P16911
Gene name |
Pka-C2 (DC1, CG12066) |
Protein name |
cAMP-dependent protein kinase catalytic subunit 2 |
Names |
Protein kinase DC1 |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG12066 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P16911
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P16911-F1 | Predicted | AlphaFoldDB |
No variants for P16911
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P16911 | |||||
No associated diseases with P16911
13 regional properties for P16911
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | B-box-type zinc finger | 95 - 136 | IPR000315 |
| domain | Zinc finger, RING-type | 16 - 61 | IPR001841 |
| domain | B30.2/SPRY domain | 293 - 482 | IPR001870 |
| domain | SPRY domain | 363 - 480 | IPR003877 |
| domain | Butyrophylin-like, SPRY domain | 309 - 326 | IPR003879-1 |
| domain | Butyrophylin-like, SPRY domain | 326 - 343 | IPR003879-2 |
| domain | Butyrophylin-like, SPRY domain | 348 - 372 | IPR003879-3 |
| domain | Butyrophylin-like, SPRY domain | 380 - 393 | IPR003879-4 |
| domain | Butyrophylin-like, SPRY domain | 423 - 447 | IPR003879-5 |
| domain | Butyrophylin-like, SPRY domain | 453 - 471 | IPR003879-6 |
| domain | SPRY-associated | 310 - 362 | IPR006574 |
| conserved_site | Zinc finger, RING-type, conserved site | 31 - 40 | IPR017907 |
| domain | Zinc finger, C3HC4 RING-type | 16 - 60 | IPR018957 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleotide-activated protein kinase complex | A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cAMP-dependent protein kinase activity | cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. |
| protein kinase A regulatory subunit binding | Binding to one or both of the regulatory subunits of protein kinase A. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| protein kinase A signaling | A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P00517 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Bos taurus (Bovine) | PR |
| Q8MJ44 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q03043 | for | cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B | Drosophila melanogaster (Fruit fly) | SS |
| P17612 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (Human) | PR |
| Q922R0 | Prkx | cAMP-dependent protein kinase catalytic subunit PRKX | Mus musculus (Mouse) | PR |
| P05132 | Prkaca | cAMP-dependent protein kinase catalytic subunit alpha | Mus musculus (Mouse) | PR |
| P36887 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Sus scrofa (Pig) | PR |
| O62846 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Macaca mulatta (Rhesus macaque) | PR |
| Q7JP68 | F47F2.1 | cAMP-dependent protein kinase, catalytic subunit-like | Caenorhabditis elegans | PR |
| P21137 | kin-1 | cAMP-dependent protein kinase catalytic subunit | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQHTSQYVF | NSKEDYNVIL | DNMSREFEER | WNHQTQSPYT | NLENYITRAV | LGNGSFGTVM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVREKSGKNY | YAAKMMSKED | LVRLKQVAHV | HNEKHVLNAA | RFPFLIYLVD | STKCFDYLYL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ILPLVNGGEL | FSYHRRVRKF | NEKHARFYAA | QVALALEYMH | KMHLMYRDLK | PENILLDQRG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YIKITDFGFT | KRVDGRTSTL | CGTPEYLAPE | IVQLRPYNKS | VDWWAFGILV | YEFVAGRSPF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AIHNRDVILM | YSKICICDYK | MPSYFTSQLR | SLVESLMQVD | TSKRLGNSND | GSSDVKSHPW |
| 310 | 320 | 330 | 340 | 350 | |
| FQGVDWFGIL | NQEVTAPYQP | TISGAEDLSN | FENFEFKDRY | KSRINRHPEL | FANF |