS
Q7SY24	prkcbb	Protein kinase C beta type	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MADVFPGNDS	TASQDVANRF	ARKGALRQKN	VHEVKDHKFI	ARFFKQPTFC	SHCTDFIWGF
70	80	90	100	110	120
GKQGFQCQVC	CFVVHKRCHE	FVTFSCPGAD	KGPDTDDPRS	KHKFKIHTYG	SPTFCDHCGS
130	140	150	160	170	180
LLYGLIHQGM	KCDTCDMNVH	KQCVINVPSL	CGMDHTEKRG	RIYLKAEVAD	EKLHVTVRDA
190	200	210	220	230	240
KNLIPMDPNG	LSDPYVKLKL	IPDPKNESKQ	KTKTIRSTLN	PQWNESFTFK	LKPSDKDRRL
250	260	270	280	290	300
SVEIWDWDRT	TRNDFMGSLS	FGVSELMKMP	ASGWYKLLNQ	EEGEYYNVPI	PEGDEEGNME
310	320	330	340	350	360
LRQKFEKAKL	GPAGNKVISP	SEDRKQPSNN	LDRVKLTDFN	FLMVLGKGSF	GKVMLADRKG
370	380	390	400	410	420
TEELYAIKIL	KKDVVIQDDD	VECTMVEKRV	LALLDKPPFL	TQLHSCFQTV	DRLYFVMEYV
430	440	450	460	470	480
NGGDLMYHIQ	QVGKFKEPQA	VFYAAEISIG	LFFLHKRGII	YRDLKLDNVM	LDSEGHIKIA
490	500	510	520	530	540
DFGMCKEHMM	DGVTTRTFCG	TPDYIAPEII	AYQPYGKSVD	WWAYGVLLYE	MLAGQPPFDG
550	560	570	580	590	600
EDEDELFQSI	MEHNVSYPKS	LSKEAVSVCK	GLMTKHPAKR	LGCGPEGERD	VREHAFFRRI
610	620	630	640	650	660
DWEKLENREI	QPPFKPKVCG	KGAENFDKFF	TRGQPVLTPP	DQLVIANIDQ	SDFEGFSYVN
670
PQFVHPILQS	AV